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Could an old antibiotic tame ulcerative colitis?

NCT ID NCT06201793

First seen Nov 18, 2025 · Last updated Jun 23, 2026 · Updated 22 times

Summary

This study tested whether adding the antibiotic minocycline to standard mesalamine treatment helps control mild-to-moderate ulcerative colitis. 46 adults took part. Researchers measured disease activity using a symptom score. The trial is complete, but results are not yet published.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Faculty of Medicine, Mansoura University

    Al Mansurah, 7650001, Egypt

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

minocycline (an antibiotic) added to standard mesalamine treatment

What this could lead to

If it works, adding minocycline could help control ulcerative colitis symptoms better than mesalamine alone.

What could go wrong

This is a small, early-phase trial with only 46 people. Results may not apply to everyone, and minocycline can cause side effects like dizziness or antibiotic resistance.

Conditions

The condition(s) this trial relates to.

inflammatory bowel disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.