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Cranberry power: could this berry boost gut health in Crohn's?

NCT ID NCT07170462

Disease control Sponsor: Ana Maldonado-Contreras Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study tests whether a daily cranberry supplement can help restore healthy gut bacteria in adults with Crohn's disease. Fifty participants will take either the cranberry supplement or a placebo for 10 weeks. Researchers will track changes in gut bacteria, inflammation, and symptoms through blood, urine, and stool samples. The goal is to find a simple, diet-based way to support gut health in Crohn's.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult CD patients between 18 and 65 years old. * Women of childbearing potential will be required to use at least one form of "highly effective" contraception throughout the study. * Confirmed diagnosis of Crohn's disease. * CD activity lower than sCDAI\<450. * Moderate to severely impaired Health Related Quality of life (HRQoL). sIBDQ score \<60. * Stable dose of medications at screening; thiopurines, natalizumab, methotrexate (12 weeks), anti-TNF, ustekinumab (8 weeks), vedolizumab (8 weeks), 5-ASA (2 weeks), * steroids (1 week). * Willingness and capacity to significantly consume the cranberry supplement daily. * Willing and able to comply with specimen collection and other study procedures, and to complete the study. * Able to provide written informed consent. * Reside in Massachusetts, USA. Exclusion Criteria: * Ostomy * Presence of symptomatic or significant stricture or history of obstruction in the past 6 months * Pregnancy * Use of Specific Carbohydrate Diet of IBD- AID within 4 weeks of screening * Use of probiotics within 4 weeks of screening * Use of antibiotics within 4 weeks of screening * \> 20mg prednisone or equivalent * Recent C. difficile colitis * Unable to provide informed consent for themselves * Prisoners * Children

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Crohn disease Crohn disease (CD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UMASS medical center

    RECRUITING

    Worcester, Massachusetts, 10655, United States

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