IRRITABLE BOWEL SYNDROME

This study tests an internet-based program called REACH for parents who have irritable bowel syndrome (IBS). The goal is to see if the program helps parents encourage healthy habits in their young children, potentially preventing future stomach problems. About 460 parents and the…

This study tests a simple, non-drug technique to reduce visible belly bloating in people with Irritable Bowel Syndrome (IBS) or indigestion. 100 adults who get visibly bloated after meals will be randomly assigned to learn special breathing exercises or take a placebo pill. The g…

This study tests whether a fecal transplant from a carefully selected donor can reduce symptoms in people with moderate to severe irritable bowel syndrome (IBS) who have diarrhea. The donor stool has low levels of certain proteins and contains a specific bacteria. The main goal i…

This study looks at whether a low FODMAP diet can ease symptoms and improve quality of life for people with moderate to severe irritable bowel syndrome (IBS) who do not have lactose malabsorption. Researchers will compare results to a lactose-free diet from a previous study. Abou…

This study tests whether a small, home-used device that gently stimulates a nerve in the ear can help young adults (ages 18-29) with irritable bowel syndrome (IBS) manage their pain and other symptoms. About 80 participants will use either the active device or a sham (fake) versi…

This study tests whether taking glutamine, a natural amino acid, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D) who also have a 'leaky gut.' Researchers will give 60 adults either glutamine or a placebo daily for 8 weeks and measure chang…

This study tests an investigational drug called brenipatide for adults with irritable bowel syndrome with diarrhea (IBS-D). About 531 participants will receive either the drug or a placebo as a shot under the skin. The goal is to see if it safely reduces daily abdominal pain and …

This study tests whether a daily oral glutamine supplement can reduce chronic stomach symptoms like pain, diarrhea, and bloating in veterans with Gulf War Illness. About 80 veterans will receive either glutamine or a placebo for 12 weeks. The goal is to see if glutamine improves …

This study tests whether psyllium, a common fiber supplement, can reduce belly pain and other symptoms in children with irritable bowel syndrome (IBS) when they eat foods containing fructans, a type of sugar. Researchers will enroll 110 children aged 12-17 who have IBS. Participa…

This study tests a new program called WISH, which uses positive psychology exercises to help people with irritable bowel syndrome (IBS). Researchers want to see if the program is easy to follow and if it can improve symptoms and well-being. About 50 adults with IBS will either ta…

This study tests whether a dietary supplement called DIELEN Protect, which contains glutamine and marine peptides, can improve symptoms in people with moderate to severe irritable bowel syndrome (IBS). About 100 adults with IBS will take either the supplement or a placebo daily f…

This study tests whether a daily synbiotic supplement (a mix of probiotics and prebiotics) can reduce IBS symptoms like belly pain, bloating, and irregular bowel habits. About 200 adults with moderate-to-severe IBS will take either the supplement or a placebo for 36 weeks. The go…

This study tests whether fecal microbiota transplantation (FMT) can reduce symptoms of irritable bowel syndrome (IBS). About 102 adults with IBS who haven't gotten better with standard treatments will receive FMT via capsules or a tube once a month for three months. Researchers w…

This study tests whether a supplement called Skål Pro, which contains a probiotic and a prebiotic, can help people with irritable bowel syndrome (IBS). Researchers will measure changes in symptoms, stool consistency, quality of life, and psychological distress in 60 adults with I…

This study tests whether eluxadoline can safely improve stool consistency in children aged 6 to 17 with irritable bowel syndrome with diarrhea (IBS-D). About 95 participants will receive either the drug or a placebo. The goal is to reduce loose stools and improve daily comfort.

This study is testing whether a single low dose of esketamine can reduce symptoms of irritable bowel syndrome (IBS) in 552 adults aged 18-60 who also have anxiety or depression. Participants will receive the drug during a colonoscopy, and their IBS severity and quality of life wi…

This study tests an experimental drug called brenipatide for adults with irritable bowel syndrome with constipation (IBS-C). About 342 participants will receive either the drug or a placebo injection under the skin for several weeks. The goal is to see if the drug safely improves…

This study compares two different exercise programs plus dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome (IBS). Thirty adults aged 30 to 65 with moderate to severe IBS and confirmed fibromyalgia will participat…

This study compares a diet app called DOMINO to the standard low FODMAP diet for people with Irritable Bowel Syndrome (IBS). About 110 adults with moderate to severe IBS will try one of the two diets to see if their symptoms improve. The goal is to find a simpler, app-based way t…

This study looks at whether regular cardiovascular exercise can reduce the severity of irritable bowel syndrome (IBS) symptoms in people who currently have a sedentary lifestyle. Researchers will enroll 30 adults with moderate-to-severe IBS and have them follow an endurance train…

This study tests whether avoiding foods identified by a skin patch test can relieve irritable bowel syndrome (IBS) symptoms. Adults with IBS receive painless patches on their back containing 80 different foods or additives. Those with positive reactions are randomly assigned to a…

This study is testing whether a special supplement called Vivatlac Synbiotic can help people with irritable bowel syndrome (IBS) by changing the bacteria in their gut. About 20 adults with moderate to severe IBS will take either the supplement or a placebo daily for 12 weeks. Res…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome can change the way the body processes certain drugs. Researchers will measure inflammation markers and immune cells in blood samples from 150 adults and children with …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study aims to see if a new online food questionnaire can accurately measure what people eat, including FODMAPs (certain carbs that can cause digestive issues). Researchers will compare the questionnaire to a standard 4-day food diary in 400 adults (ages 18-65) with and witho…

This study aims to collect medical information and biological samples (blood, urine, stool, and gut biopsies) from 2000 adults with functional digestive disorders like irritable bowel syndrome, indigestion, and constipation. The goal is to identify markers that could help diagnos…

This study is following 600 people with Irritable Bowel Syndrome (IBS) over time to learn more about how the condition changes and what factors affect it. Researchers will collect information on symptoms, lifestyle, diet, stress, and gut bacteria. No new treatments are being test…

This study checks if a new orally disintegrating tablet of Trimedat (76.95 mg) works the same as the standard 100 mg tablet in 36 healthy adults. Participants take both forms at different times to compare how the drug is absorbed and processed. The goal is to see if the new versi…

This study looks at why some people with alpha-gal syndrome (a meat allergy) get stomach pain, diarrhea, nausea, or vomiting after eating red meat. Researchers will give 30 adults pork with and without the allergy-triggering substance to see what happens inside their bodies. The …

This study looks at whether a simple breath test for lactose intolerance can predict if a lactose-free diet will improve symptoms in people with moderate to severe Irritable Bowel Syndrome (IBS). Researchers will compare symptom changes and quality of life between those who test …

This study looks at the gut bacteria of 40 people with irritable bowel syndrome (IBS) who have constipation and produce high methane. Researchers will collect stool and blood samples to understand the bacteria's role and how they change with standard treatment. The goal is to fin…

Objectives: This study aims to evaluate the clinical efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in patients with diarrhea-predominant irritable bowel syndrome (IBS-D), and to explore the potential underlying mechanisms by which rTMS alleviates clin…