IRRITABLE BOWEL SYNDROME

This study is testing if a drug called eluxadoline is safe and can help control symptoms in children and teenagers (ages 6-17) who have irritable bowel syndrome with diarrhea (IBS-D). Participants will take either the study drug or a placebo (a pill with no medicine) for 4 weeks …

This study is testing whether a fecal transplant from a carefully selected donor can help control symptoms of irritable bowel syndrome (IBS). It will involve 43 adults with moderate-to-severe IBS who have a specific gut protein activity. The main goal is to see if this procedure …

This study is testing whether a hydrogen/methane breath test can predict if people with moderate to severe Irritable Bowel Syndrome (IBS) will get better on a lactose-free diet. Researchers will enroll 90 IBS patients to see if the test results match their symptom improvement and…

This study is testing whether a treatment called fecal microbiota transplantation (FMT) can help people with irritable bowel syndrome (IBS) that hasn't improved with standard treatments. About 102 participants will receive healthy donor gut bacteria, given as capsules or through …

This study aims to see if a new, melt-in-your-mouth tablet of the drug Trimedat works the same way in the body as the existing tablet. It will involve 36 healthy volunteers who will take both forms of the drug at different times. The main goal is to check if the two forms are equ…

This study tests if an online program for parents with irritable bowel syndrome (IBS) can help prevent stomach pain in their young children. Researchers want to see if teaching parents strategies to promote child wellness can reduce risk factors for pain. About 460 parent-child p…

This study is testing if an over-the-counter supplement called glutamine can help reduce chronic stomach pain, diarrhea, and bloating in veterans with Gulf War Illness. Researchers will give 80 veterans either glutamine or a placebo pill for 12 weeks to see if it improves their s…

This study is testing whether a single, low dose of the medication esketamine can help reduce symptoms and improve quality of life for people with irritable bowel syndrome (IBS). Researchers will give the drug to about 550 adults with IBS who are scheduled for a colonoscopy and a…

This study is testing whether a 9-week positive psychology program delivered by phone can help people with irritable bowel syndrome (IBS). Researchers want to see if focusing on strengths and happiness exercises improves IBS symptoms and quality of life. The study will compare th…

This study aims to see which of two different exercise programs, when paired with dietary advice, works better to improve symptoms for people living with both fibromyalgia and irritable bowel syndrome (IBS). Thirty participants will try a combined exercise program (mixing cardio,…

This study is testing whether a simple, non-instrumental biofeedback technique can reduce visible abdominal bloating. 100 participants with meal-triggered bloating will be randomly assigned to either learn the biofeedback exercises or receive a placebo treatment. The goal is to s…

This study is testing whether a home-based device that gently stimulates a nerve in the ear can help young adults with Irritable Bowel Syndrome (IBS) manage their pain and other symptoms like anxiety and fatigue. Researchers will compare a real stimulation device to a fake one to…

This study is testing whether avoiding foods that cause a skin reaction can help people with irritable bowel syndrome (IBS). Participants get a patch test on their back to check for food allergies, then follow a special diet for 16 weeks. Researchers will compare symptom changes …

This study is testing whether regular cardiovascular exercise can help reduce symptoms for people with Irritable Bowel Syndrome (IBS) who have a sedentary lifestyle. Researchers will work with 30 adults with moderate IBS symptoms to see if a supervised exercise program improves t…

This study is testing if taking psyllium fiber with meals can help children with irritable bowel syndrome (IBS) eat foods containing fructans (like wheat and onions) without worsening their stomach pain, bloating, and gas. Researchers will measure changes in gut bacteria and gas …

This study is testing whether a daily capsule containing a blend of nine probiotic bacteria and a prebiotic fiber can improve gut bacteria and ease symptoms in people with moderate to severe irritable bowel syndrome (IBS). For 12 weeks, participants will take either the real caps…

This study is testing whether taking glutamine, a natural amino acid, can help reduce symptoms in adults with a specific type of irritable bowel syndrome (IBS-D). Researchers want to see if glutamine can improve gut health and ease symptoms like abdominal pain and diarrhea. The t…

This study is testing if a low FODMAP diet can improve symptoms and quality of life for people with moderate to severe Irritable Bowel Syndrome (IBS), specifically in those who do not have trouble digesting lactose. It will involve 60 participants who will follow the diet for 4 w…

This study is testing whether a daily capsule containing a mix of nine probiotic bacteria and a prebiotic fiber can help people with moderate to severe Irritable Bowel Syndrome (IBS). Over 36 weeks, researchers will compare the supplement to a placebo (a dummy pill) in 200 partic…

This study is testing whether a dietary supplement called DIELEN Protect can help reduce the symptoms of Irritable Bowel Syndrome (IBS). One hundred adults with moderate to severe IBS will take either the supplement or a placebo for eight weeks. Researchers will measure changes i…

This study aims to understand the connection between gut bacteria, methane gas production, and constipation in people with Irritable Bowel Syndrome (IBS). Researchers will analyze stool and blood samples from 40 adults with IBS-constipation who produce high levels of methane. The…

This study aims to understand how daily pain, mood, and activities are connected, especially as acute pain transitions to chronic pain. Researchers will enroll 800 people with acute pain, chronic pain, or no pain to use a smartphone app (SOMA) for four months to track their daily…

This study aims to test how reliable a new food questionnaire is for tracking what people eat, including FODMAPs. Researchers will compare the questionnaire to a standard 4-day food diary in 400 participants, including people with and without IBS. They will also look for connecti…

This study aims to better understand common, long-term digestive problems like irritable bowel syndrome (IBS) and chronic constipation. Researchers will collect health data and samples (like blood and stool) from 2,000 adult patients during their regular doctor visits. The goal i…

This study aims to understand how chronic inflammatory diseases like type 2 diabetes, irritable bowel disease, and kidney failure might change how the body processes medications. Researchers will collect blood samples and health records from 150 patients with these conditions to …

This study aims to better understand Irritable Bowel Syndrome (IBS) by closely following 600 people with the condition over several years. Researchers will collect detailed information about participants' symptoms, lifestyle, diet, and gut bacteria to learn what factors influence…

This study aims to understand why some people with alpha-gal syndrome get stomach pain, diarrhea, and nausea after eating red meat. Researchers will give 30 participants pork with and without the alpha-gal sugar in a blinded test to see which one triggers symptoms. They will coll…