Irritable bowel syndrome

Upper abdominal pain often comes from functional dyspepsia, irritable bowel syndrome, or uncomplicated gallstones. These conditions overlap and many patients do not know that tests and surgery may not help. Researchers are testing a personalized web-based education tool that expl…

This trial tests whether a combination of two common antihistamines, cetirizine and famotidine, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Participants take the antihistamines or a placebo for 30 days, then switch, so each person ser…

This study tests whether taking fecal microbiota transplantation (FMT) pills can improve symptoms of major depressive disorder (MDD) and irritable bowel syndrome (IBS). About 133 adults with MDD, with or without IBS, will either receive FMT or continue their usual treatment. Rese…

This study looks at whether using a 7-inch footstool while on the toilet can improve constipation symptoms. About 85 adults with chronic constipation will use either the real footstool or a very low sham stool for comparison. The goal is to see if the squatting position helps inc…

This study tests whether a probiotic called Bifidobacterium longum BBH016 can improve lower gut symptoms like abdominal pain, diarrhea, and bloating. 88 adults with these symptoms but no constipation will take either the probiotic or a placebo capsule twice daily for 8 weeks. Res…

This small pilot study is testing whether psilocybin (the active ingredient in magic mushrooms) given alongside psychotherapy can safely help adults with irritable bowel syndrome (IBS). Fourteen participants will receive two doses of 25 mg of psilocybin in a controlled setting. T…

This study tests whether the donor of a fecal transplant affects IBS symptoms. 500 patients with moderate-to-severe IBS will receive either a placebo (their own stool) or stool from one of three different donors, delivered via a tube into the small intestine. They will track symp…

This study tests a nutraceutical supplement made from pineapple and natural extracts in 94 adults with irritable bowel syndrome (IBS). Participants take the supplement or a placebo daily for 14 days. Researchers track symptom changes using questionnaires and stool tests to see if…

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical data, diet and lifestyle questionnaires, and biological samples to explore genetic, microbial, and environmental factors. The goal is t…

This pilot study aimed to see if a new care pathway could help family doctors better diagnose Irritable Bowel Syndrome (IBS) and decide when a specialist is needed. The study was withdrawn before any participants enrolled, so no results are available. It was designed for general …

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…