Painkiller dose during surgery may predict chronic pain months later

NCT ID NCT06374849

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether the dose of sufentanil, a strong painkiller given during non-major abdominal surgery, is linked to chronic pain 3 months after the operation. Researchers will interview 855 patients by phone to check for pain and its severity. The goal is to identify a risk factor that anesthesiologists can adjust to potentially lower the chance of long-term pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: sufentanil
What this could lead to: If successful, this could help anesthesiologists choose safer doses of sufentanil to reduce the chance of long-term pain after abdominal surgery.
What could go wrong: This is an observational analysis of existing data, not a controlled experiment. It may only show a link, not cause, and results may not apply to other surgeries or drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 855 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years old. * Non-major scheduled abdominal surgery. * Patient will receive Sufentanil intraoperatively for induction and maintenance of general anesthesia * Written or oral informed consent to participate in the study. Exclusion Criteria: * Intraoperative complications that are life-threatening or require the surgical procedure to be discontinued. * Repeat surgery at the same surgical site in less than 3 months. * Pregnancy. * Ambulatory surgery. * Endoscopic surgery. * Surgery with loco-regional or perimedullary anesthesia without general anesthesia * Intraoperative use of an opioid other than Sufentanil. * Hypersensitivity to sufentanil * Legally protected patients (under judicial protection, guardianship, curatorship). * Patients suffering from psychiatric pathologies. * Patients suffering from neurodegenerative pathologies. * Patients for whom self-assessment of pain using an numerical rating scale (0-10) is not feasible (language barrier, etc…)

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal surgery Chronic pain Chronic postsurgical pain Risk factors Sufentanil

Painkiller dose during surgery may predict chronic pain months later

What the study statuses mean