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Your genes may hold the key to predicting Post-Surgical pain

NCT ID NCT02383342

Knowledge-focused Sponsor: Radboud University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study aims to find out whether a person's genes and clinical profile can predict who will develop acute or chronic pain after major surgery. Researchers will follow 10,000 patients for one year after their operation, tracking pain levels and daily functioning. The goal is to identify biomarkers that could help doctors personalize pain treatment early, potentially preventing long-term suffering.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple test or checklist to predict a patient's risk of chronic pain after surgery, allowing doctors to personalize pain treatment early.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The genetic findings may be complex and require years of further research before they can be used in everyday care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2015

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All adult patients undergoing elective major surgery at Radboud university medical center (Nijmegen, The Netherlands) Patients will be recruited prospectively and consecutively via the anaesthetic preoperative outpatients' clinic.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients: * Ages 18 - 80 years, consenting, planned surgery, able to understand and answer questionnaires. Exclusion Criteria: * Non-consent, inability to give consent, unplanned and emergency surgery.

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Conditions

The condition(s) this trial relates to.

Acute Pain Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pain Chronic pain

Contacts and locations

Locations

  • Radboudumc

    Nijmegen, 6500HB, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.