Acute kidney injury

This study tests whether a personalized nursing program can prevent acute kidney injury (AKI) in people with liver cancer who undergo interventional therapy. Researchers first use a prediction model to classify patients into low, moderate, or high risk for AKI. Then, they provide…

This trial compares two sedatives—remimazolam and propofol—given during liver or pancreas surgery to see which better prevents acute kidney injury after the operation. The study includes adults aged 19 to 85 scheduled for elective hepatobiliary-pancreatic surgery. Researchers aim…

This study tests whether giving children an amino acid infusion during and after heart surgery can lower their risk of acute kidney injury and reduce time on a ventilator. About 30 children at high risk will receive either the amino acid or a placebo for up to 72 hours. The goal …

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study looks at whether changing the filter in a kidney dialysis machine more often than usual can lower the chance of new infections in critically ill patients with severe acute kidney injury. About 100 adults in intensive care will be randomly assigned to have their filter …

This study compares two blood thinners used during continuous dialysis in adults with sepsis and acute kidney injury. About 1,162 participants will receive either nafamostat mesylate or standard citrate anticoagulation. The main goal is to see which approach reduces death, ongoin…

This study looks at whether giving more protein (1.5-1.7 grams per kilogram per day) to critically ill patients with acute kidney injury who need continuous dialysis can reduce muscle wasting compared to standard protein intake (1.0-1.2 g/kg/d). About 56 adults will be randomly a…

This study compares a new, personalized way of giving a blood thinner (citrate) during kidney dialysis to the standard method. It involves 142 adults with acute kidney injury or advanced chronic kidney disease who also have liver failure or poor blood flow. The goal is to see if …

This study tests whether using a special ultrasound technique (mVExUS) to guide how much fluid is removed during dialysis can improve outcomes for critically ill patients with acute kidney injury. 126 adults in the ICU will be randomly assigned to either standard care or the ultr…

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a stan…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests a new pre-mixed fluid that contains phosphate for patients in the ICU who need continuous kidney replacement therapy (CRRT). The standard fluid often washes out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to the…

This study tests if temporarily restricting blood flow to an arm (called ischemic preconditioning) before kidney cancer surgery can reduce kidney damage. About 174 adults having partial nephrectomy will be randomly assigned to receive this technique or standard care. The goal is …

This study looks at whether giving vitamin C through a vein can help very sick patients with liver failure and severe infections recover from kidney injury. About 110 patients will get either standard care alone or standard care plus vitamin C. The goal is to see if vitamin C hel…

This study tests a new way to guide fluid treatment in patients with septic shock (a severe infection causing low blood pressure). The goal is to see if using a non-invasive arm cuff to measure blood flow pressure can help doctors give the right amount of fluids to prevent acute …

This study tests whether giving amino acids (protein building blocks) through a vein can help prevent or reduce acute kidney injury in adults on ECMO life support in the ICU. About 40 participants will receive either amino acids or a placebo. The goal is to see if this simple tre…

This study tests whether the investigational drug QRX-3 can help hospitalized children and adults with acute tubular necrosis, a type of sudden kidney failure. About 500 participants will receive either QRX-3 or a placebo alongside standard care. The main goal is to see if QRX-3 …

This study tests whether giving intravenous fluids and a blood-pressure-raising drug (norepinephrine) together early can prevent acute kidney injury in adults with septic shock. Researchers will treat 100 patients in the ICU or emergency department and monitor kidney function and…

This study tests whether taking folic acid (vitamin B9) daily for 90 days can lower the risk of death within one year for adults with acute kidney injury caused by infections. About 382 participants will either receive folic acid plus standard care or standard care alone. Researc…

This study compares two intravenous fluids—human albumin and saline—to see which better resolves acute kidney injury in people with decompensated cirrhosis. About 114 adults with moderate to severe kidney damage will receive either treatment. The goal is to improve kidney functio…

This study compares two drugs, terlipressin and somatostatin, in 64 adults with liver cirrhosis who have acute gastrointestinal bleeding and acute kidney injury. Both drugs are given intravenously for up to 5 days. The main goal is to see which drug better reverses kidney injury.…

This study tests whether the drug aminophylline can protect the kidneys of children receiving cisplatin chemotherapy. Twenty-four children will be randomly assigned to receive either aminophylline or a placebo alongside their standard chemo hydration. Researchers will measure kid…

This study tests whether N-Acetylcysteine (NAC), a common supplement, can protect kidney function in cancer patients receiving cisplatin chemotherapy. 72 adults will take either NAC or a placebo for seven days around their chemo session. Researchers will measure kidney injury mar…

This trial tests a new drug called QRX3 in 3,000 people with chronic kidney disease whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow the need for dialysis. Participants take QRX3 capsules, and researchers measure changes in kidne…

This study tests a special dialysis machine, the MultiFiltratePRO, in children with acute kidney failure. The goal is to see if it can deliver at least 80% of the prescribed treatment within 72 hours while being safe. About 43 children weighing between 8 and 40 kilograms will be …

This study tests a wearable device that continuously measures kidney function in ICU patients with acute kidney injury (AKI). The device uses a fluorescent tracer and a chest patch to track GFR in real time. Researchers will compare its accuracy to standard lab tests in 50 adults…

This study will test whether a kidney ultrasound and a urine test can predict acute kidney injury in people with sepsis. Researchers will measure kidney blood flow and specific urine markers in 130 adults shortly after sepsis diagnosis. The goal is to see if these tests can spot …

This study tests whether a simple blood test called the Systemic Immune Inflammation Index (SII) can help diagnose and predict acute kidney injury (AKI) in people with liver cirrhosis. AKI is a common and serious complication in cirrhosis, but current tests are often unreliable. …

This study will test a new handheld device that measures creatinine (a kidney health marker) from a fingerstick blood sample at home. Researchers will compare its accuracy to standard lab tests and ask 200 adults with kidney disease to try the device and rate how easy it is to us…

This study tests a new computer tool that helps doctors figure out the cause of acute kidney injury (AKI) in hospitalized veterans. AKI is common and serious, but its cause can be hard to diagnose quickly. The tool uses rules and artificial intelligence to guide doctors toward th…

This study tests whether an experimental drug called SP16 can prevent acute kidney injury in people with chronic kidney disease who are having heart surgery with a heart-lung machine. About 120 participants will be randomly assigned to receive either SP16 or a placebo, and neithe…

This study tests whether a drug called recombinant human brain natriuretic peptide (rhBNP), given continuously during and after heart surgery, can prevent acute kidney injury. It includes 694 high-risk adults undergoing elective heart surgery with a heart-lung machine. Participan…

This study tests if giving a simple amino acid infusion during heart surgery can prevent acute kidney injury, a common complication. Researchers will measure kidney damage markers in the urine of 130 adults before and after surgery. Half will receive standard care, and the other …

This study tests whether giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in high-risk patients. AKI is a common and serious complication after heart surgery with no approved prevention. The trial will include 330 adults undergoing elective h…

This study tests whether giving a common antibiotic (TMP/SMX) to adults who recently had acute kidney injury can prevent infections after they leave the hospital. About 120 participants will receive either the antibiotic or a placebo for 90 days. The goal is to see if this approa…

This study looks at how well a specific kidney filter (multiFlux 160) works when used with two different blood thinners—heparin or citrate—during continuous kidney replacement therapy. The goal is to see which approach keeps the filter working effectively while avoiding side effe…

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having bypass or valve surgery will be enrolled. Researchers will measure kidney injury markers and track how much fluid is given, ai…

This study will observe 128 critically ill patients with acute kidney injury who need dialysis to remove excess fluid. Researchers want to understand why some patients become unstable during fluid removal. They will monitor heart function, blood flow, and other signs before and d…

This study will check if a simple ultrasound of the neck vein, done before and right after anesthesia, can predict low blood pressure during surgery and kidney injury afterward. Researchers will observe 150 adults having major abdominal surgery. The goal is to see if changes in t…

This study will follow 200 adults hospitalized with upper gastrointestinal bleeding to see how many develop acute kidney injury. Researchers will also look for factors that make kidney damage more likely, such as the cause of bleeding. No new treatments are being tested—patients …

This pilot study tests whether a structured discharge summary template and a chat-based educational messaging program can improve care transitions for adults leaving the hospital after acute kidney injury (AKI). Researchers will enroll 160 adults with moderate-to-severe AKI and c…

This study will collect information from 100,000 critically ill patients worldwide who receive continuous renal replacement therapy (CRRT), a type of kidney dialysis, in intensive care units. Researchers want to understand how CRRT is used and how it affects patient survival and …

This study looks at how changes in blood pressure during the start of anesthesia and throughout surgery may affect the risk of kidney injury after non-cardiac surgery. Researchers will review medical records from 5,000 adults to find patterns. The goal is to better understand how…

This study tests whether a machine-learning tool built into electronic health records can help doctors reduce kidney injury after surgery. Over 25,000 adults having non-emergency surgery will take part. Doctors are randomly assigned to see the tool's risk prediction, see it with …

This study follows 412 patients who survived severe acute kidney injury in the ICU to see if two biomarkers (galectin-3 and CD146) can predict future heart attacks, strokes, kidney failure, or death. Researchers will track patients' health through phone interviews and medical rec…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study will test whether using a special ultrasound technique called VeXUS to guide fluid treatment can help protect kidney function in 100 ICU patients with acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and lasting kidney damage. Th…

This study looks at how sex hormones from gender-affirming therapy change kidney function. Researchers will measure kidney performance, blood flow, and insulin sensitivity in 60 transgender people before and after one year of hormone treatment. The goal is to understand why men a…

This study will observe 50 children (ages 1 month to 18 years) who come to the emergency room with kidney-related symptoms like swelling, blood in urine, or high blood pressure. Researchers want to learn which kidney diseases are most common and how children respond to initial tr…

This study examines whether blood electrolyte levels are linked to kidney damage in people who have a stroke and undergo a clot-removal procedure. Researchers will review medical records from 250 patients treated between 2018 and 2026. The goal is to identify risk factors that co…

This study looks at how certain metabolic changes in the body might help predict kidney injury after heart surgery. Researchers will study 540 high-risk patients to find patterns that could warn doctors early. The goal is to improve patient safety and outcomes by catching kidney …

This study aims to find early warning signs of acute kidney injury in children admitted to the intensive care unit. Researchers will monitor 100 children, tracking their medical history, daily fluid intake, urine output, and lab tests. The goal is to identify which risk factors—l…

This study will follow 30 runners in the Western States Endurance Run, a 100-mile race, to see how their kidneys handle the extreme stress. Researchers will use sensitive urine tests to detect early signs of kidney injury and test whether a sodium bicarbonate supplement can help.…

This study looks at whether the way you sleep before heart surgery is connected to problems like confusion (delirium) or kidney damage after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to find patterns that …

This study tracks 120 adults having heart surgery to see if continuous monitoring of blood pressure and brain oxygen levels can predict problems like confusion, memory loss, or kidney injury afterward. Researchers will measure how long and how severely these levels drop during su…

This early-stage study tests whether a new formulation of the antibiotic polymyxin B (VRP-034) is safer for the kidneys than the current version. It involves 48 healthy adult men who will receive one or more doses of either the new or standard drug. Researchers will measure kidne…

This study will develop a computer model that uses machine learning to predict a patient's risk of developing acute kidney disease after heart surgery. Researchers will collect data from 820 adults undergoing certain heart procedures to build and test the model. The goal is to cr…

This study looks at how acute kidney injury (AKI) impacts the process of removing a breathing tube (weaning) in critically ill adults in the ICU. Researchers will track 85 patients to see if AKI makes weaning harder, slower, or more risky. The goal is to learn whether kidney prob…

This study looks at two ways of giving fluids during liver surgery: one that limits fluids and one that gives more. The goal is to see which approach leads to fewer serious problems after surgery, especially kidney injury. About 90 adults having planned liver surgery will take pa…

This study will follow 1000 kidney transplant patients for one year to see if monthly blood tests for certain viruses (CMV, BK, and TTV) can help predict and prevent serious infections and kidney damage. The goal is to learn how the body's immune system and virus levels relate to…

This study looks at how the blood thinner enoxaparin works in critically ill ICU patients with kidney failure, some on dialysis and some not. Researchers will measure drug levels in the blood over 24 hours after a daily shot. The goal is to see if current dosing is enough to prev…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will follow 120 critically ill adults in the ICU to see if the amount of fluid they receive in the first 48 hours is linked to developing acute kidney injury (AKI). Researchers will track fluids hourly and check kidney function for up to 7 days. The goal is to find pat…

This study will collect blood, urine, stool, voice recordings, and other data from 3000 adults having planned heart surgery. Researchers will analyze this information to find markers that could predict complications like delirium, bleeding, kidney injury, and irregular heartbeat.…

This study looks at whether the ratio of C-reactive protein to albumin (CAR) in the blood can help predict acute kidney injury in people with acute pancreatitis. Researchers will measure CAR in 150 adults admitted to Assiut University Hospitals and see how it relates to kidney pr…

This study aims to develop and test artificial intelligence (AI) tools to help doctors prescribe and deliver acute dialysis better for patients in intensive care. Researchers will analyze data from 7,500 patients to create algorithms that can predict the best treatment approaches…

This study looks at whether combining two blood markers—uric acid/albumin ratio and lactate—can help predict which older adults (65+) with sepsis will develop kidney injury, need blood pressure support, or die within 28 days. Researchers will follow 80 ICU patients who do not hav…

This study looks at whether levels of a protein called uromodulin in the blood can help predict how well kidneys recover in adults with sepsis-related acute kidney injury. Researchers will measure uromodulin at the start, after one week, and at hospital discharge in 30 patients. …

This study will take small kidney tissue samples from 42 liver transplant patients who have hepatorenal syndrome (HRS), a condition where the kidneys stop working properly due to severe liver disease. Researchers want to see if the kidneys are actually damaged or just temporarily…

This study tests whether an AI model (ChatGPT-5) can help doctors make better decisions for critically ill patients in the intensive care unit (ICU). About 1000 adults admitted to the ICU will be randomly assigned to standard care or care where the AI provides diagnostic and trea…

This study will check if a tool called the STARZ score can accurately predict acute kidney injury in newborns admitted to the NICU. Researchers will enroll 140 infants and compare the score's predictions to standard tests. If validated, this simple score could help doctors identi…

This study looks at 1,000 older adults (60+) who fall and lie on the floor for over an hour, developing a condition called rhabdomyolysis. Researchers want to create a risk prediction model to identify who will develop serious outcomes like kidney failure or death. The goal is to…

This study looks at data from over 44,000 patients to find the best way to manage blood pressure during surgery and prevent kidney damage. Researchers will build a computer model that predicts a safe blood pressure target for each individual patient. The goal is to give doctors a…

This study tests a structured shared decision-making program for family members of ICU patients with acute kidney injury who need urgent dialysis. One hundred family members will be randomly assigned to receive either the program or standard care. Researchers will measure decisio…