ALZHEIMER DISEASE

This early-phase study tests whether using ultrasound to temporarily open the blood-brain barrier is safe when combined with an anti-inflammatory drug (etanercept) in people with mild Alzheimer's disease. The goal is to help the drug reach the brain more effectively. Only 5 parti…

This study tests whether a special light and sound device used at home for 6 months can help people with mild Alzheimer's. The device uses a 40Hz frequency to boost brain waves, which in animal studies reduced harmful protein buildup and improved memory. Researchers will measure …

This study tests bumetanide, a widely used water pill for high blood pressure, in 40 people with mild Alzheimer's. Researchers want to see if it is safe and might help slow the disease. Participants will take the drug or a placebo for several months, and their thinking, memory, a…

This study follows 120 people with early Alzheimer's disease or mild cognitive impairment who are taking lecanemab, a new FDA-approved drug that targets harmful protein clumps in the brain. Researchers will track changes in memory, daily function, and brain scans over 18 months. …

This early study tests whether a robotic system can safely perform microsurgery on deep neck lymph nodes in people with mild to moderate Alzheimer's disease. The goal is to see if the procedure is safe and possible, not yet to treat the disease. About 15 participants aged 50 and …

This study tests whether a supplement called CMA2 can improve brain function in people with Alzheimer's disease. About 845 adults aged 50 and older will take either CMA2 or a placebo twice a day for 26 weeks. The goal is to see if the supplement slows down memory and thinking pro…

This study compares two diets—a low-carb (ketogenic) diet and a low-fat diet—in 120 adults with mild cognitive impairment (early memory loss). Participants follow their assigned diet for 16 weeks, then return to normal eating. Researchers measure changes in thinking skills, brain…

This study tests a new drug called LY3954068 in people with early Alzheimer's disease. The main goal is to see if it is safe and how it affects the body. Participants will get either the drug or a placebo injected into their spinal fluid. The study lasts up to 100 weeks and invol…

This study tests whether siponimod, a drug already used for multiple sclerosis, can safely slow brain shrinkage in people with mild Alzheimer's disease. About 105 participants will receive either the drug or a placebo for 12 months, then be monitored for another 6 months. The mai…

This early-stage study tests a new drug called LY4006895 in healthy people and those with early Alzheimer's. The main goal is to check if the drug is safe and how the body processes it. The study has two parts: a single dose in healthy volunteers and multiple doses in Alzheimer's…

This early study tests a new surgical procedure that connects lymph nodes in the neck to veins, aiming to help the brain drain harmful proteins linked to Alzheimer's. Ten people with mild-to-moderate Alzheimer's will receive the surgery and be monitored for safety and any changes…

This study tests whether adding near-infrared light therapy to the drug lecanemab can safely improve thinking and memory in people with mild Alzheimer's disease. About 20 adults aged 50–90 will receive either real light therapy or a sham device along with lecanemab for 16 weeks, …

This study tests whether a device called ExAblate can safely and effectively open the blood-brain barrier in people with Alzheimer's disease. The barrier normally protects the brain but also blocks many treatments. By temporarily opening it, doctors hope to improve drug delivery.…

This study tests whether the drug fasudil can improve memory and thinking in people with early Alzheimer's disease. About 200 participants will receive either fasudil or a placebo for 12 months. Researchers will measure changes in memory, brain activity, and blood markers to see …

This study is for people with Alzheimer's disease who have already taken part in a previous SNK01 study. It will test the long-term safety of SNK01, a potential treatment, and look for early signs it might help with thinking and memory. About 30 participants will receive the trea…

This early-stage study tests whether a drug called NIO752 can reduce the brain's production of tau, a protein that forms harmful tangles in Alzheimer's disease. Ten adults with mild to moderate Alzheimer's will receive either the drug or a placebo via spinal injection. The main g…

This study tests whether sargramostim, a drug already approved for bone marrow stimulation, is safe and effective for people with mild-to-moderate Alzheimer's disease. Over six months, 42 participants will receive either the drug or a placebo. Researchers will track side effects …

This study tests a new drug, LHP588, in 300 people with mild to moderate Alzheimer's disease who also have a mouth infection called P. gingivalis. The drug targets the bacteria, hoping to slow down memory loss and other symptoms. Participants take a daily capsule for up to 48 wee…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can slow down cognitive decline in people with early Alzheimer's disease. Researchers will treat 55 participants with either real or sham rTMS over 24 we…

This study tests whether benfotiamine, a form of vitamin B1, can safely slow the progression of early Alzheimer's disease. About 406 people with mild cognitive impairment or mild dementia due to Alzheimer's will receive either the drug or a placebo for up to 72 weeks. The goal is…

This study tests an experimental drug, senicapoc, in people with mild or early Alzheimer's disease. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks. This is an early-phase …

This study tests a drug called NPC-1 (made of two compounds) in 40 adults aged 55+ who have Alzheimer's disease, mild cognitive impairment, or subjective memory concerns. The goal is to see if NPC-1 is safe and can improve blood markers related to Alzheimer's brain changes. Parti…

This study looks at whether adding the drug donanemab to standard care helps people with early Alzheimer's stay independent longer. About 6,250 participants will be followed for over 5 years in real-world clinics. The goal is to see if donanemab slows the need for daily help or n…

This study will follow 400 people with early Alzheimer's disease who are taking lecanemab, a drug that removes amyloid plaques from the brain. Researchers want to see if simple blood tests can track the drug's effects as accurately as brain scans. The goal is to make monitoring e…

This study is testing an experimental drug called ARO-MAPT-SC in healthy volunteers and people with early Alzheimer's disease. The goal is to see if the drug is safe and how the body processes it. The drug works by targeting a protein linked to Alzheimer's, with the hope of slowi…

This study tests whether the sleep aid lemborexant can lower levels of amyloid-beta and tau proteins in the blood—proteins linked to Alzheimer's disease. Researchers will enroll 201 healthy adults aged 65 and older. Participants will take either lemborexant or a placebo to see if…

This study is testing whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 people aged 55 to 89 will take rapamycin for 12 months. Researchers will monitor side effects and check if the drug reaches the…

This study is looking for a simple, non-invasive way to diagnose Alzheimer's disease by testing tears. Researchers will collect tear samples from 90 participants (people with Alzheimer's and healthy volunteers) to measure specific proteins and fats. If successful, this could repl…

This study tests whether a special PET scan tracer called [18F]PI-2620 can accurately detect tau protein buildup in the brains of people with Alzheimer's disease. About 200 adults aged 50 and older with a life expectancy of one year or less will receive the scan during life, and …

This study tests a new MRI technique to measure how cerebrospinal fluid (CSF) flows in the brain. Researchers will compare CSF flow in healthy people and those with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understa…

This study is looking for early warning signs of Alzheimer's disease in 6,000 older adults in China. Researchers will collect samples of body fluids, genes, and brain images to create a test that can diagnose Alzheimer's early and predict who might develop it within 5 years. The …

This study aims to see if a newer type of brain scan (Tau-PET) can improve doctors' ability to diagnose Alzheimer's disease compared to a standard scan (Amyloid-PET). Researchers will enroll 120 adults aged 50-85 with mild memory or thinking problems. Participants will receive bo…

This study aims to see if Alzheimer's disease can be detected by measuring specific proteins (amyloid and tau) in stool samples. Currently, diagnosis often happens late and requires invasive or expensive tests. Researchers hope this simple, non-invasive method could lead to earli…

This study tests a single dose of AMDX-2011P, a dye injected into the blood, to see if it can safely detect Alzheimer's-related amyloid in the retina. 25 adults with confirmed Alzheimer's will receive the dye and undergo eye imaging. The goal is to find a simpler, less invasive w…

This study is testing a new digital platform that uses simple, non-invasive tools like EEG, eye-tracking, and blood flow sensors to find early signs of Alzheimer's disease. It will include 100 people aged 55 to 80, some with mild memory problems and some healthy. The goal is to c…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults, including healthy volunteers and those with memory problems, using a high-sensitivity scanner…

This study tests whether smartphone usage patterns can help diagnose Alzheimer's disease and memory problems. Researchers will track how 90 people with different levels of memory loss use their phones for three months. The goal is to see if phone data can serve as a simple, non-i…

This study is testing whether a blood test (Quest AD-Detect) can help doctors identify Alzheimer's disease in patients aged 60-90 who are hospitalized with confusion or delirium. The goal is to see if the test can tell the difference between Alzheimer's and other causes of cognit…

This study is testing whether a new blood test can accurately diagnose the cause of memory problems, potentially replacing the need for a spinal tap. Researchers will compare blood test results with standard spinal fluid tests in 1,200 people at a memory clinic. If successful, it…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the eyes of 930 adults aged 30 and older, including those with these conditions and health…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during a hospital stay. One program uses hospital staff, while the other also involves family members or care partners. The goal is to see which approach works better to reduce confus…

This study looks at whether regular aerobic exercise can help prevent Alzheimer's disease and related dementias in older adults who are at higher risk. Researchers will enroll 264 inactive men and women aged 50-80 with mild memory concerns but no dementia. Participants will be as…

This study looks at whether different types of exercise can improve brain health and reduce the risk of Alzheimer's disease in older African Americans. Researchers will compare a cardio-dance fitness program to a strength, flexibility, and balance program over six months. Partici…

This study tests whether levetiracetam, a seizure medication, can prevent epileptic seizures in adults over 40 with Down syndrome who also have Alzheimer's disease. 120 participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop se…

This study tests a natural omega-3 supplement (ALA) in 20 older adults with mild memory problems and a genetic risk for Alzheimer's (APOE4). The goal is to see if ALA can protect the brain's blood vessels and barrier, potentially slowing or preventing further memory decline. Part…

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study tests whether the sleep aid suvorexant can slow the buildup of a protein called amyloid in the brain, which is linked to Alzheimer's disease. About 200 healthy adults aged 65 and older will take either the drug or a placebo for a period of time. Researchers will measur…

This study tests whether a 6-week home-based virtual reality program, guided remotely by a therapist, can improve memory, attention, and social skills in adults aged 40-80 with early memory concerns. Participants will be randomly assigned to either the VR program or traditional p…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) can improve memory and thinking in older adults who have noticed memory changes and have a family history of Alzheimer's disease. About 30 people aged 55 to 70…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—lack of interest or motivation—is common and disabling. The study includes 10 participants, some already taki…

This study tests an oral medication called IGC-AD1, made from a cannabis compound (THC), to see if it safely reduces agitation in people with mild to severe Alzheimer's dementia. About 164 participants will take the drug or a placebo twice daily for several weeks. The goal is to …

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with cognitive training can improve thinking skills and mood in people with mild cognitive impairment or early dementia. Fifty participants will receive both real and placebo stimulation in two sepa…

This study tests whether playing soft sounds during deep sleep can improve memory and slow cognitive decline in older adults. Sixty people aged 60-85 with mild memory problems will use a home device for 4 weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests whether a common painkiller (oxycodone with acetaminophen) can safely ease moderate to severe chronic pain in people with Alzheimer's disease. Ten participants will take the medication daily for 12 weeks, and researchers will monitor pain levels, quality of life,…

This study tests a new, non-invasive brain stimulation technique that combines magnetic and electrical pulses to target brain networks involved in memory. Researchers will enroll 60 people with mild Alzheimer's to see if this approach can improve thinking and daily function. The …

This study tests whether personalized, virtual music therapy sessions can boost memory and mood in people with mild Alzheimer's disease or mild cognitive impairment. Sixty participants will receive two 30-minute music sessions per week for 8 weeks. Researchers will measure change…

This study tests whether combining an NMDA-enhancing drug with an antioxidant can improve thinking and memory better than the NMDA drug alone. Researchers will enroll 80 people with early Alzheimer's or mild cognitive impairment. Participants will take the combination for 24 week…

This study tests a learning technique called structured retrieval practice (SRP) to help family caregivers of people with dementia. About 65 caregivers will be randomly assigned to learn caregiving and stress-management strategies using SRP or traditional reading. The goal is to …

This study tests whether nabilone, a synthetic cannabinoid, can safely reduce agitation in people with Alzheimer's disease. Agitation is common and distressing, with few effective treatments. About 112 participants will receive either nabilone or a placebo for 8 weeks, and resear…

This study tests whether people with mild Alzheimer's disease can learn skills to avoid falling after being exposed to controlled trips and slips in a lab. Researchers will measure how many participants fall during training and track real-life falls afterward. The goal is to impr…

This study tests a remote education program called Tele-Savvy for Latino caregivers of loved ones with Alzheimer's or dementia. The program includes weekly group sessions and videos to help caregivers feel more confident and less stressed. Researchers want to see if it improves c…

This study tests an oral medication (BMS-986368) to reduce agitation in people with Alzheimer's disease. About 120 participants will receive either the drug or a placebo. The main goal is to see if the drug can decrease agitated behaviors like restlessness or aggression, as measu…

This study tests an investigational drug called KarXT to see if it can safely reduce psychosis symptoms like hallucinations and delusions in people with Alzheimer's disease. The trial involves 406 adults aged 55 to 90 with mild to severe Alzheimer's and moderate to severe psychos…

This study tests the long-term safety of an experimental drug combination (KarXT) for treating agitation in people with Alzheimer's disease. About 600 participants who completed earlier studies will take the drug and be monitored for side effects. The goal is to see if the drug r…

This study tests a special hearing program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and confusion, and lessen the stress on caregivers. About 300 p…

This study tests whether vestibular therapy—exercises for the inner ear balance system—can reduce falls in people with Alzheimer's disease. About 100 older adults with mild to moderate Alzheimer's and balance problems will receive either the therapy or a control activity. Researc…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 participants will receive either caffeine pills or a placebo (dummy pill) to see if caffeine helps keep their minds sha…

This study explores whether intensive singing lessons can improve thinking skills and mood in people with early-stage Alzheimer's. About 113 adults aged 65 and older from Norway, Austria, and Argentina will take part. They will receive 5 months of twice-weekly music training and …

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, have MRI brain scans, and complete memory and physical te…

This study tests whether a mobile app called Brain CareNotes can reduce the stress and burden felt by unpaid caregivers of people with Alzheimer's disease. The app provides tips and support to help manage difficult behaviors like agitation or confusion. Researchers will enroll 18…

This study tests a non-invasive magnetic stimulation technique on the cerebellum to see if it can improve cognitive function and quality of life in people with mild Alzheimer's disease. Researchers will enroll 100 adults aged 50-85 who have mild Alzheimer's and stable medication.…

This study tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults with Alzheimer's-related agitation will receive either the drug or a placebo. The main goal is to see if agitation scores impro…

This study tests whether exercising to beat-accented music helps older adults with memory concerns stay active and improve thinking skills. Eighty participants aged 65+ will do strength and aerobic training for 6 months, some with music and some without. Researchers will track ph…

This study explores whether group drumming can help reduce pain and improve well-being in people with early Alzheimer's or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will take part in community drum circles while researchers measure pain…

This study tests a new drug called NSC001 in 90 people with mild to moderate Alzheimer's disease. The main goal is to see if the drug is safe and tolerable. Researchers will also explore if it helps with memory and thinking. Participants will be randomly assigned to receive eithe…

This early study tests whether low-intensity focused ultrasound (LIFU) can safely stimulate brain activity in people with mild cognitive impairment caused by Alzheimer's disease. Fifteen participants aged 45-85 will receive the non-invasive treatment while researchers monitor sid…

This early-phase study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The main goal is to see if depres…

This study tests a non-invasive brain stimulation method called tACS in 200 people with Alzheimer's, Lewy body dementia, or frontotemporal dementia. Participants receive either real or sham stimulation four times daily to see if it improves memory and thinking. The goal is to fin…

This study tests a new synbiotic formula (SCV09) in 30 people with Alzheimer's disease to see if it can improve dementia-related behavior and thinking. Participants take the supplement for a period while their symptoms and gut health are monitored. The goal is to gather early evi…

This study is testing the safety of a treatment called Transcranial Pulse Wave Stimulation (TPS) for people with Alzheimer's disease. Researchers will monitor 100 participants for side effects and see if the treatment helps with memory and daily function. The goal is to improve t…

This study tests a text message program called CuidaTEXT for Latino caregivers of relatives with Alzheimer's disease. About 288 caregivers will receive texts with tips on care, self-care, and support, or no texts. Researchers will check if the texts help reduce depressive symptom…

This study tests whether a non-invasive device that sends a mild electrical current to the brain (tDCS) can improve mood, reduce apathy, and ease other emotional symptoms in people with Alzheimer's disease. Participants use the device at home for 30-minute sessions. The study inv…

This study tests whether CBD capsules can safely reduce agitation in people with Alzheimer's disease. About 40 participants aged 55 and older will receive either CBD or a placebo, then switch. Researchers will also look for biological markers that predict who benefits most.

This study tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in adults with Alzheimer's disease. About 352 participants will receive either the drug or a placebo, and researchers will measure changes in agitation levels after 14 weeks. The g…

This early-stage study tests whether a non-invasive brain stimulation technique called deep rTMS can safely improve memory in people with mild-to-moderate Alzheimer's disease. Researchers will compare active stimulation to a placebo in 54 older adults, using memory tests, brain s…

This study tests an online education and skill-building program for people aged 60+ with early-stage dementia or mild cognitive impairment who live alone. Participants join Zoom sessions to learn ways to reduce stress, improve well-being, and plan for the future. The goal is to s…

This study looks at whether adding acupuncture to standard Alzheimer's medication (Donepezil) can improve memory, thinking, and daily living skills. Researchers will compare two groups of 90 people each over 12 weeks. The goal is to see if the combination works better than medica…

This study looks at whether eating only during a 10-hour daytime window (and fasting for 14 hours at night) can improve sleep, thinking, and brain health in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Researchers will compare two fasting schedu…

This study tests a new 3D calendar tool designed to help people with mild to moderate Alzheimer's disease improve their sense of time. Twenty participants will use the tool during a hospital stay to see if it helps them remember the date, season, and day of the week. The goal is …

This study tests whether a gentle, non-invasive brain stimulation technique (tES) can improve memory, thinking, and walking in older adults with mild cognitive impairment or mild dementia. Caregivers are trained to deliver the stimulation remotely. The goal is to see if this safe…

This study tests a computerized anxiety sensitivity treatment (CAST) in 388 older adults with mild cognitive impairment or mild Alzheimer's disease and their care partners. Participants attend two treatment sessions and are followed for six months. The goal is to see if CAST redu…

This pilot study tests whether combining two non-invasive brain stimulation methods—iTBS and tDCS—can safely ease neuropsychiatric symptoms like mood swings, apathy, and agitation in people with Alzheimer's disease. Twenty veterans aged 60-85 with mild to moderate Alzheimer's wil…

This study tests whether a new combination drug, KarXT + KarX-EC, can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 325 adults aged 55 to 90 with Alzheimer's and psychosis will receive either the drug or a placebo. The goal is to see if the …

This study tests a transitional care program for people with Alzheimer's or dementia who are leaving a skilled nursing facility to go home, to assisted living, or to long-term care. The program also supports their caregivers. The goal is to see if the program can reduce caregiver…

This study tests a program called the Green Activity Program, designed for people with mild memory issues or early Alzheimer's. The program encourages enjoyable outdoor activities like walking, gardening, or yoga with a friend or pet. Researchers want to see if the program is eas…

This study tests whether a mobile app called Brain CareNotes can reduce stress and burden for people caring for a loved one with dementia in rural areas. About 60 unpaid caregivers will use the app or a basic education app for six months. The goal is to see if the app is easy to …

This study tests if combining a medication (methylphenidate) with a type of non-invasive brain stimulation can reduce apathy in people with Alzheimer's disease or mixed dementia. Apathy, or lack of motivation, is a common and troubling symptom. The study will involve 12 participa…

This early study is testing whether a natural supplement called fisetin is safe for older adults with mild Alzheimer's disease or mild cognitive impairment. Only 5 participants will take the supplement, and researchers will closely watch for any side effects. This is a very small…

This study tests a non-invasive brain stimulation method called deep TMS in 28 adults over 60 who have Alzheimer's disease or mild cognitive impairment along with depression that hasn't improved with medication. The treatment uses a special coil to stimulate deeper brain areas fo…

This early-stage study tests whether galcanezumab, a drug used for migraines, can help people with mild-to-moderate Alzheimer's disease. Ten participants will receive injections over 24 weeks, and researchers will measure changes in brain proteins and thinking skills. The goal is…

This study tests whether daridorexant, a sleep medication, can safely improve sleep in older adults with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. About 62 participants will take the drug and have their sleep measured in a lab. The …

This study uses a special PET scan to measure tau protein buildup in the brains of 160 people with Alzheimer's disease. Researchers want to see how tau levels relate to memory, genetics, race, and blood vessel health. Participants are already part of a larger Alzheimer's study an…

This study aims to see if a quick cognitive test, given during regular check-ups, can help doctors detect early memory problems or dementia in underserved communities. Over 45,000 adults without prior diagnosis will take part across 24 clinics. The goal is to improve early detect…

This study aims to create a large, diverse group of 1,000 older adults (age 60+) to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will have yearly check-ups including memory tests, brain s…

This study collects information from 735 Alzheimer's patients aged 50-90 who are receiving FDA-approved anti-amyloid antibody treatments. Researchers will track changes in memory, thinking, and daily living skills over time. The goal is to understand how well these drugs work in …

This study explores whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Participants will receive daily brain stimulation sessions ov…

This study compares a new approach to managing infections in nursing home residents with dementia against usual care. The goal is to see if the new method reduces antibiotic use and avoids stressful procedures like hospital transfers. About 750 residents aged 60 and older with de…

This study tests a new virtual care program for veterans with early Alzheimer's disease. The program uses telehealth and streamlined tests to quickly determine who can receive a new antibody treatment. About 30 veterans will take part, and the goal is to see if this approach redu…

This study looks at how having excess body fat in midlife (ages 40-60) might increase the risk of Alzheimer's disease. Researchers will compare brain scans and blood tests from 240 cognitively healthy adults to see if those with obesity show more brain inflammation or Alzheimer's…

This study tests a special toolkit designed to help primary care doctors have better conversations about future care with people living with Alzheimer's or other dementias. About 120 patients and their doctors will take part over 18 months. The goal is to see if the toolkit leads…

This study is a registry that follows 500 people with early Alzheimer's who are receiving anti-amyloid antibody therapy. Researchers will compare their cognitive and functional decline to historical data to see if the treatment slows the disease. They will also track side effects…

This study is following 10,000 people aged 50 and older living in Scotland over many years. Researchers are collecting information on memory, thinking, lifestyle, and health risks to learn how dementia develops. The goal is to build a detailed picture of the Scottish population t…

This study aims to understand Alzheimer's disease in families across China by collecting genetic, brain scan, and memory test data from 40,000 participants. It does not test any treatment or drug. The goal is to learn how the disease runs in families and find early warning signs.

This study aims to measure levels of a protein called fibrin in the brains of people with Alzheimer's disease and related dementias, compared to healthy volunteers. Researchers will use a special PET scan with a tracer called 64Cu-FBP8 to see if fibrin levels differ between group…

This study looks at a surgery that connects tiny lymph vessels in the neck to veins, aiming to improve fluid drainage from the brain in people with Alzheimer's. Early results showed some short-term improvements in mood and memory, but it's unclear if the surgery itself or other p…

This study looks at how sleep and exercise habits may affect the risk of dementia in 30 adults who already have memory or concentration problems. Participants will wear a headband and a Fitbit to track sleep and heart health, and provide blood and urine samples. The goal is to un…

This study enrolls up to 550 adults with Down syndrome, ages 25-55, to track their thinking skills, genetics, and brain changes over time. The goal is to understand how Alzheimer's disease develops in this group and to create a pool of volunteers ready for future prevention trial…

This study looks at how slow brain waves during sleep and wakefulness are linked to memory and attention problems in normal aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and those with early Alzheimer's. They aim to better u…

This study looks at how speaking two languages (Spanish and English or Spanish and Catalan) affects language treatment in people with primary progressive aphasia (PPA), a condition that first causes speech and language problems. Researchers will give tailored speech therapy in bo…

This early-stage trial tests whether a new drug called J4 is safe for people. It is given as a dry powder capsule by mouth. The study involves 76 healthy adults aged 18 to 64. Researchers will monitor side effects and how the drug moves through the body. This is a first step befo…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study looks at whether proteins in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will test blood samples from 1,800 older adults and compare them with brain scans and thinking tests. The goal is to develop a simple blo…

This study aims to find the genes that cause Alzheimer's disease by collecting DNA samples from families where two or more members have Alzheimer's or dementia. Researchers will use these samples to better understand the disease and develop new treatments. The study does not offe…

This study follows 3,400 adults who report no memory problems to see how thinking skills change over 7 years. Researchers will use blood tests and cognitive tasks to identify early signs of Alzheimer's. The goal is to better understand who is at risk and how the disease progresse…

This study aims to create a model that better predicts how different types of dementia will progress over time. Researchers will follow 500 people with early dementia or mild cognitive impairment, using blood tests and thinking assessments. The goal is to improve prognostic confi…

This study aims to find new markers in our DNA, proteins, and metabolism that could help diagnose and track brain diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze samples from 1,200 people with these conditions using advanced technology. The goal is to be…

This study aims to understand why some people with Alzheimer's disease develop psychotic symptoms like delusions. Researchers will use brain scans to measure tau protein buildup and brain network changes in 91 older adults with and without psychosis, plus healthy volunteers. The …

This study looks at whether ovarian hormones are linked to aging and Alzheimer's disease in women. Researchers will use brain scans to measure proteins related to Alzheimer's. The study includes women aged 60 and older, including African American women at one site. It aims to und…

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans, brain wave tests, and thinking assessments to learn more about these disorders. The go…

This study looks at how certain substances in the blood and spinal fluid might help detect Alzheimer's disease earlier. Researchers will study 40 people to see if these substances are linked to early brain changes. The goal is to find better ways to diagnose Alzheimer's before sy…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and how to talk about it with doctors. About…

This study looks at whether special eye scans can detect changes in the retina that are linked to memory disorders like Alzheimer's or Parkinson's. Researchers will compare eye images from 450 people with and without memory complaints. The goal is to find non-invasive markers tha…

This study looks at whether blood markers for Alzheimer's and brain injury can help predict death and hospital readmission in older patients. Researchers will follow 400 hospitalized seniors with either acute brain problems or dementia. The goal is to create a tool that helps doc…

This study is for 244 people with mild Alzheimer's disease. Researchers want to find new blood markers that show why some people's brains resist the disease better. Participants will have memory tests and brain scans. No new treatment is given—this is an observation study to lear…

This study looks at how people with frontotemporal dementia or Alzheimer's disease understand their own social abilities. Researchers will ask 34 participants to recognize emotions in faces and rate their confidence. The goal is to learn more about the connection between self-awa…

This study looks at how different types of mindful breathing, paired with heart rate feedback, affect memory and attention in adults aged 50 to 70. Participants will practice daily for 10 weeks and provide blood samples to check for changes in Alzheimer's-related markers. The goa…

This study looks at whether special brain cells called tanycytes have trouble moving a key hormone (leptin) in people with Alzheimer's disease or frontotemporal dementia. Researchers will measure leptin levels in blood and spinal fluid from 102 participants. The goal is to unders…

This study aims to find genes that increase the risk of Alzheimer's disease. Researchers are looking for 10,000 people from families with a history of Alzheimer's, including those with and without the disease. By analyzing DNA, they hope to better understand what causes Alzheimer…

This study looks at whether a common vitamin (niacin) can get into the brain fluid of people with mild-to-moderate Alzheimer's disease. Researchers will give 30 volunteers a single 500 mg dose of extended-release niacin and measure its levels in blood and spinal fluid. The goal i…

This study is looking for early warning signs of Alzheimer's disease in 800 healthy adults aged 50 to 80. Researchers will use brain scans, spinal fluid, and blood tests to track changes over about 4 years. The goal is to find better ways to screen for Alzheimer's before memory p…

This study uses special eye cameras to look for blood vessel changes and protein deposits in the retina of people with Alzheimer's or mild dementia. Researchers will compare these eye scans to those of healthy older adults. The goal is to find a simple, noninvasive way to spot ea…

This study looks at how quickly people with stroke or memory problems can move. Researchers want to see if new short tests can help predict recovery after a stroke or help diagnose diseases like Alzheimer's earlier. About 129 adults aged 40 to 85 will take these quick tests, and …

This study tests a 4-week training program for assisted living staff (nurses, administrators, and dementia care coordinators) to improve palliative care for residents with dementia. The goal is to increase advance care planning discussions and reduce caregiver burden. About 792 p…

This study tests a web-based platform called LEAD that helps people in the early stages of Alzheimer's or mild cognitive impairment talk about and write down their end-of-life wishes. About 120 participants and their care partners will use the tool to see if it improves decision-…

This study follows 5,000 adults in Hong Kong who either have or are at high risk for brain diseases like stroke and dementia. Researchers will collect medical records, surveys, and phone interviews over many years to identify what factors lead to these conditions. The goal is to …

This study looks at how a sticky protein called amyloid builds up in the brains of people with Alzheimer's disease. Researchers will use special PET scans to measure amyloid levels and see how they relate to a person's race and heart health. The goal is to better understand Alzhe…

This study aims to understand why some people experience changes in thinking and memory as they get older. Researchers will use brain scans (MRI and PET) and memory tests to detect early signs of decline in 300 healthy adults aged 60 and older. The goal is to find better ways to …

This study follows nearly 3,000 people, including healthy volunteers and those with memory or movement problems, to track how brain diseases like Alzheimer's and Parkinson's develop over time. Researchers use advanced brain scans and tests to find early signs of disease. The goal…

This study explores whether a non-invasive device using light and sound at a specific frequency (gamma) can change brain activity in healthy adults and people with Alzheimer's disease. Researchers will use brain scans and tests to measure effects and safety during a single visit.…

This study is testing whether simple blood tests and brain scans can help doctors in primary care detect Alzheimer's disease and other memory disorders earlier and more accurately. Researchers will recruit 1,200 adults with mild memory or thinking complaints. The goal is to impro…

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis over time. The goal is to gather data, not to test a treatment, so there is no …

This study looks at whether people with Alzheimer's disease have more trouble swallowing than healthy older adults. Researchers will test swallowing, coughing, and muscle strength in 240 participants, and ask caregivers about their experiences. The goal is to better understand ho…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study looks at whether treating depression with an FDA-approved antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memo…

This study uses powerful MRI scanners to look at the brains of 700 people, including those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's, as well as healthy volunteers. The goal is to understand why some brains stay healthy while others develop disease. Re…

This study explores whether personalized brain stimulation can improve memory in people with mild Alzheimer's disease. Researchers will use non-invasive techniques to synchronize brain rhythms. The goal is to understand how Alzheimer's affects memory and to develop drug-free trea…

This study uses a special PET scan to measure tau protein buildup in the brains of people with frontotemporal lobar degeneration (FTLD), atypical Alzheimer's disease, and healthy volunteers. Researchers want to see if this scan can help tell these conditions apart. About 72 adult…

This study looks at how stress hormones and certain genes might speed up memory loss in older adults with mild cognitive impairment. Researchers will test memory and collect blood and saliva samples after a short stressful task. Participants return after two years to see if stres…

This study aims to improve how we see inflammation in the brains of people with Alzheimer's disease. Current scans can't tell which brain cells are inflamed, but this new method uses two different tracers and math to separately track microglia and astrocytes. Researchers will sca…