Could a magnetic helmet boost memory in Alzheimer's?
NCT ID NCT06669182
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests if a gentle magnetic pulse to the back of the brain (cerebellum) can help people with mild Alzheimer's disease think more clearly and feel better day-to-day. About 100 adults aged 50-85 will receive either real or fake stimulation over three months. The goal is to see if this safe, non-invasive treatment can slow down memory loss and improve quality of life.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Apr 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age: 50-85 years old 2. Meet the core clinical criteria of NIA-AA for possible Alzheimer's disease dementia, and PET or cerebrospinal fluid markers show elevated p-tau and decreased A β (1-42) 3. MMSE score ranges from 18-26 points; CDR score 0.5-1 points 4. The patient has received treatment with acetylcholinesterase inhibitors (AChEI), NMDA receptor antagonists, or mannequine therapy, and the current dosing regimen has remained stable for the 12 weeks prior to baseline assessment 5. At least one adult caregiver 6. The patient or legal guardian voluntarily signs the informed consent form Exclusion Criteria: 1. Neurodegenerative disorders other than AD. 2. Significant intracranial focal or vascular pathology seen on brain MRI scan 3. History of seizure (with the exception of febrile seizures in childhood) 4. Any of the following psychotic disorders (DSM IV-TR criteria): * Major depressive disorder (current) * Schizophrenia * Other psychotic disorders, bipolar disorder, or substance related disorders (within the past 5 years) 5. GDS score ≥ 8 points in baseline assessment 6. Cerebrovascular disease, severe infection, malignant tumor, or severe dysfunction of organs such as heart, liver, and kidney. 7. Pregnant or lactating women 8. Contraindications for TMS or MRI, metal or implanted devices in the body (such as pacemakers, deep brain stimulators). 9. Participate in AD related clinical trials within 6 months prior to research registration
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Tangdu Hospital of Air Force Military Medical University
RECRUITINGXi'an, Shannxi, China
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The First Affiliated Hospital of Xi'an Medical University
RECRUITINGXi'an, Shannxi, China
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The Third Hospital of Xi'an
RECRUITINGXi'an, Shannxi, China
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Xijing Hospital of Air Force Military Medical University
RECRUITINGXi'an, Shaanxi, 710032, China
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Other studies related to the condition(s) this trial covers.
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- Can a gentle electric current calm the mind in Alzheimer's?
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- Can a home device slow Alzheimer's? pilot study tests pulsed electromagnetic therapy