ALZHEIMER DISEASE

This early-stage study tests whether a vaccine called AV-1959D is safe for people with early Alzheimer's disease. The vaccine aims to train the immune system to target and remove harmful amyloid plaques in the brain. The trial includes 48 adults aged 60 to 85 with mild cognitive …

This study tests an experimental vaccine (JNJ-64042056) designed to help the immune system target and clear a harmful protein called tau in the brain. The goal is to slow or stop the spread of tau, which is linked to Alzheimer's disease. The trial includes 55 people with early si…

This study tests a new drug called sabirnetug, given as a monthly IV infusion, to see if it can slow down memory loss and daily function decline in people with early Alzheimer's disease. About 542 participants will receive either the drug or a placebo. The goal is to measure chan…

This study tests whether donanemab can slow memory and thinking decline in people with early Alzheimer's disease. About 1,500 participants with mild symptoms and brain amyloid plaques will receive the drug or a placebo for up to 93 weeks. The main goal is to see if donanemab help…

This study tests a new medicine called ONO-2020 in 240 people with mild to moderate Alzheimer's disease. The goal is to see if it is safe and can improve memory and thinking. Participants will receive either the drug or a placebo for 26 weeks, and researchers will monitor side ef…

This study tests an experimental drug called AR1001 in people with early Alzheimer's disease. About 1,535 participants will receive either the drug or a placebo for 52 weeks to see if it slows down memory and thinking decline. The goal is to find a treatment that helps control th…

This study tests a new treatment called ALZN002 for people with mild-to-moderate Alzheimer's. It uses a person's own immune cells to target harmful proteins in the brain. The goal is to see if it is safe and can help control the disease. About 30 volunteers aged 60 to 85 will tak…

This early-stage study tests a new drug called OLX-07010 in healthy adults and elderly volunteers to see if it is safe and how the body processes it. The drug aims to stop harmful tau proteins from clumping together, which is linked to Alzheimer's disease. 88 participants will re…

This study aimed to test the safety of using a patient's own fat-derived stem cells to treat early Alzheimer's disease. Participants would have received four intravenous infusions of their own stem cells. However, the trial was withdrawn before enrolling anyone, so no results are…

This study tests whether a device that delivers light and sound stimulation for 60 minutes each day can slow the decline in memory and daily living skills in people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inac…

This study tests whether deep brain stimulation (DBS) can improve thinking and memory in people with early Alzheimer's disease. Two participants will have electrodes placed in a brain area that produces a key memory chemical. The goal is to see if daily, one-hour stimulation sess…

This study looks at whether a time-restricted eating plan (fasting 16 hours each day) can improve memory and thinking in overweight adults over 65 who have mild memory concerns. Participants either follow the fasting plan or attend healthy aging classes for 24 weeks. The goal is …

This study tests whether a daily pill called Xanamem can safely help people with mild or moderate Alzheimer's dementia. About 247 adults aged 50 and older will receive either Xanamem or a placebo for 36 weeks, with an option to continue treatment for up to 108 weeks. The goal is …

This study uses a safe, painless eye scan (OCT) to see if early Alzheimer's can be detected by measuring how support cells in the retina respond to light. Researchers will compare 100 people with early signs of Alzheimer's to those without any signs. If successful, this could lea…

This study is testing a new way to look at brain scans, called Cortical Disarray Measurement (CDM), to see if it can help doctors better diagnose Alzheimer's disease. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results with st…

This study tests whether adding low, horizontal and vertical lights around bathroom and entry doorframes can help prevent nighttime falls in people with Alzheimer's or related dementias living in assisted living. About 335 residents will take part, and researchers will compare ho…

This study tests whether memantine, a drug already used for Alzheimer's symptoms, can help prevent the disease in people at high risk. It includes 32 adults aged 50 to 65 who have a family history of dementia and carry the ApoE4 gene. The main goal is to see if it's practical to …

This study tests whether donanemab, an experimental drug, can delay or prevent cognitive and functional decline in nearly 3,000 people who are at risk for Alzheimer's but still have normal thinking abilities. Participants receive either donanemab or a placebo for up to 332 weeks.…

This study explores whether heat therapy can improve how the body and brain handle sugar in healthy older adults (65+) who are at risk for Alzheimer's disease. Researchers will measure blood sugar control and brain energy use in 60 participants to see if heat treatments offer a s…

This study tests a website called 'Small Steps' that helps people aged 65 and older make small changes to their daily routines—like sitting less, moving more, and sleeping better—to reduce dementia risk. Participants are split into two groups and use the website for 36 weeks. The…

This study tests whether a special diet called the MIND diet can help prevent memory loss and dementia in people who have had a stroke. Researchers will compare the MIND diet to usual post-stroke care in 250 adults aged 55 and older. The goal is to see if the diet protects the br…

This study looks at whether dance or music classes can boost memory and heart health in people 62 and older who are worried about memory loss but don't have dementia. Researchers will compare taking 1, 2, or 3 classes per week for 6 months to find the best amount. Participants wi…

This study tests whether monthly transfusions of plasma from young, healthy, and fit donors are safe and can improve memory and brain function in people with early Alzheimer's disease. Sixty participants aged 50-75 will receive either the plasma or a saltwater placebo over a year…

This study explores whether making music together can improve social attention and feelings of closeness between people with mild to moderate frontotemporal dementia or Alzheimer's disease and their caregivers. About 80 patient-caregiver pairs will take part in rhythmic musical a…

This study tests whether adding a caregiver training program to a visual mapping app helps both people with dementia and their caregivers. Fifty pairs (a person with mild-to-moderate Alzheimer's or related dementia and their main caregiver) will use the app for 6 months. Half wil…

This study tests whether shining a special near-infrared light on the head can safely help people with mild-to-moderate Alzheimer's disease. About 38 participants will receive either real or fake light treatments daily for 16 weeks, then everyone can get the real light for up to …

This study tests whether coaching can help people with dementia and their caregivers after an emergency room visit. About 19,200 participants aged 66 and older will receive different combinations of support to connect them with community services. The goal is to improve care, red…

This study tests a non-invasive device that uses 40-Hz light and sound to stimulate brain waves in 20 people with Alzheimer's disease. Participants will undergo 8 weeks of therapy to see if it improves visual processing, memory, and other cognitive functions. The goal is to explo…

This study tests a light therapy that shines a special light on the forehead to see if it can help memory and thinking in people with early Alzheimer's or mild cognitive impairment. About 196 older adults (ages 65-85) will receive either the real light treatment or a fake one for…

This study tests a new, non-invasive brain stimulation method called Temporal Interference Stimulation (TIS) in 40 people with early-stage Alzheimer's. Participants will receive either real TIS or a sham (fake) treatment for 2 weeks. Researchers will check thinking skills and saf…

This study tests an online training program for nursing home staff that teaches better communication with residents who have Alzheimer's or other dementias. The goal is to reduce behavioral symptoms like agitation and rejection of care. Over 5,000 staff from nursing homes across …

This study tests a 6-week online program called Learning Skills Together (LST) for family caregivers of people with Alzheimer's or related dementias. The program teaches practical caregiving skills to help caregivers feel more confident and less depressed. 216 caregivers will be …

This early-stage study tests whether a combination of two drugs, dasatinib and quercetin, is safe and feasible for people with mild cognitive impairment or Alzheimer's disease. The drugs target senescent ('zombie') cells that accumulate with aging. Twenty participants aged 55 and…

This study tests whether adding MK-1167 to standard Alzheimer's medication can improve memory and thinking in people with mild to moderate Alzheimer's dementia. About 350 participants will receive either MK-1167 or a placebo for 24 weeks. The main goals are to see if the drug imp…

This small study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can improve thinking and memory in people with early-stage Alzheimer's disease. Six participants will receive either real TBS or a sham (fake) treatment to compare effec…

This early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who had significant anxiety or agitation. The goal was to see if it could reduce these behavioral symptoms safely. The stud…

This study tests whether the drug mevidalen can safely improve thinking, memory, and daily function in people with mild to moderate Alzheimer's disease. About 300 participants will take the drug or a placebo for 26 weeks. The goal is to see if symptoms get better, not to cure the…

This study tests a new, low-cost eye scanner to see if it can take clear pictures of the retina, the light-sensitive layer at the back of the eye. Researchers will compare images from their custom device to a standard commercial scanner. They will also measure the thickness of re…

This study looks at what happens when healthy older adults (65+) are told their personal risk of developing Alzheimer's dementia within five years. Researchers are measuring changes in mood, thinking skills, and distress after participants receive their risk results. The goal is …

This study is for adults 18 and older who have a family history of Alzheimer's or early memory concerns. Researchers will measure participants' health, blood markers, and thinking skills every six months to see how personalized care plans might help prevent or treat Alzheimer's. …

This study aims to see if it's possible to create a registry that tracks how lecanemab, a new Alzheimer's drug, affects patients and their care partners in real-world settings. Researchers will enroll 20 people with Alzheimer's who are eligible for lecanemab and their care partne…

This study uses brain scans to measure two proteins, amyloid and tau, in people with different forms of Alzheimer's disease. Researchers want to see how these protein levels change over one year. The goal is to better understand the disease, not to test a treatment. About 60 adul…

This study uses special PET/CT scans to measure brain inflammation in people with Alzheimer's disease or Lewy body dementia. Researchers want to see if inflammation is linked to memory decline and other brain changes. About 125 adults aged 60 and older will take part. The goal is…

This study tests whether using a visual consent form with pictures and simple language helps patients better understand research studies. Researchers will compare the standard consent process to a new visual version in studies on cancer and Alzheimer's disease. About 266 patients…

This study looks at a small brain area called the locus coeruleus, which may be damaged very early in Alzheimer's disease. Researchers will use MRI scans, eye tracking, and a gentle nerve stimulation technique to measure how this area affects attention and memory in 150 healthy a…

This study looks at how normal sleep changes and sleep apnea might increase the risk of Alzheimer's disease in healthy older adults. Researchers will monitor sleep and brain changes in 158 people aged 55-75 over two years. The goal is to find ways to prevent Alzheimer's by improv…

This study aims to build a mobile app that automatically scores physical and cognitive tests in older adults. Researchers will collect video data from 20-30 healthy volunteers performing a standard balance and walking test. The goal is to create a tool that helps doctors track ch…

This study looks at blood tests that may help predict Alzheimer's disease and related dementias. Researchers will track changes in these blood markers over time in over 13,000 older adults to see if the patterns differ between men and women. The goal is to create a personalized r…

This study looks at how certain genes influence brain inflammation in people with Alzheimer's disease. Researchers will use a special PET scan to measure immune cell activity in the brain. The goal is to find new genetic markers that affect this process, which could lead to bette…

This study follows 130 older adults with mild-to-moderate Alzheimer's to see if frailty (weakness, slowness, exhaustion) leads to faster loss of daily living skills like managing money or bathing. Participants are assessed at the start and after one year, with long-term check-ins…

This study tests three new radioactive dyes (tracers) for PET scans to see how well they detect tau protein buildup in the brains of people with Alzheimer's disease compared to healthy older adults. About 38 participants will receive up to three different scans to find which trac…

This study follows 1,400 people with early-stage Alzheimer's or mild cognitive impairment to track their healthcare costs, resource use, and quality of life over time. It is purely observational and does not test any new treatments. The goal is to better understand the economic a…

This study uses special brain scans (tau PET) to measure how anti-amyloid therapy changes tau protein buildup in people with mild Alzheimer's disease. Researchers will track 135 adults aged 50-90 who are already receiving anti-amyloid treatment at Mayo Clinic. The goal is to bett…

This study looks at why people with Alzheimer's disease become agitated or aggressive, and tests if a gentle brain stimulation technique called tDCS can help. Researchers will use magnetic pulses and brain wave recordings to understand brain changes in 90 participants, including …

This study is a registry that collects information from about 2,000 people with mild cognitive impairment or Alzheimer's disease. Researchers will observe how the disease progresses and how treatments are used in everyday medical care. No new drugs or procedures are given; the go…

This study compares two different radioactive tracers used in PET scans to measure tau tangles in the brain, a hallmark of Alzheimer's disease. Researchers will enroll 822 adults with normal cognition, mild impairment, or Alzheimer's dementia to see how well the two tracers work …

This study involves 100 people with Alzheimer's or similar conditions. Researchers are creating a simpler way to check if someone can understand and agree to medical decisions. They will also look at brain scans and blood markers to see how thinking ability connects to brain heal…

This program aims to build a large registry of 500,000 people aged 50-90 who are interested in Alzheimer's research. Participants provide basic health info and consent to genetic testing (APOE) without receiving their results. The genetic data is then used to match volunteers to …

This study looks at 800 people already enrolled in an Alzheimer's research center. Researchers use a special brain scan to measure amyloid, a protein linked to Alzheimer's. The goal is to see how amyloid builds up over time, which may help find the best time to start treatments i…

This study looks for biological signs of Parkinson's disease in blood, nasal brushings, and skin samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. Researchers aim to identify markers that reflect different disease processes, which cou…

This study uses special PET/CT scans to measure inflammation in the brains of people with Alzheimer's disease or mild cognitive impairment, compared to healthy volunteers. Nine participants will receive an experimental radioactive tracer to see how inflammation relates to Alzheim…

This study looks at whether a Mediterranean or Mediterranean-keto diet can improve gut and brain health in older adults living in rural areas, some with mild memory problems. About 61 people aged 55-85 will follow one of these diets for 10 weeks, with follow-ups up to a year. Res…

This study looks at whether older adults with mild memory problems or early Alzheimer's can use a tablet-based brain training app at home. Researchers want to see if the app is easy to use and acceptable to patients. 36 participants will try the app for two weeks and share their …

This study looks at how things like social support, income, and lifestyle habits are linked to mental health and brain changes in people with conditions like depression, schizophrenia, Alzheimer's, and Parkinson's. About 1,310 European adults will complete surveys and optional br…

This study looks at how live music changes brain activity, heart rate, and anxiety in people with early Alzheimer's or mild cognitive impairment, and their caregivers. Researchers will measure brain waves and heart signals while participants listen to live or recorded music. The …

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning their personal Alzheimer's risk from brain scans. It includes 100 Black and White adults with mild cognitive impairment. The goal is to…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that may lead to thinking problems in CKD patients. Participan…

This study asks 1,000 people with neurological diseases (like Alzheimer's or Parkinson's) and their caregivers to share their experiences using a head device called MemorEM. The goal is to learn how to improve the device's design and make it easier to use in future studies. No tr…

This study looks at how adults at risk for Alzheimer's react after learning their brain scan results for amyloid and tau proteins. Researchers will survey 240 participants over time to measure distress, stigma, quality of life, and willingness to seek prevention. The goal is to u…

This study looks at whether training volunteers to visit older adults with memory loss or dementia can improve the volunteers' skills and reduce loneliness in the people they visit. About 342 volunteers and clients in Minnesota are taking part. The training is part of the volunte…

This study follows 100 people aged 60–85 over 5 years to see if problems with smell, hearing, or balance speed up memory loss and lower quality of life. Participants will have tests with a neurologist, psychologist, and ear-nose-throat doctor. The goal is to understand which sens…

This study looks at whether treating sleep problems can help reduce mood and behavior issues like anxiety, agitation, and irritability in people with early Alzheimer's or mild cognitive impairment. Researchers will give 150 adults either a sleep therapy program (CBT-I) or a contr…

This study uses a special PET scan to measure tau protein buildup in the brains of healthy older African Americans. The goal is to learn how these brain changes relate to normal aging versus early Alzheimer's disease. Participants are already part of a long-term study and will ha…

This study will enroll 100,000 adults aged 45 and older to track early signs of Alzheimer's and Parkinson's disease using phone apps, voice recordings, and movement tests. Researchers aim to create better tools for early diagnosis by combining digital data with genetic and biolog…

This study uses a special MRI technique to measure brain stiffness in people with Alzheimer's, mild cognitive impairment, and healthy volunteers. Researchers want to see if brain stiffness can serve as a new marker to detect Alzheimer's disease. The study involves 450 participant…

This study is analyzing blood samples from 1,799 people with brain diseases (like Alzheimer's, dementia, depression, and schizophrenia) and healthy volunteers. Researchers want to see if certain substances in the blood can help doctors diagnose these conditions more accurately. T…

This long-term study follows 1,500 adults with normal memory, mild cognitive impairment, or Alzheimer's disease. Researchers use brain scans, memory tests, and genetic data to understand how the disease progresses and to improve future clinical trials. The study also aims to incl…

This study looks at 350 former college and professional football players to find ways to diagnose Chronic Traumatic Encephalopathy (CTE) while they are still alive. Currently, CTE can only be confirmed after death. Researchers will use memory tests, brain scans, and other biomark…