Brain scan showdown: which tracer best reveals Alzheimer's tangles?
NCT ID NCT05361382
First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 32 times
Summary
This study compares two different radioactive tracers used in PET scans to measure tau tangles in the brain, a hallmark of Alzheimer's disease. Researchers will enroll 822 adults with normal cognition, mild impairment, or Alzheimer's dementia to see how well the two tracers work over 18 months. The goal is to harmonize measurements so future studies and clinical practice can use either tracer reliably. No treatment is given; this is an observational imaging study.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Brown University
Providence, Rhode Island, 02912, United States
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Houston Methodist Neurological Institute
Houston, Texas, 77030, United States
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Lawrence Berkeley National Laboratory
Berkeley, California, 94720, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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McGill University
Montreal, Quebec, H3A 0G4, Canada
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Sant Pau Biomedical Research Institute
Barcelona, Spain, 08025, Spain
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15260, United States
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Washington University in St. Louis
St Louis, Missouri, 63130, United States
Conditions
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