ALZHEIMER DISEASE

This early-stage study tests a new vaccine called AV-1980R in 48 adults aged 65-80 who have early signs of Alzheimer's in their blood but no memory problems yet. The vaccine targets a protein called tau, which is linked to Alzheimer's damage. The main goal is to check if the vacc…

This early-stage study tests the safety of an experimental vaccine called DUVAX in 24 healthy adults aged 40-65. The vaccine aims to train the immune system to attack two proteins linked to Alzheimer's disease. Researchers will monitor side effects and measure whether the vaccine…

This study tests a treatment called AADvac1, which targets tau protein tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with early-stage Alzheimer's. The goal is to see if it safely reduces tau build…

This study tests whether new drugs that target tau protein in the brain can slow or stop Alzheimer's disease in its early stages. About 900 adults aged 50 to 80 with very mild or no symptoms will receive a tau drug, a combination of a tau drug and donanemab, or donanemab alone. T…

This study tests whether a daily dose of tricaprilin, a type of oil, can improve or maintain thinking skills and daily function in people with mild to moderate Alzheimer's disease. About 535 participants will receive either the oil or a placebo for 26 weeks. The goal is to see if…

This phase 3 trial tests whether adding masitinib, a daily pill that targets immune cells in the brain, to standard Alzheimer's medications can slow cognitive and functional decline. The study will enroll 600 people with mild Alzheimer's and measure changes in thinking skills and…

This early-stage trial tests the safety of giving multiple doses of a patient's own stem cells directly into the fluid around the brain. It is for people with mild to moderate Alzheimer's who already received one dose in a prior study. Participants will get up to 6 injections ove…

This study tests whether repeated injections of a patient's own stem cells (taken from their fat) into the brain can slow down memory and thinking problems in people with mild to moderate Alzheimer's disease. About 115 adults aged 45 to 85 will receive either the stem cells or a …

This early-phase trial tests whether stem cells from donated fat tissue are safe when given through a vein to people with mild to moderate Alzheimer's disease. Nine participants will receive different doses to find the safest one. The study focuses on side effects and immune syst…

This study tests whether a daily low dose of tadalafil (a drug used for erectile dysfunction) is safe and can slow memory loss in people with early Alzheimer's or mild cognitive impairment. Researchers believe the drug may improve blood flow in the brain. The trial will involve 2…

This study tests whether a daily pill called semaglutide, already used for diabetes, is safe and might slow Alzheimer's disease. About 60 people with mild Alzheimer's will take the drug for one year. Researchers will check for side effects and use brain scans to see if the drug p…

This study tests whether donanemab can safely reduce amyloid plaques in the brains of adults with Down syndrome, who are at high risk for Alzheimer's disease. Sixty participants aged 35-50 will receive either donanemab or a placebo every 4 weeks for 12 months, followed by a 12-mo…

This study looks at 100 healthy older adults (half with a genetic risk for Alzheimer's) to see if simple eye tests and MRI brain scans can detect early signs of the disease. The goal is to find markers that show tau protein buildup in the brain before memory problems start. If su…

This study aims to improve early detection of Alzheimer's disease by combining digital tools (like gait and speech analysis) with blood tests. Researchers will screen 1,000 adults aged 50 and older in communities to see if this approach is more efficient than traditional methods.…

This study tests whether a deep-learning computer tool can improve the quality of brain scans for Alzheimer's disease when using lower radiation doses. Researchers will compare standard scans to those processed by the algorithm in 40 patients with memory problems. If successful, …

This study aims to see if a blood test can help primary care doctors diagnose Alzheimer's disease at an early stage. Researchers will test 1,000 adults aged 55 and older who have memory concerns. The goal is to find Alzheimer-related proteins (amyloid and tau) in the blood, which…

This study tests whether the drug donanemab can delay memory and thinking problems in Chinese adults who are at risk for Alzheimer's disease but have no symptoms yet. About 140 participants will receive either the drug or a placebo through an IV every few weeks for up to 3 years.…

This study tests whether a 5-week video program called REPAIR Sleep can improve sleep and mood for people with dementia and the family members who care for them. About 120 pairs (caregiver and person with dementia) will either get the sleep program or a healthy living program. Pa…

This study tests whether giving home health aides extra training in dementia care can help reduce troubling behaviors in older adults with memory loss or dementia and improve quality of life for both patients and their care partners. About 120 patient-care partner pairs will take…

This study tests a non-invasive brain stimulation method called tACS in 160 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. Participants will receive either real or fake (sham) stimulation over several sessions. Researchers will measure changes in me…

This early-stage study will test if shining a special near-infrared light on the head can help people with mild to moderate Alzheimer's disease. The study will include 40 adults aged 50-90 and will measure changes in thinking and memory over time. The goal is to see if this light…

This study looks at whether the seizure drug brivaracetam can calm overactive brain activity in people with mild Alzheimer's or mild cognitive impairment. Researchers will place tiny electrodes in the brain to measure abnormal electrical signals. The goal is to see if reducing th…

This study looks at whether taking a daily probiotic pill is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 adults aged 60 and older and follow them for up to one year. The main goal is to check for side effects and see if people…

This study tests whether a wearable light device can improve sleep and daily rhythm problems in people with Alzheimer's disease. About 162 participants will use the device at home, and researchers will track sleep quality, behavior, and blood markers over time. The goal is to fin…

This study looks at whether doing physical and mental tasks at the same time (dual-task training) can improve thinking skills in people with mild Alzheimer's disease. Sixty older adults will be split into two groups: one doing dual-task training and the other doing regular exerci…

This study tests whether art therapy—like painting, clay modeling, and collage—can improve thinking and hand coordination in people with mild to moderate Alzheimer's. Fifty adults aged 60 and older will either attend art sessions twice a week for 8 weeks or receive no extra care.…

This study looks at whether Alzheimer's disease markers in the blood differ among ethnic groups in central Barcelona. Researchers will also explore how factors like age, income, education, and health affect these markers. The goal is to identify barriers to using these blood test…

This study tests a special monitor that tracks sleep without touching the person. It will be used for 100 people with Alzheimer's or related dementias living in long-term care homes. Researchers want to see if sharing sleep data with staff helps find and treat sleep problems fast…

This study follows 285 older adults (65+) with Alzheimer's or mild cognitive impairment, along with their caregivers, to understand how they make decisions about staying at home or moving to long-term care. Researchers will track planning over time, looking at factors like thinki…

This early-stage study tests a new drug, LY3439539, in 30 people with mild-to-moderate Alzheimer's. The main goal is to see how the drug changes certain proteins in spinal fluid that are linked to Alzheimer's. Participation lasts about 9 months with monthly visits. This study is …

This study tests whether a safe, non-invasive device that stimulates the vagus nerve can improve memory in healthy older adults. Researchers will compare memory performance with and without stimulation in 150 people aged 65-80 and a younger group. They also want to see if gut hea…

This study will enroll 1,200 older adults (65+) who are at higher risk for complications after heart or blood vessel surgery. Researchers will test a computer program that predicts risks and also study whether personalized pre-surgery coaching and special care during surgery can …