ALZHEIMER DISEASE

This study tested whether a daily pill called TRx0237 could safely slow the progression of Alzheimer's disease. It involved 598 people with mild to moderate Alzheimer's who took either the drug or a placebo for one year. The main goals were to see if the drug could help people th…

This early-stage study tested the safety of a new gene therapy, called LX1001, for Alzheimer's disease. It involved 15 people with early to moderate Alzheimer's who all carry two copies of a specific genetic risk factor (APOE4). The therapy was delivered via a single injection in…

This study tested whether a special indoor lighting system could help people with Alzheimer's disease and type 2 diabetes. Researchers wanted to see if this tailored light could improve participants' sleep, mood, and blood sugar control. The study involved 61 people living in ass…

This study tested whether a dietary supplement called citicoline could improve sleep and affect biological markers related to Alzheimer's disease in older adults with mild memory problems. One hundred participants were randomly assigned to receive either the supplement or a place…

This study tested whether gentle electronic reminders could help doctors and caregivers safely reduce unnecessary medications for people with dementia. Researchers sent automated messages to 250 primary care doctors and their dementia patients' caregivers before appointments, sug…

This small, early-stage study explored whether a drug called daratumumab, which is approved for a type of blood cancer, could help people with mild to moderate Alzheimer's disease. The drug targets a specific protein on immune cells that may contribute to brain inflammation in Al…

This study tested whether two specific diets—a ketogenic diet and a Therapeutic Lifestyles Changes diet—could help slow cognitive decline in people with early Alzheimer's disease. Researchers enrolled 84 participants to see if changing what they ate for three months would improve…

This Phase 2 study tested whether XPro1595 could help people with early Alzheimer's disease who show signs of brain inflammation. The trial involved 208 participants aged 50-85 who received either the drug or a placebo for 24 weeks. Researchers measured changes in memory, thinkin…

This study tested whether an investigational drug called AL002 could slow the progression of early Alzheimer's disease. 356 participants with early-stage Alzheimer's received either the drug or a placebo via intravenous infusion over 96 weeks. Researchers measured changes in memo…

This study tested whether a high dose of the common antiviral drug Valtrex (valacyclovir), used to treat herpes, could slow the progression of mild Alzheimer's disease. It involved 130 patients who had both Alzheimer's and evidence of a herpes simplex virus infection. Over 18 mon…

This study tested a one-year virtual support program for older adults with dementia and their caregivers. Nurses and social workers provided regular check-ins to address patient and caregiver needs, using standard plans for managing symptoms, stress, and medications. The main goa…

This study tested whether a nasal insulin spray and a diabetes pill (empagliflozin), alone or together, could help people with early memory loss or Alzheimer's disease. It involved 47 adults aged 55-85 who showed early signs of Alzheimer's. The main goal was to check if the treat…

This study tested an experimental drug called donanemab in people with early Alzheimer's disease. The main goal was to see if the drug could safely slow down the decline in memory and daily function. Researchers enrolled 272 participants and measured changes in thinking skills an…

This study tested whether an old, common blood pressure drug called spironolactone is safe and tolerable for older African American adults who have early memory and thinking problems. The goal was to see if the drug could help slow the decline in memory skills. A small group of 2…

This study tested whether using focused ultrasound waves could safely open the blood-brain barrier in people with Alzheimer's disease. Thirty-five participants received three ultrasound treatments aimed at specific brain areas, with researchers monitoring safety and looking for c…

This small pilot study tested whether combining physical exercise with a mild, non-invasive brain stimulation technique could help improve memory in people with mild cognitive impairment or early Alzheimer's disease. Researchers wanted to see if stimulating the brain during exerc…

This study tested whether a gentle, non-invasive form of brain stimulation could help people with early Alzheimer's disease. Researchers used a device to deliver a specific electrical frequency to the brain, hoping it would reduce the buildup of harmful proteins linked to memory …

This study tested whether a special daily light treatment at home could help people with early memory loss or mild Alzheimer's disease. Researchers wanted to see if the light could improve sleep, reduce body inflammation, help the body process sugar better, and slow cognitive dec…

This study tested whether a special high-fat, low-carb diet (called a ketogenic diet or JT821) could help people with mild to moderate Alzheimer's disease. Participants were randomly assigned to follow either this diet or a regular diet for 26 weeks. Researchers measured changes …

This study aimed to find the best and safest dose of a supplement called nicotinamide riboside (NR), a form of vitamin B3, for people with Alzheimer's disease. Researchers tested three different daily doses (1000mg, 2000mg, and 3000mg) against a placebo in 80 participants over 12…

This large study tested a program to help nursing home residents with Alzheimer's and their families plan for future medical care. The goal was to reduce stressful and unwanted hospital visits by making sure a patient's treatment preferences are clearly known and respected by the…

This small, early-stage study tested whether taking a choline supplement for six months could safely change brain chemistry in people with a specific gene (APOE4) that increases Alzheimer's risk. Researchers wanted to see if choline could help fix problems with fat metabolism in …

This study tested whether sending educational mail to caregivers and doctors could reduce the use of potentially harmful medications in people with Alzheimer's disease. Over 11,000 patients living at home who were taking risky drugs like sedatives or antipsychotics were part of t…

This study tested a combination of three non-drug therapies to see if they could help improve memory, thinking, and quality of life in older adults with mild cognitive impairment or Alzheimer's disease. Thirty-three participants received either the active treatment or a sham (pla…

This study tested whether a smartphone app could accurately diagnose Alzheimer's disease and mild cognitive impairment by analyzing a person's speech. Researchers compared the app's results against a doctor's diagnosis in 150 adults aged 50 and older. The goal was to see if voice…

This study tested a new computer tool called eRADAR that scans patients' existing electronic health records to identify those at high risk for dementia. The goal was to see if using this tool could help primary care doctors find more cases of dementia earlier. Over 1,200 patients…

This study investigated whether a simple eye scan could help doctors diagnose Alzheimer's disease. Researchers measured the thickness of specific nerve layers in the back of the eye (the retina) in people with Alzheimer's, people with Lewy body disease, and healthy individuals. T…

This study tested if measuring a protein called Aβ40 in spinal fluid, along with other known markers, could make diagnosing Alzheimer's disease more accurate. It involved 204 people with memory problems who were undergoing standard diagnostic tests. The goal was to see if this ne…

This study tested whether specific proteins in the blood can accurately diagnose Alzheimer's disease. Researchers compared blood test results from 342 patients with results from the current standard spinal fluid test and clinical assessments. The goal was to see if a less invasiv…

This study tested a new digital tool that scans patients' electronic health records to find older adults who might have undetected memory problems or be at risk for Alzheimer's disease. Researchers wanted to see if the tool was practical to use in primary care clinics and if send…

This study tested whether a simple, non-invasive brain wave recording (EEG) could help identify Alzheimer's disease at various stages. Researchers collected EEG data from 29 people, including those with no symptoms but at genetic risk, mild memory problems, and different stages o…

This study tested whether a new blood test could accurately diagnose Alzheimer's disease. Researchers compared blood samples from 200 people—some with Alzheimer's and some healthy—over two years. They measured two specific protein changes in the blood to see if they could reliabl…

This study tested a new, simpler way to collect blood for Alzheimer's disease testing. Researchers compared a finger prick blood sample to a standard blood draw from the arm to see if the simpler method was just as accurate for measuring a key Alzheimer's biomarker. The goal is t…

This early-stage study tested whether a new vaccine called AV-1959R is safe for healthy adults aged 40-60. Sixteen participants received either the vaccine or a placebo injection to check for side effects and measure immune response. The goal is to see if the vaccine can safely t…

This study tested whether a 2-year program of healthy lifestyle changes could protect memory and thinking skills in older adults at risk for Alzheimer's disease. It enrolled 2,000 sedentary older adults with poor diets and other risk factors, who were randomly assigned to follow …

This study tested a lifestyle program called 'Fit Mind' to see if it could lower factors linked to Alzheimer's disease risk in older adults. The 8-session program included brain games, physical activity, nutrition tips, and social activities. Researchers compared changes in risk …

This study tested whether listening to music with personal meaning could improve alertness and brain function in people with moderate to severe Alzheimer's disease. Ten participants listened to short, meaningful songs and, separately, nature sounds while researchers used brain sc…

This study tested whether a combination of two treatments could improve speech and communication in people with mild-to-moderate Alzheimer's disease. Twenty-three participants received either real or fake magnetic brain stimulation (TMS) along with intensive speech therapy. Resea…

This small study tested a tablet app called 'Gotcha!' designed to help people with mild to moderate dementia who struggle to remember names. Participants used the app at home for daily practice over six weeks, trying to relearn the names of 6-10 important people in their lives. R…

This study tested the safety and side effects of an investigational drug called SAGE-718 in people with early Alzheimer's disease or mild cognitive impairment. It involved 26 participants and aimed to see if the drug was well-tolerated while also checking for any effects on memor…

This study tested whether a safe, non-invasive brain stimulation device used at home could help people with mild to moderate Alzheimer's disease. One hundred participants used the device for 30 minutes, five days a week for six months to see if it improved memory, thinking skills…

This study tested a new smart home system designed to help Spanish-speaking caregivers of people with dementia or memory problems. The system uses sensors and internet-connected devices to monitor the person being cared for and provide support to the caregiver. Researchers wanted…

This study tested whether a special exercise program could help people with Alzheimer's disease. Thirty-four participants were assigned to either standard exercises or a program that combined physical movements with mental tasks. Researchers measured changes in balance, fear of f…

This study tested a 12-week online educational program designed to help family members caring for loved ones with Alzheimer's disease. The program provided information about the illness, stress management techniques, and a discussion forum where caregivers could connect with othe…

This study tested a home device called Care4AD (Nili) designed to help people caring for loved ones with Alzheimer's or dementia. For three months, caregivers used either a basic or an enhanced version of the device to help coordinate daily care tasks, share photos, play music, a…

This study tested a new website tool designed to help caregivers of people with dementia who also have trouble swallowing. Researchers wanted to see if using the website reduced feelings of stress and burden for caregivers. They compared two groups: one that had access to the web…

This study tested a one-year support program for Veterans diagnosed with Alzheimer's disease or traumatic brain injury and their family caregivers. The program aimed to improve the quality of life for both the Veteran and the caregiver while reducing the stress and burden felt by…

This study tested whether an online tool called WeCareAdvisor could help caregivers of people with dementia. 262 caregivers used the web-based tool for 3-6 months to get advice on managing challenging behaviors like agitation or anxiety. Researchers measured if the tool reduced c…

This study tested a new in-home technology system designed to help family members caring for loved ones with dementia or memory loss. The system uses sensors, smart devices, and apps to monitor safety and provide support, aiming to reduce the caregiver's stress, anxiety, and feel…

This study tested a new sleep education program designed for pairs (dyads) of an Alzheimer's patient and their live-in caregiver who both have sleep problems. The program taught behavioral techniques to improve sleep for both people. Researchers measured if the program improved s…

This study tested a training program to help nursing home staff provide better comfort and symptom management for residents with moderate to severe Alzheimer's disease. The program educated staff on palliative care, which focuses on relieving pain, stress, and other symptoms to i…

This study tested whether a 12-week program of paper-based brain training exercises could help improve memory and thinking skills in people with early Alzheimer's disease. It involved 70 Vietnamese patients and their caregivers, measuring changes in cognitive tests and daily livi…

This study tested whether adding game-like features to a memory-assist app could help people with mild to moderate dementia stay more engaged with the technology. Researchers compared the app with and without these features over six months to see if the gamified version improved …

This study tested a technology-based coaching and support program designed for Chinese and Korean American women aged 40-65 who are caring for a family member with Alzheimer's disease. The goal was to see if the program could reduce caregiver stress and improve their health and q…

This study tested whether a long-term exercise program could help people with moderate to severe dementia living in nursing homes maintain their ability to perform daily tasks like bathing and dressing. It compared a group doing regular exercise to a control group participating i…

This study tested whether the medication AXS-05 could safely reduce agitation in people with Alzheimer's disease. 408 participants with Alzheimer's-related agitation were randomly assigned to receive either the drug or a placebo for 5 weeks. Researchers measured changes in agitat…

This small study tested whether a gentle, at-home brain stimulation treatment called tDCS is safe and acceptable for people with Alzheimer's disease who experience behavioral symptoms like agitation or apathy. Researchers worked with 3 patients and their caregivers to see if this…

This small, completed pilot study explored whether a dietary supplement called citicoline could help improve sleep and thinking skills in people with Alzheimer's disease. Twenty participants were randomly assigned to receive either citicoline or a placebo pill daily for three mon…

This study aimed to see if caregivers of people with moderate to severe Alzheimer's disease were more satisfied with a new, quick-dissolving form of the drug memantine compared to the standard tablet. Over 100 patients were involved, and their primary caregivers answered a questi…

This study tested a specialized palliative care program for people hospitalized with late-stage Alzheimer's or related dementias and their family caregivers. The program aimed to provide better symptom management, support decision-making, and coordinate care after leaving the hos…

This study tested whether using hearing aids could help people who have both Alzheimer's disease and age-related hearing loss. For one year, researchers compared two groups: one received real hearing aids immediately, while the other started with inactive 'placebo' devices. The g…

This study tested whether an 8-week telehealth program could help people living with Alzheimer's or other dementias. The program provided occupational therapy sessions via video call, focusing on improving daily activities and managing difficult behaviors. Researchers compared th…

This study tested a program called Tele-STELLA, which uses video calls to support family members caring for a loved one with moderate to severe dementia. Over 375 caregivers worked with trained guides from their own homes to learn strategies for managing difficult behaviors like …

This study tested whether a specially designed social robot could help reduce apathy—a lack of motivation or interest—in older adults with mild cognitive impairment or dementia living in long-term care. Researchers compared the usual facility activities to the usual activities pl…

This study tested whether AXS-05 is safe and effective for reducing agitation in people with Alzheimer's disease over a long period. 456 participants who had already shown benefit from AXS-05 in previous studies were either kept on the medication or switched to placebo to see if …

This study tested a virtual companion program called MEMORI Corps. It matched trained senior volunteers with people living with dementia at home to provide regular companionship and personalized activities. The goal was to reduce social isolation for the person with dementia, eas…

This study tested two simple treatments to help people with Alzheimer's or other dementias swallow more safely. Researchers wanted to see if tongue-strengthening exercises or a saliva-moistening gel could reduce choking risk and prevent pneumonia. The study involved 76 patient-ca…

This study tested a 6-week program to help caregivers of people with dementia. Participants wore an Apple Watch to track their sleep and activity patterns and received weekly coaching calls. The goal was to help caregivers establish healthier daily routines to reduce symptoms of …

This early-stage study tested the safety of an experimental oral drug called NH280105, which is being developed for Alzheimer's disease. Researchers gave the drug to 32 healthy adult volunteers to check for side effects and see how the body absorbs and processes it. The study als…

This study aimed to understand the genetic causes of early-onset Alzheimer's disease. Researchers collected blood samples from 26 people with the condition and their family members. They analyzed DNA and RNA to identify biological markers that could help diagnose and treat the di…

This study tested whether combining two safe, non-invasive brain stimulation techniques could improve brainwave patterns linked to memory. Researchers worked with 30 healthy adults, using gentle magnetic and electrical pulses on the scalp while measuring brain activity. The goal …

This study aimed to discover new signs in blood and urine that could help detect Alzheimer's disease earlier. Researchers analyzed samples from 95 people, including those with normal memory, mild thinking problems, and different stages of Alzheimer's. The goal was to find pattern…

This study aimed to understand how the relationship between partners affects mental health and well-being as one or both face dementia. Researchers followed 544 older adults in committed relationships for three years, conducting video check-ins every six months. The goal was to l…

This study aimed to understand how a non-invasive light therapy, called transcranial photobiomodulation, affects brain blood vessel health and cognitive function like memory and thinking. It involved 24 adults aged 18-80 who received up to eight light therapy sessions over four w…

This research study aimed to understand how very early brain changes, long before memory problems appear, might affect sleep patterns and attention in older adults. Researchers studied 30 cognitively healthy adults aged 55-75, using brain scans, sleep studies, and memory tests. T…

This study aimed to understand why some women experience memory and thinking changes after menopause and how this might be linked to a higher risk of Alzheimer's disease later in life. Researchers studied 120 healthy postmenopausal women, using brain scans and memory tests to see…

This study developed and tested a communication program called KNOW to help people with early-stage Alzheimer's or dementia and their family caregivers talk about and plan for future medical care. The program taught communication and relaxation techniques to make these difficult …

This study aimed to understand if a specific protein found in red blood cells is linked to a person's risk of developing Alzheimer's disease. It involved 200 Caucasian participants, some with Alzheimer's and some without. The research compared the characteristics of this protein …

This study aimed to understand how dementia with Lewy bodies affects a person's sense of self, including their personal memories and self-concept. Researchers compared 61 older adults with Lewy body dementia, Alzheimer's disease, or healthy aging using brain scans and memory test…

This study aimed to find the best way to tell people their genetic risk for Alzheimer's disease. Researchers compared two methods: an online platform people could use on their own, and a video call with a healthcare provider. They measured how each method affected participants' a…

This study aimed to investigate a possible link between gum disease (periodontitis) and Alzheimer's disease by analyzing blood test results. Researchers compared 100 people who had both conditions to people who had gum disease alone. They looked for patterns in standard blood cel…

This study aimed to understand how compounds from plants like cocoa might interact with the bacteria in our gut, and how this differs in people with different versions of a gene linked to Alzheimer's risk (APOE). It involved 49 healthy adults who provided saliva and stool samples…

This study aimed to understand how Latino adults in New York City react to learning their personal genetic risk for developing Alzheimer's disease. Researchers compared two groups: one that learned their risk based on family history and ethnicity, and another that also learned th…

This study aimed to understand how early-stage Alzheimer's disease affects a person's ability to drive safely in real-world conditions. Researchers observed 60 older adults, half with early Alzheimer's and half without, while they drove. The goal was to identify common driving er…

This study aimed to understand if variations in a specific gene (ABCB1) are linked to a higher risk of Alzheimer's disease. Researchers compared the genes of 510 people with and without Alzheimer's to see if certain gene patterns were more common in those with the disease. The go…

This study explored whether daily breathing exercises, combined with brain training games, could influence markers of brain health and learning ability in healthy adults aged 50-70. For 12 weeks, 91 participants did daily online brain training and followed specific breathing rout…

This early-stage study tested whether baricitinib, a drug approved for rheumatoid arthritis, can get into the spinal fluid and reduce signs of brain inflammation in people with Alzheimer's disease, ALS, or early memory concerns. Seventeen participants took the pill daily for 24 w…

This study tested a new type of brain scan to see if it could better distinguish between different causes of memory loss and thinking problems, like Alzheimer's disease. Researchers compared the new scan to the current standard scan in 134 people, including healthy volunteers and…

This small, completed study aimed to understand if age-related hearing loss is linked to the common symptom of word-finding difficulty in people with Alzheimer's disease. Researchers assessed 46 French-speaking participants over 65 with mild Alzheimer's, testing their hearing and…

This study looked at whether one week of daily meditation could change levels of certain proteins in the blood that are linked to Alzheimer's disease risk. Researchers enrolled 94 healthy adults aged 18-35. Participants either meditated daily for a week or did no special task, an…

This study aimed to understand how much a specific Alzheimer's disease blood test result naturally varies from week to week in the same person. Researchers took 10 blood samples over 9 weeks from 100 adults aged 50-80, some with normal thinking and some with mild impairment. The …

This study aimed to understand why Black older adults have higher Alzheimer's risk. Researchers measured deep sleep quality and brain amyloid levels in 210 healthy seniors over time. The goal was to see if poor deep sleep helps explain racial differences in early Alzheimer's dise…

This study explores whether certain sleep medications can safely boost the brain's natural cleaning system, called the glymphatic system, to help clear harmful proteins linked to Alzheimer's disease. Researchers tested two medication combinations on 31 healthy older adults during…