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Could treating sleep apnea help prevent Alzheimer's? new study investigates

NCT ID NCT05094271

Knowledge-focused Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like apnea could affect Alzheimer's-related brain changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Supplemental oxygen and continuous positive airway pressure (CPAP) machine
What this could lead to
If successful, this study could help clarify whether treating sleep apnea might slow or prevent Alzheimer's disease.
What could go wrong
This is an early, completed study focused on understanding the link, not testing a treatment. Results may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

182 people

The number who actually took part.

Started

Oct 2021

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 65-85 years 2. Gender: Men or Women 3. MOCA \> 26 4. Independently living and able to drive 5. OSA (AHI ≥ 15/h) or no OSA 6. Subjects must consent to waiving their right to obtain their PHS score (since the score is not yet actionable and could lead to social stress and ethical dilemmas) Exclusion Criteria: 1. Currently smoking 2. History of COPD or asthma 3. Heart Failure Class III or IV, unstable cardiovascular disease, or uncontrolled hypertension 4. Neuromuscular Disease 5. Drowsy Driving (ESS \> 18/24) 6. Inability to complete study procedures, such as questionnaire that are only available/validated in English 7. Lack of decisional capacity to provide informed consent 8. Participants in whom magnetic resonance imaging Magnetic Resonance Imaging \[MRI\] is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant 9. Presence of a brain tumor or lobar stroke 10. Current drug or alcohol abuse/dependence 11. Prisoners

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Conditions

The condition(s) this trial relates to.

Alzheimer disease obstructive sleep apnea syndrome sleep apnea syndrome sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Obstructive sleep apnea OSA Sleep apnea

Contacts and locations

Locations

  • UCSD Sleep Research

    La Jolla, California, 92037, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.