ALZHEIMER DISEASE

This early-stage study tested a new drug called ADEL-Y01 in healthy volunteers and people with mild Alzheimer's or early memory problems. The goal was to check safety and how the drug moves through the body. The trial was stopped early, so no final results are available.

This study tested a new drug called ION269 in adults with Down syndrome who also had signs of Alzheimer's-related brain changes. The main goal was to check if the drug was safe and tolerable. Only one person took part before the study was stopped early.

This study tested a drug called PrimeC in people with mild to moderate Alzheimer's disease. The goal was to see if it is safe and if it helps with thinking and daily activities. The trial was stopped early, but it included 8 people who took either PrimeC or a placebo for up to 52…

This study tested an experimental drug called varoglutamstat (PQ912) in people with early Alzheimer's disease. The goal was to see if it was safe and could slow down memory and thinking problems. The trial was stopped early, but researchers looked at brain activity and cognitive …

This study tested an experimental drug called JNJ-63733657, designed to target tau protein tangles in the brain, in people with early Alzheimer's disease. The goal was to see if it could slow down memory loss and daily function decline compared to a placebo. The trial was termina…

This study tested whether anti-inflammatory drugs could help people with early Alzheimer's or mild cognitive impairment. The trial was stopped early, so only one drug was tested in 34 participants. The goal was to see if the drug improved thinking and memory, but the early end me…

This study tested the long-term safety of AXS-05, an experimental drug for agitation in people with Alzheimer's disease. It included 139 adults who had already completed earlier studies. The trial was terminated early, and its main goal was to track side effects, not to cure Alzh…

This study looked at the long-term safety and effects of a drug called XPro1595 in people with Alzheimer's disease who had already taken it in earlier studies. Only 11 people took part, and the study was stopped early. The main goal was to check for side effects and see if the dr…

This study tested a drug called simufilam in people with mild-to-moderate Alzheimer's disease. The goal was to see if it could slow down memory loss and help with daily activities. About 1,125 participants took either a placebo or one of two doses of simufilam twice a day for 76 …

This study tested an experimental drug called REM0046127 in people with mild to moderate Alzheimer's disease. Participants took either a high dose, low dose, or placebo for 28 days. The goal was to check safety and see how the drug affected brain signals and spinal fluid markers.…

This study tested a wearable EEG device that records brain waves to see if it can help doctors diagnose Alzheimer's disease and mild cognitive impairment more accurately. About 148 adults aged 50-90 with memory concerns wore the EEG cap during one session. Researchers compared th…

This study tested a new device (DDS) to see if it could accurately detect swallowing problems in people with conditions like stroke, Parkinson's disease, multiple sclerosis, Alzheimer's, or dementia. The device was compared to a standard X-ray test. The study was stopped early be…

This study explored whether a special eye scan (hyperspectral retinal imaging) can detect beta-amyloid, a protein linked to Alzheimer's disease, in the retina. Researchers aimed to see if this non-invasive test could distinguish people with Alzheimer's from healthy individuals. T…

This study tested a personalized touchscreen device (My PATI) to help people with Alzheimer's or related dementias communicate their care preferences. Researchers worked with 42 participants (people with dementia and their caregivers) to see if the device improved quality of life…

This study tested a special helmet and abdominal panel that shines near-infrared light and uses magnets on people with mild-to-moderate Alzheimer's disease. The goal was to see if it safely improves memory and thinking after 8 weeks of daily sessions. About 60 participants were s…

This study tested whether a non-invasive brain stimulation technique called TMS could improve memory in older adults with mild cognitive impairment or early Alzheimer's disease. Only 4 people took part before the study was stopped. Researchers used brain scans to see if stimulati…

This small study tested a non-drug program to improve sleep and thinking in older adults with mild memory problems or early Alzheimer's. The program combined bright light therapy and a special type of sleep coaching. The goal was to see if the approach was practical and could hel…

This early-phase study aimed to see if taking memantine, an Alzheimer's drug, for 15 days would change results on a battery of cognitive tests, brain scans, and EEGs in healthy young men aged 18-30. The goal was to validate these tests as tools for future Alzheimer's drug develop…

This study aimed to understand why people with early Alzheimer's disease have trouble making decisions and how this affects their daily lives. Researchers planned to compare 100 participants (patients and healthy controls) using thinking and decision-making tests. The study was t…