Eye test may spot Alzheimer's early, study finds
NCT ID NCT07529912
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study explored whether a special eye scan (hyperspectral retinal imaging) can detect beta-amyloid, a protein linked to Alzheimer's disease, in the retina. Researchers aimed to see if this non-invasive test could distinguish people with Alzheimer's from healthy individuals. The study included 186 adults aged 30 and older with or without Alzheimer's. The approach could offer a simpler, less invasive way to diagnose Alzheimer's compared to current methods like PET scans.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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186 people
The number who actually took part.
- Started
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Feb 2016
- Finished
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Jan 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 30 years and older * Diagnosis of Alzheimer's disease or no evidence of Alzheimer's disease (including control participants or those with other neurodegenerative conditions such as Parkinson's disease, Lewy body dementia, or vascular dementia) * Prior confirmation of Alzheimer's disease diagnosis by genetic testing or positron emission tomography (PET) scan (where applicable) * Able to undergo cognitive assessment if required (for control participants without recent testing within the past 6 months) * No major ocular conditions that would preclude retinal imaging * Willing and able to attend the Royal Victorian Eye and Ear Hospital * Able to attend with a friend or family member Exclusion Criteria: * Presence of significant ocular disease that prevents adequate retinal imaging * Inability to undergo study procedures or comply with study requirements * Any condition that, in the opinion of the investigators, would make participation unsafe or compromise data quality
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Centre for Eye Research Australia
Melbourne, Victoria, 3002, Australia
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Other studies related to the condition(s) this trial covers.
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