Autoimmune disease

Researchers are testing an experimental oral drug called PRO-1562 in healthy adults and in adults with relapsing multiple sclerosis who also have long-term vision damage from chronic optic neuropathy. The trial has two parts: a phase 1 safety and absorption study in healthy volun…

This phase 2 trial is testing whether a single infusion of a patient's own genetically modified immune cells, called C-CAR168, can safely and effectively treat lupus nephritis that has not responded to standard therapies. The cells are designed to target and eliminate specific im…

This trial tests a therapy called CTX112 in adults with severe neurologic autoimmune diseases, including progressive multiple sclerosis, neuromyelitis optica, and stiff-person syndrome. CTX112 uses donor T cells edited with CRISPR to target and deplete B cells, which are thought …

This early-phase trial tests whether a single infusion of CD19 CAR-T cells, called TranspoCART19, is safe and can push severe lupus nephritis into remission. Lupus nephritis is a serious kidney complication of lupus that often resists standard treatments. Ten adults with refracto…

This trial is testing an experimental treatment called CRT-402 for people with severe autoimmune diseases like lupus, scleroderma, and myositis that haven't improved with standard therapies. CRT-402 is a type of CAR-T cell therapy given by infusion that aims to deplete certain im…

Researchers are observing how satisfied people with relapsing-remitting multiple sclerosis are when they receive ocrelizumab as an injection under the skin instead of an intravenous infusion. The study follows about 1,800 participants across multiple countries for 12 months, incl…

Researchers are testing an experimental oral drug called VC005 in teenagers aged 12 to 17 who have non-segmental vitiligo, a condition where patches of skin lose their color. The study measures how the drug moves through the body and checks for safety over up to 24 weeks of treat…

Researchers test whether rituximab helps maintain lung function in adults with systemic sclerosis and interstitial lung disease whose disease has stabilized after initial rituximab treatment. Participants receive rituximab or placebo infusions at months 0, 6, and 12. The main mea…

This study tests whether a one-time infusion of specially engineered immune cells (CAR T cells) can improve lung function and skin hardening better than current treatments for people with active systemic sclerosis, a rare autoimmune disease. About 92 adults with lung involvement …

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

This trial tests whether efgartigimod, a drug that lowers harmful antibody levels, can improve recovery in people with Guillain-Barré syndrome (GBS), a rare nerve condition that can cause weakness and paralysis. Adults aged 18 to 70 with recent GBS onset will receive either efgar…

Researchers are testing a one-time CAR-T cell therapy called C-CAR168 in adults with progressive multiple sclerosis that has not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to target two proteins, and is given as a single intravenou…

This study tests a digital health program designed to support people with psoriatic arthritis in managing their condition. Participants use a mobile app for symptom tracking and lifestyle tips, plus tools for sleep, stress, and physical activity, along with a smartwatch. The goal…

Guillain-Barré syndrome (GBS) is a rare condition where the immune system attacks nerves, causing weakness that can progress to paralysis. Standard treatment is intravenous immunoglobulin (IVIg), but recovery is often slow. This phase 2 trial tests whether adding an experimental …

Researchers are testing an experimental antibody called JH013 in adults with primary Sjögren's syndrome, a condition where the immune system attacks moisture-producing glands and other tissues. The trial has two parts: one gives a single injection at increasing doses, and the oth…

This trial tests an experimental drug called PF-08154225 in people with autoimmune diseases like lupus, rheumatoid arthritis, myositis, or scleroderma. The drug aims to calm the immune system, which mistakenly attacks healthy cells in these conditions. Participants receive the dr…

This early-stage trial is testing an investigational injection called GT802 in people with relapsing or refractory multiple sclerosis (MS) — meaning their disease is active despite standard treatments. The study aims to check whether GT802 is safe and to get a first look at wheth…

Researchers are testing an experimental antibody called EA5 in adults with generalized myasthenia gravis whose blood contains antibodies against the acetylcholine receptor and who have not tried complement inhibitor drugs. EA5 targets complement protein C5, part of the immune cas…

Researchers are testing whether ivarmacitinib, an oral drug, works as well as prednisone for controlling arthritis and rash in adults with mild-to-moderate lupus. About 294 participants receive either ivarmacitinib or prednisone for 24 weeks. The goal is to see if ivarmacitinib c…

This trial tests whether adding nicorandil, a drug that widens blood vessels, to standard rheumatoid arthritis (RA) treatment can reduce the buildup of plaque in arteries. People with RA have a higher risk of atherosclerosis, which can lead to heart attacks and strokes. Researche…

Researchers are testing an experimental intravenous drug called F182112 in adults with autoimmune hemolytic anemia that has returned or resisted multiple treatments. The trial enrolls about 12 people and gives the drug at three increasing dose levels to check safety, tolerability…

This trial tests whether the GX-01S continuous glucose monitoring system helps adults with type 1 or type 2 diabetes improve their blood sugar control. Participants wear the sensor for about 4.5 months, with the first 15 days blinded to establish a baseline, then full access to r…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This early-phase trial tests a nebulized therapy called UC-EVs, derived from human umbilical cord cells, in adults with immune-mediated inflammatory diseases (such as IgG4-related disease or systemic sclerosis) that affect the lungs. Participants inhale the vesicles daily for 7 d…

This trial tests whether an automated insulin delivery system, the DEKA TWIIST pump with Tidepool Loop software, can safely manage glucose levels in pregnant people with type 1 diabetes. The system adjusts insulin automatically and can be set to pregnancy-specific glucose targets…

This study compares two treatment combinations for adults with psoriatic arthritis who did not get enough relief from methotrexate alone. One group will receive apremilast plus methotrexate, the other adalimumab plus methotrexate. Researchers will measure joint and skin disease a…

This study tests the drug upadacitinib (Rinvoq) in 30 people with rare genetic disorders that overactivate the JAK-STAT immune pathway. The trial has four phases over 12 months, including an open-label phase to find the best dose and a randomized withdrawal phase to compare the d…

This trial tests whether adding a selective Mediterranean diet to standard treatment can improve platelet counts and reduce bleeding in adults with immune thrombocytopenia (ITP), a condition where the immune system attacks platelets. Sixty adults aged 18 to 60 with low platelet c…

This trial gives deucravacitinib, an oral drug that calms the immune system, to adults with lupus or Sjögren's disease and to children with psoriasis or psoriatic arthritis. Participants join after finishing an earlier study of the same drug, and the goal is to see how safe and t…

This study tests a drug called ocrelizumab in children and teens aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). The goal is to see how the drug moves through the body, if it is safe, and how it affects the immune system. Participants will receive the drug as a sh…

This early-stage trial is testing an investigational drug called RO7845860, given as an injection under the skin, in people with relapsing multiple sclerosis (MS). The main goals are to check the drug's safety, how the body handles it, and its effects on immune cells. The study w…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This trial tests a single infusion of BCT301, a cell therapy made from stem cells that are engineered to target the immune system, in 6 adults with IgG4-related disease that has not improved with standard treatment. The main goal is to check whether the infusion is safe and toler…

This early-stage trial will test whether injecting adalimumab (Humira) into the eye during Boston KPro surgery is safe for 8 patients with severe corneal damage. The study focuses on side effects and tolerability, not yet on how well it works. It is for people who have run out of…

This study tests whether adding a health navigator to pediatric lupus care teams helps more children receive recommended blood pressure checks and treatments. The trial involves 16 pediatric lupus clinics, which will be randomly assigned to different implementation strategies. Re…

This study tests a drug called inebilizumab in 15 children aged 2 to 17 who have IgG4-related disease, a rare condition that causes swelling and damage in organs. The drug is given through an IV and works by lowering certain immune cells to reduce inflammation. Researchers will c…

This phase 1 trial tests a one-time infusion of AZD0120, a CAR-T cell therapy that targets CD19 and BCMA, in people with relapsed or refractory immune thrombocytopenia (ITP) or warm autoimmune hemolytic anemia (wAIHA). Participants receive a short course of bendamustine before th…

This early-phase study tests whether combining mesenchymal stem cells (MSCs) with specially engineered immune cells (CAR-T cells) is safe and can help control autoimmune diseases. About 30 adults with established autoimmune conditions will receive the treatment and be monitored f…

This study tests whether specially engineered immune cells, called CAR-T cells, can safely treat autoimmune diseases. The cells are designed to target and suppress B cells, which play a key role in many autoimmune conditions. The trial involves 30 adults and focuses on safety and…

This early-stage trial tests clonal fetal mesenchymal stem cells (cfMSCs) in 100 people with severe immune-related disorders or tissue damage. The goal is to see if the cells are safe and can reduce symptoms. Participants have no other treatment options left.

This study looks at the long-term safety and effectiveness of a drug called rozanolixizumab for adults with ocular myasthenia gravis, a condition that causes muscle weakness in the eyes. About 100 people who have already taken the drug in a previous study will continue treatment.…

This trial is testing an experimental therapy called CTA313, which uses engineered immune cells (CAR T cells) to potentially reset the immune system in people with active autoimmune diseases. The study will include adults aged 18 to 75 with systemic lupus erythematosus, progressi…

This trial is testing an experimental drug called PTC844 in people with active rheumatoid arthritis, a condition where the immune system attacks the joints, causing pain and swelling. The study aims to see if PTC844 is safe, how it moves through the body, and whether it can reduc…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This study is following people who receive a Tornier Perform™ Reversed MonoPost shoulder replacement to see how well it works and how safe it is. The implant is designed for patients with severe shoulder damage, such as from arthritis, fractures, or failed previous surgeries. Res…

This early-stage trial tests a small, soft implant that holds donor insulin-making cells (islets) and protects them from the immune system. The goal is to see if the device is safe and keeps the cells alive and working in adults with type 1 diabetes. Some participants are also on…

This trial tests whether drinking galactose, a sugar that breaks down slowly, can help refill muscle energy stores after exercise in people with type 1 diabetes. Participants will consume galactose alone or with glucose, and researchers will use PET scans to see how much galactos…

This study tests an experimental drug called remibrutinib in 20 people with relapsing or progressive multiple sclerosis (MS). Participants take the drug twice daily for 2 years and undergo powerful 7T MRI scans to measure changes in brain volume, lesions, and tissue health. The g…

This trial compares two treatment approaches for moderate to severe pemphigus vulgaris, a rare autoimmune disease causing painful blisters on skin and mucous membranes. One group receives rituximab (a biologic that targets immune B-cells) plus corticosteroids, while the other get…

This Phase 3 trial is testing whether a microneedle pad delivering botulinum toxin A can improve symptoms of Raynaud's phenomenon and digital ulcers in people with systemic sclerosis. The study compares the microneedle treatment to a placebo, measuring changes in finger temperatu…

This study tests a drug called inebilizumab in 180 adults with autoimmune hepatitis, a condition where the immune system attacks the liver. The goal is to see if the drug can reduce liver inflammation and allow patients to take lower doses of steroids. Participants will receive e…

This phase 2 trial tests whether indapamide, a common diuretic, can slow the worsening of walking ability in people with progressive multiple sclerosis (MS). Participants take one tablet daily for 12 months, with walking speed measured regularly. The study aims to see if the drug…

This trial tests whether an experimental drug called efgartigimod can reduce nerve damage and pain in adults with Sjogren's disease. Participants will receive either the drug or a placebo as a subcutaneous injection. The study measures changes in neuropathy symptoms and quality o…

This early study tests a new drug called HN2302, which aims to create CAR-T cells inside the body to target and control autoimmune diseases like lupus and scleroderma. The trial will enroll 12 adults to check safety and see if the treatment works. It is a first step, so results w…

This trial tests whether an experimental drug called ESG206 can safely reduce disease activity in adults with systemic lupus erythematosus (SLE). Participants will receive either ESG206 or a placebo, and researchers will measure how many achieve a meaningful improvement in lupus …

This trial tests whether a culturally tailored, Spanish-language onboarding and support program helps Latino youth aged 10–20 with type 1 diabetes adopt and consistently use the Medtronic MiniMed 780G automated insulin delivery system. Participants receive one-on-one nutrition su…

This trial tests whether open-source automated insulin delivery (AID) systems can control blood sugar as well as commercial systems in adults with type 1 diabetes, even when meals are not announced. Participants will use both types of systems for four weeks each, with a focus on …

This trial tests an experimental therapy called SYS6020 for people with relapsing or progressive multiple sclerosis that hasn't responded well to standard treatments. SYS6020 uses a patient's own immune cells, engineered to target and potentially reduce harmful B cells involved i…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This trial is testing whether anifrolumab, an experimental antibody, can help Chinese adults with moderate-to-severe systemic lupus erythematosus (SLE) achieve remission. Participants receive anifrolumab infusions over 52 weeks alongside standard care, with a focus on safely redu…

This early-stage trial is evaluating an investigational drug called QLS2404, given as an injection, to see if it is safe and tolerable. The study first tests single doses in healthy volunteers, then moves to multiple doses in people with systemic lupus erythematosus or primary Sj…

This pilot trial tests whether giving the immunosuppressant drug mycophenolate mofetil (MMF) for six months after a stem cell transplant can prevent systemic sclerosis from relapsing. Six adults with scleroderma who are undergoing a stem cell transplant will take MMF starting 90 …

This early-phase trial is testing an investigational drug called ACG102, given by intravenous infusion, in people with refractory active systemic lupus erythematosus (SLE) — a form of lupus that has not responded well to standard treatments. The main goals are to check the drug's…

This trial is testing an experimental drug called TLL-018 in adults with moderate-to-severe rheumatoid arthritis who haven't responded well to or couldn't tolerate standard treatments. Participants will receive either TLL-018 or a placebo for a period, and the study will measure …

This trial tests whether antiplatelet medications, specifically clopidogrel and aspirin, can reduce inflammation in the blood vessels of people with psoriasis or psoriatic arthritis. Participants take each drug or a placebo for four weeks, and researchers measure changes in infla…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This phase II trial is testing an experimental tablet called TollB-001 in adults with systemic sclerosis, a rare autoimmune disease that causes skin thickening and can affect internal organs. The study aims to see whether the drug can improve skin symptoms and overall well-being …

This trial is testing an investigational drug called velinotamig in adults with immune thrombocytopenia (ITP) or warm autoimmune hemolytic anemia (wAIHA) that has relapsed or not responded to standard treatments. Velinotamig is an engineered bispecific antibody designed to target…

This study looks at whether a wearable device that tracks both glucose and ketones can help people with type 1 diabetes avoid diabetic ketoacidosis (DKA), a serious complication. About 1,200 adults and children with type 1 diabetes will use the Abbott Continuous Dual Glucose Keto…

This study tracks the safety of secukinumab, a biologic injection, in Indian adults with axial spondyloarthritis — a group of inflammatory conditions that cause back pain and stiffness. Over 16 weeks, researchers will monitor side effects and disease activity in about 60 particip…

This trial tests whether a year-long, home-based cognitive training program can improve memory, attention, and emotional understanding in people with multiple sclerosis. Participants use the COGWEB platform plus exercises for recognizing facial expressions, with most sessions don…

This trial tests whether a one-time dose of fecal microbiota transplantation (FMT) — taking capsules containing processed donor stool — can improve blood sugar control and reduce thyroid antibodies in adults who have both type 2 diabetes and Hashimoto's thyroiditis. All 38 partic…

This phase 1 trial tests an experimental cell therapy called LMY-922 (BAFF CAR-T cells) in people aged 16 to 75 with refractory autoimmune diseases, including rheumatoid arthritis, lupus, dermatomyositis, and systemic sclerosis. The therapy uses donor immune cells engineered to t…

This phase 1 trial is testing an experimental drug called ATG-201 in adults with systemic lupus erythematosus, systemic sclerosis, or Sjögren's disease. ATG-201 is designed to bind to specific proteins on immune cells, potentially quieting the overactive immune response that driv…

This phase 2 trial is testing whether an oral drug called ICP-488 can reduce disease activity in people with primary Sjögren's syndrome, an autoimmune condition that causes dry eyes, dry mouth, and fatigue. About 240 adults aged 18 to 70 with moderate-to-active disease will recei…

This phase II trial tests whether obinutuzumab, a B-cell targeting antibody, can alone achieve complete kidney response in people with pure class V lupus nephritis—a form of lupus kidney disease with no approved treatments. Participants receive up to four infusions over seven mon…

This phase III trial tests whether lenalidomide, an immune-modulating drug, can prevent disease flares in people with IgG4-related disease who are in remission. Participants receive either lenalidomide or a placebo for 52 weeks while tapering off steroids. The goal is to see if l…

This early-phase trial tests a single infusion of universal STAR-T cells—engineered immune cells—in adults aged 18 to 65 with refractory generalized myasthenia gravis, a condition causing severe muscle weakness. The study aims to assess safety, tolerability, and signs of effectiv…

This study tests whether taking high-dose omega-3 (fish oil) pills for 12 weeks can reduce inflammation and cell damage in women with lupus who are in remission. Researchers will measure changes in blood markers and telomere length, which is linked to aging. The goal is to see if…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This phase 2 trial tests an experimental oral drug called CBP-0276 in adults with active psoriatic arthritis, a condition causing joint pain, swelling, and skin plaques. Participants receive either a low dose (200 mg), a high dose (800 mg), or a placebo daily for 24 weeks. The ma…

This study investigates whether ginkgo biloba extract can improve outcomes for people with moderate to severe rheumatoid arthritis who are already on standard disease-modifying drugs. Participants take ginkgo biloba for 12 weeks, and researchers measure changes in inflammation ma…

This study tests a program where social workers screen families of youth with type 1 diabetes for social challenges like food insecurity, then connect them to community resources. The goal is to see if this approach is practical and acceptable, and whether it can improve diabetes…

This trial tests a new gene therapy called FOXP3-T4 for people with IPEX syndrome, a rare genetic condition that causes severe immune problems. The therapy involves taking a patient's own immune cells, modifying them in the lab to work better, and giving them back via a single in…

This study follows 115 adults with multiple sclerosis who are switching from ocrelizumab to ofatumumab because their antibody levels dropped. Researchers want to see if the switch stops or slows that decline over 24 months. The goal is to better manage immune health while still t…

This phase 2 trial tests a personalized CAR T cell therapy called zolacabtagene autoleucel in 52 adults with chronic immune thrombocytopenia (ITP) or autoimmune hemolytic anemia (AIHA). The treatment uses the patient's own immune cells, modified to target and destroy faulty B cel…

This study offers continued access to anifrolumab (Saphnelo) for people with systemic lupus erythematosus, systemic sclerosis, or myopathies who completed a prior anifrolumab trial and are still benefiting from the drug. Participants receive the same treatment as before, while re…

This study tests whether a mobile app that provides structured diabetes education can help adolescents with type 1 diabetes improve their blood sugar control, confidence, and self-care habits. Participants aged 10 to 19 with type 1 diabetes and an HbA1c of 7% or higher will use t…

This early-phase trial tests a new therapy called META 10-19 for people with autoimmune hemolytic anemia (AIHA) that has not responded to standard treatments. AIHA is a condition where the immune system mistakenly destroys red blood cells, causing anemia. META 10-19 uses a patien…

This study tests anifrolumab, a drug for systemic lupus erythematosus (SLE), given either as a shot under the skin or through an IV. The goal is to see how the body processes the drug and check its safety. About 92 adults with lupus will take part.

This study tests an experimental oral drug called JAB-8263 in adults with active rheumatoid arthritis. The goal is to see if it is safe and can reduce joint inflammation and pain. Participants take the drug or a placebo every other day for 28 days. The trial is small and early-st…

This trial investigates whether a supplement called butyrate (a substance produced by gut bacteria) and an intensive lifestyle program (Mediterranean diet plus exercise) can reduce liver fat in adults with type 1 diabetes who also have fatty liver disease. Participants are random…

This study tests whether a low dose of blinatumomab, a drug originally used for leukemia, can help people with severe autoimmune encephalitis or cerebellitis that hasn't responded to standard treatments. The drug targets and depletes certain immune cells (B cells) that are mistak…

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This study tests whether high-intensity breathing exercises can improve respiratory muscle strength, lung function, fatigue, and quality of life in people with multiple sclerosis (MS). Participants are randomly assigned to high-intensity interval breathing training, low-intensity…

This Phase 3 study tests SAB-142, an antibody that targets immune cells, in 108 people aged 5 to 40 with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin over 12 months. Participants receive either the drug or a placebo alongside standa…

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This trial investigates whether combining atorvastatin (a cholesterol-lowering drug), N-acetyl-L-cysteine (an antioxidant), and romiplostim (a platelet-boosting drug) can help adults with immune thrombocytopenia (ITP) who no longer respond to steroids. The goal is to see if this …

This study tests two surgical techniques to treat stable white patches on the skin that are not caused by vitiligo. Both methods involve transplanting the patient's own skin cells, followed by laser therapy to boost color return. Twenty-two adults will each receive both treatment…

This phase 2 trial tests whether adding baricitinib to standard TPO-RA therapy helps adults with immune thrombocytopenia (ITP) who did not respond to TPO-RA alone. One hundred participants will be randomly assigned to receive either baricitinib plus TPO-RA or TPO-RA alone for 14 …

This phase 2 trial tests whether adding ianalumab to eltrombopag helps children aged 5 to 17 with primary immune thrombocytopenia (ITP) who didn't improve after steroids. The goal is to see if the combination can raise platelet counts and prevent bleeding. About 36 children will …

This phase 2a trial tests whether a daily pill called ACT-777991 can help return color to the face of adults with non-segmental vitiligo. About 30 participants will take either the drug or a placebo for 24 weeks. Researchers will measure changes in skin color using a standard sco…

This trial tests a one-time treatment called CAR-T cell therapy for people with systemic lupus erythematosus (lupus) that hasn't improved with standard medications. The therapy uses a patient's own immune cells, which are modified in a lab to find and destroy the B cells that dri…

This study tests whether removing a specific type of immune cell (naive T cells) from a donor's stem cell graft can prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The trial enrolls people with non-malignant blood di…

This early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …

This study tests whether teprenone, a stomach-protecting drug, can reduce gastrointestinal damage caused by high-dose steroids in people with lupus. One hundred participants will be randomly assigned to take either teprenone or the standard acid-blocker omeprazole for 12 weeks. T…

This study tests a new medicine called GR2301, given as shots under the skin, together with light therapy for people with vitiligo (a condition that causes white patches on the skin). The trial has two parts: first, finding the right dose, then testing how well it works. About 11…

This study tests a computer program called PRIMUS that helps neurologists choose treatments for people with relapsing-remitting multiple sclerosis (MS). The tool uses data from past patients to predict how the disease might progress under different therapies. Doctors in some clin…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study tests whether freeze-dried fecal bacteria, given as oral capsules, can improve symptoms in 40 adults with active rheumatoid arthritis that hasn't responded to standard drugs. Participants will receive either the fecal transplant or a placebo for 24 weeks. The main goal…

This study tests whether adding blood flow restriction cuffs to light leg exercises can help people with relapsing-remitting multiple sclerosis build bigger, stronger thigh muscles. Thirty participants will do the same exercise twice a week for 8 weeks, but some will have the cuf…

This study tests a new automated insulin delivery system for people with type 1 or type 2 diabetes in a hospital setting. Six participants will have their blood sugar controlled by the system for 24 hours while eating standard meals. The goal is to see if the system can keep bloo…

This study tests a new medicine called empasiprubart in teenagers aged 12 to 17 who have a rare nerve disease called CIDP. The goal is to find the right dose and see if the drug is safe and helps control the disease. Participants will receive the drug for about 27 months and be f…

This study tests whether an interactive educational video, added to standard diabetes education, helps children aged 8 to 14 with type 1 diabetes improve their blood sugar control. The video lets kids make decisions in everyday situations and see the results. Researchers will mea…

This early-stage study tests a new injection called CM336 in 30 adults with active Sjogren's syndrome. The main goal is to check safety and how the body handles the drug. Researchers will also look for signs that it helps control the disease. This is a Phase 1 trial, so it's one …

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This study will compare two drugs, tofacitinib and upadacitinib, added to standard methotrexate treatment for rheumatoid arthritis. One hundred adults in Pakistan will take one of the two drugs daily for six months. Researchers will measure disease activity and side effects to se…

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests anifrolumab, a drug already used in adults with lupus, in children aged 5 to 17. The goal is to see how the drug moves through the body and if it is safe. Twenty-four children with moderate to severe lupus will receive the drug as a shot under the skin, while con…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard narrowband UVB light treatment can help restore skin color in people with vitiligo. Five adults with non-segmental vitiligo will receive UVB twice a week for 24 …

This study tests a treatment called extracorporeal photopheresis (ECP) for people with advanced melanoma who develop severe colitis or hepatitis from immunotherapy. ECP filters a patient's blood, treats it with a light-activated drug, and returns it to the body. The trial compare…

This early-stage study tests a new drug called JCXH-213 in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The trial includes only 4 people whose ITP did not improve with standard treatments. The main goal is to…

This study tests a drug called IMM0306 in 125 people with IgG4-related disease, a condition where the immune system attacks organs causing swelling and damage. The goal is to see if IMM0306 can prevent disease flare-ups and allow patients to safely stop taking steroids. Participa…

This study tests an experimental pill (cadisegliatin) taken alongside insulin in people with type 1 diabetes who already use a hybrid closed-loop insulin pump. The goal is to see if the pill helps keep blood sugar in a healthy range more consistently. About 40 adults will receive…

This study tests whether SHR-2173, added to usual care, improves symptoms of generalized myasthenia gravis (gMG) better than a placebo. About 60 adults with confirmed gMG will receive the drug or placebo for 24 weeks. The main goal is to see if daily muscle weakness and fatigue s…

This study tests whether the shingles vaccine Shingrix and the diabetes drug semaglutide, alone or together, can help preserve the body's ability to make insulin in adults recently diagnosed with type 1 diabetes. The goal is to slow the immune attack on insulin-producing cells an…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This Phase 1 trial will test PB018, a biosimilar to the MS drug Ocrevus, in 222 people with multiple sclerosis. The study compares how the body processes PB018 versus Ocrevus and checks for safety. Participants will receive either PB018 or Ocrevus, but neither they nor their doct…

This early-phase trial tests a three-step immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months). The goal is to preserve the body's remaining insulin production by calming the immune attack and teaching the immune system to tolerate insulin. Sixty …

This early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …

This early-phase study tests whether combining two drugs (Zuberitamab and Orelabrutinib) can help people with immune thrombocytopenia (ITP) or autoimmune hemolytic anemia (AIHA) that hasn't responded to other treatments. The drugs work together to calm the immune system and stop …

This study tests a cream called ruxolitinib on children aged 2 to 11 with a common type of vitiligo (white patches on skin). The goal is to see if the cream can safely bring back skin color over 24 weeks. About 20 children will apply the cream daily and visit the clinic for check…

This study tests all-trans retinoic acid (ATRA), a form of vitamin A, in adults with immune thrombocytopenia (ITP) whose platelet counts stay low despite steroid treatment. About 192 participants will receive either ATRA or a placebo for 24 weeks. The goal is to see if ATRA can s…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This early-phase study tests a new treatment called IASO206 for people whose autoimmune hemolytic anemia (AIHA) has not responded to standard therapies. AIHA is a condition where the immune system mistakenly destroys red blood cells, causing fatigue and other symptoms. The study …

This study will give 12 families of children with type 1 diabetes and food insecurity either weekly boxes of fresh produce or semi-prepared meal kits, plus nutrition coaching. The goal is to see if these programs are practical and improve diet quality and blood sugar stability. I…

This study tests whether a structured 12-week program focusing on nutrition, exercise, sleep, and stress management can improve fatigue, physical function, and quality of life in people with relapsing-remitting multiple sclerosis. Thirty participants will first be observed for 12…

This early-stage study tests a new treatment called LVIVO-TaVec400 in 44 people with severe autoimmune diseases like lupus, multiple sclerosis, and myasthenia gravis that have not responded to standard therapies. The main goals are to check the treatment's safety and find the rig…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on weight. The goal is to see if the simpler fixed-dose method works just as we…

This early-stage study tests a new treatment called SR-02 for adults with type 1 diabetes who experience dangerously low blood sugar. The treatment involves implanting insulin-producing cells into the belly lining. Nine participants will receive the implant and must take lifelong…

This early-phase study tests whether the drug efgartigimod (VYVGART) can lower harmful collagen VII antibodies and improve wound healing in people with two rare blistering skin conditions: recessive dystrophic epidermolysis bullosa (RDEB) and epidermolysis bullosa acquisita (EBA)…

This phase IIa trial tests a personalized cell therapy for people with progressive multiple sclerosis (MS). The treatment uses the patient's own immune cells, turned into 'tolerogenic dendritic cells' that are designed to calm the immune system and stop it from attacking the nerv…

This study tests whether dihydroartemisinin, a drug used for malaria, can help treat discoid lupus erythematosus (DLE), a chronic skin condition causing red, scaly patches. Researchers will compare two doses of the drug to a standard lupus treatment (hydroxychloroquine) in 100 ad…

This study tests a new automated insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals. Participants will use either the NMX8 system or another approved system to see which helps keep blood sugar in the target range more oft…

This study looks at whether a 12-week Mediterranean diet can lower oxidative stress and improve blood sugar control in girls aged 10-18 with type 1 diabetes who have high HbA1c levels. Researchers will measure changes in blood markers and glucose levels. The goal is to see if thi…

This early-stage trial tests a stem cell injection (HS_SW01) in 21 adults with systemic sclerosis, a disease where the immune system attacks the body, causing skin hardening and organ damage. The main goal is to see if the treatment is safe and tolerable. Researchers will also ch…

This early-phase trial tests a new stem cell treatment (HS_SW01) for people with ankylosing spondylitis, a type of arthritis that causes spine pain and stiffness. The study will include 18 adults aged 18 to 65. Researchers aim to check if the treatment is safe and if it helps red…

This study looks at whether people with type 1 diabetes can safely start using an advanced hybrid closed-loop insulin pump system at home instead of in the hospital. Researchers will track blood sugar levels, quality of life, and costs over 12 months in 80 adults. Participants re…

This study tests whether exosomes from umbilical cord stem cells can safely help restore skin color in adults with vitiligo. 96 participants with active or stable vitiligo will receive either exosome infusions or injections alongside standard light therapy and ointment. The goal …

This study tests whether adding artificial intelligence to an automated insulin delivery system can improve blood sugar control for people with type 1 diabetes. The AI learns each person's meal patterns and automatically gives insulin boluses without requiring them to announce me…

This study tests whether adding sirolimus to standard steroid treatment helps people with newly diagnosed mild autoimmune hemolytic anemia (AIHA) achieve lasting remission. About 216 adults will be randomly assigned to get either steroids alone or steroids plus sirolimus for 6 mo…

This study tests whether adding a special cell secretion (called secretome) to standard light therapy helps restore skin color better in people with vitiligo. About 150 adults with stable vitiligo will receive either light therapy alone, or light therapy plus secretome applied th…

This study follows 150 adults with moderate-to-severe rheumatoid arthritis who have received the SetPoint System, an implanted device that uses nerve stimulation to control inflammation. Researchers will monitor device safety, ease of use, and how well it controls disease activit…

This study tests whether regularly measuring the amount of mycophenolate mofetil in the blood helps more people with lupus kidney disease achieve kidney remission. One hundred adults with active lupus nephritis will be split into two groups: one gets standard dosing, the other ge…

This study tests two drugs, diroximel fumarate and dimethyl fumarate, in children with relapsing multiple sclerosis. About 185 kids will be split by weight and randomly assigned to one of the drugs or a standard treatment (fingolimod). The goal is to see which drug is safer and b…

This study tests whether clemastine fumarate, an over-the-counter allergy medication, can repair damaged nerve insulation (myelin) in people with multiple sclerosis. About 44 adults with relapsing-remitting MS will receive either the drug or a placebo for 3 months, then all will …

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors, a drug class that raises DKA risk. About 75 adults with type 1 diabetes will be en…

This phase 2 study tests whether combining orelabrutinib (a targeted drug) with romiplostim (a platelet booster) can improve platelet counts in adults with chronic immune thrombocytopenia (ITP) who haven't responded well to standard treatments. About 28 participants will receive …

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This study tests a digital program that gives people with multiple sclerosis personalized strategies to avoid falls. About 80 participants who have trouble walking and have fallen recently will take part. The program uses each person's fall history to create tailored advice, and …

This study compares two treatments for generalized vitiligo: PUVA therapy (a light-based treatment) and the pill Tofacitinib. Researchers will enroll 64 adults with stable vitiligo covering more than 10% of their body. The goal is to see which treatment works better and is safer …

This early-stage trial tests whether a single infusion of ripertamab can safely improve daily living activities in 20 adults with generalized myasthenia gravis, a condition causing muscle weakness. Participants are randomly assigned to receive the drug or a placebo, and are follo…

This study will enroll 120 children and teens with type 1 diabetes who use automated insulin pumps. Participants will be randomly assigned to follow either the standard blood sugar target (70-180 mg/dL) or a tighter target (70-140 mg/dL) for 12 months. Researchers want to see if …

This early-phase trial is testing a new treatment called CRC01 for people with severe lupus nephritis, a serious kidney complication of lupus. The therapy uses a patient's own immune cells, which are modified in a lab to target and destroy certain immune cells that drive the dise…

This early-stage trial tests a new treatment called KN5501 for people with moderate to severe lupus that hasn't responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) to target and destroy faulty B cells that drive the disease. Partic…

This study looks at whether baricitinib, a drug for rheumatoid arthritis, can improve blood clotting and cholesterol levels compared to standard treatments. About 100 adults with active RA will take baricitinib for 3 months. Researchers will measure changes in clotting markers an…

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This study tests a mobile app called Diactive-1 that provides personalized resistance training and education for children and adolescents with type 1 diabetes. Over 12 weeks, participants follow a tailored exercise program (like strength training or high-intensity intervals) and …

This study tests whether two doses of stem cells, given four months apart, can improve saliva production and reduce dry mouth in people who had radiation for head and neck cancer or have Sjögren's disease. One hundred participants will receive either stem cells or a placebo. The …

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This study tests whether using a continuous ketone monitor with a lower alarm threshold (1.0 vs 1.5 mmol/L) can reduce the risk of diabetic ketoacidosis in people with type 1 diabetes who take dapagliflozin, a drug typically used for type 2 diabetes. 115 adults will wear a dual g…

This phase 2 trial tests whether combining dapagliflozin (a diabetes drug) with SC0062 (a blood vessel drug) can better protect kidneys in adults with type 1 diabetes and chronic kidney disease. Thirty-six participants will try each treatment alone and together in a cross-over de…

This early-stage trial will test an oral probiotic called R-2487 in 36 adults with Sjogren's syndrome. The main goal is to see if the probiotic is safe and tolerable. Researchers will also check for changes in disease activity and inflammation using blood and stool samples. The s…

Researchers are testing whether a smartphone app called DETECTRA can help doctors diagnose rheumatoid arthritis earlier in adults who have joint symptoms and a positive ACPA blood test. Participants are randomly assigned to receive standard care alone or standard care plus the ap…

Researchers are testing a noninvasive MRI technique that uses inhaled hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. The study includes about 51 participants, including healthy volunteers…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

Researchers at University Hospital Olomouc are studying whether a standardized driving simulator can detect differences in driving performance among people with Parkinson's disease, people with multiple sclerosis, and healthy drivers. About 100 participants with a valid driver's …

This observational study tests whether levels of MPO-DNA complexes in the blood can serve as a reliable biomarker for disease activity in systemic lupus erythematosus (SLE). Researchers will compare MPO-DNA levels in 90 participants with active versus inactive lupus, and check ho…

This study tests whether a radioactive tracer called [18F]fluorodeprenyl-D2 can make chronic active lesions visible on PET scans in people with multiple sclerosis. These lesions are areas of ongoing brain inflammation that standard MRI often misses. Researchers will compare the P…

This study tests whether blood samples collected at home using small capillary devices, like finger pricks, give the same results as traditional blood draws from a vein. Researchers will compare both methods in about 1,000 people with chronic conditions such as kidney disease, au…

This study evaluates whether the Cone Evasion Walk Test—a walking task that involves stepping around cones—is a reliable and valid way to assess balance, obstacle avoidance, and fall risk in people with multiple sclerosis (MS). Researchers will measure how consistent the test res…

This study tests whether a newer ultrasound technique, shear wave elastography, can better detect inflammation at tendon and ligament attachment sites (entheses) in people with psoriatic arthritis compared to standard ultrasound. Researchers will compare imaging results from 60 p…

This study asks whether levels of uromodulin, a protein in the blood, can indicate the severity of kidney damage in people with lupus nephritis. Researchers will compare uromodulin levels with kidney biopsy results from 90 participants, including those with different classes of l…

This study investigates whether levels of a protein called RNASE1 in the blood can serve as a biomarker for lupus nephritis, a serious kidney complication of systemic lupus erythematosus (SLE). Researchers will compare RNASE1 levels in 128 adults with SLE, some with lupus nephrit…

This trial is testing a new implantable sensor called the HALO System in people with type 1 or type 2 diabetes. The sensor is designed to continuously measure glucose, ketones, and lactate in the fluid just beneath the skin, which could give a more complete picture of metabolic h…

Lupus nephritis is a serious kidney complication of lupus that can lead to kidney failure. This study investigates whether levels of neutrophil extracellular traps (NETs)—web-like structures released by immune cells—in the blood can predict how well patients respond to therapy. R…

This study aims to see if a blood test for TTG-IgA antibodies combined with symptom information can accurately sort adults into low, intermediate, or high risk for celiac disease. Researchers will analyze data from 15,500 patients who already had both a blood test and a duodenal …

This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diag…

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study tests a urine test that detects gluten peptides in children with celiac disease who are on a gluten-free diet. The goal is to see if this test helps doctors and families identify accidental gluten exposure better than standard blood tests. One hundred children aged 2 t…

This study will screen about 2,200 children aged 2-10 for autoantibodies that signal early type 1 diabetes. The goal is to find the disease before symptoms appear and test if educational programs help families. Researchers will also check if this screening is practical and cost-e…

This study aims to translate and validate the Celiac Dietary Adherence Test (CDAT) for Polish children with celiac disease. Researchers will enroll 20 participants aged 2 to 18, along with their caregivers, to check if the Polish version accurately measures how well they follow a…

People with multiple sclerosis or neuromyelitis optica spectrum disorder who take anti-CD20 drugs have a higher risk of shingles. The shingles vaccine is recommended for them, but the drug may weaken its effect. This trial compares two dosing schedules: one gives the second shot …

This trial tests whether a short, purpose-built educational video can strengthen high-school students' belief in disaster preparedness and their perception of disaster risk. About 144 students from twelve classes at one school in West Kalimantan, Indonesia, will be randomly assig…

This trial investigates whether annual re-screening for tuberculosis infection using a blood test (IGRA) can prevent active TB in people with autoimmune rheumatic diseases who are taking biologic or immunosuppressive medications. Participants who initially test negative for TB ar…

This study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …

This trial tests whether golimumab, a drug used for arthritis, can delay or prevent type 1 diabetes in people who have early signs of the disease but normal blood sugar. Participants receive monthly injections of golimumab or a placebo for up to 6 years. The study tracks how long…

Researchers are testing a diabetes education program that combines standard self-management lessons with hands-on activities involving miniature horses. Children and teens ages 8 to 20 with type 1 or type 2 diabetes, along with their caregivers, attend four sessions led by a diab…

Researchers are testing an experimental drug called ONO-4915 in adults with primary Sjogren's disease, a condition that causes dryness, fatigue, and pain. The trial enrolls about 60 people who have moderate to severe symptoms and a positive anti-SS-A/Ro antibody. Participants rec…

This study tests a medicine called IGIV 10% (a type of antibody treatment) against a placebo in 38 adults aged 18-70 with Stiff Person Syndrome, a rare condition causing muscle stiffness and spasms. The main goal is to see if the drug helps people walk faster (measured by a 25-fo…

Researchers are testing DiaFootCare, a mobile app that teaches foot self-care, sends medication and care reminders, guides users through taking wound photos, and shares information with pharmacists. The trial enrolls 139 adults aged 40 to 60 with diabetes and an active foot ulcer…

Researchers are testing whether a wrist nerve block, which uses a local steroid injection to interrupt pain signals, can reduce wrist pain in adults with rheumatoid arthritis. The trial enrolls 180 people with oligoarticular rheumatoid arthritis that affects the wrist. Participan…

This trial tests whether a specialized form of physical therapy, called vestibular physical therapy, can improve balance in people with early multiple sclerosis (MS) who have mild disability but still feel unsteady. Participants will be randomly assigned to receive the therapy or…

This trial tests whether a virtual reality version of Mindfulness-Based Stress Reduction (MBSR-VR) can be delivered to young adults aged 16 to 20 with type 1 diabetes who report high stress. Participants will attend group sessions that teach meditation, body awareness, and mindfu…

This trial tests whether a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) can reduce lower-limb spasticity and neuropathic pain in people with multiple sclerosis. About 40 adults with MS and significant leg stiffness and pain will rece…

This trial tests whether adding a wearable postural biofeedback device to a standard exercise program can improve disease activity, pain, and function in people with axial spondyloarthritis, a type of inflammatory arthritis affecting the spine. Participants will do supervised exe…

This study explores whether a self-guided web program called 'Better Nights, Better Days for Youth' can improve sleep and reduce pain in teenagers with rheumatic diseases like arthritis and lupus. Teens aged 12-18 with sleep problems will track their sleep and pain daily, then us…

This study asks whether drinking kefir every day can reduce gastrointestinal symptoms and improve quality of life in adults with celiac disease who follow a strict gluten-free diet. In a crossover design, 30 participants will consume 200 mL of kefir daily for four weeks, then con…

This trial tests whether a structured art therapy program, grounded in positive psychology, can improve self-compassion and hope in children aged 8 to 12 who are staying in a hospital ward. Half of the 80 participants will receive the art therapy sessions alongside standard nursi…

This study tests whether a specialized cognitive behavioral therapy called TEACH can improve mental health and well-being in adolescents with childhood-onset lupus. Researchers will measure changes in brain function, blood markers of inflammation, and symptoms like depression, fa…

This study tests whether an 8-week circuit training program—combining endurance, resistance, and balance exercises—works as well when delivered via live video calls as it does in person. Adults with multiple sclerosis who can walk at least 100 meters will be randomly assigned to …

This trial tests whether a new hand rehabilitation program, called SMART-HAND, can improve hand function, joint position sense, pain, and dexterity in people with rheumatoid arthritis. The program combines sensory training, massage, joint approximation, range-of-motion exercises,…

This trial tests whether a structured self-care education program can reduce joint stiffness and improve functional ability in people with rheumatoid arthritis. Participants are split into two groups: one receives the education program alongside usual care, while the other gets u…

This study tests whether AI-based cognitive training, using the Lumosity app, combined with a tailored physical-therapy program can improve sleep and quality of life in people with multiple sclerosis. Participants aged 25-40 with mild to moderate disability will undergo the train…

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This study tests an inhaled powder called LIQ861 (treprostinil) in adults with scleroderma who have frequent, painful Raynaud's attacks—episodes where fingers or toes turn color and become numb or tingly. About 75 participants will be randomly assigned to receive either a dose th…

This study tests whether an online mindfulness-based cognitive therapy (MBCT) program can reduce depression in people with multiple sclerosis (MS) who also have mild to moderate depression. The program involves live group sessions over eight weeks. Researchers will compare change…

This trial tests whether a structured mindfulness program can reduce pain in adults with multiple sclerosis. Participants are randomly assigned to either the mindfulness group or an educational program, and their pain, fatigue, sleep, mood, and quality of life are tracked over se…

This trial tests whether a 16-week remote physical activity program, including online newsletters and video coaching, can improve motivation and behavior in people newly diagnosed with multiple sclerosis (within the last 2 years). Participants will wear a Fitbit and log steps whi…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This study tests whether a powered hip-flexion device called Hypershell X can immediately improve walking in people with multiple sclerosis who have hip weakness. Ten participants will walk short distances with the device set to different levels of assistance. Researchers will me…

This trial investigates whether taking melatonin before bed can improve sleep quality, reduce fatigue, and lower inflammation in adults with active lupus. Sixty-four participants will either receive standard care plus melatonin or standard care alone for 12 weeks. Researchers wil…

This study tests whether a 16-week personalized home exercise program can improve muscle health and reduce fatigue in adults with stable lupus. Participants do three weekly sessions combining high-intensity interval training, strength exercises, and walking. Researchers measure c…

This study tests whether an activity book called 'Think-Find-Solve' can improve insulin self-management in children aged 8-12 with type 1 diabetes. Forty children and their parents will take part, with one group using the book for three months. The goal is to see if the book help…

This study tests two types of brain training—motor imagery (mentally picturing movements) and sensorimotor training (repetitive sensory exercises)—against standard therapy for people with multiple sclerosis who have neuropathic pain in their legs. The goal is to see which approac…

This study tests whether applying citric acid during a procedure to remove dark gum pigmentation leads to better-looking results and faster healing. Adults aged 18 to 50 with natural dark gums will receive either standard depigmentation or depigmentation plus acid. The researcher…

This early-phase trial investigates whether monthly injections of hyaluronidase into the fingers can improve stiffness and hand function in people with systemic sclerosis who have sclerodactyly (tight, thickened skin on the fingers). The study enrolls 10 adults aged 18 to 60 and …

This study looks at whether a 12-session weekly yoga program, added to usual medical care, can help adults with systemic autoimmune and inflammatory diseases (like lupus) feel less tired, have less pain, and improve their mood. Researchers will also check if yoga helps people sti…

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether an AI-powered educational platform can help parents of children with type 1 diabetes count carbohydrates more accurately and manage diabetes better. About 80 parents will either use the AI platform plus usual care or usual care alone for 12 weeks. The goa…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests whether a 12-week program combining individual physiotherapy, group movement-awareness sessions, and group psychotherapy can improve physical function, reduce fatigue, and enhance quality of life in 45 adults with multiple sclerosis. Each participant serves as th…

This study tests whether a device that delivers high-intensity focused electromagnetic pulses can strengthen core muscles and improve balance in people with multiple sclerosis. Sixty participants will either receive the electromagnetic therapy plus balance exercises, or balance e…

This study tests a six-month personalized telenursing program for 110 adults with multiple sclerosis. Participants receive monthly educational videos and nurse-led video calls to help them better understand their health and navigate the healthcare system. The goal is to improve h…

This study tests whether individualized video consultations can help adults with type 1 diabetes manage exercise and blood sugar more confidently. Sixty participants will receive up to three 30-minute sessions with a doctor or exercise specialist. The goal is to improve self-mana…

This study tests whether breathing low-oxygen air for short periods right before walking training helps people with multiple sclerosis walk better and farther. Thirty-five participants will receive either the low-oxygen breathing or a sham (placebo) version, followed by treadmill…

This study tests whether an internet-based program called My MS Toolkit can help reduce depression in people with multiple sclerosis. The toolkit teaches skills based on cognitive behavioral therapy to manage common MS symptoms like fatigue, pain, and low mood. Researchers will c…

This early-stage study tests whether short periods of breathing low-oxygen air (called acute intermittent hypoxia) are safe and tolerable for people with multiple sclerosis. Nine participants at different disease stages will be closely monitored for side effects like low oxygen l…

This study looks at whether a 12-week aerobic exercise program can improve thinking skills and reduce disease activity in people with lupus. Researchers will test memory, attention, and walking ability before and after the program. The goal is to see if exercise can ease lupus-re…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests whether a daily topical blend of lavender and rosemary essential oils can reduce urinary urgency, frequency, and leakage in adults with multiple sclerosis. Sixty participants will use either the essential oil blend or a placebo oil for six weeks. Researchers will…

This study will test whether high-intensity interval training (HIIT) on a stationary bike can improve walking, balance, and thinking in people with multiple sclerosis (MS). Forty adults with mild to moderate MS will be randomly assigned to either HIIT or moderate-intensity contin…

This study tests an 8-week mindfulness program for people with type 1 or type 2 diabetes who have trouble sensing when their blood sugar drops too low. The program teaches body awareness techniques like mindful eating and body scanning to help patients catch early warning signs. …

This study tests whether the drug vilamakitug can reduce symptoms of axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. About 150 adults with active disease will receive either the drug or a placebo. The main goal is to see if more people get at lea…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This study explores whether augmented reality (AR) exercises can help people with multiple sclerosis (MS) improve both their walking and thinking at the same time. Researchers will create AR scenarios that combine physical and mental tasks, then test them in 40 adults with MS. Th…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) is safe and helpful for depression and fatigue in adults with multiple sclerosis (MS). About 20 participants will receive daily rTMS sessions for 5 days, with assessments before, after, and at a 4-…

This study tests if a gentle brain stimulation technique called tDCS can improve movement, balance, fatigue, sleep, and thinking in people with multiple sclerosis. Forty adults with MS will receive either real or sham stimulation over two weeks. Researchers will check if the trea…

This study aims to see if a stress management program can help adults with myasthenia gravis feel less anxious and stressed, and improve their quality of life. About 62 participants will take part in an 8-session program and report their symptoms before and after. The goal is to …

This study tests whether a structured progressive resistance training program can improve muscle strength in adults with rheumatoid arthritis (RA). About 118 participants will either do supervised exercises 3 times a week for 6 weeks or continue their usual care. Researchers will…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests a wearable brain-computer interface (BCI) that gives real-time feedback during mental exercises to improve arm movement in people with multiple sclerosis. Forty participants will either receive BCI training plus standard rehab or standard rehab alone for 12 weeks…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce chronic pain in people with psoriatic arthritis. Researchers will give 40 adults with low disease activity but ongoing pain either real rTMS o…

This pilot study tests whether a special virtual reality headset that delivers rhythmic light and sound (gamma sensory stimulation) can reduce fatigue in people with multiple sclerosis. Thirty participants with moderate to severe fatigue will receive either the active stimulation…

This study tests whether a 12-week program of high-intensity interval training and strength training can improve heart and metabolic health in people with psoriatic arthritis. Researchers will also measure changes in fitness, pain, fatigue, and quality of life. The trial plans to…

This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks.…

This study tests whether an advanced telerehabilitation system, which uses AI to give instant feedback, can improve mobility in people with multiple sclerosis. 94 participants will either use the smart system or follow paper-based exercises at home. The goal is to see if this tec…

This study tests whether an internet-based physical activity program can improve sexual dysfunction in women with relapsing-remitting multiple sclerosis. Thirty women with MS and sexual problems will use a website and have video chats with a coach to increase their physical activ…

This pilot study will test whether five weekly sessions of Swedish massage can reduce stress and improve blood sugar control in 20 adults with type 1 diabetes. Researchers will measure stress hormones, inflammation, and glucose levels before and after the massage program. The goa…

This study looks at whether combining resistance exercises with an anti-inflammatory diet can reduce pain, improve daily function, and boost quality of life in people with rheumatoid arthritis. About 100 adults with low to moderate disease activity will follow a structured progra…

This study tests a comprehensive rehab program for people with multiple sclerosis (MS) that includes physical therapy, counseling, and nutrition advice. The goal is to improve movement, thinking, and overall well-being. About 26 participants with MS will take part in the program …

This study tests whether teaching parents of children with type 1 diabetes can improve the child's diabetes management and quality of life. About 42 families with children aged 8-12 will take part. Parents will receive special education sessions and motivational interviews. The g…

This study tests whether a digital tool called MSCopilot Boost can reduce the impact of fatigue in people with multiple sclerosis better than standard care. The tool includes remote monitoring of walking, dexterity, vision, and cognition, plus a personalized telerehabilitation pr…

This study tests a 10-session online program called REDCHiP for parents of young children (up to age 8) with type 1 diabetes. The program uses cognitive behavioral therapy to help parents manage their fear of hypoglycemia (low blood sugar) and reduce diabetes-related distress. Ab…

This study tests a therapeutic education program designed to improve self-image and self-esteem in adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Sixty participants will complete questionnaires and interviews before and after …

This study tests whether a non-invasive device that sends mild electrical currents to the spinal cord (tSCS) can improve upper limb function in people with multiple sclerosis. Sixty participants will receive either active stimulation or a sham (inactive) version during rehabilita…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

Autoimmune hepatitis makes a child's immune system attack their liver. Researchers at Assiut University Children's Hospital want to know how many children with this liver condition also develop thyroid disorders such as Hashimoto thyroiditis or Graves' disease. The team will test…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

Researchers are studying whether aerobic fitness relates to walking, balance, and fatigue in people with multiple sclerosis. About 70 adults with relapsing-remitting or progressive MS will take walking tests and balance challenges that involve soft surfaces and head movements. Th…

This study creates a UK-wide registry for people with vitiligo, a skin condition causing white patches. It will track the safety and effectiveness of current treatments in up to 30 patients. The goal is to improve long-term care by collecting real-world data from dermatologists.

This study looks closely at children admitted to a hospital with acute flaccid paralysis, a condition causing sudden muscle weakness or paralysis. Researchers will collect information from routine medical care to describe the clinical features, possible risk factors, and outcomes…

Researchers are studying whether extracellular vesicles released by pancreatic islets can indicate islet quality and be used to improve their fitness before transplantation. The trial involves adults with type 1 diabetes who are on the waiting list for an islet transplant. The go…

This observational study aims to collect and analyze data from up to two million patients with dermatologic conditions like vitiligo, atopic dermatitis, alopecia areata, and hidradenitis suppurativa, as well as their healthcare providers. By reviewing treatment patterns, outcomes…

Researchers at the University of Copenhagen are studying why some people with newly diagnosed Graves' disease develop thyroid eye disease while others do not. The study follows about 430 participants for one year, collecting eye exams, blood and tear samples, and symptom question…

Researchers are testing whether people with rheumatoid arthritis have early, symptom-free kidney problems more often than healthy people of the same age and sex. The study compares kidney function and urine protein levels between 120 participants, including those with rheumatoid …

Researchers at Assiut University are studying whether rheumatic diseases such as rheumatoid arthritis, lupus, and Sjogren's syndrome harm the meibomian glands, the tiny eyelid glands that keep tears from evaporating. The study compares 120 people with these conditions to 30 healt…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study looks at children and teenagers with type 1 diabetes to see how many have abnormal liver function tests. Researchers will check blood samples for signs of liver stress and try to find patterns or risk factors. The goal is to understand whether liver issues are common i…

Researchers at Mass General Brigham are testing whether genetic information can help identify people who might benefit from early screening for type 1 diabetes, even before they feel sick. The study involves 150 adults from the MGB Biobank who agreed to be recontacted. Participan…

This phase 1 trial asks whether a single dose of tirzepatide changes how quickly the stomach empties in adults with type 1 diabetes who are overweight or have obesity. Researchers will give participants either tirzepatide or a placebo injection, then measure stomach emptying usin…

Researchers at Sohag University are studying 150 people with rheumatoid arthritis to see whether the Rheumatoid Arthritis Impact of Disease (RAID) questionnaire can reliably detect disease flares. They will compare the questionnaire's performance with other standard disease activ…

Researchers at Sohag University are comparing levels of a long non-coding RNA called GAS5 and a blood protein called IL-6 in people with rheumatoid arthritis versus healthy individuals. The study will measure GAS5 expression in blood samples using a technique called qRT-PCR and c…

This study looks at whether a blood protein called asprosin is linked to metabolic syndrome and heart risk in people with rheumatoid arthritis. Researchers will compare asprosin levels in three groups: rheumatoid arthritis patients with metabolic syndrome, those without it, and h…

Researchers at Assiut University are studying how psoriatic arthritis affects patients' daily lives and whether that impact matches clinical signs of disease activity. Adults with psoriatic arthritis will complete the Arabic version of the PsAID-12 questionnaire, which covers pai…

Researchers are measuring how often subclinical hypothyroidism, a mild form of underactive thyroid, occurs in people with rheumatoid arthritis compared to healthy people. They will also check whether this thyroid condition relates to higher disease activity or more severe joint i…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

Researchers at King's College London are studying how the immune system relates to neuropsychiatric symptoms, which include mental and neurological issues. They will compare blood and spinal fluid samples from people with such symptoms against samples from healthy controls. The g…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study investigates whether a protein called FCRL5, found on certain immune cells, can serve as a marker for multiple sclerosis (MS) activity and treatment response. Researchers will track MS patients with blood tests every six months for two years, and compare their results …

This study looks at how children and teens with type 1 diabetes use the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin based on glucose readings. Researchers will track how quickly families adopt the system, who chooses it, and how it affects blood sugar co…

This observational study looks at women aged 40-60 to understand how the menopausal transition relates to autoimmune or immune-mediated conditions. Researchers will measure inflammatory markers, lifestyle factors, and stress levels to see how they connect to menopause symptoms an…

This study looks at whether two blood-based inflammation markers, called SII and SIRI, can help track disease activity and predict kidney flares in people with lupus nephritis, a type of kidney inflammation caused by lupus. Researchers will follow 100 adults with confirmed lupus …

This study investigates whether certain measurements from a standard 12-lead ECG—QT dispersion, P-wave dispersion, and Tp-e dispersion—can help predict the risk of cardiac arrhythmias in people with rheumatoid arthritis. Researchers will compare these ECG values between 120 rheum…

This study looks at whether children with celiac disease may have a higher risk of heart rhythm problems compared to healthy children. Researchers will measure specific heart rhythm intervals using an ECG in children diagnosed with celiac disease and compare them to healthy child…

This study looks at whether two simple tests can spot early signs of heart disease in people under 50 who were recently diagnosed with rheumatoid arthritis (RA). The tests are a blood-based measure called the atherogenic index of plasma and an ultrasound of the neck arteries. The…

This study aims to classify the different types of chronic pain experienced by people with multiple sclerosis (MS). Researchers will use a detailed clinical assessment to categorize pain as nociceptive, neuropathic, nociplastic, or mixed. The goal is to see if different pain type…

This study tests whether continuous glucose monitors (CGMs) like the Dexcom G7 can be safely and effectively used in intensive care units. The monitors provide real-time blood sugar readings and alarms for dangerously high or low levels, potentially reducing the need for frequent…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study follows 180 people with early relapsing-remitting multiple sclerosis (MS) to understand why some experience disability progression even without relapses. Researchers will use MRI scans, eye tests, and blood biomarkers to see if they can predict this type of progression…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether levels of a protein called 15-PGDH in the blood and joint fluid are linked to the severity of osteoarthritis and ankylosing spondylitis. Researchers will measure 15-PGDH in about 51 adults with these conditions and compare it with ultrasound images and…

This study looks at how common fatty liver disease (MASLD) is in adults with type 1 diabetes. Researchers will check 250 adults with type 1 diabetes for signs of liver fat and scarring, using non-invasive tests. The goal is to understand if type 1 diabetes raises the risk of live…

This study compares two ways of giving the same experimental biosimilar drug, DRL_AB, which is designed to work like abatacept for autoimmune conditions. Healthy male volunteers receive a single dose either through an autoinjector or a prefilled syringe. Researchers measure how m…

This study uses a novel ingestible mini-pill to collect bacteria samples from different parts of the gut in people with Sjögren's disease and healthy volunteers. By comparing these samples with mouth and stool bacteria, researchers hope to understand how the microbiome relates to…

This study investigates whether physical activity and other lifestyle factors are linked to changes in myelin—the protective coating around nerve fibers—in people aged 50 to 70 who have had multiple sclerosis for over a decade. Participants will undergo MRI scans to measure myeli…

This study investigates whether the triglyceride-glucose (TyG) index, a simple blood-based measure of insulin resistance, can predict early signs of atherosclerosis in people with lupus nephritis. Researchers will measure carotid artery thickness and plaque in 156 adults with lup…

This study investigates whether nerve ultrasound patterns and biomarkers in blood and spinal fluid can predict how people with chronic inflammatory demyelinating polyneuropathy (CIDP) respond to treatment. Researchers will follow 30 adults with CIDP, including newly diagnosed and…

This study looks at how tiny particles called extracellular vesicles travel through the bloodstream in people with systemic sclerosis, an autoimmune disease that affects blood vessels and organs. Researchers will take blood samples from different points in the circulation to see …

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study looks at whether it's possible to screen children for type 1 diabetes during their regular well-child visits. Researchers will ask parents and doctors about their experience with the screening and track how many families complete the test. The goal is to find the best …

This study looks at children with immune thrombocytopenic purpura (ITP) who also have certain antibodies, as they are at higher risk of developing lupus. Researchers will analyze blood samples to track immune cell changes and markers that may signal the transition to lupus. The g…

This observational study looks at whether combining genetic information with standard clinical data can better predict who will develop multiple sclerosis after a first episode of optic neuritis (inflammation of the optic nerve). Researchers will follow 180 people aged 16 and old…

This study looks at two types of liver disease — autoimmune hepatitis and non-alcoholic fatty liver disease — to see if fats in blood cells and tiny particles called extracellular vesicles differ between them. Researchers will collect blood samples from 24 adults and analyze thes…

This study investigates whether blocking GLUT1, a protein that helps immune cells use sugar, can reduce the autoimmune attack that destroys insulin-producing cells in type 1 diabetes. Researchers will analyze stored blood samples from adults with type 1 diabetes and test immune c…

This study tracks 30 people receiving a CATALYSTEM cementless hip implant to measure how much the stem moves (subsides) in the thigh bone over two years. Using specialized CT scans, researchers aim to see if the implant stays firmly in place, which is key for long-term success. P…

This study looks at whether the time of day you eat can affect brain health in people with multiple sclerosis. Twenty-two adults with MS will follow a daily eating schedule for a set period. Researchers will measure markers of nerve health and inflammation in the blood. A small g…

This pilot study tests a new continuous glucose monitor (CGM) called SAVA in 20 adults with Type 1 Diabetes. Participants wear three SAVA sensors and one standard sensor for 15 days to check how well the SAVA measures blood sugar compared to lab tests. The study also looks at com…

This study investigates sexual and urinary problems in people with generalized myasthenia gravis, an autoimmune disease that causes muscle weakness. While visible symptoms like droopy eyelids are well-known, issues like sexual dysfunction and bladder problems are often ignored. R…

This study investigates whether a specific gene variation (ICOS) is linked to developing systemic lupus erythematosus (SLE) and how severe the disease becomes. Researchers will analyze blood samples from 30 people diagnosed with SLE to look for patterns in the ICOS gene. The goal…

This study aims to identify newborns with a high genetic risk of developing type 1 diabetes. Researchers will screen 50,000 infants using a simple genetic test to find those with a greater than 10% risk. The goal is not to treat diabetes, but to find eligible babies for future pr…

This pilot study will test how easy it is for 20 adults with diabetes to set up and use the Feetsee foot monitoring device at home over 8 weeks. Participants will use the device and app on their own, following the instructions provided. The goal is to see if people can use it cor…

This French study will collect medical data and biological samples from 800 people with autoimmune liver diseases. Researchers hope to identify new markers that explain why some patients respond well to treatment while others do not. The goal is to better understand the immune me…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This study aims to create stem cell lines from blood samples of 16 people: 4 with severe scleroderma, 4 with mild scleroderma, and 8 of their healthy relatives. These stem cells will be turned into various tissue types (like heart, skin, and immune cells) in the lab to study how …

This study will test if blocking a protein called TL1A can reverse skin scarring in systemic sclerosis, a rare autoimmune disease. Researchers will take blood and skin samples from 10 patients with early diffuse scleroderma and 10 healthy people. They will treat the samples in th…

This study looks at how different types of exercise—aerobic and resistance training—affect the immune system and physical abilities in people with relapsing-remitting multiple sclerosis (MS). Researchers will measure changes in blood markers of inflammation and functional tests l…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study will follow 2,000 people with multiple sclerosis (MS) for five years to understand why some get worse faster than others. Researchers will use brain scans, eye exams, blood tests, and activity monitors to track changes. The goal is to find factors—like inflammation, bl…

This study will test how accurate and safe two continuous glucose monitoring (CGM) systems, the Anytime 5Pro and Anytime 4Pro, are in adults with type 1 or type 2 diabetes. About 70 participants will wear both devices at the same time and have their blood sugar measured during cl…

This study will follow 400 people recently diagnosed with polymyalgia rheumatica, a condition causing shoulder and hip pain. Researchers will track symptoms, treatments, and outcomes over 5 years to better understand the disease and improve diagnosis. Participants will provide bl…

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This study will ask 75 people with diabetes and their healthcare providers about their experience using the Instara-1 continuous glucose monitor. Participants will wear the device and answer questionnaires about comfort, ease of use, and how it helps manage their diabetes. The go…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This observational study follows 400 adults with psoriatic arthritis who are starting a new biologic or targeted synthetic drug as part of their routine care. Researchers want to see if treatment response differs based on how many prior advanced therapies a person has tried, and …

This observational study will check if diathermy, a tool used during surgery to stop bleeding, affects the accuracy of continuous glucose monitors in people with Type 1 Diabetes. About 126 adults and children will have their glucose readings compared before and after diathermy us…

This study tracks 32 people who received Azer-Cel, an experimental cell therapy for B-cell related autoimmune diseases, to monitor long-term safety for up to 15 years. Participants are checked for serious side effects and disease changes. The goal is to understand risks over time…

This study tracks physical activity in 175 pregnant women with type 1 or type 2 diabetes to see how it relates to blood sugar control and mental health. Participants wear an activity monitor for a week each trimester and complete questionnaires. The goal is to understand current …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at how multiple sclerosis (MS) might change a person's sense of smell and the related nerve sensations in the nose. Researchers will test 200 women with MS using simple smell and tickle tests, along with questionnaires about mood and thinking. The goal is to bett…

This study examines patients who have internuclear ophthalmoplegia, a condition that causes trouble moving the eyes sideways, to see how many later develop multiple sclerosis (MS). Researchers will review medical records of 200 patients to identify factors that predict MS convers…

This study looks at whether a finger-stick device (Coaguchek) can accurately measure blood thickness in people with antiphospholipid syndrome who take blood thinners. Currently, these patients need regular blood draws from a vein, which is inconvenient. The study will compare fin…

This early study tests a new device: a small patch with tiny, painless needles that sits on the skin and measures glucose and ketone levels continuously. Ten people with type 1 diabetes will wear the patch for 4 hours while briefly stopping their insulin pumps. Researchers will c…

This observational study will follow 40 adults with thymic abnormalities or myasthenia gravis (MG)-related antibodies to better understand how the disease develops and progresses. Researchers will analyze blood, thymus tissue, and muscle samples, along with clinical assessments, …

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This pilot study will test whether a musical tool called Ipsilon can screen for and possibly improve cognitive function in people with multiple sclerosis (MS). Thirty-two participants will either use the Ipsilon for 15 minutes daily for a week or start with no intervention, then …

This study looks at whether people with relapsing-remitting multiple sclerosis (RRMS) can have a relapse—new or worsening symptoms—without any visible inflammation on an MRI scan. Researchers will follow 136 adults who are having a suspected relapse, performing early brain and sp…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study will check if three substances in the blood (GFAP, NfL, and VEGF) are linked to how quickly disability gets worse in people with progressive multiple sclerosis. Researchers will measure these markers and compare them to standard tests of disability and thinking. The go…

This study looks at whether fear of hypoglycemia (low blood sugar) affects the heart, physical activity, and exercise ability in children and teens with type 1 diabetes. About 67 participants aged 10-18 will answer questionnaires and have their heart rate, blood pressure, and oxy…

This observational study looks at how walking fatigability—getting tired while walking—changes the way people with multiple sclerosis walk and increases their risk of falling. Researchers will compare two groups of 62 participants: those who experience walking fatigue and those w…

The SIRENA study will follow 300 children and adults who have tested positive for islet autoantibodies, which are early markers of type 1 diabetes. Over up to 10 years, researchers will track how their blood sugar, immune system, and metabolism change. The goal is to better predi…

This study looks at how people with multiple sclerosis (MS) understand and use their medicines at home. Researchers will visit participants once to review all medications and supplements, ask about routines and challenges, and check for safety issues. No changes to treatment will…

This study looks at how different temperatures—cold, normal, and hot—affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in a special room at each temperature for two hours while researchers monitor their blood sugar, hear…

This study will examine how the painkiller nefopam works in 24 adults hospitalized with acute rheumatic pain. Researchers will measure how the drug is processed in the body, including its peak levels and how long it stays active. The goal is to better understand the drug's effect…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study looks at how the amount of fat in a meal and a woman's menstrual cycle affect blood sugar after eating in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat standardized low-fat and high-fat meals while wearing continuous glucose monitors. The goal i…

This study will follow 5,000 adults with immune system problems to see if certain blood cell mutations (called clonal hematopoiesis) are linked to their condition. Researchers will track new cases of immune-related diseases over time. No treatments or drugs are tested—this is pur…

This study will test whether a new e-learning app can help school nurses feel more confident and knowledgeable about diabetes devices like insulin pumps and continuous glucose monitors. About 86 school nurses in Pennsylvania will use the app over 16 weeks and complete surveys bef…

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This study tests whether a 'serious game'—a video game designed to train thinking skills—can change how the brain works in people with multiple sclerosis who have memory or attention problems. Forty participants will play the game and have brain scans before and after to see if b…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to use their anti-rheumatic drugs more safely. About 144 adults will either use the app or receive standard care with a website. The goal is to…

This study tests whether taking statins (a common cholesterol drug) can protect the heart and brain from the harmful effects of breathing bushfire smoke. Healthy adults aged 18-64 will be exposed to simulated smoke in a controlled setting, with some taking statins short-term (2 d…

This study compares levels of two proteins, Klotho and FGF23, in 150 adults with Hashimoto's thyroiditis versus healthy controls. The goal is to see if these proteins are linked to inflammation in the disease. No treatment is given—only blood samples are taken.

This study looks at whether it's practical to screen close relatives of people with type 1 diabetes for early signs of the disease. About 1,000 adults in Quebec will have blood tests and answer questionnaires. If they show early markers, they will be monitored either by the resea…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…

This study will look at how the lupus medication Saphnelo (anifrolumab) is being used in women aged 15 to 50 who could become pregnant. Researchers will track how many women use the drug each year and describe their health characteristics. The goal is to gather real-world informa…

This study is creating an AI tool to help doctors decide the best heart treatment for people who have both immune thrombocytopenia (ITP) and coronary artery disease. Researchers will look at past patient data to build the tool, then test it on 600 new patients. The goal is to bet…

This study looks at whether measuring a specific antibody, anti-Ro52, in the blood of people with Sjögren's syndrome can help predict who will develop serious problems like lymphoma or organ damage. Researchers will follow 150 patients over time to see if higher antibody levels a…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and the HLA-B27 gene in 84 people with ankylosing spondylitis and a healthy control group. The goal is to see if these markers are linked to disease activity and severity. No treatment i…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis and systemic sclerosis, as well as healthy volunteers, and compare them with standard tests and lung functi…

This study looks at how treatment failure impacts the quality of life, anxiety, depression, and daily activities of 150 adults with relapsing-remitting multiple sclerosis. Researchers will use questionnaires to measure patients' well-being and their experience with care. The goal…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study will analyze blood samples from 24 adults with generalized myasthenia gravis who are being treated with ravulizumab. Researchers will look for changes in thousands of proteins over 26 weeks to find markers that show how well the treatment is working and whether the ner…

This study will collect health data and samples from 100 people with multiple sclerosis over several years. Researchers will use artificial intelligence and data science to find patterns that could help predict how the disease will progress. The goal is to eventually personalize …

This study explores whether a smartphone app called MyoSense 360 can help track changes in generalized Myasthenia Gravis (gMG) symptoms over 12 months. About 100 adults with gMG will use the app at home to collect data. The goal is to see if the app can detect when symptoms get b…

This study looks at whether young people (ages 8–25) with chronic immune thrombocytopenic purpura (ITP) have lower aerobic fitness than healthy peers. Fatigue is a major problem for many with ITP, and the researchers want to see if it's linked to a 'vicious cycle' of being less a…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study will compare how often autonomic nervous system problems occur in people with neuromyelitis optica spectrum disorder (NMOSD) versus multiple sclerosis (MS). Researchers will use questionnaires and bedside heart tests to measure symptoms like dizziness, bladder issues, …

This study aims to create better MRI methods for looking at the brains of people with multiple sclerosis (MS). Researchers will test these methods on 272 healthy volunteers and MS patients using both standard (3 Tesla) and ultra-high-field (7 Tesla) MRI machines. The goal is to m…

This study will follow 100 adults with multiple sclerosis who are starting either teriflunomide or dimethyl fumarate as part of their routine care. Over 12 months, researchers will measure how well participants can walk and think during sustained activities, along with their repo…

This study tests whether wearable sensors and smartphone apps can accurately track symptoms of generalized myasthenia gravis (gMG) in 25 people starting treatment with VYVGART. Participants wear sensors to measure activity, speech, and fatigue over 16 weeks. The goal is to see if…

This study explores whether wearable sensors can effectively monitor symptoms of myasthenia gravis, a condition causing muscle weakness. Fifty adults will wear devices that track physical activity, speech, and other health signals over 12 months. The goal is to see if these digit…

This study follows 700 adults recently diagnosed with lupus across Europe for up to 5 years. Researchers will track symptoms, treatment, and quality of life, and collect blood and urine samples. The goal is to understand how lupus develops early on and find markers that predict w…

This study will look at medical and lab factors that influence how children with Guillain-Barré syndrome recover. Researchers will follow 80 children to see which ones fully recover within 3 months. The goal is to create better ways to predict outcomes and guide treatment.

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors might lead to the disease. Participants provide blood, urine, stool, and saliva samples, and answer questions about their lifestyle. The goal is to identify triggers like smok…

This study tests a digital diary called MyMedDiary in 120 children (ages 2-18) newly diagnosed with celiac disease. The app helps families track gluten-free foods and spot hidden sources of gluten. Researchers want to see if the app improves diet adherence compared to traditional…

The LUNET project is creating a registry of 1,500 Italian adults with systemic lupus erythematosus (SLE). By collecting real-world data from clinics across Italy, researchers hope to better understand the disease and improve how it is managed in daily practice. This is an observa…

This study will follow 30 veterans with multiple sclerosis who have been taking ocrelizumab for at least a year. Researchers will test their memory, attention, and fatigue levels at the start, 6 months, and 12 months using questionnaires and cognitive tests. The goal is to see ho…

This study looks at whether a special eye scan (OCT-A) can detect blood vessel changes in the retina of people with multiple sclerosis (MS) and if those changes match up with vision loss. Researchers will scan the eyes of 32 MS patients and test their visual fields. The goal is t…

This study will test whether a 10-minute virtual reality session can change balance and motion sickness in people with multiple sclerosis (MS). Researchers will compare 30 adults with and without MS, measuring sway before and after the VR stimulation. The goal is to learn how cen…

This study will collect health information, samples, and data from 100 people in Luxembourg (800 total across Europe) who have rheumatoid diseases and are starting or changing treatment. Researchers hope to find patterns that can predict which treatments work best for each person…

This study looks at 140 children with celiac disease, ages 2 to 18, who have been on a gluten-free diet for at least 6 months. Researchers will compare a questionnaire and rapid urine/stool tests to standard blood tests to see which methods best measure diet adherence. The goal i…