Can we predict who gets rheumatoid arthritis? new study aims to find out
NCT ID NCT06876064
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors might lead to the disease. Participants provide blood, urine, stool, and saliva samples, and answer questions about their lifestyle. The goal is to identify triggers like smoking, diet, or stress that could predict the onset of arthritis.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify lifestyle or environmental triggers for rheumatoid arthritis, leading to better prevention strategies.
- What could go wrong
- This is an observational study, not a treatment trial. It may not find clear causes, and results may not apply to everyone at risk.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The patients will be recruted during consultation or hospitalization.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 80 years old * Group 1: Individuals with high risk of RA (ACPA ≥ 2N or ACPA ≥ N and rheumatoid factor ≥ 2N) and clinical signs of arthralgia (CSA criteria ≥ 4). * Group 2: High-risk individuals (ACPA ≥ 2N or ACPA ≥ N and rheumatoid factor ≥ 2N) without clinical arthralgia (CSA criteria \< 4). * Group 3: First-degree relatives of RA patients (no symptoms, negative controls). * Group 4: Newly diagnosed untreated RA patients (ACPA ≥ 2N or ACPA ≥ N and rheumatoid factor ≥ 2N) (positive controls). Exclusion Criteria: * Groupe1-2-3: • Presence of clinical joint swelling (synovitis) at the time of inclusion and previously noted by a doctor * All groups: * Taking current or past background treatment for RA, even for another indication * Corticosteroid therapy ≥10 mg at baseline and in the previous week * Presence of another connective tissue disease (Sjögren's, dermatomyositis, scleroderma, Sharp syndrome, etc.) * Subject unable to read and/or write * Inability to follow the patient during the study period * Failure to obtain consent * Non-affiliation to a social security scheme, * Persons placed under legal protection, under curatorship or under guardianship * Pregnant or breastfeeding women * Person participating in another intervention research including an * exclusion period still in progress
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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CHU Montpellier
Montpellier, Hérault, 34000, France
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Other studies related to the condition(s) this trial covers.
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- Can talk therapy plus exercise beat arthritis fatigue?