New combo therapy aims to boost platelets in ITP patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. ≥18 years old; 2. Patients diagnosed with primary ITP who failed to achieve a response after 14 days of full-dose TPO-RA therapy; 3. Patients with baseline platelet count less than 30×10⁹/L, or those with baseline platelet count ranging from 30×10⁹/L to 50×10⁹/L accompanied by clinically significant bleeding (WHO bleeding score ≥2). Exclusion Criteria: * Pregnant or lactating women, and who were possibly pregnant, planning to become pregnant, or who had partners planning to become pregnant; * With active malignancy or a history of malignant tumor; * Having experienced severe bacterial, viral, fungal or parasitic infection within the past 4 weeks; * With a history of symptomatic herpes zoster infection within 12 weeks prior to screening; * Active or chronic HBV, HCV or HIV infection; * Evidence of active tuberculosis; or previous evidence of active tuberculosis without appropriate and documented treatment; or household contact with patients with active tuberculosis without appropriate and documented tuberculosis prophylaxis; * Receipt of live vaccines within the past 12 weeks, or planned live vaccination during the study period; * Prior baricitinib therapy; * History of solid organ transplant or planned surgery; * Myelodysplastic syndrome, aplastic anemia or myelofibrosis; * Patients with other diseases were undergoing treatment with immunosuppressants; * Clinically significant thromboembolic events within the past 24 weeks, or ongoing anticoagulant treatment, who are deemed ineligible for the study by the investigator; * History or presence of myocardial infarction, unstable ischemic heart disease, stroke, or NYHA Class IV heart failure; * History or active manifestations of severe or unstable cardiovascular, respiratory, hepatic, gastrointestinal, endocrine, neurological, neuropsychiatric, or other medical conditions that, in the investigator's judgment, could confer unacceptable safety risks with the investigational product or confound the interpretation of study data; * AST \> 2 times the upper limit of normal (ULN), ALT \> 2×ULN, TBIL ≥ 1.5×ULN; * eGFR \< 50 mL/min/1.73m²; * Other patients deemed unsuitable for enrollment in this study by the investigator.