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Can a specialized hand exercise protocol restore grip and ease pain in rheumatoid arthritis?

NCT ID NCT07754552

Symptom relief Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This trial tests whether a new hand rehabilitation program, called SMART-HAND, can improve hand function, joint position sense, pain, and dexterity in people with rheumatoid arthritis. The program combines sensory training, massage, joint approximation, range-of-motion exercises, stretching, strengthening, and balance-based stabilization, tailored to each person's tolerance. Participants will be randomly assigned to either the SMART-HAND protocol, conventional rehabilitation, or a control group, and their hand function will be measured after 12 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 132 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants will be 18 years of age or older. * Participants will have a diagnosis of rheumatoid arthritis for at least five years. * Participants will be referred by a rheumatologist. * Participants will have been on a stable medication regimen for the past three months. * Participants will have no history of diabetes mellitus. * Participants will have no other conditions affecting sensory function. * Participants will provide informed consent to participate in the study. Exclusion Criteria: * Individuals who have undergone hand surgery within the past six months. * Individuals with a history of upper extremity fracture within the past six months. * Individuals with other musculoskeletal pain conditions involving the muscles and/or joints. * Individuals diagnosed with a neurological disease that may affect sensory or motor function. * Individuals who are unable to fully cooperate with the assessment procedures. * Individuals who have received corticosteroid treatment within the past month. * Individuals diagnosed with another rheumatic disease. * Pregnant women. * Individuals who are illiterate. Withdrawal/Discontinuation Criteria * Participants who miss more than 10% of the intervention sessions will be excluded from the study. * Participants who change their medication dosage or medication class during the study period will be excluded from the study. * Participants will have the right to withdraw from the study at any time and for any reason.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rheumatoid arthritis Rheumatoid arthritis (RA) Rheumatoid arthritis (RA) prevention

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.