Wearable tech aims to monitor rare muscle disease
NCT ID NCT07224386
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study explores whether wearable sensors can effectively monitor symptoms of myasthenia gravis, a condition causing muscle weakness. Fifty adults will wear devices that track physical activity, speech, and other health signals over 12 months. The goal is to see if these digital tools can provide useful information for managing the disease.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Individuals with gMG with MGFA severity class IIa/b, IIIa/b or IVa/b
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Autoimmune MG with or without history of thymoma, MGFA severity Class IIa/b, IIIa/b or IVa/b at the screening visit * Diagnosed gMG through ONE of the following methods: * Positive acetylcholine receptor antibody (AChR Ab) test * Positive muscle specific kinase receptor antibody (MuSK Ab) test * Positive LRP4 antibody and abnormal neuromuscular transmission demonstrated by single-fiber electromyography (SFEMG) or repetitive nerve stimulation (RNS) OR has maintained a positive response to treatments such as AChE inhibitors, IVIG/PLEX, FcRn antagonists or C5 inhibitors * Abnormal neuromuscular transmission demonstrated by single-fiber electromyography (SFEMG) or repetitive nerve stimulation (RNS) OR has maintained a positive response to treatments such as AChE inhibitors, IVIG/PLEX, FcRn antagonists or C5 inhibitors. * Physically and cognitively able to provide informed consent and adhere to the protocol, as determined by the investigator's judgment * Ambulatory status defined as the ability to walk a distance of 10 meters independently, with or without the use of an assistive device * Male or female, between the ages of 18 years old and 80 years old * Speaks and reads English fluently Exclusion Criteria: * Inability to engage in activities that are essential for independent living, such as dressing, bathing, toileting, or eating independently. * Neurological or orthopedic problems independent of myasthenia which significantly affect gait and ADLs in the investigator's judgement. * Any significant medical, laboratory, or psychiatric condition that, in the judgment of the investigators, would potentially interfere with the ability to participate in the study. * Residence in long-term care centers or institutions, nursing facilities, skilled nursing facilities, or recipients of hospice care, or incarceration. * MGFA severity class I or V (MG crisis) * Pregnant women. * Concurrent participation in an interventional clinical trial (observational studies, biomarker studies and registries are acceptable)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Massachusetts General Hospital, Neuromuscular Diagnostic Center
Boston, Massachusetts, 02114, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could targeted exercises turn down fatigue in myasthenia gravis?
- Engineered immune cells take aim at myasthenia gravis
- Can tracking daily life unlock myasthenia gravis mysteries?
- Can engineered immune cells tame a debilitating autoimmune disease?
- Can pregnancy and neurological disease coexist safely? a new registry seeks answers
- Can DNA reveal the roots of a rare muscle disease?