Nyu Langone Health

This study tests whether an AI-enhanced digital tool called iMatter2 can help people with type 2 diabetes better manage their condition. About 353 participants will use the tool to report their symptoms and receive feedback, while researchers track changes in blood sugar levels o…

This study looks at whether people aged 60 and older with stable lupus can safely stop taking hydroxychloroquine, a common medication that can cause eye damage over time. About 330 participants will either continue the drug or switch to a placebo and be monitored for one year. Th…

This early-phase study tests a new drug called XRD-0394 combined with radiation therapy for people with high-grade gliomas, a fast-growing brain cancer. The main goal is to find a safe dose and check for side effects. About 39 adults with newly diagnosed or returning tumors will …

This study tests a new drug called elacestrant, combined with two standard biologic therapies, in people with advanced triple positive breast cancer (ER+, PR+, HER2+). The goal is to see if the combination can slow or stop cancer growth. About 50 women aged 18 and older will take…

This study tests whether using a catheter to remove blood clots from the lungs, along with standard blood thinners, helps people with submassive pulmonary embolism recover better than blood thinners alone. About 500 adults with large clots and an enlarged right heart chamber will…

This study looks at whether helping clinics offer more take-home doses of methadone (instead of daily visits) helps people stay in treatment for opioid use disorder. Researchers will work with 36 clinics and about 318 patients to see if this approach reduces emergency visits and …

This study tests whether combining remote blood pressure monitors with support from community health workers helps Latinx patients better manage their high blood pressure. About 300 adults with uncontrolled hypertension will take part. The goal is to see if this approach lowers b…

This study tests whether people with HPV-positive throat cancer can safely receive a lower dose of radiation if their tumor shrinks quickly during early treatment. About 120 participants will be monitored for 2 years to see if the reduced treatment still prevents cancer from comi…

This study tests two ways to help Chinese immigrants with type 2 diabetes control their blood sugar: watching educational videos, or videos plus a community health worker. 540 adults in NYC will join. The goal is to see if these tools lower HbA1c levels and boost confidence in ma…

This study tests whether a simple blood test that looks for tumor DNA (ctDNA) can help doctors decide when to add a third immunotherapy drug (ipilimumab) to a two-drug combination (nivolumab and relatlimab) for people with advanced melanoma. About 90 adults with metastatic or adv…

This study looks at whether time-restricted eating (eating only during a set window each day) can help adults who have recently lost weight keep it off and avoid regaining fat. About 110 adults aged 25-65 who lost at least 5% of their body weight in the last 3 months will be rand…

This study tests a treatment for people whose bone marrow doesn't work well after a stem cell transplant. Doctors will give a special dose of donor cells to help the body make enough healthy blood cells. The goal is to fix graft failure or poor graft function and reduce the need …

This study tests whether belatacept, an anti-rejection medication, is safe for adults who have just received a new heart. About 12 participants will receive the drug and be monitored for serious complications like rejection, infection, or organ failure. The goal is to find a bett…

This study compares standard ACL reconstruction using a bone-tendon-bone graft to the same surgery with an added internal brace. The goal is to see if the brace improves knee stability and healing. Researchers will enroll 90 people aged 18 to 35 who need ACL surgery. Participants…

This pilot study tests whether giving a blood thinner (rivaroxaban) and a high-dose statin (atorvastatin) to adults who had heart injury after noncardiac surgery can reduce future heart problems. The study will enroll 50 people aged 45 and older to see if this approach is feasibl…

This study tests whether adding the drug sarilumab to a standard immunotherapy combination can reduce severe side effects and work better for people with advanced melanoma that cannot be removed by surgery. About 105 participants will receive sarilumab along with ipilimumab, nivo…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study tests a program called Mom♥Health to help mothers of young children reduce their risk of heart disease. About 40 moms with kids aged 5 or younger will receive support and resources through their child's daycare center. The goal is to see if this approach is practical a…

This study tests whether the drug guselkumab can prevent psoriatic arthritis in people with psoriasis who are at high risk. 176 adults with psoriasis and early signs of joint inflammation will receive either guselkumab or standard care. The goal is to see if the drug can stop art…

This study tests a 3-month mobile health cardiac rehab program for people with INOCA (chest pain or ischemia without blocked arteries). Participants use an activity tracker, log exercise, and get weekly coaching. The goal is to see if this approach improves symptoms, daily functi…

This study tests Jornay PM, a once-daily ADHD pill taken at night, in 30 adults aged 18-60. The goal is to see if it improves focus, emotional control, and daily function from morning through early evening. Researchers will measure symptom changes over 10 weeks.

This study tests a 3-week program for older adults (65+) with or without mild dementia and their care partners. Participants get a Fitbit smartwatch, motivational texts, educational videos, and virtual physical therapy sessions. The goal is to see if this tech-based approach is e…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement surgery can reduce pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or sur…

This study tests whether using a special blood pressure cuff during physical therapy can help people with leg tendon or bone injuries regain strength and muscle faster. About 128 adults aged 18 to 65 with specific leg injuries will receive either blood flow restriction therapy or…

This pilot study tests whether neuromuscular electrical stimulation (NMES) can help people regain strength and function after ankle fracture surgery. About 20 participants will either receive NMES plus standard physical therapy or physical therapy alone. The goal is to see if the…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce PTSD symptoms and improve thinking problems. 120 adults with PTSD, half also having a mild traumatic brain injury, will take either a daily CBD pill (400 mg or 800 mg) or a placebo for 8 weeks. Resea…

This study tests an experimental drug called CpG 1018 that aims to stimulate the body's natural immune system in people with early-stage Alzheimer's disease or mild cognitive impairment. The main goal is to check the drug's safety and tolerability at three different dose levels o…

This study tests a new noise reduction algorithm designed to help cochlear implant users understand speech better in noisy environments. About 60 participants aged 12 and older will listen to sentences in quiet and noisy settings, with and without the algorithm, to see if it impr…

This study tests whether a smartphone app called SilverCloud, which teaches coping skills, can help high school students with depression or anxiety. About 120 teens will either use the app with a coach or get usual school counseling. The goal is to see if the app reduces symptoms…

This study tests whether adding extra support—like booster sessions and a website—to an 8-week telephone mindfulness program can better reduce stress, anxiety, and depression in people with heart disease or risk factors. Researchers will compare different program options in 160 a…

This study tests whether using a special cuff that partly blocks blood flow during light exercise can help people with Achilles injuries get stronger and feel less pain. About 57 adults aged 18 to 65 will be randomly assigned to receive this therapy or standard physical therapy. …

This study tests a new light-based treatment called transcranial photobiomodulation (tPBM) for people with obstructive sleep apnea who still feel sleepy during the day even after using their CPAP machine. About 22 adults with moderate to severe sleep apnea will receive tPBM to se…

This study tests whether placing a cochlear implant's ground electrode near the vagus nerve behind the ear works as well as the standard placement under a jaw muscle. Twelve adults getting a cochlear implant will join. The goal is to see if speech understanding in noise is simila…

This study looks at whether combining a modified Atkins diet (low-carb, high-fat) with a regular exercise routine can improve quality of life and physical fitness in people with malignant glioma. Fifteen adults with high-grade brain tumors will take part in a 15-week program with…

This study tests whether a gentle brain stimulation technique (tDCS) combined with standard speech therapy can reduce stuttering severity and its negative impact on daily life. Sixteen adults who stutter will receive both treatments, and researchers will measure changes in speech…

This study tests a one-month program where 46 adults with cannabis use disorder use a headset at home to deliver mild brain stimulation while listening to guided mindfulness meditation. The goal is to see if this approach is safe, practical, and helps reduce cannabis use and crav…

This study looks at how people with cochlear implants understand speech in everyday situations. Researchers will measure listening effort and comprehension in 460 adults (both with and without hearing loss) through various listening tasks. The goal is to find out what helps some …

This study looks at how social media ads with pictures of unhealthy food, likes, and people of the same race influence how many calories teenagers eat. About 480 teens aged 13-17 who use Instagram daily will take part. Researchers will track what they eat and where they look in t…

This research study looks at how children and adults who use cochlear implants or auditory brainstem implants hear and understand sounds. Participants will listen to words, sentences, and tones to see how well they identify speech and tell differences in loudness or pitch. The go…

This study looks back at the records of 2000 people who had surgery for a type of pancreatic cyst called IPMN. The goal is to better understand when surgery is needed and how to predict which cysts might turn into cancer. By comparing different patient outcomes, researchers hope …

This study looks at how the gut and kidneys work together in people with enteric hyperoxaluria, a condition that raises the risk of kidney stones. Researchers will give participants a high-oxalate diet (like spinach) and measure oxalate levels in urine and stool. The goal is to u…

This study looks at how exercise might help the brain in adults with anxiety disorders. Researchers will measure certain brain chemicals from blood samples to understand the biological effects of physical activity. The goal is to learn more about the brain's response to exercise,…

This study looks at how breathing in dust from the World Trade Center attacks may harm the heart and lungs of FDNY first responders. Researchers will measure certain substances in the blood and breathing tests to find early signs of disease. The goal is to better understand these…

This study aims to understand why some people newly diagnosed with diabetes in the emergency room do not schedule follow-up appointments. Researchers will review medical records, interview patients, and test whether a telehealth visit can help connect them to a regular doctor. Ab…

This study observes 67 adults with lumbar stenosis and low back pain to find out how many have a directional preference—meaning a specific movement (like bending forward or sideways) that eases their pain. Participants will be followed during their usual physical therapy at NYU L…

This study looks at whether remote exercise programs (using a smartphone app, live video classes, or in-person sessions) can help people at risk for heart disease become more active. About 30 adults over age 45 who are not currently meeting exercise guidelines will take part. The…

This study tests whether a culturally tailored education program helps more people complete colorectal cancer screening. About 50 adults aged 45-75 who are not up-to-date with screening will take part. The program aims to improve screening rates by addressing beliefs and barriers…

This study tests whether a digital visual communication tool can help newly diagnosed cancer patients, their caregivers, and doctors better understand treatment options and feel more satisfied with the experience. About 86 adults with breast or head and neck cancer, along with th…

This study collects medical records, circumstances, and DNA from children who died suddenly and unexpectedly between ages 11 months and 18 years. Researchers will analyze this information to find risk factors and causes, with the goal of preventing future deaths. Families of affe…

This study looks at how well a telehealth program works for veterans newly diagnosed with lung, colorectal, prostate, or breast cancer. Researchers will track how many veterans use virtual visits, the quality of care they receive, and healthcare costs. The goal is to see if this …

This study looks at whether a computer program called BrainHQ can help adults with traumatic brain injury improve their memory and attention. About 150 people with mild to severe brain injuries will either use BrainHQ or play regular brain games. Researchers will test their think…

This early-stage study is testing whether giving magnesium sulfate soon after a cardiac arrest is safe and practical for protecting the brain. Researchers will enroll 178 adults who had a cardiac arrest and had their heartbeat restored. The main goal is to see if the treatment ca…

This study looks at how the bacteria living in your gut (the microbiome) are linked to health and diseases like cancer and heart disease. Researchers will collect information from 16,000 adults over age 40 through questionnaires and samples. The goal is to build a large database …

This study looks at how mindfulness-based stress reduction (MBSR) affects the brains of 150 adults with generalized anxiety disorder. Participants will be randomly assigned to either an 8-week MBSR program or a stress education class. Researchers will use brain scans and other te…

This study partners with the Ramapough Native American Nation to understand how environmental pollution affects their health and nutrition. Researchers will test soil, water, and blood samples for heavy metals and micronutrients, and collect health surveys from 400 tribal members…

This study aims to find out why some people with epilepsy die suddenly without a clear cause (SUDEP). Researchers are asking family members of those who died to share information through a phone interview and medical records. The goal is to create a registry of cases to identify …

This study looks at how taking 81mg of aspirin twice a day affects blood platelets in pregnant women who are at high risk for preeclampsia. Researchers will collect blood samples about 4 weeks after starting aspirin to measure platelet function. The goal is to understand the best…

This study looks at the bacteria living in the lungs of people with a chronic lung condition called bronchiectasis who may also have an NTM infection. Researchers will collect sputum and airway samples from 1000 participants to compare the lung microbiome of those with and withou…

This study enrolls 3,200 adults from immigrant communities in Brooklyn to see if a program offering subsidized, culturally-tailored fresh produce boxes, along with nutrition classes and gardening workshops, can improve fruit and vegetable intake and strengthen social bonds. Parti…

This study looks at how to help parents of children with multiple chronic conditions or technology dependence care for them after leaving the hospital. The goal is to reduce problems like readmissions and medication errors. Researchers will survey parents about their understandin…

This study looks at whether a special type of scan (PSMA PET/MRI) is better than a standard MRI at finding prostate cancer that has come back one year after a focused ultrasound treatment called HIFU. About 60 men who have already had HIFU for their prostate cancer will get both …

This study is testing a mobile app called GeriKit to gather more information about older adults (75+) with ischemic heart disease. Researchers want to see if the app helps them better understand patients' health and outcomes, like hospital readmission or quality of life. About 15…

This study looks at how watching food ads in virtual reality (VR) affects snacking, hunger, and desire to buy food in Black and white young adults aged 18-24. Participants will be randomly assigned to see either food ads or non-food content in VR for a single 2-hour visit. Resear…

This study looks at whether doing special swallowing exercises for 12 weeks, with or without a daily protein drink, can strengthen the muscles used for swallowing in older adults who are starting to become frail. The goal is to see if these exercises can improve muscle strength, …

This study aims to find ways to predict which patients with chronic pancreatitis will get pain relief from a procedure called endoscopic therapy. Researchers will use brain activity tests, sensory tests, and questionnaires before the procedure. They will then follow 100 adults fo…

This study looks at how social media ads affect the food choices and calorie intake of Black and White teenagers aged 13-17. Researchers will show participants different ads and measure how many calories they buy or eat. The goal is to understand if things like ad images or socia…

This study follows 1500 adults who had COVID-19 to see how the virus affects their heart and lungs over time. Researchers will track inflammation markers and breathing problems using questionnaires. The goal is to learn more about recovery, not to test a treatment.

This study looks at how difficult childhood experiences might impact the course of multiple sclerosis (MS). Researchers will work with 300 young adults with relapsing-remitting MS, focusing on Black, Hispanic, and low-income groups often left out of research. Participants will ha…

This study explores whether seeing TikTok influencers with food makes kids aged 10-13 choose more calories when buying snacks. About 100 participants will watch influencer posts with or without food, then pick snacks in a virtual store. The goal is to understand how social media …

This study looks at whether adding video coaching to a standard parenting program helps parents and their babies. About 1,000 families with infants up to 6 months old will take part. Researchers will measure how the program affects parenting, the parent-child bond, and the child'…