Lupus drug may be stopped in seniors without flare risk, study tests

NCT ID NCT05799378

Recruiting now Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study looks at whether people aged 60 and older with stable lupus can safely stop taking hydroxychloroquine, a common medication that can cause eye damage over time. About 330 participants will either continue the drug or switch to a placebo and be monitored for one year. The goal is to see if stopping the drug leads to disease flares, helping doctors balance the risks of eye side effects against lupus symptoms.

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

Columbia University Irving Medical Center/New York Presbyterian
RECRUITING

New York, New York, 10032, United States
Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30322, United States
Hackensack Meridian Health
RECRUITING

Hackensack, New Jersey, 07601, United States
Hospital for Special Surgery
RECRUITING

New York, New York, 10021, United States
Montefiore Medical Center/Albert Einstein College of Medicine
COMPLETED

The Bronx, New York, 10461, United States
NYC Health + Hospitals/Bellevue
RECRUITING

New York, New York, 10016, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Oklahoma Medical Research Foundation
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Penn State MS Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of California: San Diego
RECRUITING

San Diego, California, 92093, United States
VA NY Harbor Healthcare System
RECRUITING

New York, New York, 10010, United States

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