Nyu Langone Health

This study tests whether offering alcohol use disorder treatment in Black churches helps more people start and stay in treatment compared to traditional specialty clinics. About 137 Black adults with alcohol use disorder will receive either church-based or clinic-based therapy. T…

This study looks at how to help people with opioid use disorder stay in treatment longer and, for those who are ready, safely stop taking medication without relapsing. Researchers are testing different combinations of medicines and counseling in 1,516 adults. The goal is to find …

This study tests two methods to help people living with HIV in South Africa cut down on smoking: e-cigarettes or nicotine patches, plus text message support. About 106 daily smokers who own a mobile phone will take part. The goal is to see which approach works better and is more …

This study tests whether a reduced-dose combination of three drugs (cyclophosphamide, abatacept, and tacrolimus) can prevent graft-versus-host disease (GVHD) in 27 adults with blood cancers receiving a stem cell transplant from a half-matched donor. GVHD occurs when donor immune …

This study looks at whether giving a blood transfusion to adults whose heart has stopped for at least 10 minutes can improve oxygen flow to the brain and other vital organs during CPR. The goal is to see if this approach is feasible and safe, and whether it helps more people surv…

This early-phase study tests whether adding two immune-boosting drugs (canakinumab and tislelizumab) to standard chemotherapy can safely shrink pancreatic tumors before surgery. Nine adults with resectable or borderline resectable pancreatic cancer will receive the combination. T…

This study uses advanced PET and MRI scans to look for signs of inflammation and blood vessel problems in the brains of 30 people with long COVID who have brain fog, anxiety, or depression. The goal is to develop better ways to diagnose these lingering symptoms, not to test a tre…

This study looks at the best time to use a special PET scan (rhPSMA-7.3) to find prostate cancer that has come back after the prostate is removed. Men with a rising PSA after surgery will get one or two scans to see where the cancer is hiding. The goal is to catch the cancer earl…

This study aims to increase colorectal cancer screening rates among underserved people in Brooklyn. Researchers will mail at-home stool tests (FIT) to 3,000 adults aged 45-75 who are due for screening. The goal is to catch cancer early and help those with positive results get fol…

This study explores whether a telephone-delivered mindfulness program can help people scheduled for spine surgery feel less anxious about pain and have better recovery. About 25 adults with high pain-related worry will take part. The program involves four weekly phone sessions be…

This study tests whether playing a low-frequency sound (1 Hz) during deep sleep can help suppress seizures in adults with epilepsy. Thirty-six participants will use a smartphone app and special headphones at home for two months. The goal is to see if this safe, non-invasive metho…

This study adapts a proven PTSD therapy (STAIR-NT) for people who use both cocaine and opioids while on methadone treatment. About 80 participants will receive either the adapted therapy or usual care to see if it reduces substance use and PTSD symptoms. The goal is to make the t…

This study tested whether a vibrating anesthesia device can reduce pain during platelet-rich plasma (PRP) scalp treatments for alopecia (hair loss). About 100 people who had already received at least one PRP treatment would have half their scalp treated with the vibrating device …

This study tests whether a targeted injection of numbing medicine near a nerve cluster in the neck (stellate ganglion block) can reduce PTSD symptoms. About 79 adults with chronic PTSD will receive either the real injection or a placebo (salt water). Researchers will measure chan…

This small pilot study tested whether low-intensity focused ultrasound (LIFU) can safely target a deep brain region (the thalamus) in people with treatment-resistant schizophrenia. Only 3 participants were enrolled, and the main goal was to see if the procedure was feasible and t…

This study aimed to see if adding a hyaluronic acid-based vaginal moisturizer to standard estrogen therapy improves symptoms of genitourinary syndrome of menopause (GSM) more than estrogen alone. It planned to enroll postmenopausal women aged 45 and older. However, the study was …

This study tests whether applying cold therapy (cryotherapy) to the hands and feet can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with stage III colon cancer. About 40 participants will be randomly assigned to receive cryotherapy or not during thei…

This study tests whether shining a special light on the forehead can help people with early Alzheimer's or mild memory problems. About 196 adults aged 65-85 will receive either real or fake light treatments for 8 weeks. The goal is to see if this painless, at-home therapy can imp…

This study compares a newer, rotator cuff sparing surgical approach to the traditional method for total shoulder replacement in 108 adults with osteoarthritis or inflammatory arthritis. The goal is to see which approach leads to better shoulder function and tendon health after su…

This study looks at whether low or high intensity exercise is better for reducing anxiety in adults who don't currently exercise. 90 people with anxiety disorders will do 8 weeks of either gentle or gradually more intense workouts. Researchers will track changes in anxiety sympto…

This study aimed to compare two types of ACL surgery—one with an extra internal brace and one without—to see which led to better knee function and less pain. However, the study was withdrawn before enrolling any participants, so no results are available. It was planned for adults…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass) plus medications, versus medications alone. Researchers want to see if one strategy leads to fewer …

This study watches how the pupil changes size when a nerve in the ear is stimulated during cochlear implant surgery. Researchers want to learn more about how this nerve works in people with hearing loss. About 30 adults having ear surgery will take part.

This study explores whether MRI scans can help doctors predict which heart failure patients will respond well to a special pacemaker treatment called cardiac resynchronization therapy (CRT). Researchers will use MRI data and computer models to better understand why some patients …

This study tested whether a 4-week course of the supplement N-acetylcysteine (NAC) affects overnight oxidative stress and inflammation differently in men versus women with obstructive sleep apnea. Fourteen participants already using standard CPAP therapy took either NAC or a plac…

This study looks at two ways to help pregnant women live healthier: one uses text messages and online videos, and the other uses community health workers for group or individual counseling. About 1,050 pregnant women will take part to see which method works better and is easier t…

This study looks at whether a 15-week program of device-guided breathing can improve heart rate variability and quality of life in people who have had takotsubo syndrome, also known as broken heart syndrome. Ten people with a history of the condition and ten healthy volunteers wi…

This study tests a new tool called Napoleon that helps doctors measure the size of the stomach opening (anastomosis) in people who had gastric bypass surgery and later regained weight. About 100 participants will have their stomach opening measured both by the doctor's eye and wi…

This study looks at whether wearing a splint and doing formal physical therapy are necessary after surgery for a broken wrist. About 230 adults with a specific type of wrist fracture will be followed to compare early movement (no splint, self-guided exercises) versus late movemen…

This study uses a new MRI method to measure the amount of saturated fat in breast tissue without needing a biopsy. Researchers will compare the fat composition in women with breast cancer versus those with benign (non-cancerous) breast lesions. The goal is to better understand ho…

This study looks at why some people don't respond well to the hepatitis B vaccine. Researchers are comparing the standard vaccine with a newer one that seems to work better. By studying the immune response in 101 adults, they hope to improve future vaccines and protect more peopl…