Nyu Langone Health

This study tests whether adding tocilizumab to standard immunotherapy (ipilimumab + nivolumab) can reduce severe immune-related side effects in people with advanced melanoma that cannot be removed by surgery. About 71 participants will receive the three-drug combination during an…

This study tests a new combination of three drugs (cyclophosphamide, abatacept, and tacrolimus) given at lower doses to prevent graft-versus-host disease (GVHD) in 27 adults receiving a stem cell transplant from a half-matched donor. GVHD is a serious condition where donor cells …

This study tests whether a culturally tailored telehealth coaching program led by community health workers can help South Asian adults with type 2 diabetes and high blood pressure get their blood pressure under control. About 450 participants will either receive the coaching or u…

This study looks at 1,200 people with clogged heart arteries and a weak heart pump (ejection fraction 40% or less). It compares three approaches: medications alone, bypass surgery, or stenting. The goal is to see which method best protects thinking skills, heart-related quality o…

This early-phase study tests whether adding the drug azeliragon to radiation therapy is safe for people whose cancer has spread to the lining of the brain and spinal cord. About 21 adults with solid tumors or aggressive brain cancers will receive the combination. The main goal is…

This study tests whether a personalized program—including patient navigation, individual health benefits, and financial help—can reduce deaths from preventable causes like heart attacks, strokes, heavy drinking, and HIV in low-income adults aged 35–64. Researchers will track chan…

This early-phase trial tests whether adding two immune-boosting drugs (canakinumab and tislelizumab) to standard chemotherapy can safely shrink pancreatic tumors before surgery. Nine adults with resectable or borderline resectable pancreatic cancer will receive the combination. T…

This study tests a program to help Black patients with high blood pressure get it under control. It combines nurse support, home blood pressure monitoring, and help with social needs like housing or food. About 500 adults from 25 clinics in New York City will take part. The goal …

This study tests whether a collaborative care model—where primary care providers work closely with care managers and behavioral health specialists—can help adults reduce their use of opioids, stimulants, and heavy alcohol. About 300 participants with moderate to severe substance …

This study compares two ways of starting treatment for opioid use disorder in the emergency department: a standard visit versus an extended observation stay. About 170 adults who are not already in treatment will be randomly assigned to one approach. The goal is to see if the lon…

This study tests a program where HIV nurses are trained to also manage high blood pressure in their patients. 830 adults with both HIV and uncontrolled high blood pressure from 30 clinics in Lagos, Nigeria are taking part. The goal is to see if this approach lowers blood pressure…

This study tests a new, faster breast MRI technique called GRASP. The goal is to see if it can accurately tell the difference between harmless and cancerous breast lumps by measuring how contrast dye moves into the tissue. About 264 women already scheduled for a standard breast M…

This study looks at the best timing for a special PET scan (rhPSMA-7.3) to detect prostate cancer that has come back after prostate removal surgery. Men with a rising PSA level will get one or two scans to see when the cancer is most visible. The goal is to find the cancer early …

This study aims to make MRI scans clearer for people with heart arrhythmia (irregular heartbeat). Researchers will test two special imaging methods on 135 participants—105 with arrhythmia and 30 healthy volunteers—to see if they reduce blurry images caused by the irregular rhythm…

This study aims to boost colorectal cancer screening rates in underserved Brooklyn communities by mailing free, at-home stool test kits (FIT) to people aged 45-75 who are due for screening. About 3,000 participants from several health centers will be randomly assigned to receive …

This early-phase study looks at whether older adults (65+) with type 2 diabetes and mild cognitive impairment can better manage their blood sugar by sharing continuous glucose monitor data with a care partner via a mobile app. Fourteen participants and their care partners will us…

This study tests whether coaching for people with dementia and their caregivers can improve care and reduce future emergency room visits. About 19,200 participants aged 66 and older with Alzheimer's or related dementias will receive different combinations of support after an ER v…

This study tests whether a cream made with caffeine can help prevent skin hardening and other complications in breast cancer patients who need radiation after mastectomy with tissue expander reconstruction. About 60 participants will use either the caffeine cream or a placebo cre…

This small pilot study is testing whether a medicated film placed under the tongue can safely and effectively stop autonomic crises in people with familial dysautonomia at home. Five adults who have had previous crises and tolerated a similar IV drug are enrolled. The goal is to …

This study aimed to see if adding a hyaluronic acid-based vaginal moisturizer to standard vaginal estrogen therapy provides extra relief for menopause-related vaginal symptoms. It planned to enroll postmenopausal women aged 45 and older who had not used these treatments recently.…

This study looks at whether special high-dissolving foods can improve feeding quality of life for children aged 6 months to 18 years after craniofacial surgery. Half of the 160 participants will receive these foods after surgery, while the other half will follow standard care. Re…

This study tests whether taking creatine supplements can improve voice quality in people over 65 who have age-related voice changes (presbyphonia). Twenty participants will be randomly assigned to receive either creatine or a placebo for 10 weeks. Researchers will measure voice f…

This study tests whether giving the drug ketamine during or right after mastectomy surgery can lower the chance of developing long-lasting pain. About 765 women having breast cancer surgery will be randomly assigned to receive a low-dose ketamine drip during surgery, a single ket…

This study aimed to see if a vibrating device could reduce pain during platelet-rich plasma (PRP) scalp treatments for hair loss. About 100 people who had already had at least one PRP treatment would have half their scalp treated with the vibrating device and the other half witho…

This study tests whether playing a low-frequency sound during deep sleep can reduce seizure activity in people with epilepsy. About 36 adults will use a smartphone app and headphones at home for two months. The goal is to see if this simple, non-invasive method is feasible and ef…

This study compares a newer surgical approach that spares the rotator cuff to the traditional method for total shoulder replacement in 108 adults with arthritis. The goal is to see which approach leads to better shoulder function and recovery. Participants will be followed for at…

This study looks at whether giving a blood transfusion during a prolonged in-hospital cardiac arrest can help deliver more oxygen to the brain and other vital organs. Researchers will test this in 30 adults who have been in cardiac arrest for at least 10 minutes. The goal is to s…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This study looks at 50 adults hospitalized with acute decompensated heart failure who need intravenous diuretics (water pills). Researchers want to see if a non-invasive monitor called the Starling System can accurately measure changes in heart function as fluid is removed. The g…

This study looks at 450 people who had a heart attack but no major blockages in their heart arteries (called MINOCA). Using advanced imaging, researchers aim to find the real cause, such as plaque disruption or artery tears. Participants are followed every 6 months for up to 10 y…

This study looks at how normal sleep changes and sleep apnea in older adults might increase the risk of Alzheimer's disease. Researchers will monitor the sleep and brain health of 158 cognitively healthy people aged 55-75 over two years. The goal is to find out which sleep proble…

This study follows about 15,000 children and young adults (ages 0-25) in the U.S. to learn more about long COVID, also called PASC. Researchers will track symptoms, health history, and test results over time to find out who gets long COVID and why. The goal is to better understan…

This study tests a simple reminder system that prompts doctors to order liver ultrasounds for patients with cirrhosis, who are at risk for liver cancer. About 1,300 adults with cirrhosis will take part. The goal is to see if the reminder increases the number of screening ultrasou…

This study explores whether MRI scans can help doctors predict which heart failure patients will respond well to a special pacemaker treatment called cardiac resynchronization therapy (CRT). Researchers will analyze MRI images from 110 adults scheduled for CRT and use computer mo…

This pilot study is testing a community-based educational program to see if it can increase knowledge about melanoma and other skin cancers and encourage people to check their own skin. About 45 adults in Bensonhurst, Brooklyn will take a class led by a community health worker an…

This study tests whether a special type of MRI, called diffusion MRI, can accurately measure how head and neck tumors change during chemotherapy and radiation. Researchers will scan 16 patients before and during treatment to see if the MRI can predict whether the cancer shrinks o…

This study looks at whether offering parenting support to all families with very young children in Flint, Michigan can help kids' development and mental health after the water crisis. About 486 families with babies up to 3 months old took part. Researchers measured parenting stre…

This study looks at whether the supplement N-acetylcysteine (NAC) affects oxidative stress and inflammation differently in men and women with obstructive sleep apnea. Fourteen adults with moderate-to-severe sleep apnea who already use a CPAP machine will take NAC or a placebo for…

This study was designed to see if adding an internal brace during ACL reconstruction surgery helps the knee heal better. It planned to compare two groups of people having ACL surgery using a quadriceps tendon graft. However, the study was withdrawn before enrolling any participan…

This study uses special MRI scans to look at kidney tumors in 39 people scheduled for surgery. The goal is to see if these scans can tell whether a tumor is cancerous and what type it is, as well as predict how well the kidney will work after part of it is removed. No new treatme…

This study looks at whether a hearing screening and counseling program during a regular primary care visit can help underserved older adults with hearing loss. About 120 participants will either get advice on affordable listening devices or be sent to a standard hearing specialis…

This study looks at how platelets (blood cells that help clotting) change during pregnancy in women at high risk for preeclampsia, a serious condition involving high blood pressure. Researchers will collect blood samples before and after starting daily low-dose aspirin to see if …

This study tracks how many relatives of ovarian cancer patients with a known BRCA or related gene mutation get tested themselves. The goal is to see if family testing (cascade testing) works in practice. About 118 patients and their first- or second-degree relatives will be follo…

This study looks at how well the mpox vaccine works and how safe it is in people with HIV compared to those without HIV. About 174 adults who either recently got the mpox vaccine or had a recent mpox infection will take part. The goal is to fill important knowledge gaps and help …