Centre Hospitalier Universitaire, Amiens

This study tested whether thalidomide could help control aggressive mastocytosis, a rare condition where too many mast cells build up in the body. Patients with relapsed or progressive disease took thalidomide pills daily for six months. The main goal was to see if the drug could…

This study tested whether using a medication (Neorecormon®) to raise hemoglobin levels in anemic kidney transplant patients could improve their quality of life and slow the decline of their transplanted kidney's function. It involved 128 patients in France who were randomly assig…

This study tested whether adding a topical gel called timolol to standard care (compression bandages and dressings) could help heal chronic venous leg ulcers faster. It involved 42 adults whose leg ulcers had not improved after at least 24 weeks of standard treatment. The goal wa…

This study tested which of two different three-drug antibiotic combinations was better at clearing a specific type of hard-to-treat lung infection. It involved 92 adults in France who had a confirmed Mycobacterium xenopi infection. The goal was to see which regimen helped patient…

This study tested an intensive treatment approach for primary plasma cell leukemia, a rare and aggressive form of blood cancer with very poor survival rates. Forty patients under age 70 received strong chemotherapy followed by stem cell transplants, with some receiving two transp…

This study tested if using a gentle breathing machine before a throat exam for cancer screening is better than normal breathing. It aimed to see which method keeps a patient's oxygen levels safe for a longer time when they briefly stop breathing during the procedure. The trial in…

This study tested a new robotic surgical method for placing cochlear implants, which are devices that restore hearing. The goal was to see if using a robot could make the delicate surgery safer and less invasive than the traditional manual technique. Nine adult patients who were …

This study tested if using a special filter called Oxiris during heart surgery could help patients recover better. The filter was designed to remove harmful inflammatory substances from the blood, which the body often produces after major surgery. Researchers hoped this would imp…

This study tested whether it is safe and effective to induce labor for mothers whose baby is in a breech position (feet or bottom first) near their due date. The goal was to help more women have a vaginal birth and avoid the potential complications of a planned cesarean section. …

This study tested whether using ultrasound guidance during tracheostomy procedures could make them safer. Researchers worked with 40 adult ICU patients who needed a tracheostomy to help them breathe. They used ultrasound to see neck structures in real-time, aiming to avoid accide…

This study tested whether giving the antibiotic teicoplanin as a subcutaneous injection (under the skin) is safe and well-tolerated for treating serious bone and joint infections. It involved 30 adult patients with infections caused by bacteria resistant to other antibiotics but …

This study tested two different settings on breathing machines used at night to help patients with severe COPD come off ventilator support. Researchers wanted to see if one method helped patients breathe on their own faster and improved their sleep quality during the weaning proc…

This study looked at whether sleeve gastrectomy, a common weight loss surgery, improves how well obese patients can walk. Researchers measured how far 99 participants could walk in 6 minutes before surgery and again 6 months later. They also tracked changes in quality of life to …

This study tested if a once-daily, extended-release version of the common diabetes drug metformin is safe and effective for controlling blood sugar in people who have both type 2 diabetes and mild-to-moderate chronic kidney disease. Researchers monitored 12 participants' glucose …

This small pilot study tested whether a common weight-loss surgery (laparoscopic sleeve gastrectomy) could be safely performed as a day-case procedure, meaning patients go home the same day instead of staying overnight. It involved 30 adults with obesity to see if this faster rec…

This study tested if adjusting the starting dose of a common anti-rejection drug (tacrolimus) based on a patient's genetics could help get the drug level right more quickly after a kidney transplant. 280 kidney transplant recipients were randomly assigned to receive either a stan…

This study tested whether removing surgical drains earlier (4 days after surgery) reduces infection rates compared to standard practice (10-15 days) in patients undergoing major pancreas surgery. It involved 141 patients across multiple hospitals in France who had their pancreas …

This study tested whether a drug called sevelamer carbonate could help control certain mineral and hormone levels in people with moderate to severe chronic kidney disease who are not yet on dialysis. 98 participants were randomly assigned to receive either the drug or a placebo f…

This study tested if a new way of monitoring a patient's breathing gases during major surgery could help doctors better manage blood flow and oxygen delivery. The goal was to see if this personalized approach, compared to standard care, could reduce serious complications like org…

This study tested a new method to help patients safely stop a blood pressure medication (norepinephrine) after heart surgery. It involved 130 adults who developed a dangerous drop in blood pressure after their operation. Doctors compared using a special measurement of artery flex…

This study tested whether patients with simple appendicitis could safely have their appendix removed and go home the same day, without staying overnight in the hospital. Researchers followed 120 carefully selected adults to see if this outpatient approach worked. They tracked whe…

This study tested whether using a personalized measurement of how much oxygen is in a patient's blood (called ScvO2) is better than using a standard hemoglobin number to decide when to give blood transfusions after heart surgery. The goal was to see if this personalized approach …

This study aimed to find out if patients need to take antibiotics after having their gallbladder removed for a mild or moderate infection. It compared the infection rates in 414 patients who either received antibiotics after surgery or did not. The goal was to see if skipping the…

This small, early-stage study aimed to see if a drug called 3,4-diaminopyridine could help patients with severe botulism. Researchers tested the drug on a few patients who had botulism and needed help breathing. They measured changes in muscle strength and breathing ability befor…

This study tested a heart procedure for people with an irregular heartbeat who have had a serious brain bleed. Because these patients cannot safely take standard blood-thinning medications to prevent strokes, doctors tested a device that plugs a small pouch in the heart where clo…

This study aimed to find out if lying on one's side or lying on one's back is better for a digital rectal exam. Doctors performed the exam on 320 men with various colon or rectal conditions to see which position allowed for a more complete check. The goal was to improve the accur…

This study tested whether a less invasive ultrasound method (over the skin) could be as accurate as the standard internal vaginal ultrasound for measuring cervical length in pregnant women. Cervical length helps doctors assess the risk of early labor. Researchers compared the two…

This study tested a monitoring method called microdialysis to see if it could detect healing problems earlier after surgery for rectal cancer. Researchers placed a tiny catheter near the surgical site in 21 patients to measure local chemical changes. The goal was to identify dang…

This study tested a new type of PET scan to help doctors tell the difference between brain cancer that has returned and damage caused by previous radiation treatment. It involved 8 adults with brain metastases who were already scheduled for a specific PET scan as part of their ca…

This study tested whether new artificial intelligence (AI)-enhanced MRI scans could improve prostate cancer detection. Researchers compared these AI scans to standard MRI methods in 34 men undergoing prostate exams. The goal was to see if the AI scans provided clearer images, mor…

This study tested whether measuring the electrical activity of the uterus (called an electrohysterogram) can help predict which pregnant women hospitalized with early labor signs will actually deliver prematurely. Researchers enrolled 100 women between 26 and 35 weeks of pregnanc…

This study tested a new scanning method to see if it could make PET scans better at finding small lung tumors. It involved 103 adults who had small lung nodules. Researchers compared images from a standard PET scan to images from a new scan that was timed with the patient's breat…

This study tested whether a special type of MRI scan could predict how well patients with normal pressure hydrocephalus (NPH) would respond to surgery. Currently, doctors use a spinal tap (lumbar puncture) to make this prediction. Researchers wanted to see if the non-invasive MRI…

This study tested whether a special type of MRI scan (called 4D flow MRI) could accurately measure pressure in the lung arteries of people with pulmonary hypertension. Researchers compared the MRI results against the current standard invasive test (right heart catheterization) an…

This study investigated whether a non-invasive eye scan could help diagnose Alzheimer's disease. Researchers compared the thickness of specific layers at the back of the eye in 55 people with Alzheimer's, Lewy body disease, and healthy individuals. The goal was to see if thinning…

This study tested whether a quick lung ultrasound scan could accurately detect dangerous fluid overload in people on dialysis. Doctors currently estimate fluid levels by physical exam, which can be imprecise. Researchers compared the scan results against other standard measuremen…

This study tested a new, non-invasive breath test to measure total red blood cell volume in people with suspected polycythemia. The goal was to see if this simpler method works as well as the current standard test, which uses a radioactive tracer and is not widely available. Rese…

This study tested whether a new AI-powered MRI method could make heart scans easier and more accurate for patients with ischemic heart disease. Instead of requiring patients to hold their breath, the new method lets them breathe normally during the scan. Researchers compared the …

This study tested whether a special green dye injected into patients' veins helps surgeons see bile ducts better during gallbladder removal surgery compared to the standard contrast method. Researchers enrolled 156 adults with acute gallbladder inflammation to see if the dye meth…

This study aimed to find the most effective method for managing pain after minimally invasive chest surgery. Researchers compared three different types of nerve blocks given before surgery to 155 adult patients. The goal was to determine which technique provided the best pain con…

This study tested whether giving a blood pressure medication called norepinephrine early during major abdominal surgery could prevent dangerous drops in blood pressure and reduce serious complications after surgery. It involved 500 patients aged 50 and older who were having major…

This small pilot study tested whether a walking program could help reduce fatigue in breast cancer patients undergoing hormone therapy. Seventeen women participated in either supervised group walks or home-based walking for 20 minutes twice weekly over six weeks. Researchers comp…

This study tested a new device that monitors a patient's pain levels during weight-loss surgery. The goal was to see if this monitor helps doctors give the right amount of pain medication more accurately than the usual method of checking heart rate and blood pressure. Researchers…

This study compared two ways to relax the abdominal muscles during keyhole abdominal surgery. Researchers tested whether a targeted nerve block injection (TAP block) works as well as a standard muscle relaxant drug (curare). The goal was to see which method provides better muscle…

This study compared two numbing medicines (levobupivacaine and ropivacaine) used in spinal anesthesia for leg surgery. Researchers wanted to see which medicine provided better pain relief and movement blocking with fewer side effects. The trial involved 50 adults having emergency…

This study tested whether the medication tetrabenazine could reduce involuntary movements in people with tardive dyskinesia—a side effect caused by long-term antipsychotic use. Fifty-four adult patients were randomly assigned to receive either tetrabenazine or a placebo pill for …

This study tested whether a 12-week relaxation training program could help people with fibromyalgia manage their chronic pain and improve their quality of life. It compared the relaxation program to a placebo treatment in 80 adult participants. The main goal was to see if this no…

This study tested whether a tiny monitoring catheter could be placed directly into transplanted bone tissue to check its health. It involved 34 patients who had bone tissue transplanted during reconstructive surgery for head and neck cancer or trauma. The goal was to see if this …

This study looked at whether measuring a protein called vasorin in the blood could help doctors predict which patients with septic shock might develop serious kidney injury or die. Researchers measured vasorin levels in 50 critically ill patients with septic shock to see if highe…

This study tested whether a specific questionnaire could detect changes in quality of life for people with COPD (chronic obstructive pulmonary disease). Researchers had 57 patients with stable COPD fill out the questionnaire before and three months after starting a new long-actin…

This study looked at how accurately people in the emergency room for alcohol intoxication could guess their own blood alcohol level. Researchers compared patients' guesses to actual medical measurements. The goal was to see if this comparison could make patients more aware of the…

This study tested whether using a lung ultrasound machine during surgery could help doctors give patients the right amount of fluids. Researchers wanted to see if the ultrasound could detect early signs of too much fluid in the lungs before it became a problem. They compared the …

This study tested whether drones could safely transport medical lab samples between hospitals. Researchers compared drone delivery to regular transport methods to see if the samples arrived on time, at the right temperature, and without damage. The goal was to validate this new t…

This study tested a new type of MRI scan designed to create a detailed 3D map of blood flow through the liver's vessels. Researchers enrolled 44 healthy adults to see if this new method could accurately measure how much blood flows into and out of the liver. The goal was to impro…

This study aimed to understand how premature babies' brains develop the ability to recognize their mother's voice. Researchers observed 22 premature infants to see when and how different sides of the brain become specialized for voice recognition. The goal was to learn how the ho…

This study aimed to discover which factors predict whether chronic venous leg ulcers will heal within six months. Researchers followed 104 patients with leg ulcers for 24 weeks, tracking their medical condition, wound characteristics, psychological state, and social situation. Th…

This study aimed to understand how pregnant women and their unborn babies are exposed to common pesticides. Researchers collected the first stool (meconium) from over 1,000 newborns and hair samples from their mothers in the Picardie region of France. They also used questionnaire…

This study aimed to find out how common obstructive sleep apnea is in adults with Type 1 diabetes. Researchers monitored 53 participants overnight in a hospital to check their breathing and blood sugar levels. The goal was to gather information, not to test a new treatment.

This study aimed to understand how often a fungus called aspergillus is found in the lungs of people with advanced COPD and whether its presence affects their symptoms and quality of life. Researchers followed 100 patients with severe COPD for six months, collecting sputum sample…

This study looked at what happened when mothers and their healthy newborns were sent home from the hospital earlier than before, following new 2014 guidelines. Researchers tracked 177 eligible mother-baby pairs for one month after they went home to see if this earlier discharge l…

This study aimed to understand if a simple, non-invasive skin scan could measure certain substances linked to diabetes and see if they are connected to erectile dysfunction. Researchers enrolled 97 men with type 2 diabetes to test this link. The goal was to see if this scan could…

This study aimed to understand why some people regain weight after sleeve gastrectomy surgery. Researchers measured the leftover stomach size in 90 patients two years after their surgery using CT scans. They wanted to see if a larger remaining stomach volume was linked to poorer …

This study investigated whether the common diabetes medication metformin is safe to use in people who also have kidney problems. Researchers gave increasing doses of metformin to 82 diabetic patients with varying levels of kidney function and measured how much of the drug accumul…

This study aimed to see if two different ultrasound methods for measuring the pumping power of the heart's right side give the same result. Researchers compared scans taken from the chest and from inside the esophagus in 90 adults having heart surgery. The goal was to help doctor…

This study used advanced 4D scans to measure how the natural attachment points of the ACL move when the knee bends. Researchers studied 30 healthy volunteers to see if the current standard surgical target is truly optimal for stability. The goal is to use this data to develop bet…

This study aimed to understand if a common virus called parvovirus might trigger Graves' disease, an autoimmune thyroid condition. Researchers compared 52 people—some with recently diagnosed Graves' disease and others with non-autoimmune thyroid issues—to see if the virus was pre…

This study investigated how well patients understand and follow the instructions they receive when leaving the emergency room without being hospitalized. Researchers followed 242 French-speaking adults who visited emergency departments and were sent home. They conducted phone int…

This study tested if using a video camera is better than the human eye for measuring a simple vital sign called 'capillary refill time' in intensive care patients. The goal was to see if the video method gives more consistent results when different people take the measurement. It…

This study looked back at the medical records of 201 very premature babies to understand why some received more blood transfusions than the national guidelines recommend. Researchers analyzed transfusion practices during the babies' first month of life to identify patterns and cl…

This study aimed to find a new way to monitor chronic kidney disease by measuring tiny particles in urine. Researchers compared urine samples from 143 healthy adults and adults with reduced kidney function. The goal was to see if the number of these particles could serve as a use…

This study looked back at how a hospital managed an outbreak of a dangerous, drug-resistant bacteria in its Intensive Care Unit (ICU) during the 2020 COVID-19 pandemic. Researchers reviewed the cases of 14 patients to understand what control measures worked to stop the bacteria f…

This study aimed to understand the role of certain antibodies found in healthy people. Researchers compared over 1,200 healthy blood donors with and without these antibodies to see if they were linked to known risk factors for heart disease. The goal was to gather knowledge, not …

This study looked back at 10 years of medical records from 2,500 kidney transplant patients to understand why some develop cancer after their transplant. Researchers examined how different anti-rejection medications and other factors might increase cancer risk. The goal is to ide…

This study aimed to understand why endometriosis can make it harder to get pregnant, even with IVF. Researchers measured a specific marker of cell damage in the blood and ovarian fluid of 114 women undergoing IVF. They compared levels between women with endometriosis and those wi…

This study aimed to understand if people with stable bipolar disorder have more difficulty recognizing facial emotions than people without the condition. Researchers tested 10 participants, including people with bipolar I, bipolar II, and healthy individuals, using a computer-bas…

This study aimed to measure how much of two common antibiotics (amoxicillin and clavulanic acid) actually reaches the infected fluid around the lungs in patients with serious chest infections. Researchers took repeated blood and chest fluid samples from 11 adult patients who need…

This study aimed to understand how deep brain stimulation (DBS) helps people with Parkinson's disease. Researchers measured blood flow in the brains of 15 patients with DBS implants while they performed simple hand movements and decision-making tasks. The goal was to see how turn…

This study aimed to understand how a rapid infusion of IV fluids changes blood flow in the liver. Researchers used MRI scans to measure blood flow in the livers of 22 healthy volunteers before and after receiving a standard saline IV drip. The goal was to gather basic knowledge a…

This study aimed to understand the safety of using two powerful pain control methods together during major abdominal surgery. Researchers measured the levels of the drugs lidocaine (given by IV) and ropivacaine (given by epidural) in the blood of 51 patients. The goal was to see …

This study aimed to better understand and measure how facial muscles move to create expressions. Researchers used MRI scans and motion-capture technology on 50 healthy volunteers to create detailed 3D models of facial movements. The goal was to gather precise data to help doctors…

This study aimed to understand which medical tests can best predict whether an elderly person's unexplained low platelet count is due to immune thrombocytopenia (ITP) or another condition like myelodysplastic syndrome (MDS). Researchers followed 37 patients over 60 years old with…

This study explored whether how people think about their pain affects their mood after physical activity. Researchers compared two thinking strategies in 47 adults with fibromyalgia: focusing on the pain (rumination) versus focusing on something else (distraction). They measured …

This study aimed to understand how often stroke survivors develop problems with memory, thinking, and behavior. Researchers tested over 1,600 people, including healthy volunteers and stroke patients, using a special set of thinking tests. The goal was to create French-language st…

This study aimed to better understand the link between repetitive negative thinking (called rumination) and the emotional symptoms often experienced by people with fibromyalgia. Researchers enrolled 107 French-speaking adults diagnosed with fibromyalgia. The main goal was to expl…

This study aimed to understand if a protein in the blood called M-CSF could be a useful marker for bone damage in multiple myeloma. Researchers compared M-CSF levels in three groups: people with multiple myeloma, people with a related but non-cancerous condition (MGUS), and healt…

This study aimed to understand if a blood marker called β-D-glucan could help doctors track serious fungal infections in the abdomen (peritonitis). Researchers measured this marker daily in 70 ICU patients who had abdominal surgery, comparing those with and without a fungal infec…