Centre Hospitalier Universitaire, Amiens

This study looked at whether placing a tiny device called iStent during cataract surgery helps lower eye pressure in people with primary open-angle glaucoma. Researchers compared 80 patients who got the implant plus cataract surgery to those who had cataract surgery alone. The go…

This study looked at 62 patients who had a hip replacement revision using a special cup (dual-mobility) cemented into a metal ring. The goal was to see if this method prevents the implant from loosening or dislocating. Patients were followed for at least 5 years after surgery.

This study tested a combination of two drugs, bevacizumab and temozolomide, given before standard chemoradiotherapy in 70 patients with newly diagnosed glioblastoma who had severe neurological symptoms. The goal was to reduce tumor size and improve symptoms enough to allow patien…

This study looked at 43 patients who had one adrenal gland removed to treat primary hyperaldosteronism, a condition where a hormone imbalance causes high blood pressure. Researchers checked blood pressure and medication use 1 month, 1 year, and many years after surgery. They foun…

This trial compares a standard mastectomy closure to a technique that adds padding stitches between the skin and chest muscle, aiming to reduce lymphoceles (painful fluid pockets). About 90 women with breast cancer undergoing mastectomy will be randomly assigned to one of the two…

This phase 2 trial investigates whether combining rituximab with lenalidomide works as well as standard rituximab-based chemotherapy for patients aged 75 and older with relapsed diffuse large B-cell lymphoma. The study focuses not only on controlling the cancer but also on mainta…

This study tested two different combinations of immunosuppressant drugs in 88 adults who received a new kidney. The goal was to see which plan better protects kidney function over the short term. All participants took lifelong anti-rejection medication, so this is about managing …

This study tested whether giving norepinephrine early during major abdominal surgery could prevent drops in blood pressure and reduce organ problems afterward. 500 adults aged 50 and older took part. One group received norepinephrine early, while the other received the standard d…

This Phase 3 trial tested whether tetrabenazine (Xenazine) can reduce involuntary movements in people with tardive dyskinesia, a condition caused by long-term use of antipsychotic medications. Fifty-four adults with persistent symptoms were randomly assigned to receive either tet…

This study tested two different antibiotics—clarithromycin or moxifloxacin—alongside standard drugs to treat a rare lung infection caused by M. xenopi bacteria. Researchers tracked whether patients' sputum samples became bacteria-free after 6 months. The goal was to find the more…

This pilot study tested a procedure to close the left atrial appendage—a small pouch in the heart where clots often form—in 58 patients with atrial fibrillation who had a prior brain bleed and cannot take standard blood thinners. The goal was to see if this approach could reduce …

This study tested whether adjusting the first dose of the immunosuppressant drug tacrolimus based on a patient's CYP3A5 gene helps reach the right blood levels faster after kidney transplant. 280 kidney transplant recipients were randomly assigned to receive either a standard dos…

This study tested the drug thalidomide in people with systemic mastocytosis, a rare disease where too many mast cells build up in the body. The goal was to see if thalidomide could reduce the amount of disease in the bone marrow or other organs after 6 months. The trial included …

This study tested whether measuring a patient's exhaled gases during surgery can help doctors better manage fluids and medications. 350 adults having major abdominal, orthopedic, or vascular surgery were randomly assigned to standard care or care guided by the respiratory quotien…

This study tested a new way to decide when to stop the blood pressure drug norepinephrine in patients who had heart surgery and developed dangerously low blood pressure. The method uses a measure called dynamic arterial compliance to guide the drug reduction. The trial involved 1…

This study looked at whether raising hemoglobin levels with a drug called epoetin (Neorecormon) could improve quality of life and slow kidney function decline in people who had a kidney transplant and now have chronic graft dysfunction. About 128 adults who had a transplant 1 to …

This trial tested a robotic system (ROSA) to assist with cochlear implant surgery, which restores hearing in people with profound hearing loss. The robot aims to make the surgery safer and less invasive by improving precision. Nine adults eligible for cochlear implants took part,…

This phase 2 trial tested a powerful combination of chemotherapy drugs followed by stem cell transplants in 40 patients under 70 with primary plasma cell leukemia, a rare and aggressive blood cancer. The goal was to see if this intensive approach could improve how long patients l…

This study tested whether a beta-blocker eye drop called timolol, applied directly to the wound, can help heal venous leg ulcers that have not improved with standard care. Forty-two adults with ulcers lasting at least 24 weeks received either timolol plus standard wound care or s…

This small pilot study tested a drug called 3,4-diaminopyridine (FIRDAPSE) in 3 people with severe botulism who needed a ventilator to breathe. The goal was to see if the drug could improve nerve signals and breathing. Because only 3 people took part, the results are very prelimi…

This study tested whether sleeve gastrectomy, a type of weight-loss surgery, improves walking ability in people with severe obesity. About 99 participants completed a 6-minute walk test before and 6 months after surgery. Researchers also measured quality of life and overall healt…

This phase 2 trial tested the safety and effectiveness of metformin extended release (XR) in 12 adults with type 2 diabetes and mild to moderate chronic kidney disease (stages 1 to 3). Participants took metformin XR tablets for 6 to 12 weeks, and researchers monitored their blood…

This study tested whether sevelamer carbonate, a drug that binds phosphate in the gut, can lower levels of a hormone called FGF-23 in people with chronic kidney disease (CKD) who are not yet on dialysis. The trial included 98 adults with moderate to severe CKD and high FGF-23 lev…

This study looked at whether giving antibiotics after gallbladder removal surgery helps prevent infections in people with mild to moderate gallbladder inflammation. Over 400 adults took part, receiving either antibiotics or no medication after surgery. The goal was to see if anti…

This study tested whether the Oxiris membrane, a filter used during heart-lung machine support, can reduce inflammation and improve blood flow in small blood vessels after heart surgery. 70 adults having elective heart surgery with a long bypass time took part. The membrane aims …

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study compares three automated blood tests (Abbott Architect, Siemens Immulite, and Diasorin Liaison) for diagnosing Epstein-Barr virus (EBV) infection. Researchers analyzed 91 blood samples from patients aged 3 to 82 to see how well each test detects key markers of EBV infe…

This study tested whether an ultra-low-dose CT scan, combined with a deep-learning AI reconstruction, can accurately detect urinary tract stones. 62 adults with known or suspected kidney stones received both a standard low-dose CT and an additional ultra-low-dose scan (less than …

This study tested a new MRI technique called diffusion tractography to better diagnose partial tears of the anterior cruciate ligament (ACL) in the knee. Standard MRI often cannot tell how severe a partial tear is, making treatment decisions difficult. Researchers enrolled 30 adu…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study tested a new diagnostic tool that uses imaging flow cytometry to examine platelets in blood samples. Researchers compared it to standard lab tests in 31 patients suspected of having platelet disorders or heparin-induced thrombocytopenia. The goal was to see if the new …

This study tested whether the Nephrocheck™ device can predict if early acute kidney injury will reverse within 72 hours in patients with septic shock. Researchers enrolled 184 adults in the ICU and measured the device's accuracy. The goal is to help doctors decide who might recov…

This study tested whether a special PET scan using florbetapir can help doctors figure out why some people develop memory and thinking problems after a stroke. The scan looks for amyloid plaques, a hallmark of Alzheimer's disease. Researchers studied 92 adults aged 40 to 80 who h…

This study tested whether an ultra-low dose CT scan, combined with a deep-learning AI reconstruction, can detect lung nodules as accurately as the standard low-dose CT. 70 adults having a chest CT for nodule check-up or follow-up received an extra ultra-low dose scan. The goal wa…

This study tested whether new deep learning (AI) technology can make prostate MRI scans faster while still finding suspicious nodules. Researchers compared standard MRI sequences with faster, AI-enhanced versions in 34 adults referred for prostate MRI. The goal was to see if the …

This study tested whether an early, quick PET scan using F-DOPA can help doctors tell the difference between a brain tumor coming back and damage from radiation therapy. Eight patients who already needed a PET scan for their brain metastases took part. The goal was to see if meas…

This study tested whether a special MRI technique called 4D flow can accurately measure blood pressure in the lungs of people with pulmonary hypertension. 28 patients had both the MRI and the standard invasive catheterization to compare results. If the MRI proves reliable, it cou…

This study tested whether a new MRI technique using artificial intelligence (deep learning) can accurately measure heart function while patients breathe normally, instead of holding their breath. The standard method requires repeated breath-holds, which can be hard for people wit…

This study tested a small probe called a microdialysis catheter to see if it could detect leaks where the bowel is reconnected after rectal cancer surgery. Twenty-one people having rectal surgery with a temporary stoma took part. The probe measures chemicals in the tissue near th…

This study tested whether a noninvasive ultrasound done on the outside of the perineum (transperineal) can accurately measure cervical length in pregnant women, compared to the standard internal (endovaginal) method. Researchers enrolled 85 women in their second or third trimeste…

This study tested a special breathing technique during PET scans to get clearer images of lung tumors. 103 people with small lung nodules (under 35 mm) had both a standard PET scan and an extra scan where they held their breath. The goal was to see if this reduces blurring from b…

This study tested a non-invasive breathing technique (CO-rebreathing) to measure red blood cell mass in people with polycythemia, a condition with too many red blood cells. The goal was to see if it works as well as the standard radioactive test. Sixty adults took part, and the r…

This study tested whether a green dye injected into the blood can help surgeons see bile ducts better during gallbladder removal for acute cholecystitis, compared to the standard contrast dye. 156 adults with mild to moderate gallbladder inflammation took part. The goal was to se…

This study looked at tiny particles called extracellular vesicles found in urine to see if they can help tell the difference between healthy kidneys and chronic kidney disease. Researchers measured these particles in 143 people, including healthy volunteers and patients with kidn…

This study looked at 363 women with a history of three or more miscarriages who carry a specific gene mutation (MTHFR C677T). Researchers compared two treatments during pregnancy: aspirin plus folic acid, or the same plus a blood thinner (enoxaparin). The goal was to see which ap…

This study tested whether wrapping premature babies in a polyethylene bag during central line placement helps prevent dangerous drops in body temperature. The procedure can take 30 minutes to 2 hours, and opening the incubator causes heat loss. 63 premature infants (32 weeks or l…

This trial investigates whether placing a biological mesh (Strattice) during colostomy creation can prevent parastomal hernia, a common complication. About 81 adults undergoing colorectal surgery with a terminal colostomy will be randomly assigned to receive the mesh or standard …

This study tested whether taking vitamin C before and after planned upper limb surgery could prevent complex regional pain syndrome (CRPS), a chronic pain condition. Nearly 1,000 adults participated, receiving either vitamin C or a placebo. The goal was to see if vitamin C reduce…

This study tested a computer system called Beacon that gives doctors advice on when to take patients off a breathing machine. 29 adults who had been on a ventilator for more than 48 hours took part. The goal was to see if using the system led to less time on the ventilator compar…

This study tested whether a software tool (Guide XT) can replace the long, exhausting process of choosing the best stimulation settings for Parkinson's patients with brain implants. Twenty-six patients took part. The goal was to see if the software was at least as good as the sta…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tested whether spinal anesthesia (numbing the lower body) helps doctors turn a breech baby (feet-first) to a head-down position more successfully than standard sedation. 186 pregnant women at 36+ weeks participated. The goal was to increase the chance of a successful v…

This study compares two ways to relax the abdominal muscles during laparoscopic (keyhole) digestive surgery. One method is a nerve block called TAP block, which numbs the abdominal wall. The other is a standard muscle relaxant drug called curare. The trial involves 60 adults aged…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This pilot study looked at whether a supervised or distance-supervised brisk walking program could help manage fatigue in breast cancer patients currently on hormone therapy. Seventeen women who had completed chemotherapy and/or radiation took part in a 6-week program, walking tw…

This study compared two numbing medicines, levobupivacaine and ropivacaine, given as spinal anesthesia for leg surgery. Fifty adults with leg injuries took part. Researchers measured how long numbness and muscle relaxation lasted. The goal was to see if one drug works better or l…

This study tested whether relaxation therapy can reduce chronic pain and improve daily life in people with fibromyalgia. Eighty adults with fibromyalgia were randomly assigned to either active relaxation sessions with a therapist or to relax alone in a quiet room (placebo) for 12…

This study looked at whether people with simple appendicitis can safely go home within 12 hours after surgery instead of staying overnight. Researchers followed 120 adults who had their appendix removed and checked if they were discharged quickly. The goal was to see if same-day …

This study tested whether giving the antibiotic teicoplanin as a shot under the skin is safe and well-tolerated in adults with bone and joint infections. Thirty patients who were already stable on IV teicoplanin received the subcutaneous version. The main goal was to check for in…

This study tested three different nerve block techniques to control pain after thoracoscopic (chest) surgery. 155 adults were randomly assigned to receive either a serratus plane block, a paravertebral block, or both together, using the anesthetic ropivacaine. The goal was to fin…

This pilot study tested whether laparoscopic sleeve gastrectomy, a common obesity surgery, can be safely performed as a day-case procedure without an overnight hospital stay. Thirty adults with obesity were enrolled, and researchers measured how many patients needed unexpected ad…

This study looked at 68 newborns to see if a non-invasive light sensor, which measures blood flow under the skin (called perfusion index), could help spot infections early. Newborn infections are hard to detect because signs are subtle, and delays can be dangerous. The researcher…

This study looked at whether blood taken from an artery or a vein gives the same clotting time result during heart surgery using a heart-lung machine. The clotting test helps doctors decide how much blood thinner (heparin) to give. 201 adults having heart surgery had paired blood…

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study measured levels of mannose-binding lectin (MBL), a protein involved in immune response, in 97 ICU patients with severe H1N1-related acute respiratory distress syndrome (ARDS). Researchers wanted to see if higher or lower MBL levels were linked to a higher risk of death…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study looked at whether a non-invasive monitoring tool (called dynamic arterial elastance, or Eadyn) can predict how a patient's blood pressure will respond when doctors reduce the dose of norepinephrine, a drug used to raise blood pressure. The study included 35 ICU patient…

This completed study examined whether a specific variation in the VEGF gene (rs699947) is linked to a higher risk of developing kidney cancer in people who have received a kidney transplant. Researchers analyzed DNA from 272 transplant patients, some of whom had kidney cancer. Th…

This study tested whether a newer type of MRI called 4D flow can more accurately measure leakage in the pulmonary valve and heart chamber size in people born with tetralogy of Fallot who had corrective surgery. Researchers compared 4D flow MRI with standard 2D MRI in 21 patients …

This completed study looked at 3000 patients having liver surgery to see if considering both medical and social factors could reduce how long they stay in the hospital. Researchers tracked things like complications and readmissions. The goal is to find ways to improve recovery an…

This completed study analyzed microRNAs in carotid artery plaques from 30 patients who had surgery to remove them. Researchers compared plaques from people who had already had a stroke (symptomatic) with those who had not (asymptomatic) to see if certain microRNAs are linked to s…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This completed study looked at 44 patients who had lung cancer surgery to understand how the arteries in the lungs can vary from person to person. Using CT scans and 3D models, researchers mapped these variations to help surgeons avoid complications during lobectomy. The goal was…

This study tested whether a protein called GLUT1 could help doctors better classify lung neuroendocrine tumors. Researchers analyzed tumor samples from 36 patients to see if GLUT1 staining patterns matched tumor type. The goal was to find a more reliable diagnostic tool than curr…

This study looked at whether exposure to pesticides affects the quality of a woman's eggs and the success of IVF. Researchers analyzed data from 633 women in France who underwent a specific type of IVF (ICSI). They compared women with a high number of eggs showing a certain abnor…

This study looked at 58 full-term newborns with suspected early-onset sepsis to find early clinical signs that could help doctors tell if a bacterial infection is present. Researchers reviewed medical records from 2013 at a single hospital. The goal was to improve diagnosis and a…

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The res…

This study looked at brain tumors (gliomas) in 128 patients under 25 treated at one French hospital. Researchers compared the genetic and imaging features of tumors in children (0-14 years) versus adolescents and young adults (15-25 years). The goal was to see if these groups hav…

This study looked at how a new oral form of midazolam (ADV6209) is processed in the body of children aged 6 months to 17 years before surgery. 37 children received a single dose based on their weight. Researchers measured drug levels in the blood to understand how age affects cle…

This study used existing MRI and CT scans from 150 healthy newborns to build a combined head template. MRI shows soft tissues well, while CT is better for bone and the soft spots (fontanelles) on a baby's skull. The goal is to create a single reference image that helps doctors mo…

This study tested a new way to analyze red blood cells in people with anemia using flow imaging and artificial intelligence. Instead of the usual method of spreading blood on a slide and staining it, the researchers used a machine that takes pictures of cells flowing in liquid. T…

This study reviewed medical records of 37 children under 18 diagnosed with rare brain tumors called DIA or DIG between 1996 and 2015 in French cancer centers. Researchers wanted to find out why some of these usually benign tumors become malignant. By analyzing clinical, genetic, …

This study looks at whether women who had a cervical procedure called LEEP (loop electrosurgical excision procedure) before age 25 face higher risks in future pregnancies, such as preterm labor or early rupture of membranes. Researchers reviewed records of 115 women who had LEEP …

This study looked at 107 women having a first-time cervical procedure (LEEP) for abnormal cells. Researchers compared how local anesthesia (cervical block) versus general or spinal anesthesia affected the size of the removed tissue. The goal was to see if the anesthesia method in…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study looks at how certain genetic changes (mutations) in the hepatitis B virus (HBV) affect the amount of virus in the blood of people with chronic infection. Researchers analyzed blood samples from 92 patients not on antiviral treatment. They found that specific mutations …

This study analyzes data from 748 patients who had their bladder removed due to bladder cancer. The goal is to find factors that can predict whether cancer has spread to the ureter, the tube that carries urine from the kidney to the bladder. By identifying these factors, doctors …

This study looked at whether a formal medication review at hospital discharge helps reduce the number of potentially harmful drugs prescribed to older adults. Researchers compared two groups of patients aged 75 and older: one group received a standardized medication check, while …

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This study looked at brain wave patterns in 28 healthy premature infants born between 26 and 32 weeks of pregnancy. Researchers used EEG to measure a specific type of brain activity called temporal theta slow-wave activity. The goal was to understand where this activity comes fro…

This study looked at whether giving women hospitalized for preterm labor a booklet about prematurity, along with a talk from a pediatrician, lowers their anxiety compared to just the talk alone. 65 women participated, and their anxiety was measured before and after the informatio…

This study looks at how different incubator settings affect the thermal comfort of very premature infants (born before 32 weeks). Researchers compare two regulation modes—standard 'Air' mode versus 'Cutaneous' (skin-based) mode—to see which reduces stress, measured by changes in …

This study looks at how well a special knee implant called the Medial-Pivot knee works over the long term. Researchers measured knee bending and checked implant survival about 10 years after surgery in 71 patients. The goal was to see if the implant helps achieve at least 120 deg…

This study looks at why some people develop pneumonia after accidentally inhaling food, drink, or stomach contents. Researchers will track patients in intensive care and general medicine who have had a known or suspected inhalation event. The goal is to identify risk factors and …

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This study looked at whether reading stories to premature babies in the hospital helps improve the connection between mother and baby. Researchers measured heart and breathing patterns in 27 mother-baby pairs. The goal was to see if reading together creates better rhythmic commun…

This study looked at whether vitamin K antagonists (a type of blood thinner) are linked to more calcium buildup in the aorta, the body's main artery. Researchers compared 73 patients—some on the drug for at least 6 months and some who never took it—using CT scans. The goal was to…

This study looked at whether a substance in the blood called D-dimer can help predict how well people recover after a stroke. Researchers measured D-dimer levels in 102 stroke patients who had received treatment to restore blood flow. They then compared these levels with standard…

This study tested whether a computer program could predict which older patients (over 75) would have unnecessary days in the hospital. Researchers analyzed electronic health records from 102 patients in an acute geriatric unit. The goal was to create an algorithm that flags when …

This study explored whether lab-grown skin models containing a patient's own melanoma cells could predict which drug combinations would work best. Researchers took a small sample of a skin metastasis and used it to create 3D cultures and artificial skin. The goal was to test diff…

This study looked at brain activity in 37 children with epilepsy using two devices: EEG (which records electrical brain signals) and NIRS (which measures blood oxygen levels in the brain). The goal was to better understand what happens in the brain during seizures and between sei…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study tested whether a new heart ultrasound measurement can predict serious heart complications after chest surgery. Researchers followed 191 adults who had lung surgery and performed heart ultrasounds before surgery, two days after, and fifteen days after. They tracked whet…

This study looked at whether measuring procalcitonin (PCT) levels in the blood could help detect infections earlier in people with stage IV non-small cell lung cancer starting chemotherapy. Researchers enrolled 45 patients and took a PCT blood sample before their first chemo sess…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study looked at whether using ultrasound to guide arterial catheter placement in intensive care patients improves success on the first try and reduces complications. Researchers enrolled 288 adults in the ICU who needed an arterial line. The goal was to see if ultrasound mak…

This study looked at how babies' brains become specialized for language, comparing preterm and full-term newborns. Researchers used EEG and NIRS to measure brain activity while babies heard sounds. The goal was to understand when and where language dominance develops, and how a p…

This study looked back at medical records of 18 intensive care patients who received hydroxocobalamin (a form of vitamin B12) for severe vasodilatory shock, a condition where blood vessels widen too much and blood pressure drops dangerously. The goal was to see if the treatment c…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study looks at whether placing a tube through the nose into the stomach (nasogastric tube) before surgery helps prevent breathing complications in infants with hypertrophic pyloric stenosis. The condition causes a blockage in the stomach outlet, leading to forceful vomiting.…

This study tested whether the POSOS app helps emergency doctors detect drug-induced harm (iatrogenesis) in simulated patient cases. 85 doctors were randomly assigned to use the app or not, and their answers were compared. The goal is to see if the app improves accuracy and speed …

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This completed study from France examined perfectionism, depression, and anxiety in 59 people with Parkinson's disease. Participants filled out standard questionnaires about perfectionism, mood, and anxiety. The goal was to better understand how these psychological factors relate…

This completed study looked at 114 adults with a type of brain bleed called subarachnoid hemorrhage from a ruptured aneurysm. Researchers measured the optic nerve sheath on early CT scans to see if the size could predict whether a patient would survive for 6 months. The goal was …

This study measured levels of a protein called IP3R3 in breast cancer tissue from 42 women. The goal was to see if this protein is involved in how cancer cells migrate and invade nearby tissues. Researchers hope this could lead to better understanding of what makes breast cancer …

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study compared two drugs used to start labor in pregnant women at full term with an unfavorable cervix. One group received oral misoprostol pills, the other received vaginal dinoprostone gel or insert. Researchers tracked how many women delivered vaginally within 24 hours, a…

This study compared two methods for measuring bioavailable testosterone in the blood: the standard lab test (radioimmunoassay) and a mathematical calculation. Researchers included 270 men and women aged 18 to 90. The goal was to see if the calculation matches the lab test closely…

This study examined 41 patients treated for non-tuberculous mycobacteria (NTM) infections, comparing those with and without cancer. The goal was to count side effects from NTM treatment in each group to understand why cancer patients often stop therapy. Researchers hope this will…

This study investigates whether analyzing bowel sounds with a computer can help measure disease activity in children with Crohn's disease. Researchers will record bowel sounds and compare them to a standard disease activity score. The goal is to find a noninvasive, painless way t…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This study used MRI to measure blood flow in the eye's main artery in 20 adults with untreated glaucoma and compared it to healthy people. The goal was to understand how blood flow problems might contribute to glaucoma damage. Participants had one MRI scan, and no treatment was g…

This study looked at health insurance records of over 75,000 people with cirrhosis in France to see if doctors follow guidelines for early liver cancer screening. The goal was to find out how often screening is done correctly and what factors might lead to missed or delayed diagn…

This study looked at a thin layer of proteins and sugars that lines blood vessels, called the glycocalyx, in 28 people having heart surgery. The goal was to see if changes in this layer relate to fluid leaking out of blood vessels, which can cause swelling. By measuring glycocaly…

This study looked at whether the constant low-level radiofrequency exposure from medical devices in the NICU affects the brain development of preterm infants. Researchers measured exposure levels over six weeks and tracked sleep patterns, brain oxygen levels, and heart rate in 40…

This study looked at 10 children aged 3 to 14 with absence epilepsy, a type of seizure that causes brief lapses in awareness. Researchers used two noninvasive tools—near-infrared spectroscopy (NIRS) and electroencephalography (EEG)—to record brain activity and blood flow changes …

This study uses a non-invasive light-based technique called near-infrared spectroscopy (NIRS) combined with EEG to measure blood flow changes in the brains of children aged 3 to 6 years during infantile epilepsy spasms. The goal is to better understand what happens in the brain b…

This study examined whether the standard dose of isoniazid, a key tuberculosis drug, is right for all adults. Researchers measured drug levels in 112 patients to see if some were getting too much or too little. The goal was to understand how individual differences in drug process…

This study looked at whether the age at which a woman had a cervical conization (removal of precancerous tissue) affects the length of her cervix during a later pregnancy. A shorter cervix can raise the risk of preterm birth. Researchers measured cervix length in pregnant women w…

This study looked for a virus called HHV6 in the skin and blood of 37 adults with blood cancers who developed a rash during hospital stays. The goal was to see if the virus is linked to the rash, which could help doctors diagnose and treat the rash more effectively. The study is …

This study tested if a system that ranks emergency surgeries by urgency leads to better results. Researchers tracked 756 adults who had non-cardiac emergency surgery. They wanted to see if delays beyond the recommended time for each urgency level increased complications or deaths…

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study looked at 181 elderly patients (65 and older) having emergency non-heart, non-lung surgery. Researchers measured brain oxygen levels during surgery and checked for confusion or memory problems (called postoperative cognitive dysfunction) up to 72 hours later. The goal …

This study looked at 30 undernourished teens with anorexia, aged 11 to 17, to see how taking oral phosphorus supplements for 6 months changes a hormone called FGF23, which helps control phosphate and vitamin D levels. The goal was to understand the link between phosphorus intake …

This study looked at how often certain gut bacteria (Enterobacteria) are resistant to a powerful group of antibiotics called carbapenems. Researchers tested samples from 287 patients in northwest France to find the rate of these resistant strains. The goal was to understand the p…

This study looked at 2,500 kidney transplant patients to find out why some develop cancer. The main focus was on the immunosuppressive drugs that prevent organ rejection, which can also raise cancer risk. Researchers tracked patients from four regions in France over 10 years to i…

This study reviewed medical records of 966 children diagnosed with Crohn's disease or ulcerative colitis between 1988 and 2011. Researchers looked at how often children needed surgery and how treatments like immunosuppressants and anti-TNF drugs were used over time. The goal was …

This study tested whether drones can safely transport blood samples between hospitals in France. Researchers compared blood samples sent by drone with those sent by car, checking for temperature changes, delays, and damage. The goal is to see if drone transport is reliable enough…

This study looked at whether a motivational interview with a doctor helps people with chronic diseases stick to a physical activity program. 114 adults from Amiens took part. The goal was to see if this simple talk could improve how much they exercise and their quality of life.

This study looked at how a type of hands-on therapy (specific back mobilizations) affects muscle activity in the back. 156 healthy adults took part. The goal was to understand the therapy's effects on muscle control, separate from placebo or natural changes.

This completed study looked at whether a protein called vasorin in the blood can help predict how severe kidney injury will be in people with septic shock. Researchers took blood samples from 50 intensive care patients on day 0 and day 3. The goal was to see if vasorin levels are…

This study tested whether the usual method of placing ACL reconstruction tunnels at the center of the natural ligament attachments actually keeps the new ligament taut (isometric) throughout knee motion. Thirty healthy volunteers had their knees scanned with a special 4D scanner …

This study looked at whether inducing labor is a safe option for women whose babies are in the breech position (feet or bottom first) at full term. Normally, these women are scheduled for a C-section. The goal was to see if offering labor induction could lower the risks of surger…

This study followed 37 adults over age 60 with unexplained low platelet counts to see if certain tests could predict immune thrombocytopenic purpura (ITP). Participants had blood tests, bone marrow biopsies, and a short course of the steroid prednisone. The goal was to find which…

This study looked at 201 very premature babies born before 31 weeks to see how often they received blood transfusions that went beyond French guidelines. Researchers found that many transfusions were given even when not recommended, possibly due to the babies' fragile health. The…

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This completed study looked at how the antibiotics amoxicillin and clavulanic acid get into the infected fluid around the lungs in people with pleural infections. Eleven adults with complicated infections had chest tubes placed and received the antibiotics. Researchers measured a…

This study looked at whether levels of cell free DNA (tiny DNA fragments) in blood and fluid around eggs are higher in women with endometriosis who are doing IVF. Researchers compared 114 women with and without endometriosis to see if these DNA levels relate to egg quality and pr…

This study looks back at an outbreak of a hard-to-treat bacteria (VIM-producing Enterobacter cloacae) in an intensive care unit during the 2020 COVID-19 pandemic. Researchers reviewed the cases of 14 ICU patients who had this superbug to understand how the hospital managed the ou…

This study aims to better understand how facial muscles work during expressions like smiling. Researchers will use MRI scans and motion capture technology to measure both the surface skin movements and the deeper muscle movements. The goal is to create a computer model that helps…

This study tested a device called ANI that measures pain during weight-loss surgery in 15 adults. The goal was to see if using the monitor helps doctors give less morphine. The study is complete and focused on improving pain control during surgery.

This study looked at what happens to mothers and their newborns in the first month after going home from the hospital earlier than usual. It included 177 mothers and babies who were sent home after a short hospital stay. The goal was to see if early discharge leads to any health …

This study tested whether a parvovirus infection might trigger Graves' disease, an autoimmune condition affecting the thyroid. Researchers compared 52 people—half recently diagnosed with Graves' disease and half with thyroid nodules or goiter—by checking their blood for parvoviru…

This study tested whether using a video to measure capillary refill time (how fast skin color returns after pressure) is more consistent than the usual visual method. Researchers compared measurements taken by different doctors in 59 ICU patients. The goal was to see if the video…

This study looked at how often sleep apnea occurs in adults with type 1 diabetes. Researchers monitored 53 participants overnight using standard sleep tests and continuous glucose monitors. The goal was to measure the link between sleep-disordered breathing and blood sugar contro…

This study looked at 100 people with advanced COPD to see if the fungus aspergillus in their sputum is linked to their quality of life and symptoms. Participants provided sputum samples and filled out questionnaires at the start, then again by phone after 1 and 3 months, and in p…

This study looked at whether a substance called M-CSF in the blood can help identify bone lesions in people with multiple myeloma. Researchers compared M-CSF levels in 111 participants: those with multiple myeloma, those with a pre-cancer condition called MGUS, and healthy contro…

This study tested whether recording the electrical activity of the uterus (called an electrohysterogram, or EHG) can help predict preterm birth in pregnant women already showing signs of early labor. Researchers monitored 100 women hospitalized for threatened premature delivery. …

This study looked at how accurately patients with alcohol intoxication in the emergency department estimate their own blood alcohol concentration (BAC) compared to a real blood test. Researchers enrolled 34 adults aged 15-64 with a BAC of 60 mg/dL or higher. The goal was to see i…

This study looked at healthy blood donors to see if certain antibodies (called antiphospholipid antibodies) are linked to heart disease risk factors like high cholesterol or inflammation. Researchers compared people with and without these antibodies to better understand their rol…

This study looked at how well people with bipolar I and bipolar II disorder recognize facial emotions compared to healthy individuals. Ten participants completed a facial emotion recognition test and questionnaires. The goal was to see if there are differences between the two bip…

This study tested whether a simple lung ultrasound can accurately detect fluid overload in people on hemodialysis. 46 patients had an ultrasound before their regular dialysis session, and the results were compared to other standard tests. The goal is to help doctors better determ…

This study tested whether a questionnaire called VQ11 can accurately measure changes in quality of life for people with COPD who start taking a long-acting bronchodilator. Fifty-seven stable COPD patients filled out the VQ11 before and after three months of treatment. The goal wa…

This study looked at how much lidocaine and ropivacaine stay in the blood when both are used for pain control during major abdominal surgery. It involved 51 adults having open abdominal surgery. The goal was to understand if combining these drugs is safe and how their levels chan…

This study tested a new 4D MRI technique to create a 3D map of blood flow in the liver. 44 adults who had fasted for 6 hours took part. The goal was to see if this method could accurately measure blood flow through the liver's main vessels. The results could improve how doctors i…

This study looked at two different methods for deciding when to give red blood cell transfusions to patients recovering from heart surgery. One method used a standard hemoglobin level threshold, while the other used a measure of oxygen in the blood (central venous oxygen saturati…

This study tested two ways to give oxygen before a throat cancer exam called panendoscopy. One method used a machine to push air into the lungs (non-invasive ventilation), while the other let patients breathe on their own with a mask. The goal was to see which method keeps oxygen…

This study tested whether lung ultrasound can help doctors give the right amount of fluid during surgery. 200 adults having various surgeries were monitored with both lung ultrasound and an esophageal Doppler. The goal was to see if a change in ultrasound pattern (from A to B lin…

This study followed 104 people with venous leg ulcers to see which factors were linked to complete healing after 24 weeks. Researchers looked at medical history, wound size, and also psychological and social factors like mood and self-esteem. The goal was to find better ways to p…

This study tested whether using ultrasound to guide a breathing tube placed through the neck (tracheostomy) is safe and practical in the ICU. Forty adult patients who needed this procedure took part. The goal was to see if ultrasound could help avoid problems like bleeding, injur…

This study compared two common positions for a digital rectal exam: lying on your side (lateral decubitus) versus lying on your back (supine). The goal was to see which position allows doctors to perform a more complete exam. The study involved 320 men with conditions like colon …

This study tested whether a small microdialysis catheter placed directly into a bone graft could monitor blood flow and healing after head and neck reconstruction. Thirty-four people having surgery with bone from their hip or leg took part. The goal was to see if the catheter cou…

This study looked at whether the diabetes drug metformin can be used safely in people with type 2 diabetes who also have kidney disease. Researchers gave increasing doses of metformin to 82 patients with different stages of kidney failure and measured the drug levels in their red…

This study tested whether a special MRI scan (flow MRI) can predict how well patients with normal pressure hydrocephalus will respond to surgery. Currently, doctors use a lumbar puncture (spinal tap) to make this prediction. The study enrolled 30 adults and measured cerebrospinal…

This study looked at how focusing on negative thoughts (rumination) versus distracting yourself affects your mood after physical activity in people with fibromyalgia. 47 adults with fibromyalgia took part. Researchers gave them instructions to either ruminate on their muscle tens…

This completed study looked at 97 men with type 2 diabetes to see if a non-invasive skin test for advanced glycation end-products (AGEs) could be linked to erectile dysfunction. AGEs build up due to high blood sugar and may damage blood vessels. Researchers used a device called A…

This completed study looked at how often thinking, memory, and behavior problems happen after a stroke. Researchers tested over 1600 people, including stroke patients and healthy volunteers, using a French version of a standard cognitive battery. The goal was to better understand…

This study looked at how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Fifteen patients who already had a DBS device implanted performed movement and impulse control tasks while their brain activity was measured using a special light-base…

This study looked at how repetitive negative thinking (rumination) affects the emotional and mental symptoms of fibromyalgia. Researchers studied 107 adults with fibromyalgia using questionnaires. The goal was to understand if rumination plays a role in depression and anxiety oft…

This study looked at whether patients follow the instructions they receive when leaving the emergency department. Researchers interviewed 242 adults by phone one week after their visit to check if they complied with discharge orders. The goal was to understand how well patients f…

This study tested two different ways of using a breathing machine at night to help people with COPD get off the machine faster. Nineteen patients were randomly assigned to one of two ventilation modes during sleep. Researchers measured how long it took to wean off the ventilator …

This study looks at when preterm babies start to recognize their mother's voice and which part of the brain handles that. Researchers used brain scans (EEG and NIRS) on 22 preterm infants to measure brain activity when they heard different sounds. The goal is to understand how ea…

This study tested over 1,000 newborns in the Picardie region of France for exposure to common pesticides. Researchers measured pesticides in the baby's first stool (meconium) and in the mother's hair, and asked mothers about their exposure. The goal was to see how much pesticide …

This study tested whether removing surgical drains early (4 days after surgery) instead of the usual 10-15 days reduces infections after pancreaticoduodenectomy, a major operation for pancreatic tumors. 141 patients were included, and those without a pancreatic leak were randomly…

This study used MRI to see how the liver's blood supply changes when healthy volunteers receive a standard fluid infusion (500 ml of saline). The goal was to understand the 'buffer response' between the hepatic artery and portal vein. 22 healthy adults participated, and the resul…

This study looked at 90 people who had sleeve gastrectomy surgery for obesity two years earlier. Researchers wanted to see if the amount of stomach left after surgery (residual gastric volume) was linked to whether the surgery failed to help them lose enough weight. The goal was …

This study looked at whether two types of heart ultrasound (TTE and TEE) give the same measurement of right ventricle function during heart surgery. Researchers measured the right ventricle's shortening fraction in 90 adults undergoing scheduled cardiac surgery. The goal was to s…

This study looked at whether a substance called β-D-glucan in the blood can help identify and track fungal infections in the abdomen (peritonitis) in intensive care patients. Researchers measured levels in 70 adults with peritonitis, comparing those with and without Candida yeast…