SYSTEMIC LUPUS ERYTHEMATOSUS

This early-stage study is testing a new cell therapy called CC-97540 for people with severe autoimmune diseases that haven't responded to multiple treatments. The therapy involves collecting a patient's own immune cells, engineering them to target specific immune cells (B cells),…

This study is testing whether an experimental drug called VENT-03 can reduce the severity of skin rashes caused by lupus. About 24 adults with active lupus skin rashes will take either VENT-03 or a placebo for 4 weeks, then all will take VENT-03 for 8 more weeks. Researchers will…

This study is testing a new combination treatment for people with severe autoimmune diseases like lupus and scleroderma who haven't responded well to standard therapies. It involves giving specially modified immune cells (AD-PluReceptor-NK cells) along with a drug called tafasita…

This early-stage study is testing a new, quickly-made cell therapy for people with severe lupus that hasn't improved with standard drugs. Doctors will collect a patient's own immune cells, modify them in the lab to target lupus-causing cells, and infuse them back. The main goals …

This is an early-stage safety study testing a single infusion of YTS109 cells in 18 adults with severe autoimmune diseases that have not responded to standard treatments. The main goal is to check for side effects and see how the body handles the cells. Researchers will also look…

This early-stage study is testing a new type of cell therapy called anti-CD19/BCMA universal CAR-T cells in people with severe autoimmune diseases that have not improved with standard treatments. The main goals are to check if the treatment is safe and to see if it can help contr…

This is the first study in people to test a new drug called surovatamig for rheumatoid arthritis and lupus. The main goal is to check its safety and how the body processes it in 48 adults with these conditions. Researchers will give the drug as an injection under the skin at diff…

This early-stage trial is testing a new type of cell therapy called P-CD19CD20-ALLO1 in people with severe lupus that hasn't responded to multiple treatments. Researchers will give 162 participants modified immune cells designed to target and remove the faulty B-cells that drive …

This early-phase study is testing a new type of cell therapy called Meta10-19 CAR-T for people with moderate to severe active lupus. The therapy involves taking a patient's own immune cells, modifying them in a lab to better target the B cells thought to drive lupus, and then inf…

This large, late-stage study is testing whether the medication upadacitinib can safely control disease activity in adults with moderate-to-severe systemic lupus erythematosus (SLE). About 1000 participants worldwide will take either the study drug or a placebo pill daily for a ye…

This is the first study in humans to test the safety and side effects of a new drug called LY4298445. It will involve both healthy volunteers and people with systemic lupus erythematosus or rheumatoid arthritis. The main goal is to see how the body handles the drug and to find a …

This study continues testing ianalumab, an investigational drug for moderate-to-severe lupus, to understand its long-term safety and side effects. It includes 550 patients who previously completed earlier phases of this research program. The goal is to see if the drug remains saf…

This early-stage study is testing a new drug called A-319 for people with active or treatment-resistant lupus (SLE). The drug is designed to guide the body's own T cells to find and destroy harmful B cells that drive the disease. Researchers will enroll about 25 participants to p…

This is an early Phase 1 study to test the safety and side effects of a new investigational drug called MK-1045. It will involve a small group of 21 people with either systemic lupus erythematosus or rheumatoid arthritis. The main goal is to find safe dose levels by checking how …

This early-stage study is testing a new, quickly manufactured cell therapy for people with severe lupus that hasn't improved with standard drugs. Doctors take a patient's own immune cells, modify them in a lab to target harmful B cells thought to drive lupus, and infuse them back…

This early-stage study is testing a new treatment called UB-VV410 in adults whose lupus or lupus-related kidney disease is still active despite standard treatments. The main goals are to find the safest and most effective dose and to check for any side effects. Researchers will a…

This study is testing the drug belimumab in adults who were recently diagnosed with lupus. The goal is to see if the drug, given as a shot at home, can help control lupus disease activity over three years and allow patients to reduce their steroid use. Researchers will track how …

This early-stage study is testing a single infusion of 'universal' CAR T-cells in adults with severe autoimmune diseases like lupus and scleroderma that have not improved with standard treatments. The therapy aims to target and remove harmful immune cells to potentially control t…

This study is testing two different drugs for people with severe autoimmune diseases that haven't responded well to other treatments. It's looking at inebilizumab for lupus with kidney problems and blinatumomab for lupus and rheumatoid arthritis. The main goals are to see if thes…

This study is testing an experimental cell therapy called CABA-201 for adults with active lupus. Doctors will collect a patient's own immune cells, modify them to target the harmful cells causing lupus, and infuse them back. The main goals are to see if this one-time treatment is…

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This study is testing if a newer drug called Telitacicept is better and safer than the standard treatment, Cyclophosphamide, for controlling lung scarring in people with early lupus. It will involve 100 adults who have both lupus and signs of lung disease. The main goal is to see…

This study is testing if a drug called anifrolumab can improve blood vessel health and reduce inflammation in people with lupus (SLE). Lupus patients have a higher risk of heart disease, and no current medications effectively lower this risk. About 45 participants will receive ei…

This study is testing a stem cell transplant procedure for children and young adults with severe, life-threatening forms of lupus or scleroderma that haven't responded to standard treatments. The goal is to use high-dose chemotherapy to wipe out the faulty immune system and then …

This early-stage trial is testing a new cell therapy for adults with severe, hard-to-treat autoimmune diseases like lupus, scleroderma, and muscle inflammation diseases. Doctors take a patient's own immune T-cells, genetically modify them to hunt and destroy harmful B-cells that …

This early-stage study is testing a new oral drug called ONTO1 for people with lupus, including a serious kidney complication called lupus nephritis. The main goal is to find the highest safe dose and see if it helps improve symptoms when taken alongside standard lupus medication…

This study aims to find out if older adults with stable lupus can safely stop taking hydroxychloroquine, a common lupus medication that can cause permanent eye damage with long-term use. Researchers will follow 330 participants aged 60+ for one year, randomly assigning them to ei…

This early study is testing a new treatment for severe lupus that hasn't responded to other therapies. Doctors take a patient's own immune cells, modify them to target lupus-causing cells, and return them to the body. The study will check if this approach is safe and shows early …

This is the first human study of an experimental drug called LBL-047 for systemic lupus erythematosus. Researchers will test single injections in healthy volunteers first to check safety, then in people with mild to moderate lupus. The main goal is to find safe dose levels and un…

This study is testing a program called CO-LEAD, designed to improve how patients with lupus and their doctors talk about medication use. It trains doctors in better communication skills and gives patients a tool to share their reasons for missing doses. The goal is to build trust…

This is the first study in people to test a new injectable drug called RO7507062 for systemic lupus erythematosus (SLE). The main goal is to check the drug's safety, side effects, and how it moves through the body in about 70 participants with active lupus. Researchers will test …

This early-stage study is testing whether adding a single injection of stem cells from umbilical cords to standard lupus treatment is safe and tolerable. It will involve 10 adults with active lupus to see if the therapy can reduce disease activity and improve kidney function. The…

This early-stage study is testing a new, quickly-made cell therapy for people with severe lupus that hasn't improved with standard drugs. The therapy, called CAR-T, involves taking a patient's own immune cells, modifying them to target lupus-related proteins, and putting them bac…

This early-stage study is testing a new mRNA-based treatment called HN2301 in people with autoimmune diseases including lupus, scleroderma, and rheumatoid arthritis. The main goal is to check if the treatment is safe and well-tolerated in 30 participants who haven't responded wel…

This early-stage study is testing a new drug called ABBV-319 in people with lupus or Sjogren's disease, two conditions where the immune system attacks the body. The main goals are to find a safe dose, see how the drug moves through the body, and check if it reduces the overactive…

This is an early-stage study to see if a new drug called alnuctamab is safe and might help control lupus in people whose disease hasn't improved with standard treatments. The drug works by guiding the body's own immune cells to attack the harmful cells thought to drive lupus. The…

This study aims to see how well the drug anifrolumab works and how safe it is for people with active systemic lupus erythematosus (SLE) in real-world clinics, not just controlled trials. It will follow 300 adult patients who are already taking or starting the drug for up to five …

This early-stage study is testing a new cell therapy for people with severe autoimmune diseases that haven't improved with standard treatments. Doctors will give patients specially engineered immune cells (CAR-NK cells) to try to reset their overactive immune systems. The main go…

This is an early safety study of an experimental drug called budoprutug for adults with active systemic lupus erythematosus (SLE). The main goal is to see if different single doses are safe and well-tolerated in about 30 participants whose lupus hasn't responded well to standard …

This early-stage study aims to test the safety and basic effects of a new experimental drug called AZD5492 in adults with lupus, inflammatory muscle diseases, or rheumatoid arthritis. Researchers will give participants one or two doses and closely monitor them for side effects an…

This study is testing whether an experimental drug called SAR441344 can safely reduce disease activity in adults with active systemic lupus erythematosus (SLE). About 116 participants will receive either the drug or a placebo for 24 weeks, in addition to their standard lupus care…

This study is testing an investigational drug called dapirolizumab pegol as an add-on to standard lupus medications. It aims to see if the drug can help people with moderate to severe lupus achieve long-term improvement in their disease activity and symptoms like fatigue. The tri…

This early-stage study is testing a new, quickly manufactured cell therapy for people with severe lupus that hasn't responded to standard drugs. Doctors take a patient's own immune cells, modify them to target harmful B cells thought to drive lupus, and infuse them back. The main…

This study is testing an intravenous medication called anifrolumab in children and teenagers aged 5 to 17 who have moderate to severe systemic lupus erythematosus (lupus). Participants will receive either the study drug or a placebo (inactive solution) in addition to their standa…

This early-stage study is testing a new cell therapy for children and young adults with severe lupus that hasn't responded to other treatments. Doctors will collect a patient's own T cells, genetically modify them in a lab to target harmful B cells, and then infuse them back. The…

This study is testing whether the shingles vaccine (Shingrix) is safe and effective for people with systemic lupus erythematosus (SLE or lupus). Researchers will give 224 adult lupus patients either the vaccine or a placebo shot to see if it causes lupus flares and if it produces…

This study is testing whether an online wellness program can help people with conditions like rheumatoid arthritis and lupus feel less tired and improve their quality of life. Researchers will enroll 200 participants to try a 6-month online course focused on diet, gentle exercise…

This study aims to understand how much of the lupus medication anifrolumab passes into breast milk and reaches nursing infants. It will enroll 16 breastfeeding mothers who are already taking this drug for their lupus. Researchers will collect breast milk and blood samples from mo…

This registry follows 1000 people with lupus during their regular doctor visits to understand how well different treatments work in real life. Researchers collect information about medications, side effects, and how the disease progresses over time. The goal is to help doctors an…

This study is monitoring the safety of the lupus medication anifrolumab by comparing patients who take it against similar patients who receive standard treatments. Researchers will track whether patients develop serious infections or cancers over time. The study is observational,…

This is the first study in humans of an experimental drug called GSK4527363. It aims to check the drug's basic safety and how the body processes it in healthy volunteers and in people with autoimmune conditions like lupus. The study will enroll 142 participants across four groups…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases, like rheumatoid arthritis and lupus. The goal is to help scientists compare different diseases to learn more about what causes them and how they pro…

This study is creating a registry to learn more about how autoimmune diseases affect pregnancy. It will follow 1,000 pregnant women with conditions like lupus or rheumatoid arthritis to identify risk factors for complications. The goal is to gather information that can help impro…

This National Institutes of Health study aims to understand how lupus develops and progresses over time by observing patients and their family members. Researchers will monitor 2,250 participants with lupus or suspected lupus through regular check-ups, blood tests, and optional p…

This study is collecting information about pregnancy outcomes in women with moderate to severe lupus who take the medication anifrolumab. Researchers will compare health results for mothers and babies exposed to the drug during pregnancy against those who used other lupus treatme…

This study aims to understand why people with lupus might experience faster aging of their immune system compared to healthy individuals. Researchers will compare blood samples from 50 lupus patients with age-matched healthy volunteers to measure immune cell aging markers. The st…

This study aims to understand the safety of the lupus medication anifrolumab during pregnancy. It will follow about 240 women with lupus who took the drug while pregnant, tracking their health and their babies' health for up to a year after birth. The main goal is to check for an…

This study aims to understand how lupus affects the lungs, physical ability, and energy levels. Researchers will compare 50 people with lupus to healthy individuals by measuring their breathing, how far they can walk, daily activity, and fatigue. The goal is to gather information…

This study aims to understand how changes in a gene called TREX1 are related to skin symptoms and overall disease activity in people with lupus. Researchers will enroll 90 adults with lupus who have skin involvement to look for patterns between their genes, symptoms, and blood te…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study aims to create better tools for diagnosing and treating children with rare, inherited immune system disorders that cause severe autoimmune diseases. Researchers will analyze blood and tissue samples from 500 children to find molecular patterns that predict how their di…

This study aims to understand why people with lupus often show false-positive results on certain antibody tests that check for organ transplant compatibility. Researchers will examine blood samples from 30 adult lupus patients who have never been pregnant, had transfusions, or re…

This study is creating a long-term registry to track how lupus changes over time in patients treated at Duke. Researchers will collect health information and optional blood samples during regular clinic visits from 1000 participants. The goal is to gather data to understand the d…