New lupus drug E6742 enters Mid-Stage trial
NCT ID NCT07515014
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether the experimental drug E6742 can reduce lupus disease activity better than a placebo. About 256 adults with lupus will take either E6742 or a placebo pill for 24 weeks. The main goal is to see if more people on E6742 achieve a meaningful reduction in symptoms while using a low dose of steroids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- E6742
- What this could lead to
- If successful, this could point toward a new treatment option for lupus that helps control disease activity while allowing lower steroid doses.
- What could go wrong
- This is an early phase 2 trial with only 256 participants, so results may not apply to all lupus patients. The drug may not work better than placebo, and side effects are still being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chang Gung Memorial Hospital, Linkou
NOT_YET_RECRUITINGTaoyuan, Taiwan
-
Chonnam National University Hospital
NOT_YET_RECRUITINGGwangju, South Korea
-
Daido Clinic
RECRUITINGNagoya, Aichi-ken, Japan
-
Dokkyo Medical University Hospital
NOT_YET_RECRUITINGMibu-Machi, Shimotsugagun, Tochigi, Japan
-
First Hospital of Shanxi Medical University
NOT_YET_RECRUITINGTaiyuan, Shanxi, China
-
Fujita Health University Hospital
RECRUITINGToyoake, Aichi-ken, Japan
-
Hiroshima Prefectural Hospital
RECRUITINGHiroshima, Japan
-
Hokkaido University Hospital
RECRUITINGSapporo, Hokkaidô, Japan
-
Hyogo Medical University Hospital
RECRUITINGNishinomiya, Hyōgo, Japan
-
Japan Community Health Care Organization (JCHO) Chukyo Hospital
RECRUITINGNagoya, Aichi-ken, Japan
-
Japan Institute for Health Security National Center for Global Health and Medicine
RECRUITINGShinjuku, Tokyo, Japan
-
Jilin Province People's Hospital
NOT_YET_RECRUITINGChangchun, Jilin, China
-
Jiujiang No.1 People's Hospital
NOT_YET_RECRUITINGJiujiang, Jiangxi, China
-
Juntendo University Hospital
RECRUITINGBunkyo, Tokyo, Japan
-
Kaohsiung Veterans General Hospital
RECRUITINGKaohsiung City, Taiwan
-
Kobe University Hospital
RECRUITINGKobe, Hyôgo, Japan
-
Kumamoto Shinto General Hospital
RECRUITINGKumamoto, Japan
-
Nanfang Hospital Southern Medical University - PPDS
RECRUITINGGuangzhou, Guangdong, China
-
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School-Main
NOT_YET_RECRUITINGNanjing, Jiangsu, China
-
National Hospital Organization Kyushu Medical Center
RECRUITINGFukuoka, Japan
-
Niigata University Medical and Dental Hospital
RECRUITINGNiigata, Japan
-
Peking Union Medical College Hospital - East Campus
RECRUITINGBeijing, Beijing Municipality, China
-
Pingxiang People's Hospital
RECRUITINGPingxiang, Jiangxi, China
-
Shanxi Bethune Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, China
-
Shinkenko Clinic
RECRUITINGNaha, Okinawa, Japan
-
Taipei Veterans General Hospital
NOT_YET_RECRUITINGTaipei, Taiwan
-
The Affiliated Hospital of Guizhou Medical University
RECRUITINGGuiyang, Guizhou, China
-
The First Affiliated Hospital of Bengbu Medical University
NOT_YET_RECRUITINGBengbu, Anhui, China
-
The First Affiliated Hospital of Guangxi Medical University
RECRUITINGNanning, Guangxi, China
-
The First Affiliated Hospital of Nanchang University - Donghu Campus
RECRUITINGNanchang, Jiangxi, China
-
The First Affiliated Hospital of Shantou University Medical College
RECRUITINGShantou, Guangdong, China
-
The First Affiliated Hospital of Soochow University - Pinghailu Campus
NOT_YET_RECRUITINGSuzhou, Jiangsu, China
-
The Second Affiliated Hospital of Soochow University
RECRUITINGSuzhou, Jiangsu, China
-
The Second Affiliated Hospital, Zhejiang University School of Medicine - Jiefanglu Campus
RECRUITINGHangzhou, Zhejiang, China
-
The Second Xiangya Hospital of Central South University
NOT_YET_RECRUITINGChangsha, Hunan, China
-
The Third Affiliated Hospital, Sun Yat-Sen University
NOT_YET_RECRUITINGGuangzhou, Guangdong, China
-
Toho University Omori Medical Center
RECRUITINGŌta-ku, Tokyo, Japan
-
Tohoku Medical and Pharmaceutical University Hospital
RECRUITINGSendai, Miyagi, Japan
-
Tokyo Metropolitan Tama Medical Center
RECRUITINGFuchū, Tokyo, Japan
-
University of Occupational and Environmental Health University Hospital
RECRUITINGKitakyushu, Fukuoka, Japan
-
Yichang Central People's Hospital - Xiling Campus
NOT_YET_RECRUITINGYichang, Hubei, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a single infusion tame tough lupus?
- Can a single drug calm three different autoimmune diseases? a new trial puts ATG-201 to the test.
- Can genetics and environment explain lupus in the gullah population?
- Can a smartphone app bridge the lupus care gap for women of color?