New Four-Pronged antibody takes aim at lupus
NCT ID NCT06857214
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This phase 1 trial tests a new drug called GNC-038, a tetra-specific antibody designed to target multiple pathways involved in lupus. The study includes adults with moderate to severe lupus who are on stable standard treatment. Researchers are evaluating the drug's safety, tolerability, and how the body processes it, while also looking for early signs of effectiveness in controlling the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GNC-038 (a tetra-specific antibody)
- What this could lead to
- If successful, this could point toward a new treatment option for people with moderate to severe lupus, potentially offering better disease control with fewer side effects.
- What could go wrong
- This is an early phase 1 trial with only 84 participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to improve lupus symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SYSTEMIC LUPUS ERYTHEMATOSUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Renji Hospital, Shanghai Jiao Tong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, China
Contact
Contact
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a smartphone app bridge the lupus care gap for women of color?
- Blood traps may reveal lupus kidney treatment success
- Can a peer coach help young people take control of their chronic illness?
- Lupus patients may get a boost from doctors checking their prescription refill records
- Engineered immune cells take aim at Hard-to-Treat autoimmune diseases
- Continued anifrolumab treatment studied for lupus and related diseases