SYSTEMIC LUPUS ERYTHEMATOSUS

This study tested whether an oral medication called enpatoran could help control symptoms of lupus, including skin rashes and overall disease activity. 456 people with lupus took either the drug or a placebo pill for 24 weeks while continuing their standard lupus treatments. Rese…

This study tested whether adding a daily probiotic supplement to standard lupus medication could help better control the disease. For 12 weeks, half of the 40 adult participants with active lupus took the probiotic alongside their usual treatment, while the other half continued w…

This early-stage study tested a new drug called KZR-616 for people with lupus, including those with kidney inflammation (lupus nephritis). The drug was given as a weekly injection under the skin for 13 or 24 weeks, in addition to patients' standard lupus medications. The main goa…

This study tested if a drug called tofacitinib, which is used for arthritis, could help control moderate to severe skin rashes caused by lupus. It involved 13 young adults and primarily aimed to see if the drug was safe and how it behaved in their bodies over 76 weeks. The resear…

This study tested whether adding a Coenzyme Q10 supplement to standard treatment could help control lupus disease activity in children. Researchers enrolled 60 children aged 6-16 with moderate to severe lupus and followed them for three months. They compared those taking the supp…

This early-stage study tested how a drug called telitacicept behaves in the bodies of children with lupus. Sixteen young patients received the drug alongside their standard lupus treatments. Researchers primarily measured drug levels in the blood and also checked for safety and e…

This study tested a drug called emapalumab in children and adults with a dangerous immune system overreaction called Macrophage Activation Syndrome (MAS). MAS can occur in people with Still's disease or lupus who don't respond well to high-dose steroid treatment. The trial aimed …

This study tested whether adding the drug belimumab to standard lupus treatment helps children aged 5-17 with active disease. Researchers compared monthly belimumab infusions against placebo infusions in 93 participants over one year, while all continued their regular medications…

This study tested whether stem cells from umbilical cords could help adults with severe lupus that doesn't respond well to standard treatments. Researchers compared patients who received a single stem cell infusion plus standard care against those who received a placebo infusion …

This study aimed to monitor the long-term safety and effectiveness of Benlysta injections for treating Systemic Lupus Erythematosus (SLE) in real-world medical practice. It followed over 1,500 patients for one year after they started treatment. The goal was to gather information …

This early-stage study tested a new injectable drug called SHR-2173 in 30 adults with lupus. The main goal was to check if the drug is safe and how the body processes it. Researchers gave multiple injections under the skin to understand side effects and how the drug behaves in pe…

This study tested a new oral medication called cenerimod in people with systemic lupus erythematosus (SLE). The main goal was to see if the drug could safely reduce the number of specific immune cells (lymphocytes) in the blood, which are thought to drive the disease. About 105 a…

This study tested whether an experimental drug called nipocalimab could better control active systemic lupus compared to a placebo. It involved 228 adults with moderate-to-severe lupus who were already on standard treatments. Participants received either the drug or a placebo for…

This study tested whether a new oral medication called cenerimod could reduce disease activity in adults with moderate-to-severe lupus. Researchers compared four different doses of cenerimod against a placebo in 427 participants over six months. The main goal was to see if the dr…

This study tested a version of the lupus drug belimumab given as an injection under the skin in Chinese children. It involved 16 children aged 5-17 who had already been receiving the drug by IV. The main goal was to measure how the drug behaved in the body at different weights an…

This study tested whether a special care management program could help lupus patients who frequently miss appointments or need emergency care. Thirty-five high-risk patients worked with a trained nurse manager to coordinate their care and address personal challenges. Researchers …

This study tested whether hydroxychloroquine, a common lupus medication, could prevent people with early signs of lupus from developing the full disease. Researchers gave the drug or a placebo to 187 people aged 15-49 who showed some lupus markers but didn't yet have the full con…

This study investigated whether a non-invasive device that stimulates a nerve in the neck (the vagus nerve) could help reduce the severe fatigue often experienced by people with lupus (SLE). 75 participants with lupus, fatigue, and signs of nervous system issues were randomly ass…

This study tested whether a stress management program could help African American lupus patients feel less stressed and improve their quality of life. Researchers worked with 30 participants to see if learning stress-reduction techniques could lower their perceived stress and cha…

This study aimed to understand why some people develop autoimmune rheumatic diseases like rheumatoid arthritis or lupus while their genetically similar siblings do not. Researchers enrolled over 1,000 participants, including sibling pairs where one was affected and one was health…

This study aimed to understand the challenges and unmet needs in caring for people with systemic lupus erythematosus (SLE). Researchers analyzed existing health data and gathered opinions from specialist doctors to identify gaps in diagnosis, treatment, and patient support. The g…

This study tested a brief training program for rheumatologists (arthritis doctors) to see if it could help them provide more equal, high-quality care to Black and lower-income patients. The training focused on getting doctors to see each patient as an individual, rather than rely…

This was a small, completed lab study that tested whether specially engineered versions of a natural immune protein (called IL-2 muteins) could selectively boost a type of calming immune cell (regulatory T cells) taken from patients with various autoimmune and inflammatory diseas…

This study tested a new computer-based decision aid designed to help people with lupus and their doctors make treatment choices together. Researchers worked with 15 clinics and nearly 1,900 patients to see how well the tool could be put into regular practice. They measured how ma…

This study aimed to understand how the immune system in people with lupus affects their body's response to exercise. 55 adults with lupus were randomly assigned to either complete a 12-week high-intensity exercise program or continue their usual care. Researchers measured fitness…

This study followed over 3,100 adults with active lupus for five years to track the safety and effectiveness of the drug Benlysta (belimumab) compared to standard treatments. Participants were either taking Benlysta or other standard lupus medications, and doctors could change tr…

This completed study aimed to understand how immune cells called B lymphocytes differ in people with inactive systemic lupus erythematosus compared to healthy people. Researchers analyzed the gene activity profiles of these purified cells from 30 participants. The goal was to ide…

This study aimed to understand why rheumatoid arthritis symptoms often improve during pregnancy while lupus symptoms may get worse. Researchers followed 50 pregnant women with either condition to analyze tiny molecules in their blood and tissues. The goal was to find clues that c…

This study aimed to gather real-world information about adults with lupus nephritis, a serious kidney complication of lupus, in five Gulf countries. Researchers followed 193 participants for a year to document their symptoms, the treatments they received, their quality of life, a…

This study aimed to gather real-world information about patients in Russia living with moderate to severe systemic lupus erythematosus (SLE), a complex autoimmune disease. Researchers collected existing medical records and followed about 600 patients for over a year to understand…