SYSTEMIC LUPUS ERYTHEMATOSUS

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This early-phase study tested the safety of a new drug, CUG252, in 40 adults with mild-to-moderate systemic lupus erythematosus (SLE). Participants received multiple doses of the drug or a placebo by injection. The main goal was to see if the drug is safe and tolerable, and to un…

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This early-phase trial tested an experimental drug called DS-7011a in 26 adults with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The study aimed to check the drug's safety and how the body processes it, not yet to prove it works. Participants received either…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This study looked at the long-term safety and effectiveness of Benlysta, a medication for systemic lupus erythematosus (SLE), in over 1,500 patients in everyday medical practice. Researchers tracked participants for 52 weeks, monitoring side effects, disease activity, and quality…

This study tested an oral medication called GLPG3667 in 186 adults with active systemic lupus erythematosus (SLE). Participants took the drug or a placebo once daily for 48 weeks. The goal was to see if the drug could reduce lupus disease activity and improve symptoms, while moni…

This study looked at whether adding belimumab to standard treatment is safe and effective for Chinese children aged 5 to 17 with active lupus. 67 participants received belimumab plus their usual therapy. The main goal was to check for serious side effects and see if lupus disease…

This study looked at whether the drug anifrolumab, when added to standard lupus treatments, can reduce long-term organ damage compared to standard care alone. Researchers analyzed data from 561 adults with active lupus, comparing those who took anifrolumab in earlier trials to si…

This study tested the drug belimumab in children aged 5 to 17 with active lupus. Participants received either belimumab or a placebo alongside their usual treatments. The goal was to see if belimumab could safely reduce lupus disease activity over 52 weeks.

This completed Phase 2 trial tested the long-term safety of deucravacitinib (BMS-986165), a daily pill, in 261 people with systemic lupus erythematosus (SLE). Participants had already completed an earlier study and continued taking the drug to monitor side effects and lab abnorma…

This study tested whether taking coenzyme Q10 (a natural supplement) along with standard lupus treatment can improve health in children with lupus. Sixty children aged 6-16 with moderate to severe lupus took either CoQ10 or a placebo for 3 months. Researchers measured changes in …

This early-stage study tested a drug called telitacicept in 16 children with lupus. The goal was to see how the drug moves through the body and if it helps control the disease. While not a cure, it may offer a new way to manage lupus symptoms in young patients.

This study tested the drug tofacitinib in 13 young adults aged 18 to 45 with moderate to severe lupus skin disease. The goal was to see if the drug is safe and can reduce skin symptoms. Participants took the drug for up to 76 weeks, and doctors measured how well it worked using a…

This study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…

This study tested whether a single infusion of stem cells from donated umbilical cords could help adults with lupus that does not respond to standard treatments. 81 participants received either a low dose, high dose, or placebo infusion, while continuing their usual medications. …

This early-stage study tested an experimental drug called SHR-2173 in 30 adults with systemic lupus erythematosus (SLE). The drug was given as multiple injections under the skin. The main goal was to see if it is safe and tolerable, and to measure how the body processes it. This …

This Phase 2 trial tested nipocalimab, an intravenous drug, in 228 adults with active systemic lupus erythematosus (SLE). Participants received either nipocalimab or a placebo, alongside standard treatments. The main goal was to see if nipocalimab could reduce lupus disease activ…

This study tested an experimental drug called enpatoran in 456 people with lupus, a chronic autoimmune disease. Participants took either a low, medium, or high dose of enpatoran or a placebo for 24 weeks. The goal was to see if the drug safely reduces skin and overall disease act…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study tested a new drug called KZR-616 (zetomipzomib) in 69 people with lupus, some of whom also had kidney inflammation (lupus nephritis). Participants received weekly injections for 13 or 24 weeks. The main goals were to check safety and see if the drug could reduce protei…

This study tested whether taking probiotics (beneficial bacteria) can help people with active lupus, an autoimmune disease. Forty adults with lupus took probiotics to see if it would reduce disease activity and improve their quality of life. The goal was to find a simple, safe wa…

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already received the IV form for 48 weeks. The goal was to check the drug levels in the blood and see if switching to a shot under the skin is safe. Sixteen children took par…

This study tested four doses of cenerimod, a daily pill that calms the immune system, against a placebo in 427 adults with moderate-to-severe lupus. The main goal was to see if cenerimod could reduce lupus disease activity over six months. Researchers also checked for safety and …

This study tested a new drug called cenerimod in 105 people with systemic lupus erythematosus (SLE), an autoimmune disease. The goal was to see if the drug could safely lower certain immune cells (lymphocytes) in the blood, which may help control the disease. Participants continu…

This study tested a nurse-led care management program for lupus patients at high risk of missing appointments or ending up in the emergency room. Nurses received special training on lupus and social barriers to care, then reached out to patients to help them attend rheumatology v…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tested whether hydroxychloroquine, a drug already used for lupus, could slow or prevent the disease in 187 people who had early signs but not full lupus. Participants received either the drug or a placebo for up to two years. Researchers tracked lupus symptoms, immune …

This study tested whether practicing Qi Gong, a gentle mind-body exercise, could improve quality of life in people with systemic lupus erythematosus (SLE). Thirty-three participants took part in weekly Qi Gong sessions for six months. Researchers measured changes in physical func…

This phase 2 study tested whether JBT-101 (lenabasum) can reduce joint pain in people with systemic lupus erythematosus (SLE). 109 adults with active arthritis and at least moderate pain took either the drug or a placebo for 84 days. The main goal was to see if pain scores improv…

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a gentle electrical pulse applied to specific points on the body — could reduce period pain and inflammation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women rec…

This study tested a 6-week stress management program for 30 African American adults with lupus. Half took part in group sessions while the other half received usual care. Researchers measured stress levels, saliva stress hormones, and quality of life to see if the program helped.

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study looked at the genes inside B cells from 30 people with inactive lupus and compared them to healthy donors. The goal was to find what makes lupus B cells different, even when the disease is quiet. No treatment was given; this is a pure research study to better understan…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at tiny particles called microparticles in the blood and urine of people with lupus or scleroderma. Researchers wanted to see if these particles could help explain how these diseases work and possibly lead to better diagnosis or treatment. Over 200 adults partic…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This study looked at how often people with active lupus take their medication as prescribed. Researchers measured blood levels of hydroxychloroquine in 307 patients to find out who was skipping doses. The goal was to understand how common non-adherence is, especially in those wit…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study looked at how lupus affects breathing, daily activity, and tiredness. Researchers compared 50 people with lupus to healthy volunteers using breathing tests, a 6-minute walk, and questionnaires. The goal was to find early signs of lung problems so doctors can treat them…

This 5-year study tracked over 3,000 adults with active lupus to see how safe and effective Benlysta (belimumab) is compared to standard care alone. Researchers monitored serious infections, cancers, and other side effects. The goal was to gather real-world data to help doctors a…

This study followed 356 adults with lupus over time to see how the disease impacts their quality of life. Participants filled out questionnaires about their symptoms, fatigue, mood, and daily activities. The goal was to better understand what factors affect well-being in lupus, w…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) in five Gulf countries. Researchers collected information on their symptoms, treatments, and quality of life, but did not test any new medicine. The goal was to better understand the diseas…

This study looked at how faithfully people with lupus take their hydroxychloroquine (Plaquenil). Researchers used a simple questionnaire to measure compliance in 102 patients. The goal was to find which questions best identify those who skip doses, so doctors can catch problems e…

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This completed study looked at 621 people with moderate to severe systemic lupus erythematosus (SLE) in Russia. Researchers collected information about their disease activity and background to better understand the condition. The study did not test any new treatment, but aimed to…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This study tested a computerized decision-aid called SMILE that gives lupus patients information about their disease and treatment options. Nearly 1,900 adults with lupus from multiple clinics used the tool during their visits. The main goal was to see how many eligible patients …

This completed study looked at 1,000 women with autoimmune diseases (like lupus) who had a C-section. Researchers wanted to find out how many had severe bleeding (postpartum hemorrhage) and what factors increased that risk. By analyzing medical records, they hope to identify high…

This study looked at how lupus, a chronic autoimmune disease, affects the emotional and social lives of 160 patients and their spouses. Researchers used interviews and questionnaires to understand the couple's experience, beliefs about the disease, and quality of life. The goal i…

This study looked at how a 12-week program of high-intensity interval training (HIIT) affects fitness and fatigue in 55 people with lupus. Researchers wanted to understand if certain immune system signals (interferons) change how the body adapts to exercise. Participants were ran…