SYSTEMIC LUPUS ERYTHEMATOSUS

This study tested an experimental drug called KZR-616 in 69 people with lupus, some of whom also had lupus-related kidney disease (lupus nephritis). The goal was to see if the drug is safe and can help control the disease by reducing protein in the urine, a sign of kidney damage.…

This study tested a new drug, nipocalimab, against a placebo in 228 adults with active systemic lupus erythematosus (SLE). The goal was to see if nipocalimab could reduce lupus disease activity without worsening symptoms. Participants received either the drug or a placebo, and re…

This study tested whether a daily coenzyme Q10 supplement, added to standard lupus treatment, could improve disease activity and cell health in children with lupus. Sixty children aged 6-16 with moderate to severe lupus took either the supplement or standard care alone for 3 mont…

This study tested an experimental drug called cenerimod in 105 adults with active lupus. The goal was to see if it could safely reduce certain immune cells that cause inflammation. Participants took the drug or a placebo for up to 12 weeks while continuing their usual lupus medic…

This study tested a new drug, cenerimod, in 427 adults with moderate to severe systemic lupus erythematosus (SLE). The goal was to see if it could safely reduce lupus disease activity compared to a placebo over six months. Participants took one of four doses of cenerimod or a pla…

This study tested an experimental pill called enpatoran in 456 adults with lupus (SLE) or lupus affecting the skin (CLE). Participants took the drug or a placebo for 24 weeks while continuing their usual treatments. The goal was to see if enpatoran safely reduces skin rashes and …

This study tested if a single infusion of stem cells from donated umbilical cords could help adults with severe lupus that wasn't controlled by standard treatments. 81 participants received either the stem cells or a placebo, plus their usual care. The main goal was to see if the…

This study followed over 3,100 adults with active lupus for up to 5 years to compare the safety and effectiveness of Benlysta (belimumab) plus standard care versus standard care alone. Researchers tracked serious infections, cancers, psychiatric events, and deaths. The goal was t…

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already received the IV form for 48 weeks. The goal was to check the drug levels in the blood and see if switching to a shot under the skin is safe. Sixteen children took par…

This study tested whether taking probiotics (beneficial bacteria) can help control disease activity in people with active lupus. 40 adults with lupus took probiotics to see if it reduced flare-ups and improved quality of life. The goal was to manage the disease, not cure it.

This early-stage study tested a drug called telitacicept in 16 children with lupus. The main goal was to see how the drug moves through the body and to check for early signs of effectiveness. All children were already on standard lupus treatments.

This early-stage study tested a new drug called SHR-2173 in 30 adults with systemic lupus erythematosus (SLE). The main goal was to see if multiple injections under the skin are safe and how the body processes the drug. Participants received the drug or placebo, and researchers m…

This study tested the long-term safety of an experimental drug called BMS-986165 in 261 people with systemic lupus erythematosus (SLE). Participants had already completed an earlier study and continued taking the drug. Researchers monitored side effects, serious health events, an…

This study tested a drug called belimumab in children aged 5 to 17 with active lupus. The goal was to see if adding belimumab to their usual treatment could better control the disease. The trial measured how many kids had less lupus activity after one year. Belimumab is not a cur…

This study looked at how safe and effective Benlysta is for people with lupus when used in everyday medical practice. Over 1,500 patients were followed for one year after starting the drug. Researchers tracked disease activity, quality of life, and any side effects to ensure the …

This study looked at whether tofacitinib, a drug that calms the immune system, is safe and helpful for young adults (ages 18-45) with moderate to severe lupus skin disease. Thirteen people took part over 76 weeks. The goal was to see if the drug reduces skin symptoms and how the …

This study tested a drug called emapalumab in 33 children and adults with a life-threatening immune overreaction (macrophage activation syndrome) linked to Still's disease or lupus. The goal was to see if the drug could safely calm the immune system and improve blood markers and …

This study tested whether hydroxychloroquine, a medicine used for malaria, can slow down or prevent lupus in people who show early signs of the disease. 187 participants with mild symptoms and positive antibody tests were randomly given either the drug or a placebo. Researchers t…

This study tested a program to help African American adults with lupus manage stress. Thirty participants learned stress-reduction techniques, and researchers measured their stress levels and quality of life. The goal was to see if this approach could reduce stress and improve we…

This study tested a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it can reduce fatigue in people with lupus. 75 adults with lupus and fatigue took part. Half received active stimulation, half received a sham (inactive) device. The goal…

This study looked at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compared their blood cells, genes, and environmental exposures to find clues about why one got sick. Over 1,000 people took part, inclu…

This study tested a computerized decision-aid tool to help people with lupus and their doctors make treatment decisions together. Nearly 1,900 adults with lupus from multiple clinics took part. The main goal was to see how many eligible patients actually used the tool and whether…

This study looked at 50 pregnant women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) to see if changes in microRNAs (tiny molecules that control genes) during pregnancy are linked to disease activity. Researchers collected blood, urine, and placenta samples…

This study looked at how faithfully people with active lupus take their medication. Researchers measured blood levels of hydroxychloroquine in 307 patients to find out who was not taking it as prescribed. The goal was to understand how common non-adherence is, especially in those…

This study looked at 621 adults with moderate to severe lupus to track how active their disease is over time. Researchers collected medical records and checked disease activity using a standard scoring tool. The goal was to better understand lupus patterns, not to test a new trea…

This study tested a training program for rheumatologists to help them break unconscious bias habits when treating Black and low-income patients. 201 patients and their doctors took part. The goal was to see if the training led to better quality care, communication, and patient tr…

This study looked at 193 adults with lupus nephritis (kidney inflammation from lupus) across five Gulf countries. Researchers collected information on patients' symptoms, treatments, and quality of life using surveys and medical records. The goal was to better understand the dise…

This study looked at how lupus changes the way the body adapts to exercise. Researchers included 55 adults with lupus who did a 12-week aerobic exercise program. The goal was to understand how certain immune signals affect fitness and fatigue improvements.

This study looked at how systemic lupus erythematosus (SLE) affects breathing, physical activity, and tiredness. Researchers compared 50 lupus patients with healthy people to see if lung problems are linked to daily function and fatigue. The goal is to help doctors spot lung issu…

This study looked at B cells (a type of immune cell) in 30 people with non-active systemic lupus erythematosus and compared them to B cells from healthy volunteers. The goal was to find genetic differences that might explain lupus even when symptoms are quiet. No treatment was gi…

This study tested a care management program for 35 adults with lupus who were at high risk for emergency room visits or hospital stays. The program assigned a nurse manager to help patients get better outpatient care and stick with their appointments and medications. Researchers …

This completed study looked at information from 1,000 people with lupus to understand the challenges they face. Researchers reviewed existing data, talked with doctors, and built agreement among experts on how to improve patient care. The goal was to identify gaps in diagnosis an…

This study tested specially engineered versions of a natural immune protein (IL-2) in blood samples from 67 people with autoimmune or inflammatory diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal was to see if these modified proteins could selectively a…