New lupus pill shows promise in Mid-Stage trial

NCT ID NCT03742037

Completed Disease control Sponsor: Viatris Innovation GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study tested four doses of cenerimod, a daily pill that calms the immune system, against a placebo in 427 adults with moderate-to-severe lupus. The main goal was to see if cenerimod could reduce lupus disease activity over six months. Researchers also checked for safety and how well participants tolerated the drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cenerimod (a daily pill that calms the immune system)
What this could lead to: If it works, cenerimod could offer a new daily pill option to help control lupus flares and reduce disease activity.
What could go wrong: This is a mid-stage trial with only 427 people, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

connective tissue disorder systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

A.O. Mauriziano Umberto I di Torino

Torino, Torino, 10128, Italy
Accelerium, S. de R.L. de C.V.

Monterrey, 64000, Mexico
Accurate Clinical Management

Stafford, Texas, 77477, United States
Accurate Clinical Research

Houston, Texas, 77034, United States
Advanced Research Institute Inc Allergy & Rheumatology

St. Petersburg, Florida, 33708, United States
Altoona Center for Clinical Research

Duncansville, Pennsylvania, 16635, United States
Amarillo Center for Clinical Research

Amarillo, Texas, 79124, United States
Angeles University Foundation Medical Center

Angeles City, Philippines
Aversi Clinic LTD

Tbilisi, 0160, Georgia
Axiom Clinical Research of Florida

Tampa, Florida, 33603, United States
Azienda Ospedaliera San Camillo Forlanini

Roma, 00158, Italy
Biológicos Especializados S.A. de C.V.

Mexico City, 6700, Mexico
Biomedica Research Group

Santiago, 7500710, Chile
Bnai Zion Medical Center

Haifa, 3339419, Israel
CCR Pardubice

Pardubice, Vychodocesky KRAJ, 530 02, Czechia
Cambridge University Hospitals NHS Foundation Trust

Cambridge, CB2 0QQ, United Kingdom
Center for Rheumatology Immunology and Arthritis

Fort Lauderdale, Florida, 33309, United States
Centre Hospitalier Regional Universitaire Brest Hôpital de la Cavale Blanche à Brest

Brest, Brittany Region, 29609, France
Centro Integral en Reumatología S.A. de C.V.

Guadalajara, 44160, Mexico
Centro Reumatologico de Caguas

Caguas, 00725, Puerto Rico
Centro de Atención e Investigación Cardiovascular del Potosí, S.C.

San Luis Potosí City, Mexico
Centro de Investigación Clínica GRAMEL, S.C.

Mexico City, 03720, Mexico
Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed

Brasov, 500283, Romania
Centrum Medyczne Plejady

Krakow, 30-363, Poland
Chelyabinsk Regional Clinical Hospital

Chelyabinsk, 454076, Russia
City Clinical Hospital #15 named after O.M. Filatova

Moscow, 111539, Russia
Clinic of State Institution "National Scientific Centre "Acad. Strazhesko Institute of Cardiology"

Kyiv, 03151, Ukraine
Clinical Research Chile SpA

Valdivia, 5110683, Chile
Clinical Rheumatological Hospital Number 25

Saint Petersburg, 190068, Russia
Consultorio Médico del Dr. Federico Galván Villegas

Guadalajara, 45040, Mexico
Consultorio Particular Dr. Miguel Cortés Hernández

Cuernavaca, 62448, Mexico
Consultorio Privado de Especialidad del Dr. José Javier Orozco Alcalá

Guadalajara, 44650, Mexico
D&H National Research Centers INC

Miami, Florida, 33155, United States
DJL Clinical Research

Charlotte, North Carolina, 28210, United States
Davao Doctors Hospital

Davao City, 8000, Philippines
Diagnostic Consulting Center Fokus-5

Sofia, 1463, Bulgaria
Diagnostic and Consulting Center "Aleksandrovska" EOOD

Sofia, 1431, Bulgaria
Egyesitett Szent Istvan es Szent Laszlo Korhaz Rendelointezet

Budapest, Budapest, 1097, Hungary
Enroll SpA

Santiago, 7500588, Chile
Far Eastern University - Nicanor Reyes Medical Foundation

Quezon City, 1118, Philippines
Federal State Budget Scientific Research Institution "Scientific Research Institute of Rheumatology n.a. V.A. Nasonova"

Moscow, 115522, Russia
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Fondazione Policlinico Universitario A. Gemelli

Roma, 00168, Italy
Galilee Medical Center

Nahariya, 2210001, Israel
General Hospital of Athens "Laiko"

Goudi, 11527, Greece
Guy's and Saint Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom
Hospital Clinic i Provincial de Barcelona

Barcelona, 08036, Spain
Hospital Quirónsalud Infanta Luisa

Seville, SEVILLA, 41010, Spain
Hospital Universitario "Dr. Gonzalo Valdés Valdés"

Saltillo, 25000, Mexico
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Doctor Peset

Valencia, 46017, Spain
Hospital Universitario Regional de Málaga

Málaga, MALAGA, 29009, Spain
Hôpital Haut-Lévêque

Pessac, 33604, France
Icle S.C.

Guadalajara, 44600, Mexico
Iloilo Doctors Hospital

Iloilo City, 5000, Philippines
Innovative Health Research

Las Vegas, Nevada, 89128, United States
Institute of Arthritis Research

Idaho Falls, Idaho, 83404, United States
Integral Rheumatology & Immunology Specialists

Plantation, Florida, 33324, United States
Intermedius Uslugi Medyczne

Kościan, 64-000, Poland
Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V.

Zapopan, 45030, Mexico
Istanbul Universitesi Istanbul Tip Fakultesi

Istanbul, 34098, Turkey (Türkiye)
JSC "Center of Family Medicine"

Yekaterinburg, 620043, Russia
Joint Muscle Medical Care and Research Institute - Lilington Office

Charlotte, North Carolina, 28204, United States
Jose R. Reyes Memorial Medical Center

Manila, 1003, Philippines
Kaohsiung Medical University Hospital

Kaohsiung City, 80756, Taiwan
Kaohsiung Veterans General Hospital

Kaohsiung City, 81362, Taiwan
Karla Adriana Espinosa Bautista

Mexico City, 01120, Mexico
Kohler & Milstein Research S.A. de C.V.

Mérida, 97070, Mexico
Kyiv City Clinical Hospital №3

Kyiv, 02125, Ukraine
LLC "Innova"

Tbilisi, 0186, Georgia
LLC Raymann

Tbilisi, 0186, Georgia
LTD "New Plasma Clinic"

Batumi, 6010, Georgia
LTD "Tbilisi Heart Center"

Tbilisi, 0186, Georgia
LUPUS CLINIC c/o DIMI

Genova, 16132, Italy
Life Clinical Trials

Margate, Florida, 33063, United States
Lipa Medix Medical Center

Lipa City, Batangas, 4217, Philippines
Ltd. Mtskheta Street Clinic

Tbilisi, 0179, Georgia
Lviv Regional Clinical Hospital

Lviv, 79010, Ukraine
Makati Medical Center

Makati City, 1229, Philippines
Medi Club Georgia Ltd.

Tbilisi, 0160, Georgia
Medical Center "Health Clinic", LLC

Vinnytsia, 21009, Ukraine
Medical Center "Zdorovaya Semiya", LLC

Novosibirsk, 630099, Russia
Medical Center Maksimum Zdorovia

Saint Petersburg, 650066, Russia
Medical Centre "Consilium medical"

Kyiv, 04050, Ukraine
Medical Research Institute, LLC

Saint Petersburg, 196006, Russia
Medicore

Tbilisi, 0186, Georgia
Meditek Ltda.

Santiago, 8330008, Chile
Military Medical Academy S.M. Kirov

Saint Petersburg, 191045, Russia
Millennium Research

Ormond Beach, Florida, 32174-1139, United States
Morales Vargas Centro de Investigación S.C.

León, 37000, Mexico
Multiprofile Clinic Consilium Medulla

Tbilisi, 0186, Georgia
Multiprofile Hospital For Active Treatment Trimontium

Plovdiv, Plodiv, 4002, Bulgaria
Municipal Institution "Zaporizhzhya Regional Clinical Hospital"

Zaporizhzhya, 69600, Ukraine
Municipal Institution Kyiv Regional Council "Kyiv Regional Clinical Hospital"

Kyiv, 04107, Ukraine
Municipal Nonprofit Institution "Vinnytsia City Clinical Hospital №1"

Vinnytsia, 21018, Ukraine
Municipal Nonprofit Institution of Lviv Regional Council

Lviv, 79000, Ukraine
Municipal Nonprofit Institution of Lviv Regional Council "Lviv Regional Clinical Hospital"

Lviv, 79000, Ukraine
Municipal institution "Regional Clinical Hospital n.a. O.F. Herbachevskoho"

Zhytomyr, 10002, Ukraine
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi

Konya, 42080, Turkey (Türkiye)
New York Presbyterian Columbia University Medical Center

New York, New York, 10032, United States
Non-governmental private healthcare organization, Scientific Clinical Centre of JSC Russian Railways

Moscow, 125315, Russia
North Georgia Rheumatology Group - Duluth

Lawrenceville, Georgia, 30046, United States
Office of Ramesh C. Gupta, MD

Memphis, Tennessee, 38119, United States
Orenburg State Medical University

Orenburg, 460018, Russia
Ospedale San Raffaele

Milan, 20132, Italy
Paramount Medical Research and Consulting

Middleburg Heights, Ohio, 44130, United States
Pinnacle Research Group

Anniston, Alabama, 36207, United States
Poltava Regional Clinical Hospital named after M.V. Sklifossovsky

Poltava, 36011, Ukraine
Polyclinic of Private Security and Detectives

Saint Petersburg, 192007, Russia
Private Small Scale Medical Center "Pulse"

Vinnytsia, 21001, Ukraine
Prosalud

Santiago, 8380456, Chile
Rajavithi Hospital

Bangkok, 10400, Thailand
Rambam Healthcare Campus

Haifa, 3109601, Israel
Robert W Levin MD PA

Clearwater, Florida, 33765, United States
SC Sana Monitoring SRL

Bucharest, 11025, Romania
SMIQ, S. de R.L. de C.V.

Querétaro, 76070, Mexico
San Marcus Research Clinic

Miami Lakes, Florida, 33014, United States
Saratov Regional Clinical Hospital

Saratov, 410053, Russia
Scientific and Research Institute of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU,

Vinnytsia, 21029, Ukraine
Songklanagarind Hospital

Songkhla, 90110, Thailand
Southwest Rheumatology Research, LLC

Mesquite, Texas, 75150, United States
Spitalul Clinic "Sf. Maria"

Bucharest, 11172, Romania
Spitalul Clinic Judetean de Urgenta Cluj-Napoca

Cluj-Napoca, 400006, Romania
St. Luke's Medical Center

Quezon City, 1102, Philippines
State Institution of Health Protection "Clinical Hospital #8"

Yaroslavl, 150030, Russia
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Städtisches Klinikum Karlsruhe gGmbH

Karlsruhe, 76133, Germany
Sun Research Institute

San Antonio, Texas, 78215, United States
Szpital Specjalistyczny im. J. Dietla w Krakowie

Krakow, 30-121, Poland
Szpital Uniwersytecki Number 2 im. dr. Jana Biziela w Bydgoszczy

Bydgoszcz, 85-168, Poland
Ternopil University Clinic - Rheumatology department

Ternopil, 46001, Ukraine
The Chaim Sheba Medical Center

Ramat Gan, 5265601, Israel
The First Medical Center Ltd.

Tbilisi, 0180, Georgia
Tomakomai City Hospital

Tomakomai-shi, 053-0034, Japan
Twoja Przychodnia Poznańskie Centrum Medyczne

Poznan, 61-293, Poland
UBAM Unidad Biomédica Avanzada Monterrey

Monterrey, 64460, Mexico
Unidad de Atención Médica e Investigación en Salud

Mérida, 97000, Mexico
Unidad de Investigaciones Reumatológicas A.C.

San Luis Potosí City, 78290, Mexico
University Multiprofile Hospital for Active Treatment Pulmed

Plovdiv, 4002, Bulgaria
University of California San Diego

La Jolla, California, 92037-0493, United States
University of Colorado School of Medicine

Aurora, Colorado, 80045, United States
University of Santo Tomas Hospital

Manila, 1015, Philippines
University of the Philippines Manila - Philippine General Hospital

Manila, 1000, Philippines
Valerius Medical Group and Research Center

Los Alamitos, California, 90720-5403, United States
Vinnytsya Regional Clinical Hospital - Rheumatology Department

Vinnytsia, 21018, Ukraine
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Zakarpattya Regional Clinical Hospital n.a. A.Novak - Rheumatology Department

Uzhhorod, 88000, Ukraine
Śląskie Centrum Reumatologii, Rehabilitacji i Zapobiegania Niepełnosprawności im gen. Jerzego Zi

Ustroń, 43-450, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.