SYSTEMIC LUPUS ERYTHEMATOSUS

This study tests whether a diet tailored to a person's genetic makeup can help control lupus and improve quality of life. About 100 adults with lupus will be screened for specific genes (HLA DQ2 and DQ8) and then randomly assigned to either a personalized diet plan or no special …

This study looks at whether regularly measuring the amount of mycophenolate mofetil (an immunosuppressant) in the blood can help more people with lupus-related kidney disease achieve kidney remission. About 100 adults with active lupus nephritis will be randomly assigned to eithe…

This early study tests a new treatment called HN2302 in 12 adults with lupus or scleroderma. The goal is to see if it is safe and how well it works. The treatment is a type of cell therapy that may help control the immune system.

This study compares two drugs, telitacicept and belimumab, for treating systemic lupus erythematosus (SLE) in 180 adults aged 18-65. Participants choose their treatment with their doctor. The goal is to see which drug better controls lupus symptoms and kidney problems. This is an…

This early-stage study tests a new treatment called P-CD19CD20-ALLO1 for people with severe lupus that hasn't improved with standard therapies. The treatment uses specially engineered immune cells to target and reduce harmful B cells. The study involves 162 adults aged 18-75 and …

This early study tests a new treatment called CD19 UCAR-T cell therapy for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses a patient's own immune cells, modified to target and calm the overactive immune system. The main goals are t…

This study tests a new medicine called TQH3906 in about 198 people with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The goal is to see if the drug can reduce lupus disease activity better than a placebo over 32 weeks. Participants will receive either TQH3906…

This early-phase study tests a universal (donor-derived) CAR T-cell therapy called QT-019C in 15 adults with lupus or inflammatory myositis that has not responded to standard treatments. The therapy targets two immune-cell markers (CD19 and BCMA) to reset the faulty immune system…

This early study tests a new treatment called CHT105 for people with lupus nephritis that hasn't responded to standard therapies. CHT105 uses specially engineered immune cells from healthy donors to target and destroy the faulty immune cells driving the disease. The main goals ar…

This study tests whether virtual Reiki therapy can help reduce pain and improve quality of life for people with lupus. Twenty adults with lupus will receive weekly virtual Reiki sessions for 8 weeks, in addition to their usual care. The goal is to see if this gentle, remote thera…

This study looks at how a type of cell death called ferroptosis, which is linked to iron, plays a role in systemic lupus erythematosus (SLE). Researchers will measure certain markers in immune cells from 120 adults with lupus, comparing them to people with other inflammatory dise…

This study aims to better understand certain immune cells (B cells) that mistakenly attack the body in autoimmune diseases like lupus and scleroderma. Researchers will analyze blood samples from 200 adults with these conditions or with immune deficiencies. The goal is to identify…

This study will collect medical information and biological samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. The goal is to create a database and biobank to help researchers identify biological markers and un…

This early-stage study tests the safety of a new drug called ACT100 in 48 healthy adults. Participants will receive either the drug or a placebo, and researchers will monitor side effects and how the drug moves through the body. The goal is to find a safe dose before testing it i…

This study will track the use of Saphnelo (anifrolumab) in up to 26 million women with lupus who are of childbearing age. The goal is to see how often the drug is prescribed and understand its safety in pregnancy. No new treatments are given—researchers will simply observe real-w…