SYSTEMIC LUPUS ERYTHEMATOSUS

This early-phase study is testing a new type of 'off-the-shelf' CAR T-cell therapy for people with severe, hard-to-treat autoimmune diseases like lupus and inflammatory myopathy. The therapy uses immune cells from a healthy donor, modified to target and remove certain harmful B c…

This study will compare two existing medications for systemic lupus erythematosus (SLE) to see which works better and is safer. Researchers will observe 180 adults with moderate-to-severe lupus who choose either telitacicept or belimumab alongside their current treatments. The st…

This study is testing a weekly injection called anifrolumab for people with systemic lupus erythematosus (SLE) who have not yet tried strong immunosuppressant drugs. The main goal is to see if the treatment can help patients achieve a state of very low disease activity or remissi…

This study is testing whether a personalized diet, created based on a patient's genetic test results, can help people with lupus better manage their disease. Researchers will compare the diet to no special diet to see if it reduces lupus activity and improves quality of life. Abo…

This study is testing whether a new antibody treatment called MIL62 can help control systemic lupus erythematosus, a serious autoimmune disease. About 316 adults with active lupus will receive either MIL62 or a placebo injection over 52 weeks to see if it reduces disease activity…

This study is testing a new type of cell therapy called CD19 UCAR-T in people with various autoimmune diseases that haven't responded well to standard treatments. The main goals are to see if the treatment is safe and if it can help control the diseases. It will involve a small g…

This study is testing an investigational injection called SHR-2173 to see if it can reduce disease activity in adults with active systemic lupus erythematosus (SLE). About 245 participants will be randomly assigned to receive either the drug or a placebo for nearly a year, and re…

This is a first-in-human study to test the safety and tolerability of a new investigational drug called GSK5926371. It is designed for adults with autoimmune rheumatic diseases like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The main goal is to find a safe …

This study is testing a new oral medication called BI 3000202 to see if it can help control disease activity in adults with moderate to severe systemic lupus erythematosus (SLE). About 405 participants will be randomly assigned to receive one of four different doses of the drug o…

This small pilot study is testing whether virtual Reiki, a complementary energy therapy, can help reduce pain and improve well-being for people with lupus. Twenty participants will receive weekly virtual Reiki sessions for eight weeks while continuing their standard medical care.…

This is a very early-stage study to check the safety of a new drug called ACT100, which is being developed for lupus. It will be tested in 48 healthy volunteers to see how their bodies react to it and how the drug moves through their system. The main goal is to find a safe dose a…

This study aims to understand how a specific type of cell death, called ferroptosis, is involved in systemic lupus erythematosus (SLE). Researchers will measure markers of this process in blood cells from 120 participants, including people with lupus and a control group with othe…

This study aims to understand how young women of childbearing age use the lupus drug Saphnelo (anifrolumab) in real-world settings. It will track treatment patterns and gather safety information, particularly regarding pregnancy, by reviewing existing health records from millions…

This French study aims to better understand how autoimmune diseases like lupus and scleroderma start. Researchers will analyze blood samples from 200 patients to identify and measure specific 'rogue' immune cells that mistakenly attack the body. The goal is to gather knowledge ab…