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New drug shows promise for lupus and kidney complications

NCT ID NCT03393013

Completed Disease control Sponsor: Kezar Life Sciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called KZR-616 (zetomipzomib) in 69 people with lupus, some of whom also had kidney inflammation (lupus nephritis). Participants received weekly injections for 13 or 24 weeks. The main goals were to check safety and see if the drug could reduce protein in the urine, a sign of kidney improvement. The trial is now complete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
KZR-616 (zetomipzomib)
What this could lead to
If successful, this could point toward a new treatment option for lupus and lupus-related kidney inflammation.
What could go wrong
This is an early-phase trial with only 69 participants, so results may not apply to everyone. The drug may cause side effects and may not prove effective in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lupus nephritis nephritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS NEPHRITIS SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

  • Academic Medical Research Institute

    Los Angeles, California, 990022, United States

  • Accurate Clinical Management, LLC

    Houston, Texas, 77084, United States

  • Accurate Clinical Research, Inc.

    Houston, Texas, 77034, United States

  • Advent Health Medical Group

    Tampa, Florida, 33614, United States

  • Arthritis Center, Inc

    Palm Harbor, Florida, 34684, United States

  • Bioclinica

    Lodz, 90-368, Poland

  • Centro Integral de Reumatologia SA de CV

    Guadalajara, Jalisco, 44160, Mexico

  • Centro Integral de Reumatologia de Caribe CIRCARIBE S.A.S

    Barranquilla, Atlántico, 080020, Colombia

  • Centro de Investigación Clínica Trujillo E.I.R.L/ Clínica Peruano Americana S.A.

    Trujillo, La Libertad, 13011, Peru

  • Clinica de Artritis Temprana

    Cali, Valle del Cauca Department, 076001, Colombia

  • Clinica de la Costa

    Barranquilla, Atlántico, 080020, Colombia

  • Harmoniya Krasy

    Kyiv, Kyiv Governorate, 01135, Ukraine

  • Hope Clinical Trials, Inc.

    Miami, Florida, 33165, United States

  • Hospital Universitario Dr José Eleuterio Gonzalez

    Monterrey, Nuevo León, 64020, Mexico

  • Inland Rheumatology Clinical Trials, Inc.

    Upland, California, 91786, United States

  • Instituto Nacional de Cardiología Ignacio Chavez

    Mexico City, 14080, Mexico

  • Instituto Nacional de Ciencias Médicas y Nutricion "Salvador Zubiran"

    Mexico City, 14080, Mexico

  • Investigaciones Clinicas SAC

    Lima, 15023, Peru

  • Kuzbass Clinical Hospital

    Kemerovo, 650066, Russia

  • MedResearch, Inc.

    El Paso, Texas, 79902, United States

  • Medical Center Revma-Med

    Kemerovo, 650070, Russia

  • Medicity SAS

    Santander, Bucaramanga, 680003, Colombia

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • NYU Langone Orthopedic Center - Seligman Center for Advanced Therapeutics

    New York, New York, 10016, United States

  • Northwell Health

    Great Neck, New York, 11021, United States

  • Omega Research Maitland

    Orlando, Florida, 32808, United States

  • Ramesh C. Gupta, MD

    Memphis, Tennessee, 38119, United States

  • SC Nephrology & Hypertension Center, Inc.

    Orangeburg, South Carolina, 29118, United States

  • Servimed S.A.S.

    Bucaramanga, Santander Department, 680003, Colombia

  • SouthCoast Research Center, Inc.

    Miami, Florida, 33136, United States

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • The Royal Melbourne Hospital

    Parkville, Victoria, 3050, Australia

  • Tolyatti City Clinical Hospital #1

    Tolyatti, 445009, Russia

  • Unidad de Investigacion en Reumatologia e Inmunologia Clinica San Juan Bautista

    Lima, 15431, Peru

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Rochester Medical Center

    Rochester, New York, 14620, United States

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