ESOPHAGEAL ADENOCARCINOMA

This is the first study in people for a new drug called KK2269. It aims to find a safe dose and see how well the body tolerates it. The study will test KK2269 alone in people with various advanced solid tumors, and also test it combined with a standard chemotherapy drug (docetaxe…

This study aims to find the best approach for managing Barrett's esophagus with low-grade dysplasia, a condition that can sometimes lead to esophageal cancer. Researchers are comparing two common strategies: regular monitoring with camera exams and biopsies versus procedures that…

This early-stage trial is testing a new drug called BL-M05D1 in people with advanced cancers that have spread and stopped responding to standard treatments. The study will enroll 120 patients with specific cancers like stomach, pancreatic, and esophageal cancer to determine the s…

This early-stage study is testing whether an experimental drug called NRM-823 is safe and can help control advanced cancers that have stopped responding to standard treatments. Researchers will give NRM-823 alone and combined with immunotherapy to about 150 adults with various so…

This early-stage study is testing the safety and effects of an experimental cancer drug called PF-08046876 in adults with advanced solid tumors. The drug is an antibody drug conjugate designed to target and kill cancer cells. Researchers will give the drug through an IV to about …

This study is for people with advanced cancer that started in the upper digestive tract (like the stomach, pancreas, or bile ducts) and has spread to only a few other places. After three months of chemotherapy, if a special blood test finds no cancer DNA, patients are randomly as…

This early-stage trial is testing whether adding a more precise form of radiation (MR-guided radiotherapy) to standard chemotherapy before surgery can better control esophageal cancer. The study aims to find the safest and most effective radiation dose for 39 patients with a spec…

This study is testing whether adding propranolol, a common blood pressure medication, to standard chemoradiation treatment helps people with esophageal adenocarcinoma. Researchers want to see if this combination is safe and more effective at controlling the cancer. The trial will…

This is the first-ever human study of an experimental pill called PLX-61639. It is being tested in adults with advanced cancers that have a specific genetic flaw (SMARCA4 mutation) and have stopped responding to standard treatments. The main goals are to find a safe dose and see …

This early-stage trial is testing whether combining a newer immunotherapy drug (tislelizumab) with standard chemotherapy (FLOT) is safe and tolerable when given before surgery for certain stomach and esophagus cancers. The goal is to see if giving more chemotherapy before surgery…

This early-stage trial is testing a new experimental drug called AZD5863 for people with advanced stomach, esophageal junction, esophageal, or pancreatic cancers that have spread. The study aims to find the safest dose and see if the treatment can shrink tumors. It's for adults w…

This early-stage study is testing the safety of a new cell therapy for advanced stomach and esophageal cancers that have spread to the abdominal lining. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them directly…

This study is testing a new oral drug called zongertinib for adults with advanced HER2-positive cancers that have spread and stopped responding to prior treatments. The main goals are to find the safest and most effective dose of zongertinib when given alone or combined with othe…

This study is testing if adding an experimental drug called givastomig to standard immunotherapy and chemotherapy works better for controlling advanced stomach or esophageal cancer. About 180 adults whose cancer has spread and who have not yet received treatment for their advance…

This study is testing a new combination of drugs for adults with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery. Researchers want to find the safest and most effective dose of an experimental drug (telisotuzumab adizutecan) whe…

This is a first-in-human study to test the safety and find the right dose of a new drug called TJ033721 (givastomig) for people with advanced or metastatic solid tumors. It will enroll about 330 patients whose cancer has progressed despite standard treatments or who have no other…

This early-stage trial is testing an experimental drug called sigvotatug vedotin for people with advanced solid tumors that have spread or cannot be removed by surgery. The study will first determine safe doses, then test the drug alone and in combination with other cancer medica…

This study is testing whether adding a common antifungal drug, itraconazole, to standard chemotherapy and radiation can help eliminate more cancer before surgery for esophageal cancer. Researchers believe the drug may block cancer growth pathways and make tumors more sensitive to…

This trial is testing whether combining two drugs, cabozantinib and durvalumab, is safe and effective for people with advanced cancers of the digestive system. It is for adults whose stomach, esophageal, liver, or colorectal cancer has progressed after standard treatments. The go…

This study is testing whether a simple 'sponge-on-a-string' device, swallowed like a pill, can accurately detect Barrett's esophagus and early esophageal cancer. It aims to provide a less invasive alternative to endoscopy for screening people at risk. The research will measure ho…

This study is testing a simple, swallowable sponge device called Cytosponge as an easier way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. The goal is to see if this non-invasive test, which collects cells from the esophagus, can accurately id…

This study is testing a new, simpler way to find Barrett's esophagus, a condition that can lead to a deadly type of esophageal cancer. Researchers want to see if a swallowable balloon device (EsoCheck) and a lab test (EsoGuard) can effectively screen people over 50 who are at ris…

This study is testing if a drug called obeticholic acid can prevent Barrett's esophagus, a condition that can lead to esophageal cancer, from getting worse. Researchers will give the drug or a placebo (inactive pill) to 30 adults with Barrett's esophagus for six months. They want…

This study asks cancer patients which way they prefer to receive their immunotherapy drugs: as a quick injection under the skin or through a longer IV infusion. Researchers will enroll 480 people with various advanced cancers to compare comfort, convenience, and quality of life b…

This study aims to find out how common Barrett's esophagus is in people with eating disorders who frequently make themselves vomit or regurgitate food. Researchers will use a simple, non-invasive test on 25 adults who have been purging for at least five years. The goal is to gath…

This study is a national registry that aims to collect information on how patients with advanced stomach or esophageal cancer are actually treated in everyday practice in Germany. It will follow about 1,900 patients for up to two years to understand common treatment sequences and…

This study aims to prepare for a larger future trial by testing new methods for collecting and analyzing cells from the esophagus. Researchers will enroll 50 adults with Barrett's Esophagus to collect cell samples using a small brush during routine endoscopies and have participan…

This is an open label, phase II, multi-site trial evaluating the efficacy and safety of the combination of 5-FU, oxaliplatin, nal-IRI, and immunotherapy (plus trastuzumab for HER2-positive tumors) as first-line therapy for participants with advanced Esophageal and Gastric Adenoca…