ESOPHAGEAL ADENOCARCINOMA

This study is testing whether a new drug called PF-08634404 works better when combined with standard chemotherapy for people with advanced stomach, esophageal, or gastroesophageal cancers. The trial has two parts: first checking safety and early effectiveness, then directly compa…

This study is testing if a very low dose of radiation can make tumors sensitive again to immunotherapy drugs in patients with advanced esophageal cancer that has stopped responding to standard treatment. About 32 adults who have progressed after first-line chemo-immunotherapy wil…

This study is testing whether injecting an experimental treatment called RP2 directly into stomach or esophagus tumors, along with standard chemotherapy (FLOT), is safe and works better than chemotherapy alone before surgery. Researchers want to see if this combination kills more…

This study is testing if adding the drug itraconazole to the standard heat treatment (ablation) can better prevent esophageal cancer in people with high-risk Barrett's esophagus. It will involve 64 participants who will receive either itraconazole or a placebo pill alongside thei…

This study is testing if freezing a tumor with liquid nitrogen before starting standard chemotherapy helps people with locally advanced esophageal cancer. Researchers want to see if this two-step approach leads to a better response and helps the body's immune system fight the can…

This study aims to improve early detection of Barrett's esophagus, a condition that can lead to esophageal cancer. Researchers are testing a combination of an AI-powered risk assessment tool and a less invasive 'sponge on a string' screening test, supported by nurse guidance. The…

This is a very early, small study to see if a single dose of two immunotherapy drugs can change the immune cells inside certain stomach and esophageal tumors. It will involve 34 adults with early-stage cancer who have a specific genetic change (ARID1A mutation) and have not had a…