ESOPHAGEAL ADENOCARCINOMA
Clinical trials for ESOPHAGEAL ADENOCARCINOMA explained in plain language.
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Personalized radiation pulses could boost esophageal cancer treatment
Disease control Not yet recruitingThis trial tests whether adding a personalized, ultra-precise radiation technique called PULSAR to standard chemotherapy and immunotherapy is safe for people with esophageal or gastro-esophageal junction cancer. The study aims to find the best radiation dose that can be given wit…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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New drug XYA02 takes on tough cancers in first human trial
Disease control Not yet recruitingThis study tests a new biologic drug called XYA02 in 190 adults with advanced solid tumors (including lung, ovarian, and pancreatic cancers) that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumo…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: XYone Therapeutics, Inc • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Cancer-Killing virus injected into tumors before surgery: a new hope?
Disease control Not yet recruitingThis study tests whether injecting a virus called RP2 directly into stomach and esophageal tumors, combined with standard FLOT chemotherapy, is safe and works better than chemotherapy alone before surgery. About 34 people with stage II or higher non-metastatic gastroesophageal ca…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New combo may let esophageal cancer patients skip surgery
Disease control Not yet recruitingThis study tests whether giving additional chemotherapy after the usual chemoradiation can better control esophageal cancer and reduce the need for surgery. About 60 adults with stage II to IVA esophageal adenocarcinoma will receive chemoradiation followed by more chemotherapy. T…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Duke University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New study tests if All-Keyhole surgery beats hybrid approach for esophageal cancer
Disease control Not yet recruitingThis phase 3 trial will compare two surgical techniques for esophageal cancer: totally minimally invasive esophagectomy (TMIE) using only keyhole incisions, versus a hybrid approach that combines keyhole and open chest surgery. The study aims to see if TMIE reduces severe complic…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: NA • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Could a tiny dose of radiation reboot cancer immunotherapy?
Disease control Not yet recruitingThis phase II trial tests whether a single low dose of radiation to all visible tumors can help immunotherapy work again in people with advanced esophageal cancer that has stopped responding to standard treatment. Thirty-two adults will receive the radiation and continue their or…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Fudan University • Aim: Disease control
Last updated Jun 26, 2026 16:43 UTC
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Sponge on a string and AI could revolutionize esophageal cancer screening
Diagnosis Not yet recruitingThis study will test whether a combination of an AI-powered risk tool, a simple 'sponge on a string' test, and nurse navigation can improve screening for Barrett's esophagus and esophageal cancer. Over 1,000 adults at higher risk will be enrolled. The goal is to see if these less…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: NA • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 14:02 UTC
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Could skipping the breathing tube make esophageal cancer surgery safer?
Symptom relief Not yet recruitingThis study tests whether using a laryngeal mask instead of a breathing tube during esophageal cancer surgery can reduce complications and speed up recovery. About 500 adults with resectable esophageal cancer will be randomly assigned to one of two anesthesia methods. The goal is …
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: NA • Sponsor: The First Affiliated Hospital of Guangzhou Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Blood test may let some stomach cancer patients skip harsh chemo
Knowledge-focused Not yet recruitingThis study tests whether a personalized blood test (Signatera) can identify gastric cancer patients who, after surgery, have no detectable cancer DNA and can safely receive a milder immunotherapy (durvalumab) instead of standard chemotherapy. About 1000 adults with stage II-IVa g…
Matched conditions: ESOPHAGEAL ADENOCARCINOMA
Phase: NA • Sponsor: Natera, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC