ESOPHAGEAL ADENOCARCINOMA

This study tests whether a single, low dose of radiation to all visible tumors can help immunotherapy drugs work again in people with advanced esophageal cancer that stopped responding to standard treatment. About 32 adults will receive the radiation and continue their current im…

This early-phase study tests whether a single dose of two immunotherapy drugs can increase cancer-fighting immune cells inside tumors. It includes 34 adults with untreated stomach or esophageal cancers that have not spread and carry a specific gene change called ARID1A. The goal …

This study tests whether injecting a new treatment called RP2 directly into stomach or esophageal tumors, along with standard chemotherapy (FLOT), is safe and works better than chemo alone before surgery. About 34 people with stage 2 or higher non-metastatic cancer will take part…

This study tests a new drug called denikitug, alone or with other treatments, in people with advanced HER2-negative stomach, gastroesophageal junction, or esophageal cancer that has spread or come back after initial therapy. About 120 participants will be randomly assigned to rec…

This study tests whether freezing esophageal cancer tumors with liquid nitrogen before chemotherapy improves treatment. About 40 adults with advanced esophageal cancer will be randomly assigned to receive either cryotherapy plus chemo or chemo alone. The goal is to see if the fre…

This study tests three gentler methods to find Barrett's esophagus, a condition that can lead to esophageal cancer. The methods include an AI tool that checks health records, a sponge-on-a-string test that collects cells from the throat, and nurse help to guide patients through s…

This study tests whether adding the antifungal drug itraconazole to standard heat ablation therapy can better prevent esophageal cancer in people with high-risk Barrett's esophagus. About 64 participants will receive either itraconazole or a placebo alongside their usual endoscop…