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Cancer-Killing virus injected into tumors before surgery: a new hope?

NCT ID NCT07059611

Not yet recruiting Disease control Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether injecting a virus called RP2 directly into stomach and esophageal tumors, combined with standard FLOT chemotherapy, is safe and works better than chemotherapy alone before surgery. About 34 people with stage II or higher non-metastatic gastroesophageal cancer will receive the injections before each chemo cycle, then undergo surgery. The main goal is to see if the cancer is completely gone at the time of surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
RP2 (a virus injected into tumors) and FLOT chemotherapy (5-fluorouracil, leucovorin, oxaliplatin, docetaxel)
What this could lead to
If it works, this could lead to a more effective pre-surgery treatment that kills more cancer cells and improves outcomes for people with gastroesophageal cancer.
What could go wrong
This is an early Phase 2 trial with only 34 people, so results may not apply widely. The combination could cause more side effects than chemo alone, and the virus injection may not be safe or effective for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus esophageal adenocarcinoma gastric adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL ADENOCARCINOMA GASTRIC ADENOCARCINOMA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA

Contacts and locations

Locations

  • Abramson Cancer Center at the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

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