Cancer-Killing virus injected into tumors before surgery: a new hope?
NCT ID NCT07059611
First seen Oct 31, 2025 · Last updated Jun 23, 2026 · Updated 33 times
Summary
This study tests whether injecting a virus called RP2 directly into stomach and esophageal tumors, combined with standard FLOT chemotherapy, is safe and works better than chemotherapy alone before surgery. About 34 people with stage II or higher non-metastatic gastroesophageal cancer will receive the injections before each chemo cycle, then undergo surgery. The main goal is to see if the cancer is completely gone at the time of surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Abramson Cancer Center at the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RP2 (a virus injected into tumors) and FLOT chemotherapy (5-fluorouracil, leucovorin, oxaliplatin, docetaxel)
What this could lead to
If it works, this could lead to a more effective pre-surgery treatment that kills more cancer cells and improves outcomes for people with gastroesophageal cancer.
What could go wrong
This is an early Phase 2 trial with only 34 people, so results may not apply widely. The combination could cause more side effects than chemo alone, and the virus injection may not be safe or effective for everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.