ESOPHAGEAL ADENOCARCINOMA

This large Phase 3 study is testing whether a new drug combination works better than the current standard treatment for advanced HER2-positive stomach and esophageal cancers that cannot be removed by surgery. The trial will involve 920 patients and compares zanidatamab plus chemo…

This study is testing whether adding two immunotherapy drugs, nivolumab and ipilimumab, to standard chemotherapy and radiation can better treat certain cancers of the esophagus and stomach junction. It involves patients who are scheduled for surgery. The goal is to see if this co…

This study is testing whether a powerful combination of treatments can shrink or eliminate tumors before surgery for esophageal and gastroesophageal junction cancers. Patients receive standard chemotherapy and radiation alongside an immunotherapy drug (pembrolizumab), followed by…

This study is testing whether adding a drug called tucatinib to standard cancer treatments is safe and effective for people with HER2-positive cancers of the digestive system, like stomach, colon, and gallbladder cancers. It involves about 40 participants who have advanced cancer…

This study is testing whether adding an experimental drug called futibatinib to standard immunotherapy and chemotherapy can better control advanced esophageal or pancreatic cancer. It is for adults who have not yet received treatment for their advanced disease. The main goal is t…

This study tests whether a combination of two drugs (trastuzumab deruxtecan and nivolumab) given for one year after surgery can help prevent cancer from returning in patients with HER2-positive esophageal or gastroesophageal junction cancer. The treatment is for patients who have…

This study is testing whether adding two new immunotherapy drugs, durvalumab and tremelimumab, to standard chemotherapy and radiation is safe and effective for treating esophageal and gastroesophageal junction cancer. The trial involves 64 patients who will receive the drug combi…

This study is testing a new, simpler device called Endosign to see if it can be used instead of regular endoscopies to monitor people with Barrett's esophagus, a condition that can lead to esophageal cancer. The device is swallowed like a capsule to collect a small tissue sample,…

This study is testing a new, simpler way to screen for Barrett's esophagus and esophageal cancer. Researchers are using a small sponge on a string that patients swallow, which collects cells from the esophagus. They are checking if lab tests on these cells can accurately spot dan…

This study is testing whether a daily aspirin pill can help prevent Barrett's esophagus from returning after it has been successfully treated with a procedure called radiofrequency ablation. It involves 21 people who have had their Barrett's esophagus cleared. Participants are ra…