Metabolic disease
MONDO:0005066A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.
Also known as: disorder of metabolic process, metabolic disease, metabolic disorder, metabolic process disease, disease of metabolism
7369 clinical trials for this condition and its sub-types, 246 tagged with Metabolic disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Metabolic disease
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Glucose metabolism disease 62 trials · 4,139 incl. sub-types
9 sub-types
- Diabetes mellitus 1,275 trials · 3,825 incl. sub-types Sub-types →
- Prediabetes syndrome 445 trials
- Glucose intolerance 149 trials
- Hyperglycemia 132 trials
- Hypoglycemia 119 trials
- Hyperinsulinism 34 trials · 42 incl. sub-types Sub-types →
- Disorder of gluconeogenesis 0 trials · 1 incl. sub-types Sub-types →
- Glyceraldehyde-3-phosphate dehydrogenase deficiency 0 trials
- Triosephosphate isomerase deficiency 0 trials
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Inborn errors of metabolism 48 trials · 2,231 incl. sub-types
93 sub-types
- Inherited lipid metabolism disorder 201 trials · 644 incl. sub-types Sub-types →
- Inborn carbohydrate metabolic disorder 3 trials · 370 incl. sub-types Sub-types →
- Abdominal obesity-metabolic syndrome 302 trials · 359 incl. sub-types Sub-types →
- Lysosomal storage disease 38 trials · 303 incl. sub-types Sub-types →
- Inborn disorder of energy metabolism 2 trials · 235 incl. sub-types Sub-types →
- Inborn disorder of amino acid and other organic acid metabolism 0 trials · 225 incl. sub-types Sub-types →
- Waldenstrom macroglobulinemia 136 trials Sub-types →
- DNA repair disease 13 trials · 105 incl. sub-types Sub-types →
- Hereditary amyloidosis 19 trials · 79 incl. sub-types Sub-types →
- Inborn disorder of porphyrin metabolism 0 trials · 63 incl. sub-types Sub-types →
- Mucopolysaccharidosis or mucopolysaccharidosis-like disorder 0 trials · 62 incl. sub-types Sub-types →
- Inborn metal metabolism disorder 1 trial · 60 incl. sub-types Sub-types →
- Disorder of metabolite absorption and transport 0 trials · 59 incl. sub-types Sub-types →
- Inborn disorder of purine or pyrimidine metabolism 1 trial · 50 incl. sub-types Sub-types →
- Plasma protein metabolism disease 0 trials · 47 incl. sub-types Sub-types →
- Peroxisomal disease 2 trials · 38 incl. sub-types Sub-types →
- Congenital disorder of glycosylation 7 trials · 36 incl. sub-types Sub-types →
- Monogenic diabetes 9 trials · 24 incl. sub-types Sub-types →
- Glycoprotein metabolism disease 1 trial · 23 incl. sub-types Sub-types →
- Disorder of lysosomal-related organelles 0 trials · 17 incl. sub-types Sub-types →
- Familial intrahepatic cholestasis 1 trial · 17 incl. sub-types Sub-types →
- Hereditary lipodystrophy 2 trials · 17 incl. sub-types Sub-types →
- Hypophosphatasia 13 trials Sub-types →
- Familial hypoparathyroidism 0 trials · 10 incl. sub-types Sub-types →
- Inborn disorder of biogenic amine metabolism and transport 0 trials · 10 incl. sub-types Sub-types →
- Inherited thyroid metabolism disease 0 trials · 8 incl. sub-types Sub-types →
- Neurodegeneration with brain iron accumulation 1 trial · 8 incl. sub-types Sub-types →
- Inborn vitamin metabolic disorder 0 trials · 7 incl. sub-types Sub-types →
- Inborn aminoacylase deficiency 0 trials · 6 incl. sub-types Sub-types →
- Disorder of peptide and amine metabolism 0 trials · 4 incl. sub-types Sub-types →
- Congenital disorder of deglycosylation 0 trials · 2 incl. sub-types Sub-types →
- Diastrophic dysplasia 2 trials
- Hypercalcemia, infantile 2 trials Sub-types →
- Hypoalphalipoproteinemia, primary, 1 2 trials
- 2-hydroxyglutaric aciduria 0 trials · 1 incl. sub-types Sub-types →
- Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome 1 trial
- Diabetes mellitus, noninsulin-dependent, 1 1 trial
- Diabetes mellitus, noninsulin-dependent, 2 1 trial
- Familial hypocalciuric hypercalcemia 0 trials · 1 incl. sub-types Sub-types →
- Fish eye disease 1 trial
- Hereditary recurrent myoglobinuria 0 trials · 1 incl. sub-types Sub-types →
- Thiopurine metabolic disease 0 trials · 1 incl. sub-types Sub-types →
- 4-hydroxyphenylacetic aciduria 0 trials
- 5-nucleotidase syndrome 0 trials
- APO A-i deficiency 0 trials
- CFTR-related metabolic syndrome/CF screen positive, inconclusive diagnosis 0 trials
- Ehlers-Danlos syndrome, spondylodysplastic type 0 trials Sub-types →
- Lane Hamilton syndrome 0 trials
- NAD(P)HX dehydratase deficiency 0 trials
- SQSTM1-related multisystem proteinopathy 0 trials Sub-types →
- Achondrogenesis type IB 0 trials
- Antigen-peptide-transporter 2 deficiency 0 trials
- Apolipoprotein c-III deficiency 0 trials
- Aromatase excess syndrome 0 trials
- Atelosteogenesis type II 0 trials
- Autosomal dominant dopa-responsive dystonia 0 trials Sub-types →
- Autosomal dominant myoglobinuria 0 trials
- Autosomal dominant proximal renal tubular acidosis 0 trials
- Autosomal recessive proximal renal tubular acidosis 0 trials
- Cardiomyopathy hypogonadism metabolic anomalies 0 trials
- Chondrocalcinosis 2 0 trials
- Chondrodysplasia with joint dislocations, gPAPP type 0 trials
- Combined ApoA-I and ApoC-III deficiency 0 trials
- Defective apolipoprotein b-100 0 trials
- Deficiency of coenzyme q cytochrome c reductase 0 trials
- Diabetes mellitus, noninsulin-dependent, 3 0 trials
- Diabetes mellitus, noninsulin-dependent, 4 0 trials
- Diabetes mellitus, noninsulin-dependent, 5 0 trials
- Familial hyperphosphatemic tumoral calcinosis/hyperphosphatemic hyperostosis syndrome 0 trials
- Ferro-cerebro-cutaneous syndrome 0 trials
- Gluthathione peroxidase deficiency 0 trials
- Hemolytic anemia due to diphosphoglycerate mutase deficiency 0 trials
- Hypercholesterolemia, familial, 4 0 trials
- Hypermanganesemia with dystonia 0 trials Sub-types →
- Hypertriglyceridemia 1 0 trials
- Hypertriglyceridemia 2 0 trials
- Hypoalphalipoproteinemia, primary, 2 0 trials Sub-types →
- Hypotonia-failure to thrive-microcephaly syndrome 0 trials
- Inborn disorder of aspartate family metabolism 0 trials Sub-types →
- Inborn glycerol kinase deficiency 0 trials Sub-types →
- Inherited threoninemia 0 trials
- Multiple epiphyseal dysplasia type 4 0 trials
- Normophosphatemic familial tumoral calcinosis 0 trials
- Renal tubular acidosis, distal, 3, with or without sensorineural hearing loss 0 trials
- Spondyloepimetaphyseal dysplasia, PAPSS2 type 0 trials
- Spondyloepiphyseal dysplasia with congenital joint dislocations 0 trials
- Striatonigral degeneration 0 trials Sub-types →
- Sulfide quinone oxidoreductase deficiency 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 1 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 2 0 trials
- Tumoral calcinosis, hyperphosphatemic, familial, 3 0 trials
- Uridine-cytidineuria 0 trials
- Weinstein kliman scully syndrome 0 trials
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Proteostasis deficiencies 1 trial · 561 incl. sub-types
4 sub-types
- Amyloidosis 133 trials · 323 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- TDP-43 proteinopathy 3 trials
- SQSTM1-related multisystem proteinopathy 0 trials Sub-types →
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Hyperlipidemia 307 trials · 401 incl. sub-types
3 sub-types
- Familial hyperlipidemia 8 trials · 130 incl. sub-types Sub-types →
- Hyperalphalipoproteinemia 0 trials Sub-types →
- Laminopathy type Decaudain-Vigouroux 0 trials
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Carbohydrate metabolism disease 4 trials · 385 incl. sub-types
6 sub-types
- Inborn carbohydrate metabolic disorder 3 trials · 370 incl. sub-types Sub-types →
- Carbohydrate transport disease 0 trials · 156 incl. sub-types Sub-types →
- Scurvy 13 trials
- Intestinal disaccharidase deficiency 0 trials · 2 incl. sub-types Sub-types →
- Acquired carbohydrate metabolism disease 0 trials
- Glycerol metabolism disease 0 trials
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Developmental anomaly of metabolic origin 0 trials · 384 incl. sub-types
57 sub-types
- Inborn mitochondrial metabolism disorder 59 trials · 127 incl. sub-types Sub-types →
- Fabry disease 64 trials
- Mucopolysaccharidosis 14 trials · 62 incl. sub-types Sub-types →
- Sterol biosynthesis disorder 0 trials · 45 incl. sub-types Sub-types →
- Fanconi anemia 29 trials · 42 incl. sub-types Sub-types →
- Hypophosphatasia 13 trials Sub-types →
- Oligosaccharidosis 0 trials · 11 incl. sub-types Sub-types →
- Pseudohypoparathyroidism 8 trials · 9 incl. sub-types Sub-types →
- Zellweger spectrum disorders 6 trials · 7 incl. sub-types Sub-types →
- Cockayne syndrome 6 trials Sub-types →
- Creatine transporter deficiency 6 trials
- Mucolipidosis 4 trials · 5 incl. sub-types Sub-types →
- Classic homocystinuria 4 trials
- Mucosulfatidosis 4 trials
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency 2 trials
- AICA-ribosiduria 1 trial
- Nijmegen breakage syndrome 1 trial
- SLC35A2-congenital disorder of glycosylation 1 trial
- Arthrogryposis-renal dysfunction-cholestasis syndrome 1 trial Sub-types →
- Encephalopathy due to sulfite oxidase deficiency 0 trials · 1 incl. sub-types Sub-types →
- Occipital horn syndrome 1 trial
- ALDH18A1-related de Barsy syndrome 0 trials
- Al-Gazali syndrome 0 trials
- B4GALT1-congenital disorder of glycosylation 0 trials
- CADDS 0 trials
- CHIME syndrome 0 trials
- COG1-congenital disorder of glycosylation 0 trials
- COG7-congenital disorder of glycosylation 0 trials
- Ehlers-Danlos syndrome, musculocontractural type 0 trials Sub-types →
- Ehlers-Danlos syndrome, spondylodysplastic type 0 trials Sub-types →
- Larsen-like syndrome, B3GAT3 type 0 trials
- MGAT2-congenital disorder of glycosylation 0 trials
- Neu-Laxova syndrome 0 trials Sub-types →
- Nijmegen breakage syndrome-like disorder 0 trials
- Peters plus syndrome 0 trials
- RFT1-congenital disorder of glycosylation 0 trials
- SHORT syndrome 0 trials
- SLC39A8-CDG 0 trials
- SSR4-congenital disorder of glycosylation 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- XYLT1-congenital disorder of glycosylation 0 trials
- Autism spectrum disorder - epilepsy - arthrogryposis syndrome 0 trials
- Autosomal recessive cutis laxa type 2 0 trials Sub-types →
- Cutis laxa, autosomal dominant 3 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 15 0 trials
- Hyperphosphatasia-intellectual disability syndrome 0 trials Sub-types →
- Mandibuloacral dysplasia 0 trials Sub-types →
- Mucopolysaccharidosis-plus syndrome 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 1 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 2 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 3 0 trials
- Permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome 0 trials
- Pontocerebellar hypoplasia type 1 0 trials Sub-types →
- Progressive hypotonia-intellectual disability-facial dysmorphism syndrome due to FYVE-defective RBSN 0 trials
- Temtamy preaxial brachydactyly syndrome 0 trials
- Transketolase deficiency 0 trials
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Diabetic retinopathy 148 trials · 260 incl. sub-types
3 sub-types
- Diabetic macular edema 120 trials
- Background diabetic retinopathy 26 trials Sub-types →
- Proliferative diabetic retinopathy 19 trials
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Acquired metabolic disease 0 trials · 183 incl. sub-types
13 sub-types
- AL amyloidosis 93 trials · 99 incl. sub-types Sub-types →
- Paroxysmal nocturnal hemoglobinuria 73 trials Sub-types →
- Acquired lipodystrophy 3 trials · 9 incl. sub-types Sub-types →
- Acquired hyperprolactinemia 1 trial Sub-types →
- Auto-brewery syndrome 1 trial
- Acquired adrenogenital syndrome 0 trials
- Acquired carbohydrate metabolism disease 0 trials
- Acquired lactic acidosis 0 trials
- Acquired mineral metabolism disease 0 trials
- Acquired porphyria 0 trials Sub-types →
- Acquired xanthinuria 0 trials
- Bladder fermentation syndrome 0 trials
- Carotenemia 0 trials
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Amino acid metabolism disease 2 trials · 160 incl. sub-types
4 sub-types
- Inborn disorder of amino acid metabolism 6 trials · 159 incl. sub-types Sub-types →
- Creatine biosynthetic process disease 0 trials · 1 incl. sub-types Sub-types →
- Glycine metabolism disease 0 trials Sub-types →
- Valine metabolism disease 0 trials Sub-types →
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Disorder of organic acid metabolism 0 trials · 154 incl. sub-types
20 sub-types
- Disorder of phenylalanine metabolism 0 trials · 60 incl. sub-types Sub-types →
- Pyruvate metabolism disorder 0 trials · 31 incl. sub-types Sub-types →
- Disorder of fatty acid oxidation and ketogenesis 1 trial · 16 incl. sub-types Sub-types →
- Scurvy 13 trials
- Inborn disorder of bile acid synthesis 2 trials · 12 incl. sub-types Sub-types →
- Inborn disorder of methionine cycle and sulfur amino acid metabolism 0 trials · 11 incl. sub-types Sub-types →
- Disorder of tyrosine metabolism 0 trials · 8 incl. sub-types Sub-types →
- Cerebral creatine deficiency syndrome 0 trials · 6 incl. sub-types Sub-types →
- Inborn disorder of branched-chain amino acid metabolism 0 trials · 4 incl. sub-types Sub-types →
- Inborn disorder of ornithine metabolism 0 trials · 4 incl. sub-types Sub-types →
- Biotin metabolic disease 0 trials · 3 incl. sub-types Sub-types →
- Creatine biosynthetic process disease 0 trials · 1 incl. sub-types Sub-types →
- Gamma-amino butyric acid metabolism disorder 0 trials · 1 incl. sub-types Sub-types →
- Inborn serine deficiency 0 trials · 1 incl. sub-types Sub-types →
- Inherited lipoic acid biosynthesis defect 0 trials · 1 incl. sub-types Sub-types →
- Glycine metabolism disease 0 trials Sub-types →
- Inborn disorder of histidine metabolism 0 trials Sub-types →
- Inborn disorder of proline metabolism 0 trials Sub-types →
- Inborn disorder of tryptophan metabolism 0 trials Sub-types →
- Valine metabolism disease 0 trials Sub-types →
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Mineral metabolism disease 2 trials · 137 incl. sub-types
13 sub-types
- Calcium metabolic disease 5 trials · 62 incl. sub-types Sub-types →
- Phosphorus metabolism disease 1 trial · 33 incl. sub-types Sub-types →
- Iron metabolism disease 2 trials · 22 incl. sub-types Sub-types →
- Sulfur metabolism disease 0 trials · 14 incl. sub-types Sub-types →
- Potassium deficiency disease 4 trials · 5 incl. sub-types Sub-types →
- Diastrophic dysplasia 2 trials
- Achondrogenesis type IB 0 trials
- Acquired mineral metabolism disease 0 trials
- Atelosteogenesis type II 0 trials
- Chondrodysplasia with joint dislocations, gPAPP type 0 trials
- Multiple epiphyseal dysplasia type 4 0 trials
- Spondyloepimetaphyseal dysplasia, PAPSS2 type 0 trials
- Spondyloepiphyseal dysplasia with congenital joint dislocations 0 trials
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Diabetic kidney disease 133 trials
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Hyperlipoproteinemia 8 trials · 106 incl. sub-types
4 sub-types
- Familial hypercholesterolemia 58 trials · 94 incl. sub-types Sub-types →
- Familial lipoprotein lipase deficiency 6 trials
- Hyperalphalipoproteinemia 0 trials Sub-types →
- Hypercholesterolemia, familial, 4 0 trials
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Steroid metabolism disease 1 trial · 104 incl. sub-types
4 sub-types
- Sterol metabolism disorder 0 trials · 60 incl. sub-types Sub-types →
- Adrenogenital syndrome 0 trials · 41 incl. sub-types Sub-types →
- Vitamin D hydroxylation-deficient rickets, type 1B 3 trials
- Corticosterone methyloxidase type 1 deficiency 0 trials
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Gout 103 trials
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Hypertriglyceridemia 75 trials
2 sub-types
- Hypertriglyceridemia 1 0 trials
- Hypertriglyceridemia 2 0 trials
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Disorder of GPI anchor biosynthesis 0 trials · 73 incl. sub-types
11 sub-types
- Paroxysmal nocturnal hemoglobinuria 73 trials Sub-types →
- Developmental and epileptic encephalopathy, 55 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Developmental and epileptic encephalopathy, 80 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 15 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 16 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 17 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 18 0 trials
- Glycosylphosphatidylinositol biosynthesis defect 25 0 trials
- Inborn disorder of glycosphingolipid and glycosylphosphatidylinositol anchor glycosylation 0 trials Sub-types →
- Neurodevelopmental disorder with hypotonia and cerebellar atrophy, with or without seizures 0 trials
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Porphyrin metabolism disease 0 trials · 64 incl. sub-types
2 sub-types
- Inborn disorder of porphyrin metabolism 0 trials · 63 incl. sub-types Sub-types →
- Porphyria 8 trials · 25 incl. sub-types Sub-types →
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Lipodystrophy 30 trials · 48 incl. sub-types
5 sub-types
- Partial lipodystrophy 7 trials · 19 incl. sub-types Sub-types →
- Hereditary lipodystrophy 2 trials · 17 incl. sub-types Sub-types →
- Generalized lipodystrophy 8 trials · 11 incl. sub-types Sub-types →
- Acquired lipodystrophy 3 trials · 9 incl. sub-types Sub-types →
- Localized lipodystrophy 0 trials · 4 incl. sub-types Sub-types →
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Bilirubin metabolism disease 0 trials · 48 incl. sub-types
2 sub-types
- Inborn disorder of bilirubin metabolism 0 trials · 39 incl. sub-types Sub-types →
- Hyperbilirubinemia 28 trials Sub-types →
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Disorder of acid-base balance 6 trials · 28 incl. sub-types
1 sub-type
- Acidosis disorder 4 trials · 23 incl. sub-types Sub-types →
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Vitamin B12 deficiency 12 trials · 15 incl. sub-types
1 sub-type
- Inborn disorder of cobalamin metabolism and transport 1 trial · 3 incl. sub-types Sub-types →
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Purine metabolism disease 0 trials · 14 incl. sub-types
1 sub-type
- Inborn disorder of purine metabolism 0 trials · 14 incl. sub-types Sub-types →
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Pyrimidine metabolism disease 0 trials · 11 incl. sub-types
1 sub-type
- Inborn disorder of pyrimidine metabolism 0 trials · 11 incl. sub-types Sub-types →
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Lactic acidosis 8 trials
3 sub-types
- Acquired lactic acidosis 0 trials
- Cardiomyopathy-hypotonia-lactic acidosis syndrome 0 trials
- Mitochondrial DNA depletion syndrome 9 0 trials
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Chondrocalcinosis 5 trials · 7 incl. sub-types
3 sub-types
- Chondrocalcinosis due to apatite crystal deposition 2 trials
- Chondrocalcinosis 1 0 trials
- Chondrocalcinosis 2 0 trials
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Hypoalphalipoproteinemia 1 trial · 7 incl. sub-types
6 sub-types
- LCAT deficiency 1 trial · 4 incl. sub-types Sub-types →
- Apolipoprotein A-I deficiency 0 trials · 2 incl. sub-types Sub-types →
- Tangier disease 0 trials
- Apolipoprotein A-II deficiency 0 trials
- Combined ApoA-I and ApoC-III deficiency 0 trials
- Familial apolipoprotein gene cluster deletion syndrome 0 trials
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Glutaric aciduria 0 trials · 5 incl. sub-types
3 sub-types
- Glutaryl-CoA dehydrogenase deficiency 4 trials
- Multiple acyl-CoA dehydrogenase deficiency 1 trial Sub-types →
- Glutaric acidemia type 3 0 trials
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Tumor lysis syndrome 3 trials
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Dopa-responsive dystonia 1 trial · 2 incl. sub-types
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Ochronosis disorder 1 trial
1 sub-type
- Exogenous ochronosis 0 trials
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Xanthoma 1 trial
1 sub-type
- Verruciform xanthoma of skin 0 trials
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Xanthinuria 0 trials · 1 incl. sub-types
2 sub-types
- Hereditary xanthinuria 0 trials · 1 incl. sub-types Sub-types →
- Acquired xanthinuria 0 trials
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Collagenous sprue 0 trials
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Disorder of glutamate decarboxylase 0 trials
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Skeletal fluorosis 0 trials
Most studied deeper sub-types
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Heart showdown: which diabetes drug shields the heart better?
Disease control CompletedThis large phase 3 trial compares two injectable diabetes medications, tirzepatide and dulaglutide, to see which one better prevents major heart problems like heart attacks, strokes, or death from cardiovascular causes. The study includes over 13,000 adults aged 40 and older with…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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New drug aims to tame dangerous fat levels in blood
Disease control CompletedThis study tested a drug called pegozafermin in 369 adults with severe hypertriglyceridemia, a condition where blood fat levels are dangerously high. Participants received either the drug or a placebo for 26 weeks. The main goal was to see if the drug could safely lower triglycer…
Phase 3 • Sponsor: 89bio, Inc. • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Herbal mix may restore ovulation in PCOS women
Disease control CompletedThis study tests a combination of herbs (Melats P) in 116 women aged 18-40 with PCOS and insulin resistance. The goal is to see if the treatment can restore regular periods and ovulation, helping overcome infertility. Participants will be monitored for 4 months using ultrasound a…
Phase 1 • Sponsor: Jinnah Postgraduate Medical Centre • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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Ancient herb takes on PCOS: new hope for millions?
Disease control CompletedThis study tested a herbal extract from a Himalayan plant (Nepeta adenophyta) in 116 women with PCOS. Participants took either the herb, the standard drug metformin, or both for 4 months. The goal was to see if the herb could help restore regular menstrual cycles and improve meta…
Phase 1 • Sponsor: Jinnah Sindh Medical University • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Fasting vs. keto vs. both: which diet boosts metabolic health best?
Disease control CompletedThis study compares three dietary approaches—intermittent fasting (16:8 schedule), a clean ketogenic diet (20g carbs per day from whole foods), and a combination of both—in healthy adults. Researchers measure changes in body composition, cholesterol, triglycerides, and blood suga…
Sponsor: The University of Tennessee at Martin • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Gut bacteria may tame antipsychotic side effects in schizophrenia
Disease control CompletedThis study tested whether a probiotic supplement (Pediococcus acidilactici) could reduce metabolic problems like high cholesterol and blood sugar caused by antipsychotic drugs. 36 adults with first-episode psychosis or schizophrenia took the probiotic or a placebo alongside their…
Sponsor: Manuel Jesús Cuesta Zurita • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Orange you glad you ate that? study tests fruit against fatty liver
Disease control CompletedThis study looked at whether eating 400 grams of fresh oranges daily for a month could improve metabolism in 60 adults with metabolic-associated fatty liver disease (MAFLD). Participants either ate oranges or other fruits. Researchers measured changes in liver fat and blood fats.…
Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Brain surgery breakthrough? sedative may shield the brain!
Disease control CompletedThis study looked at whether a sedative called dexmedetomidine can protect the brain during surgery to remove a brain tumor. 56 adults having brain tumor surgery received either the drug or a placebo. The goal was to see if the drug reduces brain damage and inflammation, helping …
Phase 4 • Sponsor: Georgia Tsaousi • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New diabetes pill shows promise in early safety trial
Disease control CompletedThis study tested a new oral drug called LY3549492 in 92 Japanese volunteers, some with type 2 diabetes and some healthy. The main goal was to check safety and how the body processes the drug. Participants took multiple doses over several weeks, and researchers monitored side eff…
Phase 1 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 11:04 UTC
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Can diabetes drugs fix Post-Transplant metabolism? new trial investigates
Disease control CompletedThis study looked at whether two diabetes drugs, metformin and empagliflozin, can safely improve metabolic problems (like unhealthy fat buildup and blood sugar issues) in people who have had a kidney transplant. 105 kidney transplant recipients with good kidney function were rand…
Sponsor: West China Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Overripe banana powder shows promise for diabetes control
Disease control CompletedThis study tested whether a daily supplement of overripe banana powder can improve blood sugar control in adults with type 2 diabetes. Sixty participants took either the banana supplement or a standard formula for 12 weeks. Researchers measured changes in fasting blood sugar, HbA…
Sponsor: Universiti Sains Malaysia • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Money stress and diabetes: new study tests a Two-Pronged solution
Disease control CompletedThis pilot study tested whether combining financial navigation (help with costs) and peer support (connecting with others) can help adults with diabetes better manage their condition. 61 participants were randomly assigned to receive either financial navigation alone or financial…
Sponsor: University of Michigan • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC
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New weekly shot could help control blood sugar in type 2 diabetes
Disease control CompletedThis study tested a new weekly medicine called retatrutide in 537 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either the medicine or a placebo for about 11 months. The goal was to see if retatrutide safel…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Can a simple supplement tame PCOS hormones?
Disease control CompletedThis study tested whether inositol, a natural dietary supplement, can lower high testosterone levels in women with polycystic ovary syndrome (PCOS). 154 women took either a placebo or one of three doses of inositol powder for a set period. Researchers measured changes in testoste…
Phase 2 • Sponsor: Milton S. Hershey Medical Center • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New drug shows promise for reversing liver damage in NASH patients
Disease control CompletedThis study tested a new drug called BIO89-100 (Pegozafermin) in 222 adults with NASH, a serious fatty liver disease with liver scarring. Participants received weekly injections of the drug or a placebo for about 6 months. The goal was to see if the drug could reduce liver inflamm…
Phase 2 • Sponsor: 89bio, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Smart coaching helps diabetics manage blood sugar
Disease control CompletedThis study tested whether personalized, automatic coaching messages based on continuous glucose monitor readings and mood assessments could help people with insulin-treated type 2 diabetes improve their blood sugar control. 46 adults participated over 12 weeks. The goal was to se…
Sponsor: Samsung Medical Center • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Electric pulses to the gut: a new hope for diabetes?
Disease control CompletedThis early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had …
Sponsor: Endogenex, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New surgery shows promise for obesity and diabetes
Disease control CompletedThis study tested a surgery that combines two procedures to help people with obesity and type 2 diabetes lose weight and control their blood sugar. 18 adults aged 19-65 with a BMI between 35 and 50 took part. Researchers measured weight loss and metabolic changes over time.
Sponsor: GI Windows, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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New shot cuts dangerous fat levels in blood
Disease control CompletedThis study tested a new medicine called olezarsen in 446 people with very high levels of blood fats (triglycerides). The goal was to see if it could lower these fats more than a placebo. Participants received shots under the skin and followed a healthy diet.
Phase 3 • Sponsor: Ionis Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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New diabetes drug shows promise for teens in landmark trial
Disease control CompletedThis study tested a medication called tirzepatide in children and teenagers aged 10 to 17 with type 2 diabetes. Participants were already taking metformin or insulin but still had high blood sugar. The goal was to see if tirzepatide could safely lower blood sugar levels better th…
Phase 3 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Could a 5:2 diet melt fat from your liver?
Disease control CompletedThis study looked at whether an 8-week 5:2 intermittent fasting diet could help people with fatty liver disease. Eighty adults with excess liver fat followed the diet, eating normally for 5 days and restricting calories to 500 kcal on 2 non-consecutive days each week. Researchers…
Sponsor: Beijing Chao Yang Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Could a simple breath test spot hidden diseases early?
Diagnosis CompletedThis study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…
Sponsor: Respyr • Aim: Diagnosis
Last updated Jun 27, 2026 13:07 UTC
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Bhangra beat: could folk dance be the key to better metabolic health?
Prevention CompletedThis study tests whether a 12-week Bhangra dance program can improve metabolic health, physical function, and mental well-being in women aged 40-70 from the Indian diaspora. Participants will attend dance classes twice a week and undergo health assessments before and after. The g…
Sponsor: University of Wolverhampton • Aim: Prevention
Last updated Aug 19, 2026 00:00 UTC
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Time-Restricted eating may cut gestational diabetes risk in High-Risk pregnancies
Prevention CompletedThis study tests whether limiting eating to a 10-hour window each day can lower the chance of developing gestational diabetes in pregnant women at high risk. Researchers will compare this approach to usual eating habits over 3 months in 240 women. The goal is to see if this simpl…
Sponsor: Fudan University • Aim: Prevention
Last updated Jul 30, 2026 00:00 UTC
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Personalized nutrition may stop weight gain after spinal injury
Prevention CompletedThis study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…
Sponsor: Sunnaas Rehabilitation Hospital • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC
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Timing your meals may lower breast cancer risk, study finds
Prevention CompletedThis study looked at whether time-restricted eating (eating only during a set window each day) can lower biological and behavioral risk factors for breast cancer. It involved 178 women aged 50 or older with metabolic issues like prediabetes or type 2 diabetes. Participants follow…
Sponsor: University of Toronto • Aim: Prevention
Last updated Jun 27, 2026 07:53 UTC
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New combo drug for obesity tested in japanese volunteers
Symptom relief CompletedThis study tested the safety of a new drug called LY3841136, given alone or with another drug (tirzepatide), in 128 Japanese adults who are obese or overweight. Researchers monitored side effects and how the body processes the drugs over several months. The goal was to see if the…
Phase 1 • Sponsor: Eli Lilly and Company • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Psoriasis study probes hidden heart risks
Knowledge-focused CompletedThis completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Can exercise and diet rewire your cells to fight diabetes?
Knowledge-focused CompletedThis study looked at how different types of aerobic exercise (moderate continuous training vs. high-intensity interval training) and diet counseling affect cell health in people with type 2 diabetes. Researchers measured changes in mitochondria (the cell's power plants) and oxida…
Sponsor: University of Cadiz • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Night eating in pregnancy linked to blood sugar in new study
Knowledge-focused CompletedResearchers at KK Women's and Children's Hospital are studying whether the timing of meals and snacks during pregnancy relates to blood sugar levels. About 300 pregnant women in Singapore, between 18 and 21 weeks gestation, will keep food diaries and use a food record app. The te…
Sponsor: KK Women's and Children's Hospital • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Childhood brain tumor survivors face hidden hormone risks years later
Knowledge-focused CompletedThis study looks at long-term hormone and metabolic problems in people who survived a childhood brain tumor. Researchers will check survivors for issues like growth, thyroid, and blood sugar problems, and see how these relate to the tumor and its treatment. The goal is to help do…
Sponsor: Institute of Oncology Ljubljana • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC
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Carbs last or first? study tests best pre-workout meal order for athletes
Knowledge-focused CompletedThis study looked at whether eating carbohydrates at the end of a pre-exercise meal (instead of at the start) changes how the body burns fat and carbs during exercise and affects cycling performance. Eighteen healthy, trained male athletes ate a standard meal in two different ord…
Sponsor: Universidade do Porto • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:08 UTC
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Ultra-Processed foods hijack your metabolism and brain, study finds
Knowledge-focused CompletedThis study looked at how eating ultra-processed foods (like packaged snacks) affects your metabolism and brain compared to minimally processed foods (like whole fruits and vegetables). Fifty-seven healthy adults ate both types of meals in a special room that measured their energy…
Sponsor: Virginia Polytechnic Institute and State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Plant protein processing: friend or foe to your gut?
Knowledge-focused CompletedThis study looked at how different levels of processing in plant-based protein foods change the bacteria in your gut and your body's chemistry. 38 healthy adults ate these foods so researchers could measure changes in metabolism, gene activity, and inflammation. The goal was to u…
Sponsor: University of Turku • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Ketone drink study reveals muscle secrets in aging men
Knowledge-focused CompletedThis study tested whether a ketone drink improves muscle function in 25 healthy men (12 young, 12 older). Participants drank a ketone monoester and underwent MRI scans, tracer infusions, and bike/dynamometer tests. Researchers compared results within and between age groups to see…
Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Kisspeptin's secret role in metabolism revealed?
Knowledge-focused CompletedThis study looked at how the hormone kisspeptin affects the body's response to sugar. Sixteen healthy adults received either kisspeptin or a placebo during an oral glucose tolerance test. Researchers measured changes in insulin sensitivity to better understand kisspeptin's role i…
Phase 1 • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Gut bacteria byproducts may control Appetite—Study tests where they work best
Knowledge-focused CompletedThis completed study looked at how short-chain fatty acids (SCFA), which are made when gut bacteria break down fiber, affect hunger-related hormones. Twenty-eight healthy adults took capsules that released SCFA in either the small intestine or the colon. Researchers measured horm…
Sponsor: KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Gut check: where you absorb fatty acids matters
Knowledge-focused CompletedThis study looked at how short-chain fatty acids (SCFAs) enter the bloodstream when delivered to different parts of the gut. Thirteen healthy adults took capsules that released SCFAs in either the small intestine or the colon. Researchers took blood samples over 12 hours to compa…
Sponsor: KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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When you eat matters: study reveals meal Timing's impact on metabolism
Knowledge-focused CompletedThis study measured how the number of calories and the time of day you eat affect your body's energy use and blood vessel health. Twenty healthy adults ate test meals while researchers tracked their metabolism and pulse. The goal was to understand how meal choices influence metab…
Sponsor: George Washington University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Veterans study: shedding pounds and moving more may cool inflammation
Knowledge-focused CompletedThis study looked at 100 overweight veterans to see if losing weight and doing aerobic exercise could lower inflammation linked to aging. Researchers measured inflammatory chemicals from fat tissue and checked fitness, body composition, and blood sugar. The goal was to understand…
Sponsor: University of Maryland, Baltimore • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Sitting all day may sabotage your workout, new study shows
Knowledge-focused CompletedThis study looked at how a day of inactivity (less than 5,000 steps) affects the way muscles and energy systems respond to exercise the next day. Eleven healthy adults who were not regular exercisers took part. Researchers measured fat and carbohydrate burning and muscle gene act…
Sponsor: Concordia University Wisconsin • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Can exercise curb teen appetite? new study investigates
Knowledge-focused CompletedThis study looked at how regular aerobic exercise changes appetite and metabolism in sedentary overweight teenagers. Researchers measured hunger levels and blood markers after a meal, comparing teens who exercised with those who didn't. The goal is to understand if exercise alone…
Sponsor: Children's Mercy Hospital Kansas City • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Powerlifting may boost testosterone and improve cholesterol in athletes
Knowledge-focused CompletedThis study looked at how an 8-week powerlifting program (squats, bench press, deadlifts) affects hormones, metabolism, and cholesterol in 30 male basketball players aged 18-24. Participants were randomly assigned to either powerlifting training or their usual basketball routine. …
Sponsor: Ramazan Erdoğan • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Smart algorithm could transform ICU diabetes care
Knowledge-focused CompletedThis study aims to create a new algorithm that uses continuous glucose monitoring to assess insulin resistance in real time for critically ill patients. Current methods are often invasive or impractical in the ICU. Researchers will analyze data from 179 patients to see if this ne…
Sponsor: Chinese Medical Association • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Exercise's secret messages: Muscle-to-Fat cell talk revealed
Knowledge-focused CompletedThis study looks at tiny particles called extracellular vesicles that muscles release after a single session of strength training. Researchers want to see if these particles carry signals to fat cells, and whether this process differs between healthy-weight and obese young adults…
Sponsor: Yuan Wen • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Army study: fiber fuel may improve 5K run times
Knowledge-focused CompletedThis study looked at whether short-chain fatty acids (SCFAs), which are produced when gut bacteria break down certain fibers, can improve aerobic endurance. 21 healthy, active adults ate a low-fiber diet with either a SCFA-boosting starch or a regular starch for one week, then di…
Sponsor: United States Army Research Institute of Environmental Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Sugar gap may reveal hidden metabolism clues in ICU patients
Knowledge-focused CompletedThis study looked at 140 critically ill adults to see if the difference between blood sugar and tissue sugar (the glucose gap) can help predict metabolism and survival. Researchers measured this gap using a small sensor placed under the skin. The goal was to find a simpler, less …
Sponsor: Chinese Medical Association • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Brown fat study reveals how your body handles carbs, fat, and protein
Knowledge-focused CompletedThis study looked at how brown adipose tissue (brown fat) helps the body process nutrients from food. Thirty healthy adults with or without active brown fat were given separate test meals of carbs, fat, or protein. Researchers measured blood sugar, fats, and energy use to see if …
Sponsor: University Hospital, Basel, Switzerland • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Study reveals HPV vaccine gaps in teens with chronic illness
Knowledge-focused CompletedThis study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Sugar gap may reveal hidden danger in ICU patients
Knowledge-focused CompletedThis study looked at 140 critically ill ICU patients to see if the difference between glucose levels in the blood and in the fluid just under the skin (interstitial fluid) can help predict death risk and metabolic problems. Researchers measured this gap and compared it to energy …
Sponsor: Chinese Medical Association • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Could a simple drink before pregnancy shape your child's future health?
Knowledge-focused CompletedThis study followed 461 children whose mothers took a special nutritional drink before and during pregnancy. Researchers want to understand how parents' diet, lifestyle, and metabolism influence child growth, thinking skills, and overall well-being. The goal is to identify factor…
Sponsor: University of Southampton • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Sleep loss may worsen heart risks in women, study finds
Knowledge-focused CompletedThis study looked at how long-term lack of sleep affects heart health and weight in women. Researchers compared premenopausal and postmenopausal women to see if sleep loss raises blood pressure, blood sugar, and belly fat. The goal was to understand if sleep is more important for…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Harvard scientists track what happens inside your body after eating
Knowledge-focused CompletedThis completed study from Harvard University aimed to find biological markers in urine, blood, and stool that change after eating specific foods. Researchers gave 115 healthy adults controlled meals and measured hundreds of compounds to better understand how the body processes fo…
Sponsor: Harvard School of Public Health (HSPH) • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Heart attack mystery: study probes why 1 in 5 victims have no known risks
Knowledge-focused CompletedThis completed study looked at 1,000 heart attack patients to understand why some have no standard risk factors like smoking, high blood pressure, or diabetes. Researchers compared these 'SMuRF-less' patients to those with risk factors, examining their medical history, lab tests,…
Sponsor: Aristotle University Of Thessaloniki • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Scientists dig into gut bugs to unlock secrets of obesity and diabetes
Knowledge-focused CompletedThis completed study looked at gut bacteria in 90 adults with obesity, type 2 diabetes, or neither. Researchers collected samples from the small intestine and colon during routine endoscopies. They compared these to stool samples to see which bacteria are linked to metabolic heal…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:05 UTC
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What happens inside you after eating? new study maps nutrient processing
Knowledge-focused CompletedThis study measured how the body handles different nutrients—sugar, protein, and fats—by giving 147 healthy adults various food tolerance tests. Researchers tracked changes in hormones and other substances in the blood to understand nutrient processing patterns. The goal is to le…
Sponsor: Nanjing Medical University • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:51 UTC
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Plant-Based diet may lower cholesterol in genetic heart condition
Knowledge-focused CompletedThis study tested whether a whole-food plant-based diet, compared to a standard North American diet, can lower LDL cholesterol in 50 adults with heterozygous familial hypercholesterolemia (HeFH). Participants followed each diet for 28 days in a crossover design. Researchers also …
Sponsor: Laval University • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:37 UTC