Inherited disease susceptibility

This study tests whether adjusting chemotherapy doses for each patient can improve outcomes after a stem cell transplant for blood cancers caused by a RUNX1 gene mutation. Up to 98 people aged 4 to 70 with these cancers will receive a transplant from a half-matched donor. The goa…

This study tests whether adding letrozole, a drug commonly used for breast cancer, to the standard medication misoprostol can improve the complete termination of second-trimester pregnancies (14-20 weeks). The trial will compare the combination against misoprostol alone in 80 wom…

This study tests whether a new drug called Bmab1700 works the same as the approved immunotherapy Opdivo in people with melanoma who have had their tumors surgically removed. The trial will involve 120 adults with stage IIB to IV melanoma. Researchers will compare how the drugs mo…

This Phase 2 trial tests a combination of two drugs—blinatumomab (given as a shot under the skin) and olverembatinib (a pill)—in 60 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). The goal is to see if this combo can control the disease safely. Pa…

This study tests a new way to treat a fast-growing blood cancer called BCR-ABL positive B-cell acute lymphoblastic leukemia. About 80 adults will receive two drugs: ponatinib pills and blinatumomab injections under the skin. The goal is to see if this combination can control the …

This phase 1b trial tests an experimental drug called ST316 in adults with familial adenomatous polyposis (FAP) who have already had their colon removed but still develop new polyps. The study aims to see if ST316 is safe and can reduce the number and size of polyps that grow bac…

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This trial tests whether adding the immunotherapy drugs cemiplimab (with or without fianlimab) to standard chemotherapy before chemoradiation can improve outcomes for people with advanced nasopharyngeal cancer. About 60 adults with non-metastatic, EBV-positive nasopharyngeal carc…

This study is testing whether an experimental drug called FXS6837 can safely reduce protein in the urine and help preserve kidney function in people with IgA nephropathy, a disease that can lead to kidney failure. About 60 patients who previously completed a shorter study of FXS6…

This trial tests the drug mercaptopurine in people with hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a rare genetic condition that raises the risk of skin, uterine, and kidney tumors. The study aims to find the safest dose and see if the drug can shrink kidney canc…

This trial investigates whether a sensitive blood test (Signatera) can detect when it is safe to pause immunotherapy in people with advanced solid tumors like lung cancer, melanoma, and colorectal cancer. Participants are randomly assigned to either continuous standard immunother…

This phase 2 trial is testing whether the combination of avutometinib and defactinib can stop or shrink malignant peripheral nerve sheath tumors (MPNST) that have returned or cannot be removed with surgery. The study enrolls people over 12 years old with relapsed, refractory, met…

This trial is testing an experimental drug called GB268, a tri-specific antibody that targets three key pathways involved in cancer growth. It is being studied alone or in combination with other treatments in people with locally advanced or metastatic breast cancer. The goal is t…

This trial investigates whether eating purple-fleshed potatoes daily for four weeks can improve blood pressure and other heart health markers in men with prehypertension. Participants will consume either purple or white potato puree in a crossover design, with measurements taken …

This study tests a drug called 2-HOBA in 20 adults with salt-sensitive high blood pressure. The drug aims to calm overactive immune cells that may worsen blood pressure when salt is eaten. Researchers will measure blood pressure changes and blood vessel health after taking 2-HOBA…

This trial tests several drugs in people with NF2-related schwannomatosis, a condition that causes tumors on nerves and in the brain. The study uses a flexible 'platform' design to evaluate treatments for four tumor types: vestibular schwannomas, non-vestibular schwannomas, menin…

This phase II trial tests whether a personalized dendritic cell vaccine targeting the Survivin protein can improve survival in people with newly diagnosed glioblastoma, an aggressive brain cancer. Participants receive the vaccine alongside standard chemotherapy after surgery. The…

This trial tests the drug selumetinib in people with NF2-related schwannomatosis, a genetic condition that causes non-cancerous tumors on nerves, often leading to hearing loss. The study includes both adults and children whose tumors cannot be surgically removed or are growing. R…

This trial tests whether combining two drugs—luvometinib (a targeted therapy) and serplulimab (an immunotherapy)—can shrink tumors and improve hearing in people with NF2-related schwannomatosis. Participants have progressive vestibular schwannomas or meningiomas that are not suit…

This early-phase trial tests a combination of three drugs—selumetinib, ZEN-3694, and durvalumab—in people with advanced sarcomas, including malignant peripheral nerve sheath tumors (MPNST) linked to NF1. The study first checks safety and dosing, then looks at whether the treatmen…

This study tests whether pelvic floor muscle training (PFMT) with a handheld biofeedback device can improve erectile function and sexual quality of life in men with functional hypogonadism (low testosterone) and erectile dysfunction. Participants are randomly assigned to PFMT wit…

This study tests the drug upadacitinib (Rinvoq) in 30 people with rare genetic disorders that overactivate the JAK-STAT immune pathway. The trial has four phases over 12 months, including an open-label phase to find the best dose and a randomized withdrawal phase to compare the d…

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests whether a special device placed during disc surgery can help people return to normal activities faster by preventing the disc from herniating again. About 120 adults with a herniated disc in the lower back will be randomly assigned to different post-surgery activ…

This early-phase trial tests whether giving healthy stem cells from the mother to a fetus diagnosed with Fanconi anemia can safely improve the baby's blood cell production. The treatment is a one-time injection into the fetus during pregnancy. The study will enroll 12 pregnant wo…

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This phase 2 trial is testing a new way to treat adults newly diagnosed with a specific type of acute lymphoblastic leukemia (Ph-negative B-ALL). Instead of standard high-dose chemotherapy, patients receive a mix of low-dose chemo plus several targeted drugs (inotuzumab ozogamici…

This study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with PHTS and social difficulties will take either everolimus or a placebo for …

This phase 2 trial tests a combination of two drugs—becotatug vedotin (a targeted therapy) and pucotenlimab (an immunotherapy)—as a first treatment for advanced head and neck squamous cell carcinoma. It is for patients whose cancer has returned or spread and who cannot tolerate p…

This early-stage trial tests a new drug called LP-118 alongside standard treatments for adults newly diagnosed with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). The study will enroll 26 people to find the safest dose and see if the combination helps control the d…

This study tests two low doses of rapamycin, a drug usually used to prevent organ rejection, in 25 teenagers (ages 12-17) with familial adenomatous polyposis (FAP), a genetic condition that causes many colon polyps and raises cancer risk. The main goal is to see if the drug is sa…

This early-phase trial tests a gene therapy called VGN-R08b in 17 people with Parkinson's disease who have a GBA1 gene mutation. The therapy is injected directly into the brain's fluid spaces to try to improve symptoms. The main goals are to check safety and see if it works.

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This Phase 3 trial tests whether adding a targeted drug (Becotatug Vedotin) to standard immunotherapy and chemo-radiation can improve outcomes for people with high-risk nasopharyngeal cancer. About 514 participants will be randomly assigned to receive either the new combo or stan…

This study looks at whether people with type 1 diabetes can safely start using an advanced hybrid closed-loop insulin pump system at home instead of in the hospital. Researchers will track blood sugar levels, quality of life, and costs over 12 months in 80 adults. Participants re…

This phase 2 trial tests the drug mirdametinib, alone or with radiation, in people with NF1-related high-grade gliomas (aggressive brain tumors). It includes three groups: those with recurrent sporadic glioblastoma, newly diagnosed NF1-associated glioblastoma, and other NF1-relat…

This study tests an experimental drug called FXS6837 in 60 adults with IgA nephropathy, a kidney disease. Participants will receive either the drug or a placebo for about 6 months. The main goal is to see if the drug lowers protein in the urine, a sign of kidney damage.

This Phase 2 trial tests an experimental drug called HS-10542 in 90 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants will receive either a high dose, low dose, or placebo for a set period. The main goal is to see if the drug reduces prot…

This early-stage trial tests whether two cancer drugs, cabozantinib and selumetinib, can safely shrink plexiform neurofibromas in people aged 16 and older with neurofibromatosis type 1 (NF1). About 30 participants will receive the combination daily. The study first finds the safe…

This study compares a new method that combines a non-invasive genetic test (NICS) with artificial intelligence (AI) against the standard way of picking embryos by looks alone. It includes 520 women aged 35-43 or with a history of recurrent miscarriage who are doing IVF. The goal …

This phase 2 trial tests whether combining olverembatinib (a targeted pill) with inotuzumab ozogamicin (an antibody-drug conjugate) can clear remaining leukemia cells in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) who still have detectable …

This study tests giving an immunotherapy drug (pembrolizumab) before surgery to people with a specific type of colon cancer (dMMR). The goal is to see if the drug can shrink or eliminate the tumor so some patients may avoid surgery and instead be closely monitored. About 152 adul…

This phase 2 trial is testing whether a combination of the experimental drug QL1706, standard chemotherapy, and bevacizumab can shrink tumors in people with advanced non-squamous non-small cell lung cancer that has specific gene changes and has stopped responding to targeted ther…

This study tests whether giving immunotherapy drugs (nivolumab with or without ipilimumab) or immunotherapy plus radiotherapy before surgery can improve outcomes for people with a specific genetic type of colorectal cancer called MSI-H/dMMR. About 114 participants will be randoml…

This early study tests whether adding vitamin C to the drug methenamine hippurate (Hiprex) helps prevent recurrent urinary tract infections (UTIs) in women. Twenty women will take either Hiprex alone or Hiprex plus vitamin C for six months each, and researchers will compare how m…

This early-phase study tests whether combining focused ultrasound with the immunotherapy drug pembrolizumab is safe and feasible for people with recurrent glioblastoma, a severe brain cancer. Only 8 participants with a specific genetic feature (mismatch repair deficiency) will be…

This Phase 3 trial will test whether adding anlotinib (a drug that cuts off tumor blood supply) to standard immunotherapy and chemotherapy with radiation can improve outcomes for 412 people with high-risk nasopharyngeal cancer. Participants will receive either the new combo or st…

This study tests two immunotherapy drugs (iparomlimab and tuvonralimab) in 30 women with a specific type of endometrial cancer that is mismatch repair-deficient. The goal is to see if the treatment can make the cancer disappear or shrink enough to avoid surgery. Participants must…

This study tests a vaginal probiotic containing Lactobacillus crispatus, a 'good' bacteria, in women with recurrent urinary tract infections (UTIs). Over 150 participants will use the probiotic for 3 months, and researchers will measure how well the bacteria colonize the vagina a…

This phase 2 trial tests two different drug combinations given before surgery for people with a specific type of stomach cancer (dMMR/MSI-H). Participants will receive the immunotherapy drug adebrelimab plus either chemotherapy or another immunotherapy drug (SHR-8068). The goal i…

This phase 3 trial will test whether a shorter course of the immunotherapy drug tislelizumab, combined with chemotherapy and radiation, works as well as a longer course for people with advanced nasopharyngeal cancer. About 418 participants will be randomly assigned to receive eit…

This early-phase trial tests an oral drug called Trineumin (PRG-N-01) in 25 adults with neurofibromatosis type II (NF2), a genetic condition that causes non-cancerous tumors on nerves. The study has two parts: first finding a safe dose, then checking if that dose can shrink tumor…

This study reviews medical records of 103 adults with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) who received ponatinib as their first treatment in regular care. Researchers want to see how many patients achieve a complete molecular response (undetectable leukem…

This phase 2 trial will test a combination of immunotherapy drugs and chemotherapy given before surgery for people with a specific genetic subtype of stomach cancer (dMMR/MSI-H). The study aims to see how well this approach clears the tumor and to understand why some patients do …

This study tests whether giving two drugs (pembrolizumab and MRG-003) before standard chemoradiation can shrink tumors in people with advanced nasopharyngeal cancer linked to Epstein-Barr virus. About 35 adults with stage III-IVa disease will receive 3 cycles of the drug combo, t…

This early-stage trial tests an experimental drug called ACC-1898, taken as a daily pill, in adults with advanced solid tumors (like liver, kidney, or stomach cancer) that have not responded to standard treatments. The main goals are to find a safe dose and see how the body handl…

This study tests whether combining an immunotherapy drug (cadonilimab) with a chemotherapy pill (capecitabine) can prevent a rare mixed liver cancer from returning after surgery. About 75 adults who had their tumor completely removed but are at medium-to-high risk of recurrence w…

This study will track 600 people in Korea with advanced breast cancer who are already being prescribed Talzenna. Researchers will watch for side effects and see how well the drug works in everyday medical practice, not in a strict research setting. The goal is to confirm the drug…

This study tests whether adding NG101m capsules to standard chemoradiation helps people with newly diagnosed glioblastoma live longer. About 52 adults will receive NG101m alongside usual care. The goal is to see if the combination is safe and improves 2-year survival.

This study is looking at whether a blood test called Galleri can help detect ovarian cancer early in people with BRCA1 or BRCA2 gene changes, who are at higher risk. Participants will give a blood sample and answer questionnaires about their experience. The study will also check …

This trial is testing a new implantable sensor called the HALO System in people with type 1 or type 2 diabetes. The sensor is designed to continuously measure glucose, ketones, and lactate in the fluid just beneath the skin, which could give a more complete picture of metabolic h…

This study tests whether annual liquid biopsies (from blood, urine, stool, and vaginal swabs) can safely replace colonoscopies every 18 months for people with Lynch syndrome. 2,000 participants will be split into two groups: one gets standard care (colonoscopy every 18 months), t…

This trial tests three ways to manage urinary symptoms in women aged 65 and older who have frequent urinary tract infections. Some participants receive antibiotics right away, while others get treatment only after a urine test or a lab culture. The goal is to find out which appro…

This study will compare a new radioactive tracer, 18F-AmBF3TATE, to the standard tracer 68Ga-DOTATATE for PET scans in people with neuroendocrine tumors. The goal is to see if the new tracer is as good or better at finding tumors. About 51 participants will receive both tracers a…

This study tests whether a swallowable capsule camera (colon capsule endoscopy) can effectively screen for colorectal cancer in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. Researchers will compare the capsule's ability to find polyps and ot…

This study will test whether adding a T2 mapping sequence to a standard MRI can improve detection of early knee osteoarthritis. Researchers will compare MRI scans from 28 healthy volunteers and 28 patients with early OA. The goal is to see if this extra scan can measure cartilage…

This study compares a new DNA sequencing platform (MGI) against the current standard (Illumina) for diagnosing hereditary cancers like breast and ovarian cancer, Lynch syndrome, and intestinal polyposis. Researchers will analyze 248 patient samples using both platforms to see if …

This phase 1 trial tests whether sirolimus (rapamycin), an FDA-approved medication, can improve blood flow and energy use in the brains of women aged 45 to 65 who carry the ApoE4 gene — a gene that raises the risk of developing Alzheimer's disease. Participants are randomly assig…

This phase III trial tests whether a vaccine made from a person's own immune cells can prevent cancer in 372 adults with Lynch syndrome, a genetic condition that raises cancer risk. Participants receive either the vaccine or a placebo and are monitored for tumor development. The …

This early-phase trial tests a personalized vaccine made from a person's own immune cells (dendritic cells) loaded with cancer-specific markers. The goal is to train the immune system to recognize and destroy precancerous cells in people with Lynch syndrome, who have a high risk …

This study tests whether low doses of two hormone-blocking drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure side effects and quality of lif…

This study tests a language intervention called Milieu Teaching-AV for infants aged 6-12 months who have an older sibling with autism, putting them at higher risk for autism or language delays. The intervention encourages babies to look at caregivers' faces and mouths during play…

This study tests a robot-aided elliptical trainer designed to improve knee control in directions other than just bending and straightening. The goal is to reduce knee pain and improve function in 36 adults aged 45-85 with knee osteoarthritis. Participants will use the device to r…

This trial tests whether a hands-on spinal manipulation technique, called lever positioning manipulation, can ease the leg and back pain caused by a herniated disc. About 84 adults with a herniated disc will receive either the real manipulation or a sham version three times a wee…

This trial tests whether pain reprocessing therapy (PRT) — a brief psychological treatment that combines education, cognitive restructuring, and body-focused techniques — can reduce chronic pain. Adults with persistent pain lasting over three months are randomly assigned to full …

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether giving magnesium during back surgery can reduce the confusion and agitation some patients feel when waking up. 70 adults having a single-level lumbar microdiscectomy will receive either magnesium or a placebo. Researchers will monitor agitation, pain, and…

This study looks at two ways to help people recover after surgery for a slipped disc in the lower back. One group will start moving early, and the other will do the same plus get mild electrical stimulation on their muscles. The goal is to see which approach reduces pain and impr…

This study tests whether osteopathic manipulative treatment (OMT) — a gentle, hands-on therapy — can reduce the need for ear tube surgery in children with chronic or recurrent ear infections. Two hundred children aged 6 months to 7 years will receive either OMT or a placebo manua…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

This study looks at whether adding high-intensity laser therapy to exercise can reduce pain and improve daily function for people with a slipped disc in the lower back. About 150 adults aged 18 to 65 will be split into three groups: exercise alone, exercise plus laser, or exercis…

This study tests whether adding diphenhydramine (an antihistamine) to standard sedation medicine reduces pain during first-trimester abortion. About 98 adults will receive either diphenhydramine or a placebo alongside usual care. The goal is to see if this simple addition improve…

This study looks at whether doing physical therapy in the daytime or evening helps people with a herniated disc in their lower back sleep better and feel less sleepy during the day. It includes 60 adults who also have a high risk for obstructive sleep apnea. Participants will be …

This study tests whether using virtual reality to educate patients before lumbar disc surgery reduces their anxiety more than standard education. About 56 adults scheduled for back surgery will be randomly assigned to either a VR education session or routine education. Researcher…

This study looks at people with a single herniated disc in the lower back who are getting laser disc surgery. Some will also receive a steroid injection during the same procedure. Researchers will track pain, daily function, and need for more treatments to see if the extra inject…

This study compares two surgical techniques for fusing bones in the lower back: using two straight cages or one curved (banana-shaped) cage. The goal is to see which method provides better pain relief, faster recovery, and fewer complications. About 30 adults with chronic back pa…

This pilot study will test whether five weekly sessions of Swedish massage can reduce stress and improve blood sugar control in 20 adults with type 1 diabetes. Researchers will measure stress hormones, inflammation, and glucose levels before and after the massage program. The goa…

This study compares two types of nipple-sparing mastectomy: one done with a robotic arm through a small side incision, and the standard open surgery. Researchers want to see if the robotic method improves women's satisfaction, body image, and recovery over 12 months. The trial wi…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study will test two different levels of positive pressure (PEEP) on a breathing machine during lumbar spine surgery performed face-down. The goal is to see which setting helps patients breathe better and maintain good oxygen levels. Sixty adults aged 18-65 having elective ba…

This study looks at whether the stiffness of the cornea influences how much astigmatism (blurring from an irregularly shaped cornea) develops after cataract surgery in people with pseudoexfoliation syndrome, a condition that weakens eye tissues. Researchers will measure corneal b…

This study follows 70 adults aged 50 and older who are having routine cataract surgery. Half have pseudoexfoliation syndrome, a condition that can weaken eye tissues, and half do not. Researchers measure corneal stiffness before surgery and at several points afterward to see whet…

This study tests a program to help people with certain genetic mutations share their results with at-risk relatives and make informed decisions about genetic testing and care. About 2100 adults in the U.S. who speak English or Spanish will take part. The program provides free gen…

This study is creating and testing two new patient-reported tools to measure recurrent urinary tract infection (UTI) symptoms. One is a daily symptom diary for adults, and the other is adapted specifically for people aged 65 and older. About 200 participants with recurrent UTIs w…

This study looks at how people feel emotionally when they go through cancer genetic testing, and whether talking to a psychologist helps. It follows 220 adults who are having their first genetic counseling session. Some choose to use the psychological support offered, while other…

This study investigates why colorectal adenomas (precancerous polyps) sometimes return after being surgically removed. Researchers will collect tissue samples from 30 patients and use advanced genetic sequencing to compare polyps that recur with those that do not. The goal is to …

This study tests an online tool called 'Let's Talk' designed to help people with Lynch syndrome encourage their relatives to get screened for the condition. Lynch syndrome is a genetic disorder that raises cancer risk, and only about half of close relatives currently get tested. …

This study looks at whether a tumor's DNA repair status (MMR) changes how well the presence of cancer cells in lymph vessels predicts spread to lymph nodes in stomach cancer. Researchers will review medical records of 3,000 patients who had surgery. The goal is to improve risk as…

This study looks at why some women have abortions later in pregnancy (14-16 weeks) at Avignon Hospital in France. Researchers want to understand the personal, social, and healthcare barriers these women face. By interviewing 30 women, they hope to find ways to improve access to c…

This study reviews medical records of 120 adults with low back pain who completed 15 sessions of physical therapy. Researchers will group patients based on their MRI results (disc herniation, disc degeneration, or normal findings) to see if certain types of back pain respond bett…

This study will test how accurate and safe two continuous glucose monitoring (CGM) systems, the Anytime 5Pro and Anytime 4Pro, are in adults with type 1 or type 2 diabetes. About 70 participants will wear both devices at the same time and have their blood sugar measured during cl…

This study looks at the best way to help prostate cancer survivors learn about and get genetic testing for inherited cancer risks. About 500 participants will be randomly assigned to a digital guide, a printed guide, or standard care. Researchers will track who requests testing a…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study tests a web-based program called Kindred that helps African American families understand their genetic cancer risk and talk about testing. About 150 people will use the tool to see if it improves knowledge and testing rates. The goal is to make genetic information more…

This study tests whether a new online program can help families understand their inherited cancer risk and encourage relatives to get low-cost genetic testing. Researchers will enroll 400 adults who carry a cancer-related gene change and their family members. The goal is to see i…

This study looks at how young children with neurofibromatosis type 1 (NF1) walk, to see if simple walking tests can help doctors spot and predict movement problems early. Researchers will measure walking speed and other skills in 56 children under 6 years old. The goal is to crea…

This study tests a program to help people with inherited cancer gene mutations (like BRCA or Lynch syndrome) stick to recommended cancer screening schedules. Researchers will interview 80 female participants and provide standard care to see if this approach improves adherence and…

This study will collect blood and tumor tissue from up to 50,000 adults with hereditary or genetic-linked cancers. Researchers will use these samples to create lab-grown tumor models, like mini-tumors, to study how these cancers work and test new treatments. The goal is to better…

This study looks at whether one session of magnetic brain stimulation can temporarily change how the heart and brain communicate in women who have had multiple pregnancy losses and are overweight. Sixty women will receive either real or fake stimulation while their heart activity…

This study looks at how abnormal proteins, like alpha-synuclein and tau, build up and affect brain function in people with Parkinson's disease. Researchers will use brain scans, blood tests, and skin biopsies to track these changes. The goal is to find better ways to diagnose and…

This study looks at whether a polygenic risk score—a measure based on many small genetic variations—can help predict who might develop pancreatic ductal adenocarcinoma (PDAC). Researchers will compare the genetic profiles of about 1,140 people with and without the disease. The go…

This study looks at 96 adults with lower back pain to see if the damage shown on an MRI matches how much pain they actually feel. Participants will fill out pain and disability questionnaires and get a physical exam. The goal is to help doctors better understand and treat back pa…

This study aims to better understand a condition called multilocus imprinting disorder (MLID), where multiple genes are affected by abnormal chemical marks. Researchers will test a new technique to detect these marks in 96 people, including those with known imprinting disorders a…

This study looks at how overdose prevention centers (OPCs) in New York City impact the risk of fatal and non-fatal overdoses, as well as mental health crises, among adults who use multiple drugs. Researchers will track 500 people who use OPCs or syringe services to see if these c…

This study will test whether structured educational sessions can improve how maternity nurses care for patients experiencing abortion. Sixty nurses will attend training covering lectures, demonstrations, and discussions. Researchers will observe their practices before and after t…

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to fin…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at how a common genetic change (the T allele at rs7903146) affects the pancreas's own production of GLP-1, a hormone that helps control blood sugar. Researchers will give 80 healthy adults a drug that blocks GLP-1 receptors to see how their insulin and glucagon l…

This study will follow 120 adults with sciatica from a herniated disc who receive a standard steroid injection. Researchers want to see if the speed and pattern of pain relief in the first few days and weeks can predict whether the treatment is still working at 3 and 6 months. Pa…

This study aims to discover rare genetic changes that make people more likely to develop cancer. Researchers will collect blood, saliva, and tumor samples from 100 participants who have had multiple cancers or have a strong family history of cancer, along with their relatives. By…

This study will design and test web-based decision aids for parents in Canada considering screening their children for type 1 diabetes. Researchers will work with parents and experts to create the tools, then test them in online studies with 350 participants. The goal is to see i…

This study will observe how different spinal problems—like scoliosis, stenosis, or herniated discs—change the way people walk and use their back muscles. Researchers will compare 120 older adults (age 60+) with these conditions to healthy volunteers using motion cameras and muscl…

This study will test 100 women with repeated miscarriage of unknown cause for H. pylori infection using a stool test. The goal is to see if the infection is more common in these women. If a link is found, it may lead to future research on screening or treatment.

This study will follow 100 people who need a stoma (an opening in the belly to pass stool) after surgery. Some will have their stoma site marked and get education before surgery, while others will not. The goal is to see if these steps improve quality of life and reduce problems …

This study will include 30 people newly diagnosed with glioblastoma, the most common and aggressive brain tumor. Researchers will use a special MRI technique called magnetic resonance spectroscopy (MRS) to measure chemicals in the tumor, and also test blood for certain markers. T…

This study will follow 100 adults with diabetes and foot ulcers to see how non-vascular factors like nerve damage, infection, and poor blood sugar control affect ulcer severity and healing. Researchers hope to find which risk factors can be changed to prevent ulcers from coming b…

This study looks at how receiving positive urine culture results impacts stress levels and bladder symptoms in women with recurrent urinary tract infections (UTIs). Researchers will follow 170 women, including those with interstitial cystitis or bladder pain syndrome, using quest…

This study compares two minimally invasive surgical techniques—uniportal and biportal endoscopy—for treating a single-level lumbar disc herniation. Sixty adults aged 18-70 with persistent symptoms will be randomly assigned to one of the two procedures. The main goal is to see whi…