Could a stem cell shot before birth fix fanconi anemia?
NCT ID NCT07408583
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether giving healthy stem cells from the mother to a fetus diagnosed with Fanconi anemia can safely improve the baby's blood cell production. The treatment is a one-time injection into the fetus during pregnancy. The study will enroll 12 pregnant women and focus on safety for both mother and baby, while also checking if the stem cells help the child's bone marrow work better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- maternal bone marrow-derived CD34+ hematopoietic stem cells
- What this could lead to
- If it works, this could offer a way to treat Fanconi anemia before birth, potentially reducing the need for lifelong blood transfusions or later bone marrow transplants.
- What could go wrong
- This is a very early, small trial (12 participants) testing safety first. The procedure carries risks for both mother and fetus, and it is unknown if the stem cells will take hold or provide lasting benefit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Stanford University
Stanford, California, 94305, United States
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University of California, San Francisco
San Francisco, California, 94143, United States
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