Hypnic headache

This trial tests whether taking two inexpensive migraine prevention drugs together works better than taking either one alone. Adults aged 18 to 55 who have at least four migraines per month will receive propranolol, flunarizine, or both for 12 weeks. The goal is to see which appr…

This study tests whether a set of dietary supplements taken at different phases of a migraine cycle can improve quality of life and reduce headache days in adults with migraine. Participants take a daily foundational supplement, with additional supplements during the luteal phase…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This pilot study tests a procedure called TEMMA, where doctors insert small coils into an artery in the lining of the brain to treat migraine. The study will enroll 25 adults aged 18-60 who have migraine at least 8 days per month and have not gotten relief from at least two preve…

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild brain injury, can reduce headache days and prevent short-term post-traumatic headaches from becoming long-term. About 80 adults with migraine-like post-traumatic headaches will receive eithe…

This study tests whether a single injection of fremanezumab, a drug used to prevent migraines, can stop acute mountain sickness (AMS) in healthy adults. Thirty volunteers will receive either the drug or a placebo one week before climbing to a high-altitude hut. Researchers will t…

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over …

This study will test two FDA-approved migraine drugs, rimegepant (a tablet that dissolves on the tongue) and zavegepant (a nasal spray), in 100 adults visiting the emergency department for a migraine. The goal is to see if these drugs provide pain relief within 2 hours without ne…

This study tests whether neurofeedback—a type of brainwave training—can help adults with episodic migraine have fewer and less severe headaches. Participants will undergo 60 sessions over 12 weeks, learning to regulate their brain activity through real-time feedback. The goal is …

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests a physiotherapy program that combines neck muscle exercises with a gentle nerve stimulation technique (transcutaneous vagus nerve stimulation) in 50 adults with migraine. The goal is to see if this approach can reduce pain, improve daily function, and boost quali…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tests a virtual behavioral program for people with chronic migraine. Researchers want to find the best combination of techniques and see if letting patients choose their treatment helps. The goal is to reduce migraine frequency and intensity.

This study tests whether an 8-session self-hypnosis program, delivered online in groups, can help adults with migraines reduce disability and improve well-being. Forty participants are randomly assigned to either the hypnosis training or a waitlist. The program teaches self-hypno…

This study tests whether adding fire needling (a technique using heated needles) to standard acupuncture can better reduce headache days in people with both chronic migraine and tension-type headache. Eighty-eight adults will receive either the combined treatment or acupuncture a…

This study tests if a procedure called middle meningeal artery embolization can help people with frequent migraines. The procedure uses tiny coils to block a blood vessel in the head. Researchers want to see if it reduces migraine days and the need for migraine medications. The s…

This study looks at whether anti-IL-6 drugs, used for inflammatory conditions like rheumatoid arthritis, can also reduce migraine frequency and intensity. Researchers will compare 320 people taking anti-IL-6 drugs to those on anti-TNF drugs. Participants will report how their mig…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This study compares a combination of two drugs (dexamethasone and metoclopramide) against standard painkillers (paracetamol or NSAIDs) for treating severe primary headaches in the emergency department. 94 adults aged 18-60 with a pain score of 5 or higher will be randomly assigne…

This study tests whether using a virtual reality headset to practice a type of mindfulness therapy called Acceptance and Commitment Therapy (ACT) can reduce migraine-related disability. About 160 adults with episodic migraine will either continue their usual care or add VR sessio…

This study tests whether a nerve block injection at the back of the head can help people with migraine who overuse painkillers. The injection contains lidocaine and a steroid. 130 participants will receive either the active injection or a placebo. Researchers will track headache …

This study will monitor the safety and effectiveness of NURTEC ODT 75 mg (rimegepant) in 3000 Korean adults with migraine. Participants will take the drug as prescribed for acute attacks or prevention. Researchers will track side effects and how well the drug works, including pai…

This study tests whether a new drug called NB001 can quickly stop migraine pain and other bothersome symptoms. About 120 adults with migraines will take different doses of NB001 or a placebo at the start of an attack. Researchers will check if pain and symptoms go away within 2 h…

This study tests whether osteopathic manipulation—gentle manual techniques on the neck and head—can reduce migraine pain and its impact on daily life. 45 adults with frequent migraines will receive the therapy. The goal is to see if this drug-free approach offers real relief.

This study tests three different types of tinted lenses—FL41 glasses, Biomedics55 contacts, and Altius grey-green contacts—to see which works best for reducing light sensitivity (photophobia) in people who get migraines or have other eye conditions. About 200 volunteers who have …

This study tests whether combining Botox injections with a nerve block at the back of the head works better than either treatment alone for chronic migraine. About 90 adults with frequent migraines will receive one of the treatments or both. The goal is to see if the combination …

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This study compares two procedures—a nerve block and a pulsed radiofrequency treatment—to see which works better for people with chronic migraine. About 70 adults who have not found relief from standard treatments will take part. The goal is to reduce headache pain and improve qu…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This early-phase trial at Boston Children's Hospital will test whether adding virtual reality (VR) to standard treatments like biofeedback and cognitive behavioral therapy can help 12 adolescents with chronic dizziness. The goal is to see if VR can safely and feasibly reduce dizz…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This pilot study tests whether manual lymphatic drainage, a gentle massage technique, can help people with migraine. Twenty adults aged 20-55 who have at least 4 migraines per month will receive either the massage or standard care. Researchers will measure pain, disability, and q…

This study tests a minimally invasive nerve treatment called pulsed radiofrequency (PRF) for chronic migraine in people aged 65 and older. The goal is to see if it reduces pain and headache days, and to find out which patients respond best. Researchers will also look at frailty a…

This study will test whether a smartphone app called Health enSuite Migraine can help people aged 18 to 50 reduce how often they get migraine headaches. The app teaches simple techniques like managing triggers, relaxing, and changing negative thoughts. About 415 Canadian adults w…

This pilot study tests a new, non-drug treatment for vestibular migraine, a condition causing repeated dizziness and headaches. Fifty adults will receive either real or sham electrical stimulation behind the ears over six sessions. The main goal is to see if the treatment is safe…

This study tests if injecting the numbing medicine lidocaine into two brain arteries can ease chronic, hard-to-treat migraines. About 80 adults with severe migraines will receive either the injection or a placebo, and researchers will track changes in headache impact over time. T…

This study looks at whether eating less glutamate—a natural compound found in many foods—can reduce the number and severity of migraine attacks in adults. Forty participants will either follow a low-glutamate diet or continue their usual eating habits while tracking their headach…

This study tests whether a personalized physiotherapy program—including manual therapy, neck exercises, balance training, and pain education—can reduce pain, fatigue, and improve physical function in people with migraine. Fifty adults aged 18-55 with 2-8 migraine attacks per mont…

This study tests a headband-like device called Nettle that delivers gentle electrical stimulation to parts of the brain involved in pain. Twenty adults with chronic migraine will use it at home for 20 minutes each day over three months. The main goal is to see if people can stick…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study tests whether adding gentle eye muscle techniques to standard neck and jaw manual therapy can reduce pain and disability in people with migraine without aura. Eighty-four adults aged 18–65 will receive six physiotherapy sessions over eight weeks. Half will get the comb…

This phase 2 trial tests whether low sodium oxybate (Xywav) can reduce nighttime cluster headache attacks in people with chronic cluster headache. About 52 participants will receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug lowers the number o…

This study will test CGRP-targeted medications in 2,000 Chinese adults with vestibular migraine, a condition causing severe vertigo and dizziness. The goal is to see if these drugs can reduce the severity and frequency of attacks, both as immediate treatment and for prevention. P…

This study will follow 460 migraine patients who receive a nerve block injection in the back of the head. Researchers want to find out which patient traits—like migraine type or headache patterns—predict a good response. The goal is to help doctors choose the right treatment for …

This study will test whether using a mind-body mobile app combined with a guided, gentle movement program can help people with chronic pain. One hundred adults aged 19 to 75 with persistent pain for at least 6 months will use the app daily and follow audio-guided movement session…

This study looks at whether a type of immune cell called regulatory T cells works properly in people with chronic migraine. Researchers will compare blood samples from 24 women with chronic migraine to healthy controls. The goal is to understand if problems with these cells contr…

This study follows 50 adults with migraines who have had or plan to have a procedure called middle meningeal artery embolization as part of their regular care. Researchers will look at how headache frequency, severity, medication use, and quality of life change over 12 months. Th…

This study will test whether wearing a magnet helmet every day can change brain inflammation linked to migraines. Ten adults with migraines will use the helmet and have brain scans before and after the treatment period. Researchers will also track migraine symptoms through questi…

This study will measure how sensitive people with episodic and chronic migraine are to pressure pain, and how that relates to their headache burden and quality of life. Researchers will compare a standard pressure pain device with a new tool called Algopeg, which is like a calibr…

This study looks at whether people with migraine have different motor imagery abilities—like mentally picturing movements—compared to healthy people. Researchers will use questionnaires, mental timing tests, and brain scans to measure these abilities. They also want to see if the…

This study aims to validate a questionnaire called VM-PATHI for adolescents aged 10-20 with vestibular migraine, a condition causing dizziness and other symptoms. Researchers will test whether the tool accurately measures symptom severity and meaningful improvement. About 70 part…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …

This study aims to find out how often headaches happen in people with MOGAD, a rare disease that affects the brain and nerves. Researchers will look at the medical records of 25 adults and also follow them forward in time to describe headache patterns. The goal is to better under…

This study gives a natural brain chemical called adrenomedullin to 26 people with migraines to see if it triggers an attack. Participants first receive a migraine-preventing drug (erenumab) to block related receptors. The goal is to understand how migraines start, not to test a n…

This study compares uric acid levels in 80 adolescents (12-18 years) with and without primary headaches. Researchers aim to see if there is a link between uric acid and headaches, which could help understand what causes them. Participants will provide a blood sample and have thei…

This study looks at whether pramlintide, a drug similar to the hormone amylin, can cause migraine attacks in people who get migraines without aura. Researchers will give 21 participants either pramlintide or a placebo and watch for headaches over 12 hours. The goal is to understa…

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

This study will give 21 people with migraine with aura an infusion of a protein called PACAP-38, or a placebo, to see if it can trigger an aura attack. The goal is to better understand what causes migraine aura, not to test a treatment. Participants will be monitored for 12 hours…

This study will use a non-invasive technique called transcranial magnetic stimulation (TMS) to measure brain activity in 20 people—10 with migraine and 10 healthy controls. By comparing how the brain's motor cortex responds, researchers hope to learn more about how migraine affec…

This study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…