Hypnic headache

This study looks at how well the migraine prevention drug atogepant works in real-world settings. Over 1000 adults with migraine who are already prescribed atogepant will be followed for 2 years. Researchers will measure how much patients feel their migraines have improved since …

This study tests whether Dysport injections can prevent chronic migraines in adults. Chronic migraine means having at least 15 headache days per month, with 8 being migraines. Participants receive injections into head, neck, and shoulder muscles every 12 weeks for up to 60 weeks.…

This trial tests a nasal spray called MIG-SPRAY for preventing migraines in 45 adults aged 18-55. The spray forms a protective film inside the nose to possibly stop migraine triggers. Participants use it three times daily for three months, and researchers track side effects and m…

This study tests whether galcanezumab, a monthly injection, can prevent chronic migraine in 312 adolescents aged 12 to 17. Participants receive either the drug or a placebo for 3 months. The main goal is to see if the drug reduces the number of migraine days per month.

This study compares two treatments for chronic migraine: a nerve block and a radiofrequency procedure. Researchers will measure blood levels of migraine-related proteins (CGRP and PACAP38) before and one month after treatment. The goal is to see which procedure works better and w…

This study tests whether galcanezumab, a monthly injection, can prevent migraines in children and teens aged 6 to 17 with episodic migraine. Over 500 participants received either the drug or a placebo for 3 months. The goal is to see if the drug reduces the number of migraine day…

This study is tracking 500 Italian adults with migraine to see how well the daily pill atogepant works in everyday life. Researchers will measure changes in monthly migraine days over a year. The goal is to find out if atogepant is a safe and effective preventive treatment for pe…

This phase 3 study tests whether erenumab (Aimovig), a monthly injection already approved for adults, can prevent migraines in children aged 6 to 17 with episodic migraine. About 457 participants receive either the drug or a placebo for 3 months. The main goal is to see if the dr…

This study tests a new medicine called atogepant to prevent migraines that happen around a woman's period. About 430 adult women with regular cycles and a history of migraines will take either atogepant or a placebo daily for 3 menstrual cycles. The goal is to see if the drug red…

This phase 3 study tests whether Dysport (a botulinum toxin type A) injections can prevent episodic migraine in adults. About 751 participants receive either Dysport or placebo injections every 12 weeks for up to 36 weeks. The goal is to see if the treatment reduces the number of…

This study tests whether desvenlafaxine, a drug typically used for depression, can help prevent migraines in adults who have frequent attacks. Researchers will compare the drug to a placebo in 440 participants over 12 weeks. The goal is to see if it reduces the number of migraine…

This pilot study is testing whether yoga-based movements, done online or in person, can help people with chronic migraine or cluster headache. Twenty adults aged 18-65 will participate. The goal is to see if yoga improves headache frequency, sleep quality, and overall well-being …

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

This study looks at whether a treatment called pulsed radiofrequency (PRF) on a nerve at the back of the head can help people with migraines. Researchers measured pain sensitivity and disability in 100 adults before and up to 3 months after the procedure. The goal is to see if th…

This study tests whether a brief behavioral class called Empowered Relief can reduce disability and symptoms in adults with chronic migraine. 300 participants will be randomly assigned to the class, a health education session, or usual care, all done remotely. The goal is to see …

This pilot study tests whether a 7-week virtual lifestyle medicine program can help teens aged 14-18 with frequent migraines. Participants attend weekly group sessions covering sleep, nutrition, stress management, physical activity, and social connection. The main goal is to see …

This study is testing a new device that uses gentle vibrations on the belly, back, or temples to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, or migraine. About 50 adults will try the real device or a placebo to see if it safely reduce…

This early study tests a new device called PRIMUS that stimulates nerves in the head and face to treat chronic migraine. Only 7 people with hard-to-treat migraines are taking part. The main goal is to see if the device is safe, not yet if it works.

This early study tests the safety of a new device called PRIMUS that uses mild electrical pulses on nerves in the forehead and back of the head to treat chronic cluster headache. Five people with frequent, hard-to-treat attacks will be enrolled. The goal is to see if the device i…

This study tests whether a mindfulness-based program (MBCT) delivered by phone or video can help people with migraines and depressive symptoms. About 145 adults with 4-20 headache days per month and mild to moderate depression will be randomly assigned to phone, video, or usual c…

This study tests a device that uses mild electrical pulses to treat chronic migraine. About 250 adults with frequent, hard-to-treat migraines will receive either the active device or a sham (inactive) device. The goal is to see if the device safely reduces the number of headache …

This study tests whether a program combining exercise, healthy eating advice, and education about migraine can reduce the number of attacks in people with frequent or chronic migraines. About 140 adults who are not very active will take part. The goal is to see if lifestyle chang…

This study tests an online program called Migraine Manager for teens aged 11 to 17 with frequent migraines (8 or more per month). The tool gives personalized tips on healthy habits like drinking water, eating regularly, exercising, and sleeping well. Researchers will compare 80 t…

This study was designed to see whether the drug amitriptyline or lifestyle changes work better for people with vestibular migraine, a condition that causes dizziness and headache. The plan was to randomly assign adults with definite vestibular migraine to one of the two treatment…

This study tests whether inhaling lavender, peppermint, or a mix of both can change how sensitive people with migraine are to pressure pain. Two hundred adults with migraine will inhale one of the oils or a control solution for 15 minutes. Researchers measure pain thresholds befo…

This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main go…

This study tests a small device that sends gentle electrical pulses to nerves far from the head (called Ultra-Distal TENS) to see if it can reduce migraine pain and related symptoms like nausea and sensitivity to light or sound. About 206 adults with frequent migraines will use t…

This study tests whether a medicine called fremanezumab can reduce migraines that happen around a woman's period. Women aged 18 to 45 with menstrual migraines will get either the medicine or a placebo injection every three months for six months. Researchers will track migraine da…

This pilot study aimed to see if blocking a specific artery in the brain could help people with chronic migraines that don't respond to drugs. The procedure, called middle meningeal artery embolization, uses tiny particles or coils to block the vessel. However, the study was with…

This study looks at how well Rimegepant works for treating migraine attacks in everyday life. About 3,000 adults with migraine will take the drug as prescribed by their doctor and report their pain levels, relief timing, and satisfaction. The goal is to see if Rimegepant helps re…

This study tested whether a nasal spray called zavegepant could relieve migraine pain within 2 hours. Adults with migraines for at least a year were to use the spray at home for up to 4 attacks. The study was withdrawn before enrolling participants, so no results are available.

This study looks at whether using the Nerivio wearable device more frequently than the label says is safe for people with migraines. About 2000 participants who already use Nerivio will use it at higher frequencies. The goal is to check for side effects and see if it remains safe…

This study tests an 8-week app-based breathing program that uses heart rate feedback to help people with chronic migraine. Thirty adults will use the app daily for 10 minutes, and researchers will track changes in migraine frequency and psychological well-being. The goal is to se…

This study looks at whether acupuncture can reduce migraine pain and lower signs of inflammation and brain stress in the blood. Researchers will compare three types of gentle stimulation: laser, electro, and traditional acupuncture. 75 adults with migraines will receive treatment…

This study planned to test a combination of naltrexone and acetaminophen for treating migraine attacks. It was designed in two stages: first comparing the combo to each drug alone and placebo, then finding the best dose. However, the trial was withdrawn before any participants we…

This pilot study is testing whether the Transcendental Meditation technique can reduce how often migraines happen and how much they interfere with daily life. Thirty adults with migraines will practice meditation twice a day for 20 minutes over three months while continuing their…

This study tests whether common migraine medications can reduce the impact of sudden tinnitus (ringing in the ears) in 100 adults aged 25 to 85. Participants receive the drugs and complete questionnaires about their symptoms, plus brain scans to look for changes. The goal is to f…

This study tests a client-centered coping skills training program for people with migraine. Over 8 sessions, participants learn techniques like stress management and activity pacing to reduce pain and improve quality of life. The trial follows 60 adults for 6 months to see if the…

This study looks at whether data from wearable devices like smartwatches can track and even predict migraine headaches. Twenty adults with chronic migraine will use a phone app and a smart device to record heart rate and movement. The goal is to see if this information can help f…

This study looks at whether brain scans can help predict which people with migraine will respond to a class of drugs called CGRP antibodies. Researchers used MRI to measure brain structure, activity, and blood flow in 219 adults with frequent migraine before and after 12 weeks of…

This study uses brain scans to see how the brainstem and other brain areas respond to mild electrical pulses on the face and arm in 40 healthy volunteers. The goal is to better understand the brain circuits involved in facial pain and touch, which could help future research on mi…

This study follows 250 adults in the UK who already use rimegepant for migraine attacks. Over 12 weeks, they report how quickly the drug eases pain and other symptoms. The goal is to see how consistently rimegepant works in everyday life.

This study compares 120 adults with primary headaches (migraine or tension-type) to healthy individuals. Researchers will measure tenderness in head and neck muscles and general pain sensitivity elsewhere in the body. The goal is to understand how these factors relate to headache…

This study looks at how headaches work by using capsaicin (the spicy part of chili peppers) and ice water to trigger mild, temporary pain in people with and without headache disorders. Researchers measure changes in pain signals and tear production to better understand conditions…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study looks at whether the migraine medication rimegepant is safe to take during pregnancy. Researchers will compare pregnancy outcomes in women who took rimegepant to those who did not. The study includes women aged 16 to 49 with migraine. However, only one person has been …

This study looks at how headaches, especially migraines, affect the work and daily life of Libbs employees. Researchers will analyze data already collected from over 1,300 workers through a health app. No new treatments or tests are given—the goal is to understand headache patter…

This study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is …

This study explores how sex hormones (like testosterone and estrogen) during puberty relate to migraine pain and sensitivity in adolescents aged 11-15. Researchers will test pain responses and track migraine disability in 100 teens with and without migraines. The goal is to bette…

This study from the Cleveland Clinic is looking at whether certain migraine medications (CGRP inhibitors) can also improve bladder symptoms like urgency, frequency, and pain. About 200 women with hard-to-treat migraines and bladder issues will be followed for 3 months. Their symp…

This study looks at whether alexithymia—trouble recognizing or describing emotions—is linked to how often women get migraines. Researchers will track 350 female migraine patients aged 12-65 using questionnaires. The goal is to understand if emotional awareness affects migraine se…

This study looks at how a high-fat, high-carb meal affects inflammation and stress responses in women with migraine compared to healthy women. Thirty women aged 18-35, with and without migraine, will have blood tests and pain tests after eating a test meal. The goal is to underst…

This study uses advanced MRI scans and artificial intelligence to investigate small brain spots called white matter hyperintensities (WMH) in women with migraine. Researchers aim to tell these spots apart from those caused by other conditions like multiple sclerosis or small vess…