ER headache relief: could a steroid combo beat standard painkillers?
NCT ID NCT07605065
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a combination of two drugs (dexamethasone and metoclopramide) against standard painkillers (paracetamol or NSAIDs) for treating severe primary headaches in the emergency department. 94 adults aged 18-60 with a pain score of 5 or higher will be randomly assigned to one of the two treatments. The goal is to see which approach provides faster and more effective pain relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dexamethasone plus metoclopramide (given intravenously)
- What this could lead to
- If it works, this could offer a faster, more effective way to relieve severe headaches in the emergency room.
- What could go wrong
- This is a small, single-hospital trial (94 people) and may not apply to all headache types. Side effects from the drugs are possible.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.