Heart disorder

This international registry study looks at a small device called a transcatheter pulmonary flow restrictor, which doctors implant in the lung arteries of young children with congenital or acquired heart disease. The goal is to see whether the device safely and effectively control…

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests whether a procedure called pulsed field ablation (PFA) is safer and more effective than anti-arrhythmic drugs as a first treatment for people with persistent atrial fibrillation, a type of irregular heartbeat. About 484 participants will be randomly assigned to r…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This trial tests whether taking a 15-minute hot bath after each exercise session improves recovery in people who recently had a heart attack. Half of the 30 participants will do standard exercise rehab plus hot water immersion, while the other half does exercise alone. The study …

This study follows 250 people with severe aortic stenosis who receive the SAPIEN 3 transcatheter heart valve as part of their standard care. The goal is to see how safe and effective the valve is over the long term in everyday clinical practice. Researchers will track how many pa…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This study tests whether using the Impella heart pump during a high-risk stenting procedure helps people with weak hearts and blocked arteries. About 1,250 participants will be randomly assigned to get either Impella-supported stenting or standard care. The goal is to see if the …

This study tests a small sensor implanted in the lung artery that sends daily pressure readings to doctors. It involves 81 adults with advanced heart failure (NYHA Class III). The goal is to see if the device is safe and accurate, helping patients avoid hospital stays by catching…

This study tested a small sensor placed in the lung artery to help doctors monitor heart failure patients remotely. 738 people with advanced (NYHA Class III) heart failure took part. The goal was to see if using the sensor could reduce hospitalizations and deaths compared to a ta…

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart at…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 patients aged 70 and older with heart block. The goal is to see if the leadless version works just as well for exercise capacity. Participants are randomly assigned to receive one …

This study tests whether a new leadless pacemaker (Micra AV) is better than a traditional wired pacemaker for people aged 75 and older with heart block. The goal is to see if the leadless device improves quality of life, patient acceptance, and exercise ability. Eighty participan…

This study tests a new device called the PULSTA valve, which is placed inside the heart through a tube in a blood vessel, avoiding open-heart surgery. It is for 58 people with a leaky or narrowed pulmonary valve, often due to a birth defect. The goal is to see if the valve is saf…

This study tests a new device called the Cardiovalve, which is threaded through a blood vessel in the leg to fix a leaky mitral valve without open-heart surgery. It includes 30 people with severe mitral regurgitation who are too high-risk for traditional surgery. The goal is to s…

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study is tracking 251 patients with symptomatic coronary heart disease who received the EucaLimus stent, a sirolimus-coated device designed to keep arteries open. The goal is to see how well the stent works and how safe it is over the long term in real-world use. Researchers…

This study compares two types of stents (small mesh tubes) used to open blocked heart arteries in people with severe three-vessel coronary artery disease. About 1,550 participants will receive either the SUPRAFLEX Cruz or SYNERGY stent. The goal is to see which stent is safer and…

This study tests a temporary heart pump called the Supira System in 71 people with severe coronary artery disease who need a high-risk procedure to open blocked arteries. The pump supports the heart for up to 4 hours during the procedure to prevent dangerous drops in blood pressu…

This study is tracking 282 patients with coronary artery disease who received a paclitaxel-coated balloon catheter (Support C DCB) during routine care. Researchers are monitoring for heart-related events like cardiac death, heart attack, or the need for repeat procedures over the…

This study tests a new, less invasive heart valve (SAPIEN 3) for people with severe aortic stenosis who are at low risk for standard surgery. About 1,000 participants will be randomly assigned to get the new valve or traditional open-heart surgery. The goal is to see if the new v…

This study tests whether colchicine, a drug used for gout, can improve blood vessel stiffness and heart function in people with high blood pressure. About 150 adults with hypertension and additional risks like diabetes or high cholesterol will take colchicine or a placebo daily f…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This study is testing whether a machine learning algorithm can accurately detect heart murmurs that point to structural heart disease. Researchers will record heart sounds from 125 adults using two different digital stethoscopes and compare the algorithm's findings to standard ec…

This Phase 3 trial tests whether NH002, a contrast agent made of tiny gas-filled microspheres, can improve the quality of heart ultrasound images in people with heart disease. Participants receive NH002 through an IV before a standard echocardiogram. The study compares the clarit…

This study tests whether combining an AI-enhanced electrocardiogram (ECG) with a focused heart ultrasound can better detect structural heart disease in people without symptoms. About 2,705 adults with no known heart problems will get an AI-ECG, and if it flags a concern, they'll …

This study is testing whether a smart blood pressure cuff called the Withings BPM Core can accurately detect atrial fibrillation, a common heart rhythm problem. Researchers will compare the device's single-lead ECG readings to a standard 12-lead ECG in 160 adults. If it works wel…

This study will screen 200 adults in urban Cameroon for undiagnosed cardiometabolic disease risk factors like high blood pressure, diabetes, and obesity. Participants will receive a simple health check to find hidden conditions. The goal is to improve early detection and connect …

This study is testing whether a new risk score can help find people who have atrial fibrillation (an irregular heartbeat) but don't know it yet. About 1,955 adults at higher risk will use a remote ECG monitor at home. The goal is to see if the risk score correctly identifies who …

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This study compares a common heart procedure called pulmonary vein isolation (PVI) to a fake (sham) version to see if it truly reduces symptoms of atrial fibrillation. About 262 people with symptomatic AF will be randomly assigned to receive either the real procedure or a sham pr…

This study tests which nerve block technique better controls pain after open-heart surgery. 66 adults will receive one of two ultrasound-guided injections before surgery. The goal is to reduce the need for strong painkillers (opioids) and improve comfort during recovery.

This study tests whether an 8-week mindfulness meditation program (MBSR) can reduce anxiety and depression in heart patients who have completed cardiac rehab. About 74 participants will either take the meditation course or continue with standard rehab. Researchers will measure ch…

This study tests a culturally tailored counseling and support program for Chinese and Korean American caregivers of relatives with dementia. The program includes family counseling sessions and online peer support groups. Researchers will measure whether it reduces stress, depress…

This study tests whether adding blood flow restriction (BFR) to standard resistance training helps heart rehab patients get stronger and healthier. Twenty adults with stable heart disease will do exercises with and without a special cuff that limits blood flow to the arms and leg…

This study tests whether a nerve block given before heart surgery can reduce pain and the need for opioid painkillers afterward. About 150 adults having heart surgery will receive either a long-acting or standard form of the numbing drug bupivacaine via ultrasound-guided injectio…

This study tests a short program that helps heart patients and their families explore what gives life meaning during cardiac rehab. About 80 people in Denmark will try one of three formats: one-on-one, with a relative, or in a group. The goal is to see if this approach can reduce…

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

Researchers in Uzbekistan are studying common respiratory and heart conditions in children from birth to age 15. They will analyze medical records and examine blood samples to understand immune and antioxidant function in affected children. The goal is to develop and test improve…

This study looks at whether training doctors on quickly starting and adjusting heart failure medications (called GDMT) during a hospital stay leads to better treatment after discharge. About 438 adults with heart failure and reduced ejection fraction will be observed across multi…

This study evaluates an AI system designed to help people with little ultrasound experience capture clear images of the heart. Researchers will review previously recorded ultrasound clips to see if the system's on-screen guidance correctly corrects the probe position and whether …

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease.…

This study collects blood and tissue samples from up to 500,000 adults, including heart patients, their family members, and healthy individuals. Researchers will analyze these samples to find molecular and genetic markers linked to heart disease. The goal is to improve understand…

This study follows over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to under…

This study investigates whether a protein called DISC1, known for its role in schizophrenia, is also linked to heart function in people with the condition. Researchers will measure DISC1 levels in blood and use heart imaging (echocardiograms, cardiac MRI, and ECGs) to assess hear…

This study follows over 6,000 people over many years to see if feelings like hostility and other psychological factors are linked to heart disease. Researchers are tracking who develops heart problems and looking for patterns. The goal is to better understand how our minds and em…

This study is gathering health information from 4,600 people in rural areas of Alabama, Kentucky, Louisiana, and Mississippi. Researchers will look for risk factors that lead to heart and lung disease. No treatments or drugs are being tested. The goal is to learn more about what …

This study follows about 35 people with dilated cardiomyopathy caused by a BAG3 gene mutation, a condition that weakens the heart muscle. Over three years, researchers will monitor heart function, symptoms, and quality of life using tests like imaging and blood work. The goal is …

Over two million people in the UK have a chronic condition like diabetes or heart disease without knowing it. This study will use information from 4.5 million hospital patients to build a digital platform that spots those at risk. The goal is to help doctors diagnose these condit…

This study looks at whether a pre-surgery test called FFR can predict how well arterial bypass grafts work six months after coronary artery bypass grafting (CABG). About 120 patients with multi-vessel heart disease will have an FFR test during their diagnostic angiogram. Six mont…

This study is a large registry that collects medical data and tissue samples from 30,000 people with heart disease and healthy volunteers. Researchers will analyze this information to better understand risk factors, treatments, and outcomes for various heart conditions. The goal …

This study tests whether the PulsePoint app can increase the number of people who receive CPR or a defibrillator from bystanders before paramedics arrive. About 340 adults who suffer sudden cardiac arrest in public places will be included. Half of the 911 calls will trigger the a…

This study enrolls 80 people with implanted heart devices to see if collecting extra health data from wearables and a phone app can improve care. Participants must have had a heart failure event in the past year. The goal is simply to gather data, not to test a new treatment.

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study tests whether changing how people interact in online social networks can improve their attitudes and intentions toward COVID-19 vaccination. Over 4,400 adults in the US with internet access will be placed into different online groups and answer health questions while s…

This study looks at whether adding special blood tests (biomarkers) to the usual heart-lung exam can help doctors pick the right therapy for people with pulmonary hypertension. About 100 adults undergoing a routine heart catheterization will have extra blood samples taken from th…

This study tests a smartphone app that listens to your voice to catch early signs of heart failure getting worse. 123 people who were in the hospital for heart failure will record their voice daily for 6 months. The app looks for voice changes that might signal a problem, but doc…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This study looks at how the heart changes after a procedure to replace a leaky tricuspid valve in people with severe heart failure who cannot have open-heart surgery. It focuses on patients who develop unstable blood pressure right after the procedure. Researchers will track surv…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study tests whether an educational video can help adults with serious cancer understand and use palliative care. 172 participants will either receive standard care plus brochures, or standard care plus a tailored video and extra materials. Researchers will track knowledge, a…

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive strategy (like stents or bypass surgery) plus medication, or medication alone. Researchers want to see which approach leads to better survival over 10 years. The goa…

This study follows over 2,300 South Asian adults in the US to understand why they have high rates of heart disease and stroke, even without traditional risk factors. Participants are aged 40-84 and have no prior heart events. Researchers will track heart scans, diabetes, and othe…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study follows 450 people starting or continuing gender-affirming hormone therapy to see how it affects their heart and blood vessels over time. Researchers will use advanced heart scans, blood tests, and surveys to track changes. The goal is to provide clear information abou…

This study follows 30 people with mucopolysaccharidoses (MPS) over three years to see how their heart and arteries change. Researchers use neck ultrasounds and blood tests to measure artery thickness, stiffness, and signs of inflammation. The goal is to better understand cardiova…

This study tests newer ways to perform heart MRI that capture how the heart and lungs interact during breathing. Researchers will compare these methods to standard scans in 100 people with heart disease. The goal is to see if the new software produces clearer images and is practi…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring them for delayed effects on cancer, dementia, disability, and death. The goal is to see if aspirin has any long-term benefits or risks years after stopping the …

This registry follows 75 pregnant women with heart disease to better understand the risks and outcomes for both mother and baby. Researchers will track health data for one year and check vital status at five years. The goal is to fill knowledge gaps and improve future care for th…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study looks at whether giving people a personalized genetic risk score for coronary artery disease helps doctors make better decisions about prevention. About 1,000 adults with moderate heart risk will be randomly assigned to receive their risk score or not. Researchers will…