New study tracks rare genetic heart condition to guide future treatments

NCT ID NCT05981092

Ongoing Knowledge-focused Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows about 35 people with dilated cardiomyopathy caused by a BAG3 gene mutation, a condition that weakens the heart muscle. Over three years, researchers will monitor heart function, symptoms, and quality of life using tests like imaging and blood work. The goal is to understand how the disease progresses naturally, which could help design better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help researchers better understand BAG3-related heart disease and design future treatments.
What could go wrong: This is an observational study with only 35 participants, so findings may not apply to everyone. It does not test any new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiomyopathy dilated cardiomyopathy dilated cardiomyopathy 1HH heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BCL-2 ANATHOGENE-3 (BAG3) DILATED CARDIOMYOPATHY (DCM) CARDIOMYOPATHY, DILATED

Contacts and locations

Locations

Research Site

Palo Alto, California, 94305, United States
Research Site

Aurora, Colorado, 80045, United States
Research Site

Boston, Massachusetts, 02115, United States
Research Site

Rochester, Minnesota, 55905, United States
Research Site

The Bronx, New York, 10467, United States
Research Site

Philadelphia, Pennsylvania, 19104, United States
Research Site

Amsterdam, Amsterdam, 1105 AZ, Netherlands
Research Site

Maastricht, Maastricht, 6229 HX, Netherlands
Research Site

Warsaw, Warszawa, 04-628, Poland
Research Site

A Coruña, A Coruna, 15006, Spain
Research Site

Madrid, Madrid, 28041, Spain
Research Site

Majadahonda, Madrid, 28222, Spain
Research Site

El Palmar, Murcia, 30120, Spain
Research Site

Harefield, London, UB9 6JH, United Kingdom
Research Site

London, London, EC1A 7BE, United Kingdom

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