Brain infarction

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This trial investigates whether a procedure to remove blood clots from arteries in the back of the brain can improve recovery in people who had a stroke more than 24 hours ago but within the last 7 days. Participants will either receive standard medication alone or the clot-remov…

This study looks at 518 adults with a severe stroke caused by a blockage in the main artery at the back of the brain. It compares two standard treatments: a procedure to remove the clot (endovascular therapy) versus medication alone. The goal is to see which approach leads to bet…

This study tests a new drug called ASP2246 for adults who have trouble moving after a stroke. In the first part, small groups get increasing doses via brain surgery to check safety. In the second part, some get the drug and others get a sham surgery, with neither patient nor doct…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This Phase 3 trial tests whether the drug tirofiban can help people who have had a stroke but missed the usual treatment window (more than 24 hours after symptoms start). The study uses a special MRI scan to select patients whose stroke is caused by a specific type of artery bloc…

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achi…

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This study tests whether a clot-busting drug called tenecteplase can help people who have a stroke affecting the back part of the brain. Participants must start treatment between 4.5 and 24 hours after their first symptoms. The goal is to see if the drug improves recovery and dai…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a major stroke and undergone a procedure to remove a blood clot from a large brain artery. Even when the clot is successfully removed, many patients still have significant disability. …

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study is testing a drug called Mexidol in people who have had an ischemic stroke (a stroke caused by a blocked blood vessel in the brain). The goal is to see if Mexidol can reduce the size of the brain injury and improve recovery. The trial will involve 120 adults aged 18 to…

This study is testing a device that sends mild electrical pulses to the vagus nerve in the neck, paired with physical therapy, to help people who had a stroke months or years ago. The goal is to see if this approach can safely improve arm and leg movement. About 40 adults with ch…

This study tests whether tilting a stroke patient's head down 15 degrees for 30-90 minutes before a clot removal procedure can improve blood flow to the brain. About 118 adults with a specific type of stroke will be randomly assigned to either the head-down tilt or standard posit…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study tests whether adding the drug cilostazol to the usual two blood thinners (aspirin and clopidogrel) can better prevent early stroke recurrence in people who had a stroke caused by narrowed arteries in the brain or neck. About 2,340 adults will be enrolled within 72 hour…

This study tests a new brain-computer interface called MindEx that uses four small chips implanted in the brain to help people with severe paralysis control a computer or tablet just by thinking. The goal is to improve independence and quality of life by allowing users to type, p…

This study tests whether bringing blood pressure down very quickly (below 120 mmHg) after a stroke clot removal procedure improves recovery. About 910 stroke patients will be randomly assigned to either intensive or standard blood pressure management. The goal is to see if this a…

This large trial is testing whether AI-guided robotic surgery can improve outcomes for people with a hemorrhagic stroke (bleeding in the brain). The study will compare this new, less invasive technique to standard surgery or medical management. Researchers hope the robotic approa…

This study tests whether giving aspirin within 3 hours of clot-busting treatment for stroke can improve recovery without causing dangerous bleeding. About 1,184 adults who had an ischemic stroke will receive either aspirin or a placebo. The goal is to see if early aspirin leads t…

This study tests whether a noninvasive arm cuff therapy, called remote ischemic conditioning, can improve recovery in people who have had a major stroke and undergone a clot-removal procedure. The therapy involves briefly inflating and deflating a cuff on the upper arm to protect…

This study tests whether common stroke-preventing medications—aspirin, clopidogrel, and statins—can reduce the risk of future stroke, heart attack, and dementia in people who have small, symptomless areas of brain damage called covert brain infarcts (CBIs). These are often found …

This study tests whether a specific set of anesthesia targets, called NeuroFirst, can reduce silent brain injury and thinking problems in older adults having heart surgery. About 900 patients aged 60 and older will be randomly assigned to either the NeuroFirst approach or standar…

This study tests a brain implant that records brain signals to help people with locked-in syndrome control a computer. Two participants will have 128 electrodes placed on their brain surface. Researchers will train them to use the system at home for one year, aiming for accurate …

This phase 3 trial is testing whether two drugs—colchicine (used for gout) and ticagrelor (a blood thinner)—can prevent future strokes, heart attacks, and other vascular events in people who have already had a stroke. About 2,800 high-risk participants will be enrolled. The goal …

This study is developing and testing an artificial intelligence (AI) model to help diagnose a specific type of stroke called branch atheromatous disease (BAD)-related stroke. BAD strokes are hard to identify because symptoms are not specific, and diagnosis requires combining clin…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study tests whether a new CT-angiography method can accurately diagnose brain death compared to the standard four-vessel angiography. About 50 adults with severe brain injury will receive both tests. If the CT method works as well, it could offer a faster, less invasive way …

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

This study is testing a new type of MRI scan called eASL that measures blood flow in the brain without needing a contrast injection. It will include 50 children with conditions like Moya-moya or sickle cell disease that affect brain arteries. The goal is to see if eASL gives clea…

This study tests whether extra support—like personalized mask fitting, monthly phone calls, and a tracking app—helps stroke patients with sleep apnea use their CPAP machine more consistently during rehab. About 250 participants will be randomly assigned to either this intensive s…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study tests whether a non-invasive brain stimulation technique called TMS, combined with language therapy, can improve speech in people who have aphasia after a stroke. Researchers will compare real TMS to a sham (fake) version in 63 participants who had a stroke 2 to 6 week…

This pilot study tests whether a mild electrical stimulation applied to the spinal cord, combined with balance training, can improve stability and reduce fall risk in people who had a stroke over a year ago. Sixteen community-dwelling adults will be randomly assigned to receive e…

This pilot study tests whether a low-cost virtual reality (VR) system can help people recovering from a first-time stroke improve their arm movement. Researchers will compare VR therapy to standard care in 40 adults with moderate to severe arm weakness. Participants will use a Me…

This study tests whether a 12-week high-intensity exercise program can improve language, thinking, and physical health in 120 adults with aphasia (trouble speaking or understanding language) after a stroke. Participants are randomly assigned to either high-intensity or low-intens…

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This study tests whether combining Transcranial Magnetic Stimulation (TMS) with speech therapy can improve language in people with mild aphasia after a stroke. About 24 adults who had a left-brain stroke at least 6 months ago will receive either real or fake TMS along with 10 day…

This study tests whether using EEG neurofeedback — a way to train brain activity — can improve arm movement in people who recently had a stroke. Forty adults with a stroke within the past three weeks will either get real or fake (sham) neurofeedback, plus standard rehab. The goal…

This study tests whether adding real-time biofeedback (like visual or audio cues) to balance exercises helps people who had a stroke more than standard training alone. 66 chronic stroke patients in Lahore will be split into three groups: task-specific training with biofeedback, w…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can help with lingering symptoms like weakness…

This study tests whether a daily dose of acetyl-leucine (a modified amino acid) can improve balance and coordination in people who have had a stroke affecting the back part of the brain. Two hundred adults who recently had a stroke and have trouble walking or staying steady will …

This study tests whether stimulating the vagus nerve through both ears can improve movement and sensation in people who recently had a stroke. Forty participants will receive daily 30-minute sessions for four weeks. Researchers will measure changes in motor function, sensation, a…

This study tests whether a gentle electrical current applied to the front of the brain (tDCS) can reduce fatigue and improve language and attention in people who have had a stroke. Sixty participants will receive either real or fake tDCS during 10 sessions of speech therapy. The …

This study investigates the specific cognitive strengths and weaknesses of children and adults with Sturge-Weber Syndrome (SWS), a rare condition affecting blood vessels in the brain, skin, and eyes. Participants complete a series of tests measuring memory, attention, language, a…

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study looks at 50 adults who had a stroke caused by a blocked middle brain artery and were treated with a clot-removal procedure called thrombectomy. Researchers will use special MRI scans to measure brain activity and metabolism in the damaged area. The goal is to find earl…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This study looks at blood clots removed from stroke patients during a procedure called thrombectomy. Researchers will also take a small blood sample. They want to see if the clot's makeup and blood markers can tell us more about what caused the stroke, how well treatment worked, …

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study uses a virtual reality driving simulator to see how people with vision loss from a stroke steer a car. Researchers will compare driving accuracy between 40 participants with and without vision loss. The goal is to understand how the brain adapts to missing parts of the…

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use MRI scans to see which brain areas are damaged and how they respond to visual training. The goal is to better understand how the brain can adapt and restore some vision. About 1…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…

This study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers studying new ways to improve recovery. No treatments or tests are given—just observation and data collection.

This study aims to learn how blood flow and oxygen use in the brain change as children grow, especially in those with sickle cell disease who are at risk for stroke. Researchers will use MRI scans and have participants breathe in small amounts of carbon dioxide to see how well th…