Brain infarction

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecte…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This phase 2b trial tests whether injecting allogeneic neural stem cells (CC-101) into the brain near a prior stroke lesion can improve motor function in adults with chronic ischemic stroke and lasting movement problems. About 36 participants will receive either stem cells plus s…

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This study looks at whether giving a low-dose aspirin just 2 hours after clot-busting treatment for stroke is better than waiting the standard 24 hours. About 210 adults aged 18-65 who had a stroke will be randomly assigned to get aspirin early or at the usual time. The goal is t…

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This study tests whether giving a large amount of IV saline (about 2-2.5 liters) right after clot-busting treatment helps people recover from a stroke better than giving only a small amount. The trial will enroll 752 adults aged 18-80 who had an ischemic stroke and received throm…

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This early study tests whether a drug called RK-4 can be safely injected through the skull into the brain of people having a severe stroke. Only 6 participants will receive the injection once a day for 3 days, using a special device. The main goal is to see if the procedure is fe…

This study tests whether adding the anti-inflammatory drug baricitinib to standard clot-removal treatment helps people recover better after a severe stroke caused by a blocked artery in the front of the brain. About 750 adults will receive either baricitinib or a placebo for five…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests a new device called Supernova that removes blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. The study will include 3,000 participants and measure how well the device works and…

This study tests whether a procedure to remove blood clots from the brain can help people who have had a severe stroke. The trial will include 308 adults aged 18 to 80 with a large area of brain damage. Doctors will use special tools to clear the blocked artery and then check how…

This study tests whether two medicines, isosorbide mononitrate and butylphthalide, can reduce disability in people who recently had a lacunar stroke (a small stroke deep in the brain). About 3,156 adults aged 30 and older will receive one or both drugs or placebos for up to a yea…

This early-phase study tests a new drug called RK-4 for people with a severe type of stroke (large hemispheric infarction) who cannot have standard clot-removal treatment. The drug is injected directly into the skull bone marrow once daily for three days. The main goals are to ch…

This study tests a new drug called RK-4, injected directly into the skull bone marrow, for people with a severe type of stroke (large hemispheric infarction) who cannot have standard blood vessel treatments. About 194 participants will either get the RK-4 injection daily for 3 da…

This study will test a new radioactive tracer called FBFP in 30 stroke patients and 20 healthy volunteers. The tracer is used with a PET/MR scanner to take detailed pictures of the brain. The goal is to see if FBFP can help doctors diagnose and understand stroke better. Participa…

This study tests whether closing the left atrial appendage (a small pouch in the heart) during valve surgery can prevent silent brain injuries in 100 adults without atrial fibrillation. Participants will have brain scans after surgery to check for hidden strokes. The goal is to f…

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This trial tests whether an intensive, personalized speech therapy program (ICAP) helps people with post-stroke aphasia communicate better and feel better. 334 adults who had a stroke at least 3 months ago will be randomly assigned to either ICAP (100 hours over 4 weeks) or stand…

This study will test whether different frequencies of electroacupuncture (low, medium, or high) can improve swallowing problems in 90 stroke survivors. Participants will receive daily 30-minute sessions over several weeks. The goal is to find the best frequency and understand how…

This study tests whether a mild electrical current applied to the scalp (tDCS) can improve naming ability in people who have trouble speaking after a recent stroke. Twenty-eight adults with aphasia will receive either real or sham stimulation over five days. The goal is to see if…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study tests whether four popular AI chatbots — ChatGPT, DeepSeek, Gemini, and Claude — can correctly classify surgical risk using anonymous patient vignettes. Researchers compare the AI's risk scores to those given by a panel of senior anesthesiologists. If successful, AI co…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This study looks at two common anesthetics used during carotid artery surgery to see which one better protects the brain from small areas of damage. About 160 adults having planned carotid surgery will get either an intravenous or inhaled anesthetic. Researchers will compare brai…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study will look at brain scans (MRI/CT) and symptoms of over 1,100 people with cerebrovascular disease. The goal is to find patterns linking specific scan findings to different types of the disease. This could help doctors diagnose and treat these conditions more accurately …

This study looks at immune activity in the brain of people who had a severe stroke and needed surgery to relieve pressure. Researchers will compare these patients to others having brain surgery for different reasons. The goal is to better understand the body's inflammatory respon…

This study will compare how quickly stroke-related brain damage worsens in 135 Afro-Caribbean patients in Guadeloupe versus patients from mainland France. Researchers will use brain scans to track blood flow and collateral circulation. The goal is to learn if stroke progression d…