Anus disorder

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study tests whether a blood test (ctDNA) can help doctors customize the dose of chemoradiation for people with anal cancer. Depending on how the tumor responds, some patients may get a lower radiation dose to reduce side effects, while others may get a higher dose or an adde…

This phase I trial tests a surgical procedure called utero-ovarian transposition (UOT) to temporarily move the uterus, ovaries, and fallopian tubes out of the radiation field in women aged 18-40 with pelvic cancers. The goal is to preserve fertility and ovarian function during wh…

This phase 2 trial tests a new way to deliver radiation therapy for anal cancer using MRI guidance to adjust doses based on each patient's risk level. About 80 adults with anal squamous cell carcinoma will receive different radiation schedules depending on their tumor risk group.…

This study tests whether a single infusion of a patient's own genetically engineered immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before the patient receives standard treatment like chemo-radiation or surgery. The trial enrolls 15 adults with advanced…

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This study tests a combination of two drugs, nilotinib (a pill) and paclitaxel (given by IV), for people with rare advanced cancers that have not responded to standard treatments. The goal is to see if the drugs can shrink or stop tumor growth. About 82 adults with specific rare …

This early-stage trial tests whether curcumin (the active ingredient in turmeric) can reverse high-grade anal precancerous lesions in people living with HIV. Participants insert curcumin capsules into the anus daily for 14 days. The main goal is to find the safest dose, not yet t…

This early-stage study tests whether a cream made from two HIV drugs (lopinavir/ritonavir) can be safely placed inside the anus to treat high-grade anal growths (AIN 2/3) in people living with HIV. About 21 participants will receive the cream for a few months and be followed for …

This study is testing whether giving radiation therapy along with immunotherapy before surgery can improve outcomes for people with sinonasal or anorectal mucosal melanoma, two rare and aggressive cancers. About 40 participants will receive combination immunotherapy (such as ipil…

This study tests whether adding an immunotherapy drug (anti-PD-1) to standard chemoradiation can better control anal squamous cell cancer and reduce the chance of it coming back. It includes 241 adults aged 18-75 with different stages of the disease, from early to advanced or rec…

This early-phase study tests a new drug (PLN-101095) alone or with pembrolizumab in adults whose advanced solid tumors have stopped responding to standard immunotherapy. About 124 participants will receive the treatment to check safety and early signs of tumor shrinkage. The goal…

This study tests whether combining two drugs, lenvatinib and pembrolizumab, can shrink or control advanced anal or rectal cancer that has spread and stopped responding to standard chemotherapy. About 35 adults with this type of cancer will receive the drug combination. The goal i…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can improve outcomes for people with early-stage anal cancer. About 23 participants will receive the combination treatment, followed by maintenance therapy. The main goal i…

This study tests an experimental drug called SMP-3124LP, which is a liposomal (fat-encapsulated) version of a cancer-fighting compound. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial has two parts: first, finding the safest d…

This pilot study tests whether using artificial intelligence to adjust radiation plans daily can better target tumors while sparing healthy organs in people with locally advanced anal cancer. Twenty participants will receive standard radiation over six weeks, but each day's plan …

This program provides retifanlimab, an immunotherapy drug, together with standard chemotherapy (carboplatin and paclitaxel) to adults with advanced squamous cell carcinoma of the anal canal who cannot join other clinical trials. The goal is to offer a potential treatment option w…

This study is testing a simple blood test that looks for tumor DNA from HPV-related cervical and anal cancers after radiation treatment. The goal is to see if this test can replace expensive imaging scans and help doctors find early signs of cancer returning. If the test is posit…

This study is for people with advanced gastrointestinal cancers that are growing despite immunotherapy. Researchers want to see if adding targeted radiation to one tumor can help the immune system attack other tumors throughout the body. About 28 participants will receive radiati…

This study is for people with early-stage anal cancer. It tests whether skipping radiation to the groin (when scans and biopsies show no cancer there) works just as well as giving it, while causing fewer side effects and better quality of life. About 45 participants will receive …

This study tests a new drug called LCB84, which targets a protein (TROP2) found on many cancer cells and delivers a toxic payload directly to them. It is being tested alone and together with an immunotherapy drug (anti-PD-1) in 300 people with advanced solid tumors that have not …

This early-stage trial is testing an experimental drug called LB1410, a bispecific antibody designed to block two immune checkpoints (PD-1 and TIM-3) and help the immune system fight cancer. It involves 100 adults with advanced solid tumors or lymphoma who have exhausted standard…

This phase 3 trial tests whether giving a specific chemotherapy combination (mDCF) before standard chemoradiotherapy can improve outcomes for people with locally advanced anal cancer. About 310 adults with stage T3-4 or N1 anal cancer will be randomly assigned to either standard …

This study looks at different screening methods to find anal precancer in people at high risk, such as those with weakened immune systems or a history of certain genital cancers. Researchers will compare tests like high-resolution anoscopy, HPV testing, and cell samples to see wh…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This phase 2 trial tests whether a vaginal DHEA suppository can safely improve vaginal health in 25 women who had radiation for gynecologic, anal, or rectal cancer. Radiation often causes dryness, burning, and pain, similar to menopause. DHEA is a hormone replacement that may hel…

This study is for women with anal cancer who need pelvic radiation. It tests whether using a vaginal dilator during each radiation session can reduce the risk of vaginal narrowing (stenosis) after treatment. Half of the 60 participants will use the dilator during radiation, and t…

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study tests a newer type of radiation therapy that adjusts to daily changes in a patient's body shape. The goal is to safely use smaller treatment areas to reduce side effects like bladder and bowel problems. About 280 adults with pelvic cancers (prostate, bladder, rectal, a…

This study tests whether a daily probiotic pill (Pendulum Glucose Control) can safely reduce stomach and bowel problems in people receiving radiation for cancers of the pelvis, such as prostate, gynecologic, or lower GI cancers. About 20 adults will take the probiotic during thei…

This study tests a nerve block called ganglion impar neurolysis to see if it can reduce pain caused by radiation therapy for anal cancer. Five adults with localized anal cancer who are getting chemotherapy and radiation will receive the nerve block. Researchers will track pain sc…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study is observing 300 women with female sexual organs who are receiving radiotherapy for certain cancers. Researchers want to understand why some patients have more sexual side effects than others. They will track sexual quality of life and look at radiation doses to find p…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study follows 50,000 people with colorectal, small bowel, or anal cancer to learn why some respond better to treatment than others. Researchers will collect data on genetics, lifestyle, and side effects to improve care for all patients, not just those in clinical trials. Par…

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…

This study is for Black adults newly diagnosed with gastrointestinal cancer. It focuses on ensuring patients receive proper biomarker testing and evidence-based care, helping them find and join clinical trials if they choose, and providing easy-to-understand information about the…

This study looks at whether letting people collect their own anal samples at home can increase the number of high-risk individuals who follow through with clinic appointments for anal cancer screening. About 572 participants from Chicago, Houston, and Milwaukee will either self-s…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…

This study looks at how chronic perianal conditions like fistulas and abscesses impact a person's sexual health and body image—something often overlooked by doctors. Researchers will survey 60 adults using questionnaires to measure these effects and identify gaps in communication…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study looks at 500 children with a rare birth defect affecting the anus and rectum. Researchers will compare different surgical techniques to see which one leads to better bowel control and fewer complications. The children will be followed for up to 6 years after surgery. T…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study looks at whether a blood test can detect HPV DNA in people with HPV-related anal or cervical cancer who are receiving radiation therapy. Researchers will collect blood samples before, during, and after treatment to see if the virus's genetic material shows up and if it…

This study checks if a bowel control questionnaire, the Baylor Continence Scale, works well for Turkish-speaking children aged 6 to 18 who had surgery for anorectal malformations. Researchers will translate the scale and test its accuracy and reliability. The goal is to give doct…

This study aims to understand which types of HPV are linked to anal cancer in China and how common the disease is. Researchers will collect samples and health data from 300 patients across multiple hospitals. The goal is to learn more about the virus and disease patterns, not to …

This study will follow 150 people with radiation rectal injury to see if different subtypes of the condition lead to different outcomes. Researchers will collect medical records, endoscopy images, and test results but will not change any treatments. The goal is to fill gaps in kn…

This study is creating a registry of 100 women with extramammary Paget's disease (EMPD) of the vulva or perianal area. Researchers will collect health information, tissue samples, and skin swabs to learn more about the disease and the bacteria living on affected skin. The goal is…

This study looks at 40 newborns with isolated rectal bleeding to see how many have a cow's milk protein allergy versus a temporary condition called transient neonatal colitis. By removing and then reintroducing cow's milk from the diet, doctors can confirm an allergy if bleeding …

This trial is testing whether taking daily fiber supplements can change the types and amounts of bacteria living in the colon. The study involves 120 adults with benign anal or colorectal conditions who are not currently on fiber supplements. Researchers will compare gut bacteria…

This observational study follows 80 women treated with chemoradiotherapy for anal cancer to understand how radiation affects their vaginal and sexual health. Participants will have a gynecological exam, complete questionnaires about quality of life and sexual health, and allow re…

This study follows up with 100 men who took part in the ANRS IPERGAY HIV prevention trial to see how many have developed high-grade anal lesions or anal cancer a decade later. Researchers will use a special test to look for HPV mutations and viral DNA integration in the body. The…

This study collects and stores tissue and blood samples from people with stomach, esophageal, pancreatic, liver, and other gastrointestinal cancers. The goal is to build a large database of samples and medical information to help researchers understand these cancers better. Parti…

This study will collect blood and tumor samples from 1,100 people with various cancers, including head and neck, ovarian, cervical, lung, and brain cancers. Researchers want to learn how immune cells called T cells behave in these tumors. The goal is to better understand why some…