Anus disorder

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This study tests a combination of three immunotherapy drugs—PDS0101, M7824, and NHS-IL12—in people with advanced HPV-related cancers such as cervical, anal, and throat cancers. The goal is to see if the mix can shrink tumors or stop them from growing. Participants receive the dru…

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This study tested a new experimental treatment called HPVST cells in 32 people with HPV-related cancers that had returned or not responded to standard care. The cells are grown from the patient's own blood and trained to attack HPV-infected cancer cells. The goal was to find a sa…

This study tested a probiotic called INF108F in 20 breastfed infants with a food allergy that causes blood in their stool. The goal was to see if the probiotic could improve the balance of gut bacteria and reduce symptoms like reflux and fussiness. While the treatment aims to con…

This trial tested a new therapy for cancers caused by HPV-16, such as cervical, anal, and throat cancers. Researchers took patients' white blood cells, genetically engineered them to recognize a protein called E7 found in HPV cancer cells, and infused them back. Patients also rec…

This study tested whether hyperbaric oxygen therapy (HBOT) can help heal severe tissue damage caused by past radiation treatment. 39 adults who had radiotherapy and developed serious radiation injuries received HBOT sessions in a pressurized chamber while breathing pure oxygen. T…

This pilot study tested a newer, more precise form of proton radiation called pencil beam scanning, given alongside standard chemotherapy drugs (5-FU and mitomycin-C), for people with anal cancer. The goal was to see if this combination is practical and might cause fewer skin sid…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This Phase 3 trial tested whether adding the immunotherapy drug retifanlimab to standard chemotherapy (carboplatin and paclitaxel) helps people with advanced anal cancer that cannot be removed by surgery. The study enrolled 308 adults who had not received chemotherapy for their a…

This study tested two ways to stimulate sacral nerves in 48 children aged 2-17 with severe constipation and fecal incontinence that didn't improve with standard care. One group got an implanted nerve stimulator, the other a non-invasive patch. The goal was to see if either approa…

This study tested a simple blood test to screen for anal dysplasia, a precancerous condition linked to HPV. Researchers enrolled 104 people with past or current anal HPV, plus some healthy controls. The goal was to see if the blood test could detect and classify anal dysplasia wi…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether an education and support program can help family caregivers of cancer patients feel more confident and less anxious. About 484 caregivers and patients took part. Researchers compared different types of support to see which worked best.

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This early-stage study tested a new mind-body program designed to help female survivors of colorectal and anal cancer improve their sexual well-being. Six women who had finished initial cancer treatment took part in group sessions. The main goal was to see if the program was acce…

This completed phase 3 trial tested whether taking psyllium husk fiber capsules during pelvic radiation therapy could reduce gut inflammation and urgency symptoms. 354 adults with pelvic cancers (like rectal, prostate, or gynecological) took either fiber or placebo capsules daily…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study followed 110 people with anal cancer to see if PET/CT scans can help doctors monitor the disease after initial treatment. Researchers tracked how long patients stayed cancer-free and measured metabolic activity in tumors. The goal is to find better ways to detect relap…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked for the most effective and practical way to screen for anal high-grade lesions (a precancerous condition) in Thai men who have sex with men and transgender women. Researchers tested different screening methods in 950 participants to see which approach finds the …

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study tested whether a deeper self-collected swab (5 cm) collects better cell samples from the anal canal compared to a shallower one (3 cm). Fifty adults at higher risk for anal cancer participated. The goal was to see which depth gives a more useful sample for screening, w…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study looked at people with advanced solid tumors (like lung, bladder, or melanoma) who had been on immunotherapy for one year and whose disease was stable. Half stopped treatment and half continued. The goal was to see if stopping early affected how long until the cancer pr…

This study takes small tissue samples from people with inflammatory bowel disease (IBD) and healthy volunteers to grow 'mini guts' (organoids) in the lab. Researchers will then expose these organoids to radiation to mimic radiation enteritis and test potential treatments. The goa…