Imperforate anus

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at 500 children with a rare birth defect affecting the anus and rectum. Researchers will compare different surgical techniques to see which one leads to better bowel control and fewer complications. The children will be followed for up to 6 years after surgery. T…

This study checks if a bowel control questionnaire, the Baylor Continence Scale, works well for Turkish-speaking children aged 6 to 18 who had surgery for anorectal malformations. Researchers will translate the scale and test its accuracy and reliability. The goal is to give doct…

This trial is testing whether taking daily fiber supplements can change the types and amounts of bacteria living in the colon. The study involves 120 adults with benign anal or colorectal conditions who are not currently on fiber supplements. Researchers will compare gut bacteria…