University Hospital, Rouen

This study compared two treatments for deep endometriosis affecting the rectum in women aged 35-50 who do not plan pregnancy. One group received continuous hormone therapy for 24 months, while the other had rectal surgery followed by hormones. The main goal was to see which appro…

This study looked at 102 adults with a severe infection in the belly from a burst colon pocket (diverticulitis). It compared doing one surgery to reconnect the colon right away versus doing a first surgery to remove the infected part and a second surgery later to reconnect. The m…

This study looked at whether a plant-based omega-3 supplement can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured change…

This study tested two treatment combinations for acquired hemophilia, a rare condition where the body attacks its own blood-clotting factor. 110 adults received either steroids plus cyclophosphamide or steroids plus rituximab. The goal was to see which combo better eliminates the…

This study tested giving chemotherapy before surgery for people with pancreatic cancer that can be removed. The goal was to see if this approach helps patients live longer and have fewer complications. 153 participants received either standard treatment (surgery then chemo) or ch…

This study tested a weekly combination of two chemotherapy drugs (cisplatin and irinotecan) along with radiation in 43 people with advanced esophageal cancer that had not spread. The main goal was to see if the cancer completely disappeared after treatment. Researchers also track…

This study tested whether a personalized medication plan, created by a pharmacy intern, could help people with non-cancer pain stop taking strong opioids sooner. The goal was to keep treatment under 28 days to reduce the risk of addiction. The study involved 100 adults hospitaliz…

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study tested whether adding a collagen-elastin dermal matrix under a thin skin graft leads to better skin flexibility and less scarring than a skin graft alone. About 92 adults with skin loss from injury or surgery took part. The main goal was to measure skin foldability one…

This study tested a surgery that reconnects nerves to help people with paralyzed vocal cords breathe and speak better. Four adults who had not improved with earlier treatments took part. The surgery uses a nerve from the diaphragm and neck nerves to restore movement, with results…

This study tested whether a single cycle of the drug rituximab could control bullous pemphigoid, a painful blistering skin condition. Researchers followed 18 adults for up to 2 years to see if the treatment worked and was safe. The goal was to reduce the need for long-term steroi…

This study tested whether dapagliflozin, a drug used for diabetes, could improve blood vessel function in 32 adults with chronic kidney disease (CKD). Participants took the drug for 12 weeks, and researchers measured changes in artery health using ultrasound and other tests. The …

This study compared two chemotherapy combinations (GC and HD-MVAC) given before or after bladder removal surgery in 500 patients with advanced bladder cancer. The goal was to see which regimen better delays cancer progression. Both treatments aim to control the disease, not cure …

This study looked at whether a specific chemotherapy regimen (FOLFIRI) plus radiation is practical for stomach cancer patients. 63 people with non-spreading stomach cancer received the treatment either before or after surgery. The goal was to see if this approach is feasible and …

This study followed 80 adults with pemphigus, a rare autoimmune blistering skin disease, who had previously received rituximab in the Ritux 3 trial. Researchers tracked long-term side effects and how many patients stayed in remission over several years. The goal was to understand…

This study looked at whether using a noninvasive ventilation mask (NIV) can help patients with chronic respiratory failure get off a breathing tube more successfully. Researchers compared three weaning methods in 205 patients who had trouble breathing on their own. The goal was t…

This study tested a new way to diagnose COVID-19 using a saliva sample instead of the standard nose/throat swab. Researchers compared the new method to the usual one in 130 adults at a hospital in France. The goal was to see if the saliva test works just as well, which could make…

This study tested a new tool called EndoFLIP to see if it can better diagnose anismus, a condition where the anal muscle doesn't relax properly during bowel movements, causing severe constipation. Researchers measured anal stretch in 61 adults with long-term constipation and comp…

This study tested a special microscope (confocal endomicroscopy) that can be inserted through a bronchoscope to look at lung nodules in real time. The goal was to see if it can find nodules and tell whether they are cancerous or benign without taking a tissue sample. 120 adults w…

This study looked at 140 children with peanut or egg allergies to see if a blood test called the Basophil Activation Test (BAT) could accurately diagnose their allergies. Currently, the best way to diagnose food allergies is through an oral food challenge, where children eat incr…

This study looked at whether a new blood marker called EM66 can help doctors tell the difference between high blood pressure caused by rare adrenal tumors (pheochromocytoma or paraganglioma) and regular high blood pressure. Researchers measured EM66 levels in 60 adults with suspe…

This study looked at whether a gynecological exam done while lying on the side (lateral decubitus) works well enough to be a regular option. Many women find the standard exam uncomfortable or embarrassing, which can lead to skipping important checkups. Researchers tested this sid…

This study tested whether applying a numbing medicine (ropivacaine) to the area where a thin skin graft was taken reduces pain after surgery. 58 adults who needed a small skin graft were randomly assigned to receive either the numbing medicine or a saltwater solution on their wou…

This study tested whether adding a second nerve block (serratus plane block) to a standard one (paravertebral block) reduces the amount of opioid painkillers needed after video-assisted lung surgery. 112 adults aged 18 to 75 scheduled for lung removal took part. The main goal was…

This study tested whether spraying a drug called terlipressin into the airways before taking biopsy samples could reduce bleeding and allow doctors to take more samples. The goal was to improve the chances of getting enough tissue to diagnose lung cancer. The trial involved 130 a…

This study looked at whether using a fast-acting opioid called remifentanil during general anesthesia for emergency C-sections is safe for premature babies. It compared two groups of mothers and their preterm infants: one group received remifentanil, the other did not. The main g…

This study looked at whether avoiding morphine during heart surgery can lower the risk of serious side effects like breathing trouble, confusion, and bowel problems. 268 adults having planned heart surgery took part. Instead of morphine, doctors used a mix of other pain medicines…

This study tested whether injecting botulinum toxin (like Botox) into the rectum can reduce episodes of accidental bowel leakage and urgent bathroom needs in people with fecal incontinence. Researchers enrolled 200 adults whose condition did not improve with standard treatments. …

This study tested a web platform designed to help people with mild memory loss or early dementia and their caregivers. The platform offers social networks, activities, and health tips to improve quality of life and delay the need for full-time care. 48 pairs (person with memory i…

This study looked at whether a newer type of deep brain stimulation (called directional stimulation) can help improve walking and balance problems in people with Parkinson's disease. Nineteen patients who were already eligible for standard deep brain stimulation took part. Resear…

This study tested whether breathing in morphine through a mask works as well as getting it through an IV for severe pain in the emergency room. 226 adults with intense pain were randomly assigned to receive either inhaled morphine plus a fake IV, or IV morphine plus a fake inhale…

This study looked at whether a special exercise program on a foam surface can help women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). 88 women took part. The goal was to see if these balance-focused exercises reduce the amount of urine …

This study looked at 200 adults having day surgery with general anesthesia. It compared giving pain medication prescriptions before surgery versus after surgery. The goal was to see which approach reduced moderate-to-severe pain at home within the first 24 hours.

This study tested a non-invasive brain stimulation technique called rTMS for people with psychogenic paralysis (paralysis with no physical cause). 66 participants received either real or fake rTMS over two days. The goal was to see if the treatment could quickly improve movement …

This study tested different methods for removing surgical drains after total hip replacement to see which one hurts the least. 87 adults who had hip replacement surgery took part. The main goal was to measure pain during drain removal using a 0-to-10 pain scale. Researchers also …

This study tested two breathing machines—CPAP and bilevel pressure support—in adults with severe fluid buildup in the lungs (pulmonary edema). The goal was to see which device improves breathing faster. Participants were adults in respiratory distress. The study measured blood ga…

This study looked at whether a diet low in FODMAPs (certain carbohydrates) can ease symptoms of Irritable Bowel Syndrome (IBS). Researchers tested 112 adults with IBS to see if a fructose breath test could predict who would benefit from the diet. The goal was to find a simple way…

This study looked at whether a breath test can detect bacterial overgrowth in the small intestine that might cause gas incontinence. Sixteen adults with gas incontinence for over 3 months were tested. Those with positive results received antibiotics to see if their symptoms impro…

This study looked at how the drug cladribine affects the immune system in people with multiple sclerosis (MS). Researchers wanted to better understand its anti-inflammatory and possible nerve-protecting effects. The study included 77 adults with different types of MS, as well as …

This study followed 255 people with severe obesity who had weight loss surgery. Researchers wanted to see if losing weight improved liver scarring (fibrosis) using simple blood tests instead of a liver biopsy. The main goal was to check how well two blood tests (Fibrotest and tra…

This study looked at how often sleep disturbances occur in people with bullous pemphigoid, a blistering skin condition. Researchers compared 122 patients with bullous pemphigoid to a control group with other skin issues using a sleep questionnaire. The goal was to understand if s…

This study looked at whether a very strong steroid cream (clobetasol propionate) causes fluid retention in 30 adults with bullous pemphigoid, a blistering skin condition. Researchers measured changes in body water using a special scale over 30 days. The goal was to understand if …

This study aimed to find the normal range of certain heart MRI measurements (T1, T2, and T2* relaxation times) in healthy adults aged 18 to 69. A total of 175 volunteers underwent cardiac MRI scans. The results help doctors better understand what is healthy versus diseased, aidin…

This study looked at how certain immune cells (monocytes) behave in people with a rare genetic condition called hereditary bradykinetic angioedema, which causes sudden swelling. Researchers compared gene activity of two receptors (B1 and B2) on these cells between 30 patients and…

This study followed 300 people with severe aortic stenosis who had a minimally invasive heart valve replacement. Researchers wanted to see how long patients stayed in the hospital and what caused some to stay longer than 3 days. The goal is to help doctors identify who can safely…

This study looked at 5 families where a child has a developmental disorder with no known cause. Researchers checked if new genetic changes found in the child were also present in the father's sperm. The goal was to better understand the risk of these changes happening again in fu…

This study looked at 232 people with cerebral venous thrombosis, a rare stroke that mostly affects young women. Researchers measured two blood markers (thrombin generation and D-Dimers) at several time points to see if they relate to how the disease starts, its severity, and reco…

This study tested whether adding glutamine to the feedings of premature babies (born at 30-33 weeks) helps their stomachs empty faster and reduces the time they need IV nutrition. Forty healthy preterm infants received either glutamine-enriched or standard feedings. Researchers m…

This study looked at whether the gut lining becomes more permeable in women with anorexia nervosa due to severe malnutrition. Researchers tested 23 patients and 46 healthy women using sugar-based urine tests to measure intestinal barrier function. The goal was to understand how s…

This study measured levels of a recently discovered hormone called 26RFa in 62 women. Researchers compared obese women with or without type 2 diabetes to healthy-weight volunteers. They also checked how the hormone changed after weight-loss surgery (sleeve gastrectomy). The goal …

This study looked at how well two different tools measure balance during walking in 50 healthy adults aged 20 to 40. The goal was to see which method gives more consistent results. This research may help improve ways to prevent falls in the future.

This study looked at 216 people with stage II or III colorectal cancer who had surgery to remove their tumor. Researchers compared two blood tests—one that looks for tumor DNA and another that looks for tumor cells—to see which one better predicts if the cancer will come back wit…

This small pilot study looked at whether aprepitant, a drug used for nausea from chemotherapy, can change levels of aldosterone (a hormone that affects blood pressure) in people with type 2 diabetes and high blood pressure. Five participants took either aprepitant or a placebo fo…

This study looked at a type of cell stress called endoplasmic reticulum stress in 53 adults having heart surgery with a heart-lung machine. Researchers took blood samples before and after the machine was used to measure changes in stress markers. The goal was to better understand…

This study looked at sleep problems in 42 adult intensive care patients. Researchers used a simple questionnaire to measure sleep quality and track changes over time. The goal was to see if moving patients to a special rehabilitation unit helps improve their sleep.

This study looked at how different types of brain damage (from stroke, tumors, or diseases like Alzheimer's) affect specific thinking skills like memory or attention. Researchers used brain scans and cognitive tests in 346 people (patients and healthy volunteers) to map which bra…

This study looked at how common gut inflammation and leaky gut are in people with blood cancers who are in the intensive care unit (ICU) for severe infections. Researchers measured markers like calprotectin and zonulin in 80 patients. The goal was to better understand gut problem…

This study looked at whether sleep problems like insomnia are linked to a lower pain threshold in the gut for people with Irritable Bowel Syndrome (IBS). Researchers measured pain sensitivity using a balloon-like device in 70 adults, including those with IBS, insomnia, both, or n…

This study followed 26 people with Anderson-Fabry disease to see how their heart muscle changed over time using MRI scans. Some participants were taking the drug Replagal® (agalsidase alpha) and some were not. The goal was to see if a special MRI measurement called T1 time could …

This study reviewed medical records of 52 adults with Crohn's disease who had anal fistulas and were treated with biologic drugs. Researchers looked at MRI scans taken at the start of treatment and again after 1 and 3 years to describe how the fistulas changed over time. The goal…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients had standard 4-hour sessions three times a week, while others had 2-hour sessions six times a week. The goal was to find out which schedu…

This study looked at how bevacizumab (Avastin), a drug used to treat advanced colorectal cancer, affects blood vessels. Researchers measured artery stiffness and blood pressure in 13 patients before and after 4 months of treatment. The goal was to better understand the drug's sid…

This study tested whether ultrasound can detect early signs of rheumatoid arthritis (RA) returning in patients treated with rituximab, before they feel symptoms. Thirty adults with RA who had not responded to other treatments took part. The goal was to see if ultrasound could pre…

This study looked at 74 people with metastatic colorectal cancer starting their first chemotherapy. Researchers checked if early changes in blood markers (like CEA and tumor DNA) could predict whether the cancer would shrink after 3 months. The goal is to see if blood tests can h…

This study looked at how a curved spine (kyphosis) changes the way people walk. Researchers used a special camera system (Vicon) to track body movements in 36 healthy men while they wore a corset that mimicked a hunched back. The goal was to see if the Vicon system could detect t…

This study looked at whether mental training could lower stress in anesthesiology residents before they perform epidural pain relief for childbirth. 32 residents were split into two groups: one received mental preparation, the other did not. Their stress levels were measured befo…

This study looked at whether certain combinations of gene changes can raise the risk of colorectal cancer (CRC) in people who don't have a known inherited form. Researchers compared 700 patients with strong family history or early-onset CRC to 350 healthy controls. The goal is to…

This study looked at the bacteria living in the bladders of women with and without urinary tract infections (UTIs). Using advanced DNA testing, researchers found that many bacteria are missed by standard urine cultures. The goal was to understand how changes in the bladder's bact…

This study looked at a thin layer inside blood vessels called the glycocalyx in 78 adults having major abdominal surgery. Researchers wanted to see if measuring changes in this layer could help doctors better manage fluids and anesthesia during and after surgery. The goal was to …

This study looked at how fructose, a sugar found in many foods, affects anxiety and mood in healthy young men. Researchers compared those with and without fructose malabsorption (trouble digesting fructose) to see if gut bacteria play a role. The goal was to understand the link b…

This study looked at 80 kidney transplant recipients to see if certain genetic variations affect how well the new kidney works over time. Researchers measured kidney function and blood vessel health at several points after transplant. The goal was to find early clues that could h…

This study tested a new, more detailed method (high-resolution manometry) to measure anal muscle function in 60 people—some with fecal incontinence and some healthy. The goal was to see if this technique gives better information than older methods. Participants had their squeeze …

This study tested a program to reduce the time it takes for patients with aortic stenosis to get a TAVI procedure. The program included an e-health tool for patients and families, plus organizational changes at hospitals. Researchers measured how many patients received TAVI withi…

This study looked at how anxious people feel before getting allergy tests. Researchers measured anxiety in 300 adults using a simple 0-to-10 scale and a questionnaire. The goal was to better understand patient worries and improve their experience during testing.

This study looked at 40 adults with operable pancreatic cancer to measure circulating tumor DNA (ctDNA) in blood from a vein and from the portal vein during surgery, as well as in fluid from the abdomen. The goal was to see if these DNA levels could help predict how the disease p…

This study measured how stiff the heart muscle is in people having surgery for aortic stenosis (a narrowed heart valve) compared to those having bypass surgery. Researchers used a special ultrasound technique called elastography directly on the heart during the operation. The goa…

This pilot study tested a very small, specially shaped wire (lead) for heart pacing in 20 adults who needed a cardiac resynchronization device. The goal was to see if the lead could successfully pace the left ventricle from multiple spots. The study measured how often the lead wo…

This study looked at whether cannabis use changes sperm quality in men with fertility problems. Researchers compared sperm from cannabis users and non-users, focusing on DNA abnormalities. The goal was to understand how cannabis might affect male fertility.

This study looked at whether regular check-ins by a nurse could detect early signs of rheumatoid arthritis (RA) flare-ups in patients taking the drug rituximab. Researchers followed 51 adults with RA who were in remission or had low disease activity. The goal was to see if nurse …

This study looked at 60 women with deep endometriosis affecting the rectum. It compared two surgeries: removing the affected part of the rectum (colorectal resection) versus just cutting out the endometriosis nodules while keeping the rectum intact. The goal was to see which appr…

This study looked at swallowing problems in 34 patients who were minimally conscious after a severe traumatic brain injury. Researchers used a special X-ray video to see how well patients could swallow. The goal was to better understand these swallowing issues and how they relate…

This study tested whether a drug that lowers heart rate (ivabradine) can improve the flexibility of arteries in healthy people. 30 volunteers aged 25-65 with a resting heart rate of 70 or higher took either the drug or a placebo for 8 days. Researchers measured artery stiffness a…

This study looks at whether a surgery called STARR, which helps people with severe constipation caused by a rectocele or intussusception, also harms the muscles that control bowel movements. Researchers will use a special balloon device to measure muscle function before and after…

This study tested whether placing a small pain-relief catheter a few centimeters under the skin (tunneling) reduces bacterial growth compared to standard placement. 338 adults having knee surgery with a femoral nerve catheter took part. Researchers checked the catheter tip for ge…

This completed study involved 103 adults with septic shock, a life-threatening condition. Researchers measured levels of a protein called VEGF-A and tracked how much fluid patients retained. The goal was to see if higher VEGF-A levels are linked to more fluid buildup, which can w…

This study tested whether a substance called tPA-PAI-1 in umbilical cord blood can predict brain bleeding in very premature infants (born before 30 weeks). Researchers measured this and other markers in 175 babies and compared those who later had a brain bleed with those who did …

This study looked at whether a nurse practitioner can safely monitor people with colorectal cancer who are getting intravenous chemotherapy, compared to a doctor. About 207 adults took part. The goal was to see if the number of serious side effects and quality of life were simila…

This study looked at whether information from a national health insurance card—such as past antibiotic use and hospital stays—can help predict if a person's urinary tract infection (UTI) will be resistant to standard antibiotics. Over 1,100 adults with community-acquired UTIs too…

This study tested a new way of removing a breathing tube after digestive surgery to see if it prevents low oxygen levels. About 208 adults having surgery lasting over an hour were randomly assigned to either the standard method or a method that keeps positive pressure on the lung…

This study looked at whether a device called ATPmetry can accurately measure how clean a patient's skin is before surgery. Currently, nurses just look at the skin, which can be unreliable. The study involved 200 adults having day surgery. Researchers compared the device's reading…

This study looked at 140 colon cancer patients to see if the distance they lived from Rouen University Hospital affected how quickly they started chemotherapy after surgery. The goal was to find out if longer travel times lead to delays in treatment. The results could help improv…

This study looked at whether pregnant women would be willing to participate in research on the clitoris's possible ability to reduce pain. 32 pregnant women took part to see if the procedure was acceptable. The goal was to gather information, not to provide treatment.

This study looked at 52 adults with septic shock to understand why they lose muscle mass. Researchers measured a protein called PTP1B and a gut barrier marker called zonulin, linking them to muscle changes seen on ultrasound. The goal was to gather knowledge, not to test a new tr…

This study looked at how antibiotics used to treat urinary tract infections (UTIs) can change the bacteria living in the gut. Researchers collected stool samples from 61 hospitalized adults before and after antibiotic treatment to see if resistant bacteria grew in the digestive t…

This study looked at 56 people who had surgery for early-stage colon cancer to see if the number and type of immune cells in their tumors could predict whether the cancer would come back. Researchers measured different immune cells in both blood samples and tumor tissue. The goal…

This study looked at whether proteins in the blood can help screen for colorectal cancer. Researchers tested blood samples from 350 people who were already scheduled for a colonoscopy. The goal was to see if certain protein markers could reliably spot advanced growths, and to fin…

This study looked at how being socially excluded affects the memory of children with ADHD. Twenty-four children completed memory tests before and after playing a computer game designed to make them feel left out. The goal was to see if social rejection changes how well they remem…

This study looked at how to keep a hormone called ACTH stable in blood samples. ACTH is hard to measure because it breaks down quickly. Researchers tested a substance called aprotinin in 10 healthy adults to see if it helps. The goal was to improve the accuracy of ACTH lab tests.

This study examined whether people with eating disorders have autoantibodies that target appetite-regulating neuropeptides like ghrelin and alpha-MSH. Researchers collected blood samples from 211 participants, including patients with anorexia, bulimia, or binge eating, and health…

This pilot study tested a very small, specially shaped wire (lead) for cardiac resynchronization therapy, a treatment that helps the heart beat in sync. Researchers wanted to see if this tiny wire could successfully pace the left ventricle in 39 adults getting a new pacemaker or …

This study looked at how eating disorders, like anorexia or bulimia, impact blood sugar levels in women aged 18-40 with type 1 diabetes. Researchers compared glucose control between those with and without eating disorders. The goal was to better understand this link and improve s…

This study tested a new method to measure how well the body can suppress parathyroid hormone (PTH) using a single oral dose of cinacalcet. It involved 36 participants: healthy adults and patients with primary hyperparathyroidism. The goal was to see if the cinacalcet test works a…

This study tested whether a mild, non-invasive electrical stimulation applied under the chin could change brain activity related to swallowing. Ten healthy adults without swallowing problems took part. The goal was to see if this simple technique could affect the brain's control …

This study explored whether specific gene variations are linked to suicide attempts in teenagers. Researchers compared the DNA of 250 adolescents, some who had attempted suicide and some who had not. The goal was to identify genetic risk factors that might help predict and preven…

This study looked at 196 adults with septic shock in intensive care to see if a blood test measuring immature platelets could predict their risk of death or organ failure at 28 days. The goal was to find a cheap, routine test to identify high-risk patients early. The study did no…

This study looked at how the immune system's T-cells respond to the COVID-19 virus in hospitalized patients. Researchers measured the number of T-cells that produce a key immune signal (interferon-gamma) when exposed to the virus's spike protein. The goal was to better understand…

This study looked at why some people with pemphigus, a rare skin disease, feel more vulnerable than others. Researchers interviewed 48 patients to understand how misdiagnosis, disagreements with doctors, and use of health information affect their experience. The goal was to ident…

This study looked at whether women who have never given birth (nulliparous) feel more pain during IUD insertion than those who have (multiparous). Researchers measured pain right after insertion and 5 minutes later using a 0-10 scale. The goal is to help doctors better prepare pa…

This study looked at whether certain genetic changes in colon cancer tumors can help predict if the cancer will return after surgery. Researchers tested tumor tissue from 401 people with stage II or III colon cancer using a special method called QMPSF. The goal was to see if thes…

This study looked at 99 healthy full-term newborns to count and classify ear shape differences. Doctors took photos and sorted each ear as normal or having an anomaly, then labeled anomalies as either deformities (caused by outside forces like position in the womb) or malformatio…

This study looked at whether L-lysine, a common amino acid, can change levels of the hormones aldosterone and cortisol in healthy men. Twenty volunteers took L-lysine or a placebo for 13 days, then switched. The goal was to learn how the body controls these hormones, not to treat…

This study looked at 27 adults in intensive care to understand the inflammation behind macrophage activation syndrome (MAS) triggered by bacterial sepsis. MAS is a serious condition with a high death rate, and current treatments are not well-defined. By measuring specific inflamm…

This study looked at families with at least two members diagnosed with Alzheimer's before age 65. Researchers searched for new genes that might cause the disease, beyond the three already known. The goal was to better understand the biology of Alzheimer's and improve genetic test…

This study examined 22 people with early-stage lung cancer to see if immune cells in the blood match those inside tumors. Researchers used advanced cell analysis to create a detailed immune profile. The goal was to find a simple blood marker that could help doctors monitor the im…